SESSION TITLE: Global Case Report Posters SESSION TYPE: Global Case Reports PRESENTED ON: 10/23/2019 09:45 AM - 10:45 AM INTRODUCTION: Antineutrophil cytoplasmic autoantibody (ANCA) - associated vasculitides are rare immune mediated diseases, associated with the crosstalk between an initiating event and a host’s immune response. We present a critically ill patient with ANCA-vasculitis temporarily associated with H1N1 Influenza A infection, with alveolar hemorrhage, acute respiratory distress syndrome (ARDS) and glomerulonephritis, requiring extracorporeal membrane oxygenation (ECMO) support and renal replacement therapy (RRT). CASE PRESENTATION: A 22 years old previously healthy female was admitted to a general hospital complaining about fever and productive cough for five days. On her admission, she presented with hypoxemic respiratory failure and her chest X-ray revealed bilateral opacities, consisted with ARDS. She was intubated, and prone mechanically ventilated in the intensive care unit (ICU) because of refractory hypoxemia. A multiplex polymerase chain reaction (PCR) test revealed H1N1 Influenza A virus in bronchial secretions, and oseltamivir was administered. She also developed hemoptysis and progressive anemia, consistent with alveolar hemorrhage. Moreover, she showed hematuria, while the urine sediment revealed dysmorphic red blood cells and casts. Her serologic testing was positive for cANCA and anti-proteinase 3 (PR3). Therefore, a diagnosis of cANCA vasculitis with respiratory tract and renal involvement was confirmed. The patient was treated with rituximab, cyclophosphamide and intravenous methyl prednisone. She also required veno-venous ECMO support for 12 days due to refractory hypoxemia, and RRT because of acute kidney injury. Her organ dysfunction gradually improved, permitting weaning from ECMO, mechanical ventilation and RRT, and subsequent discharge from ICU fifteen days later and from hospital on day twenty-three DISCUSSION: We presented a case of cANCA vasculitis possibly associated with Influenza A infection. The pathogenesis of this heterogeