Postmortem Computed Tomography Research Articles

The usability of postmortem CT head as a means of identification

The usability of postmortem CT head as a means of identification

Pericardial Effusion Detection on Post-Mortem Computed Tomography Images Using Convolutional Neural Networks.

Pericardial effusion can be a sign of significant underlying diease and, in some cases, may lead to death. Post-mortem computed tomography (PMCT) is a well-established tool to assist death investigation processes in the forensic setting. In practice, the scarcity of well-trained radiologists is a challenge in processing raw whole-body PMCT images for pericardial effusion detection. In this work, we propose a Pericardial Effusion Automatic Detection (PEAD) framework to automatically process raw whole-body PMCT images to filter out the irrelevant images with heart organ absent and focus on pericardial effusion detection. In PEAD, the standard convolutional neural network architectures of VGG and ResNet are carefully modified to fit the specific characteristics of PMCT images. The experimental results prove the effectiveness of the proposed framework and modified models. The modified VGG and ResNet models achieved superior detection accuracy than the standard architecture with reduced processing speed.

Forensic age estimation of the knee by post-mortem DR, CT, and MR imaging: a comparative study

It is believed by many that reference data for age estimation purposes must be imaging-modality specific. A study from our department has however proven otherwise. We therefore found it interesting to investigate this further by looking at the level of agreement between different imaging modalities. The aim of this study was to investigate the level of agreement between the three radiological modalities, computed tomography (CT), magnetic resonance imaging (MRI), and digital radiography (DR), in assessing the ossification of the epiphyses of the knee. A total of 34 deceased individuals of 10–25 years of age, brought in for a medicolegal autopsy at our department, were scanned by CT, MRI, and DR. The ossification stages of the three bones of the right knee, distal femoral, proximal tibial, and proximal fibular epiphysis were assessed using the established combined staging method by Schmeling et al. and Kellinghaus et al. Analysis of the results by Cohen’s weighted kappa showed a good agreement between CT and DR (K = 0.61–0.70), and MRI and DR (K = 0.68–0.79) but only moderate agreement between CT and MRI (K = 0.55–0.57). This leads us to conclude that different radiological images cannot be used interchangeably for age estimation purposes, so reference material needs to be imaging-modality specific. However, to make a more general conclusion research on a larger population is needed.

Death due to sickle cell crisis: a case report.

Sickle cell disease (SCD) is the most common hereditary hemoglobinopathy worldwide. It results in characteristic acute and chronic findings on postmortem computed tomography (PMCT), macroscopic and microscopic examinations. While the diagnostic imaging and macroscopic features are not specific for SCD on their own, when coupled with microscopic features such as sickled erythrocytes and evidence of chronic venous congestion (i.e., Gamna-Gandy bodies), these clues can help alert forensic pathologists to the presence of SCD. Despite the prevalence of the disease and the constellation of findings alluded to above, SCD is not often explored in forensic pathology literature. This case demonstrates classic acute and chronic features of SCD on PMCT, macroscopic and microscopic examinations. It explores the pathophysiology leading to sudden and unexpected death in a person with SCD and possible pitfalls in attribution of cause of death.

Postmortem chest computed tomography in COVID-19: A minimally invasive autopsy method

ObjectivesPerforming autopsies in a pandemic scenario is challenging, as the need to understand pathophysiology must be balanced with the contamination risk. A minimally invasive autopsy might be a solution. We present a model that combines radiology and pathology to evaluate postmortem CT lung findings and their correlation with histopathology. MethodsTwenty-nine patients with fatal COVID-19 underwent postmortem chest CT, and multiple lung tissue samples were collected. The chest CT scans were analyzed and quantified according to lung involvement in five categories: normal, ground-glass opacities, crazy-paving, small consolidations, and large or lobar consolidations. The lung tissue samples were examined and quantified in three categories: normal lung, exudative diffuse alveolar damage (DAD), and fibroproliferative DAD. A linear index was used to estimate the global severity of involvement by CT and histopathological analysis. ResultsThere was a positive correlation between patient mean CT and histopathological severity score indexes - Pearson correlation coefficient (R) = 0.66 (p = 0.0078). When analyzing the mean lung involvement percentage of each finding, positive correlations were found between the normal lung percentage between postmortem CT and histopathology (R=0.65, p = 0.0082), as well as between ground-glass opacities in postmortem CT and normal lungs in histopathology (R=0.65, p = 0.0086), but negative correlations were observed between ground-glass opacities extension and exudative diffuse alveolar damage in histological slides (R=−0.68, p = 0.005). Additionally, it was found is a trend toward a decrease in the percentage of normal lung tissue on the histological slides as the percentage of consolidations in postmortem CT scans increased (R =−0.51, p = 0.055). The analysis of the other correlations between the percentage of each finding did not show any significant correlation or correlation trends (p ≥ 0.10). ConclusionsA minimally invasive autopsy is valid. As the severity of involvement is increased in CT, more advanced disease is seen on histopathology. However, we cannot state that one specific radiological category represents a specific pathological correspondent. Ground-glass opacities, in the postmortem stage, must be interpreted with caution, as expiratory lungs may overestimate disease.

Living and post-mortem CT scans in the gross anatomy lab: A study investigating differences in first-year medical students' exam performance and perceptions.

Basic competency in radiological imaging is essential for physicians to identify and manage diseases. An optimal place in which to include imaging in the medical curriculum is during anatomy as students can correlate the 3D anatomy from their body donors with the 2D cross-sectional anatomy. The goal of this project was to enhance first-year medical students' knowledge of cross-sectional imaging in the gross anatomy lab and to investigate whether there are benefits to learning cross sectional imaging via scans from body donors versus living individuals. Student participant performance was evaluated on laboratory practical examinations, CT image questions and spatial anatomical knowledge in the thorax and abdomen sections of gross anatomy. Students learned the cross-sectional imaging during dissections where they accessed the images relevant to their study on Pacsbin, a web-based Digital Imaging and Communication in Medicine viewer, via iPads. Results showed no statistically significant differences in practical examination scores, spatial anatomical knowledge, or identification of anatomical structures on CT image questions between participants who learned from images on body donors versus living individuals. In a questionnaire given at the end of the course, participants cited that the CT images improved their anatomical and imaging knowledge and that they felt better prepared to use imaging software and interpret diagnostic imaging results upon entering clerkships. While there were no differences in academic performance between the groups, positive outcomes regarding student perceptions of anatomical and imaging knowledge and preparedness for use of imaging software were identified in this study.

Postmortem temporal chest CT and its pathological correlation in piglets.

Post-mortem computed tomography (PMCT) is a useful tool to investigate the cause of death. To appropriately use PMCT for cause-of-death analysis, it is necessary to know natural courses after death such as hypostasis in the lungs. We aimed to investigate the natural time-course change of postmortem chest CT findings and its pathological correlation in piglets. Serial chest PMCT scans of four piglets were performed each hour for 24 h and the chronological changes of the lung were evaluated. Immediately after the final CT scan, the autopsy was conducted and bilateral lungs were taken for pathological examination. Two additional piglets were sacrificed and pathological specimens were prepared immediately after death for reference. On pulmonary PMCT, ground glass attenuation (GGA) appeared after the first several hours and increased gradually. Histologically, GGA corresponded to pulmonary edema. The time-related increase in CT attenuation was more prominent in the dorsal lung. Consolidation, endotracheal air defects, and pleural effusion were not observed on PMCT. GGA appeared after the first several hours and increased gradually, and it corresponded to pulmonary edema. GGA in the lung as one of the natural postmortem processes needs to be distinguished from pathogenic findings depending on the time elapsed since death. J. Med. Invest. 71 : 232-236, August, 2024.

Finding the Truth: Cadaver and CT scan Study of Differences in Glenoid Width Size in the Indian Population.

Glenoid mass issues have been extensively published in the recent literature. The controversy arose from our need to compare and obtain the appropriate implant size for reverse shoulder arthroplasty patients. Some well-known authors and surgeons say that Indian patients have a smaller glenoid than their Western friends and patients. Therefore, we decided to examine the glenoid size obtained on a computed tomography (CT) scan and the size obtained on a cadaver, preferably the same cadaver in tertiary care medical school. Necessary permissions were obtained from the relatives of the cadaver, the ethical board, the anatomy department, and the radiology department. We evaluated 3D CT scans of 100 patients from our medical college during the global pandemic. Of these, we evaluated only 12 patients whose families agreed to postmortem studies and CT scans. Our research focuses on the shoulder of non-orthopedic diseases conducted at KCGMCH and measured the glenoid height, width, and version using a commercially available computer. The mean age of the patients was 38.5 (range 19-59). The mean glenoid height was 33.8 ± 3.2 mm, maximum glenoid width was 24.3 ± 2.2 mm. The mean glenoid version is 3.48 ± 4 retrospectively. The glenoid width appears to be 23-25 mm on CT scan film, which is similar to cadaver studies. The findings from the cadaver study indicate that the average glenoid size is smaller in the Indian demographic when compared to CT scans. Glenoid width is less in one subset of the population, especially female patients than of the average population than Westerners. However, our studies are limited by the small size of the population and a larger study is recommended in our institution in the future. A better understanding of this glenoid size could help us design a smaller glenoid plate plan, especially for patients in the Indian subcontinent.

Noninvasive postmortem investigation of cases refusing autopsy using computed tomography

Background: CT is a well-known tool to assess several conditions in living patients. The post-mortem CT (PMCT) has been introduced to determine the cause of death in dead subjects. CT is also the imaging modality of choice for the analysis of autopsy findings including fracture, hematoma, gas collection and gross tumor injury. The rate of standard autopsy is continuing to decline and there are several reasons for refusing autopsy. Objective: The current research endeavor is investigate the usefulness of computed tomography (CT) in cases refusing autopsy. Materials and Methods: In this study, the PMCT were evaluated in 150 subjects in different contexts of death. The causes of death were classified into four categories which include a definite cause of death, a possible cause of death, a minor pathological finding and no fatal findings. For the definite cause of death and the possible cause of death, the specific lesions are described in detail. Results: The definite cause of death was detected in 48 (32%) of the subjects. The possible cause of death was detected in 18 (12%) of the subjects. The remaining 84 subjects were classified into minor pathological findings and no fatal findings in 46 (30.7%) and 38 (25.3%) of the patients, respectively. The fatal lesions of PMCT were found in 93 lesions(48 subjects) that were demonstrated by anatomical locations into the traumatic bone, intracranial, spine, thoracic, heart leak and abdominal lesions. We found definite causes of death in 6 subjects, which had no history of trauma and malignancy and were mentioned about a cardiopulmonary failure as a cause of death at first. Conclusion: The PMCT is a useful tool for identifying the cause of death in many cases that have limitations for conventional autopsy. The morphological change such as intracranial hemorrhage is easily diagnosed with PMCT. The PMCT appears to be an alternative tool to assess the cause of death in any reason of objections.

Noninvasive estimation of heart organ mass by postmortem magnetic resonance imaging and computed tomography compared to conventional autopsy in fetuses: a pilot study

ObjectivesThe purpose of this pilot study is to investigate the accuracy of mass estimation of the heart using postmortem MRI and CT in this population. MethodsThe mass of the heart was estimated using three different methods: sequential segmentation of the right and left ventricles by MRI in 30 patients; sequential segmentation of the left ventricle chamber using CT and an ellipsoid method of the left ventricle (LV) using CT in 6 patients. The estimated mass by each method was compared to conventional autopsy mass using linear regression. ResultsThe correlation between estimated and measured cardiac mass using postmortem MRI measurements of the right and left ventricles, CT derived volumes of the left ventricle, or by the LV ellipsoid CT method are as follows: y = 0.87744x - 0.74813 (R2 = 0.958); y = 0.6004x - 2.16 (R2 = 0.8681); y = 0.6019 - 2.1615 (R2 = 0.8599), respectively. When separating the fetuses evaluated by pmMRI into a ≤20 weeks subset or >20 weeks subset, the correlation are as follows: y = 0.5176x + 0.2428 (R2 = 0.645) and y = 0.91237x - 1.53647 (R2 = 0.9475), respectively. ConclusionMass of the heart at autopsy modestly correlates with MRI derived volumes measuring the right and left ventricles. The small sample in the CT derived volume of the left ventricle alone or by the simplified estimated method using the ellipsoid measurements of the left ventricle by CT compared to autopsy weights make it difficult to conclude CT's utility using these methods.

Normal Distal Tibiofibular Syndesmosis Assessment Using Postmortem Computed Tomography (PMCT).

Distal tibiofibular syndesmotic injuries, often misdiagnosed, can lead to substantial morbidity. This study utilized postmortem computed tomography (PMCT) to define normal syndesmotic relationships in 131 subjects. Three parameters were measured: fibular rotation (FR), sagittal translation (ST), and incisura depth (ID). Interobserver reliability was excellent for FR and ID but moderate for ST. Anatomical variability was wide, with FR ranging from -0.4° to 16.6°, ST from 0.33 mm to 3.49 mm, and ID from 1.89 mm to 6.05 mm. Side-to-side variability within subjects was minimal. Gender-specific differences were observed in ST, possibly due to size variations, highlighting the need for gender-specific diagnostic criteria. Although establishing universal reference values is challenging, using contralateral ankles for comparison can enhance diagnostic accuracy in syndesmotic injuries. This study, the first of its kind, offers valuable insights into normal distal tibiofibular syndesmotic relationships based on PMCT data. Future validation studies in patients with syndesmotic injuries can further improve diagnostic accuracy.

Detection of pulmonary thrombembolism and postmortem clotting on postmortem magnetic resonance imaging

The purpose of this study was to develop a feasible imaging protocol superior to postmortem computed tomography (PMCT) and to establish diagnostic parameters for diagnosing pulmonary thromboembolism (PE) on postmortem magnetic resonance imaging (PMMR).The study collective of 113 subjects was prospectively investigated by PMMR for the presence of PE and / or postmortem clotting (cruor). PE was detected in 20 cases; the remaining 93 cases were investigated for the morphology of cruor. Age grading was performed by PMMR, autopsy and histology. The postmortem sedimentation effect was used for the applied imaging protocol on PMMR (supine and prone position). Visual distension of the pulmonary arteries in PE was seen in all cases, but not in the controls. Re-positioning of the corpse from supine in prone position proved to be beneficial in 90 %. Postmortem motion artifacts are firstly described in 20.4 %. Hyperacute PE (grade 1) presented with a homogenous and hypointense signal on T2w images, acute PE (grade 2) with slightly heterogeneous, but still homogenous hypointense signal, subacute PE (grade 3) was with heterogeneous and slightly hyperintense signal and chronic PE (grade 4) with predominately homogenous with scarce portions of heterogeneous but hyperintense signal. PMMR allowed for the detection of PE and for in situ depiction of combined age grading.

Post-mortem CT service structures in non-suspicious death investigations

Abstract Post-mortem CT (PMCT) is increasingly used in adult post-mortem investigations as a non-invasive alternative to traditional autopsies. Using PMCT supports death investigations in the face of severe pathologist workforce shortages and the less invasive nature maintains respect for cultural sensitivities. This article reviews the diverse service structures of PMCT, highlighting the importance of customizing these structures to meet the specific needs of various coronial jurisdictions. These jurisdictions often face challenges such as limited access to imaging facilities and logistical issues with geographically dispersed mortuaries. We outline options for leading and operating PMCT services, including models led by pathologists, radiologist, or a hybrid of the two; use of static, relocatable, or mobile CT scanning units; as well as making the most of existing resources such as NHS or private scanning facility scanners already in place. We also explore different PMCT reporting structures through in-house NHS radiologists, combined in-house and teleradiology, or fully outsourced teleradiology services. Each of these offerings provides different levels of efficiency, cost-effectiveness, data security and challenges to set-up. Where applicable, we present and describe real-world examples as case studies for readers interested in replicating existing models.

Knowledge and attitudes of Polish prosecutors and general Polish population in regard to post-mortem computed tomography in 2019.

Post-mortem computer tomography (PMCT) is an imaging technique that is gaining popularity both worldwide and in Poland. It provides certain benefits in death investigation that a conventional autopsy is not able to, however, it has significant limitations. As PMCT and post-mortem computed angiography (PMCTA) continue to develop in this country, it is critical to become aware what people know and think about these imaging techniques, especially the prosecutors who officially order such examinations to be performed. In 2019, two concurrent surveys were administered to Polish prosecutors and general Polish population, respectively, regarding their current knowledge and opinions on PMCT. The results were collected both online and on paper, and then subjected to analysis. In total, 92 prosecutors and 227 non-prosecutors responded to the survey. The present authors observed that while prosecutors were more likely to have heard of this examination than the general public, their knowledge was often inadequate or incorrect. Conventional autopsy was still held as the gold standard in death investigation. However, a good popular sentiment towards PMCT was shown, and a desire to learn more about it - not just among prosecutors, but among the general public as well. The present authors' recommendation is that more courses and training should be organised for Polish prosecutors to compensate this knowledge gap.

Technical note: Interest of focused fields in post-mortem computed tomography using photorealistic images for age at death estimation from the pubic symphysis

IntroductionThe morphological assessment of the pubic symphysis using the Suchey-Brooks method is considered a reliable age at death indicator. Age at death estimation methods can be adapted to the images obtained from post-mortem computed tomography (PMCT). The aim of this study is to evaluate the utility of pubic symphysis photorealistic images obtained through Global illumination rendering (GIR) for age at death estimation from whole-body PMCT and from focused PMCT on the pubic bone. Materials and MethodsWe performed virtual age at death estimation using the Suchey Brooks method from both the whole-body field of view (Large Field of View: LFOV) and the pubis-focused field of view (Small and Field of View: SFOV) of 100 PMCT. The 3D photorealistic images were evaluated by three forensic anthropologists and the results were statistically evaluated for accuracy of the two applied PMCT methods and the intra- and inter-observer errors. ResultsWhen comparing the two acquisitions of PMCT, the accuracy rate reaches 98.5% when using a pubic-focused window (SFOV) compared to 86% with a whole-body window (LFOV). Additionally, the intra- and inter-observer variability has demonstrated that the focused window provides better repeatability and reproducibility. ConclusionAdding a pubic-focused field of view to standard PMCT and processing it with GIR appears to be an applicable technique that increases the accuracy rate for age at death estimation from the pubic symphysis.

Examination of the Cerebellomedullary Cistern Using Postmortem Computed Tomography in Various Types of Intracranial Hemorrhage

Intracranial hemorrhage is a major cause of sudden unexpected death and its identification is important for death investigations. Cisternal puncture of the cerebellomedullary cistern (CMC) can be used to identify intracranial hemorrhage during postmortem examination. Intracranial hemorrhage comprises various types of hemorrhage, and the possibility of hemorrhage identification by cisternal puncture can differ according to the type of intracranial hemorrhage. Postmortem computed tomography (PMCT) is non-invasive and can be performed before autopsy. In this study, we aimed to identify the hemorrhage in the CMC using PMCT in cases of various intracranial hemorrhage. PMCT was performed before the autopsy. Autopsy reports and PMCT were retrospectively reviewed for 108 cases of intracranial hemorrhage confirmed by conventional autopsy. Hemorrhagic regions showed ≥60 Hounsfield units on PMCT. Hemorrhage in the CMC was identified in 42.6% (46/108) by PMCT and was frequently identified in the cases of basal subarachnoid hemorrhage (SAH) (19/21). Hemorrhage in the CMC was identified in approximately 50% of patients with non-basal SAH and intracerebral hemorrhage. Detection of hemorrhage in the CMC by PMCT is hindered by several factors, such as dental artifacts. This study does not guarantee the usefulness of postmortem cisternal puncture. However, this study verified hemorrhage in the CMC according to the various types of intracranial hemorrhages using PMCT and showed its possibilities and limitations.

Classification of rib fracture types from postmortem computed tomography images using deep learning.

Human or time resources can sometimes fall short in medical image diagnostics, and analyzing images in full detail can be a challenging task. With recent advances in artificial intelligence, an increasing number of systems have been developed to assist clinicians in their work. In this study, the objective was to train a model that can distinguish between various fracture types on different levels of hierarchical taxonomy and detect them on 2D-image representations of volumetric postmortem computed tomography (PMCT) data. We used a deep learning model based on the ResNet50 architecture that was pretrained on ImageNet data, and we used transfer learning to fine-tune it to our specific task. We trained our model to distinguish between "displaced," "nondisplaced," "ad latus," "ad longitudinem cum contractione," and "ad longitudinem cum distractione" fractures. Radiographs with no fractures were correctly predicted in 95-99% of cases. Nondisplaced fractures were correctly predicted in 80-86% of cases. Displaced fractures of the "ad latus" type were correctly predicted in 17-18% of cases. The other two displaced types of fractures, "ad longitudinem cum contractione" and "ad longitudinem cum distractione," were correctly predicted in 70-75% and 64-75% of cases, respectively. The model achieved the best performance when the level of hierarchical taxonomy was high, while it had more difficulties when the level of hierarchical taxonomy was lower. Overall, deep learning techniques constitute a reliable solution for forensic pathologists and medical practitioners seeking to reduce workload.

Applicability of postmortem CT organ-selective volume rendering in evaluating liver and heart injuries

ObjectivesPostmortem computed tomography (PMCT) is widely used in forensic cause-of-death investigations, and 3D volume rendering is commonly employed for visualizing PMCT data. However, no studies have investigated the effectiveness of organ-selective 3D volume rendering for detection of organ injuries such as liver and heart. This study aimed to assess whether selective volume rendering could enhance the detectability of organ damage that is generally difficult to observe in 2DCT images. Material and methodsUsing 22 selected cases of liver or heart injury, the detectability of the injury in 2DCT images and selective volume-rendered images was compared with actual autopsy findings. ResultsAmong 15 cases of liver injury confirmed at autopsy, 2DCT imaging detected two, whereas selective volume-rendered imaging detected one. Furthermore, among 17 cases of cardiac injury, 2DCT imaging detected two, whereas selective volume-rendered imaging detected four. Thus, a small proportion of liver and heart injury cases were detectable using 2DCT imaging or selective volume rendering. In all cases where selective volume rendering identified an injury, the injury was not identified by radiologist interpretation of the 2DCT images, although a review of the 2DCT images did allow identification of the injury when corroborated by the findings of selective volume rendering. One additional case demonstrated the usefulness of selective volume rendering for estimation of puncture wound direction. ConclusionsAlthough selective volume rendering has seldom been effective in detecting heart or liver damage, organ-selective volume rendering may provide clues for detection of injuries that are often overlooked in 2DCT images alone.

Fatal upper aerodigestive tract obstruction in an East Asian finless porpoise (Neophocaena asiaeorientalis sunameri): findings in post-mortem computed tomography.

The present case report aims to outline the post-mortem findings of an East Asian finless porpoise with upper aerodigestive tract obstruction using different post-mortem computed tomography (PMCT) visualization techniques and discusses the potential cause of death of this individual. A dead-stranded adult male East Asian finless porpoise was recovered from the Northern coast of Jeju Island, Republic of Korea. The carcass was frozen in Jeju National University within 2h upon first reported. The PMCT examinations were performed at 120 kVp, 200 mAs with a section thickness of 1mm. The scan field of view (sFOV) was set to 400mm. Four image rendering techniques, including multi-planar reconstruction, three-dimensional volume rendering, perspective volume rendering, and minimum intensity projection technique, were used to aid the diagnosis of upper aerodigestive tract obstruction in the stranded finless porpoise. Conventional necropsy was performed to provide a complete necropsy report. Using PMCT, a Sebastidae of 24cm measured length was found to be lodged in the left pharyngeal food channel and esophagus of the finless porpoise. Hard rays of the pectoral fin of the lodged fish have impaled the esophageal mucosa. Fishing gear was found to embed at the dorsal side of the lodged fish. The trachea was compressed ventrally and the arytenoepiglottic tube opening has been narrowed, which may precipitate to the finless porpoise difficult breathing. Pulmonary hyperinflation, pulmonary edema, pneumothorax, pneumopericardium, and pneumorrhachis were observed. This case report represents the first documentation of potential radiological indicators of upper aerodigestive tract obstruction in the East Asian finless porpoise using PMCT. Spatial location of the lodged item could be rendered in situ as the time of death. It has demonstrated that PMCT could provide objective measurements to adjunct the necropsy findings in diagnosis of fatal aerodigestive tract obstruction in stranded cetaceans.

On the estimation of hip joint centre location with incomplete bone ossification for foetus-specific neuromusculoskeletal modeling

Childbirth is a complex physiological process in which a foetal neuromusculoskeletal model is of great importance to develop realistic delivery simulations and associated complication analyses. However, the estimation of hip joint centre (HJC) in foetuses remains a challenging issue. Thus, this paper aims to propose and evaluate a new approach to locate the HJC in foetuses. Hip CT-scans from 25 children (F = 11, age = 5.5 ± 2.6 years, height = 117 ± 21 cm, mass = 26 kg ± 9.5 kg) were used to propose and evaluate the novel acetabulum sphere fitting process to locate the HJC. This new approach using the acetabulum surface was applied to a population of 57 post-mortem foetal CT scans to locate the HJC as well as to determine associated regression equations using multiple linear regression. As results, the average distance between the HJC located using acetabulum sphere fitting and femoral head sphere fitting in children was 1.5 ± 0.7 mm. The average prediction error using our developed foetal HJC regression equations was 3.0 ± 1.5 mm, even though the equation for the x coordinate had a poor value of R2 (R2 for the x coordinate = 0.488). The present study suggests that the use of the acetabulum sphere fitting approach is a valid and accurate method to locate the HJC in children, and then can be extrapolated to get an estimation of the HJC in foetuses with incomplete bone ossification. Therefore, the present paper can be used as a guideline for foetus specific neuromusculoskeletal modelling.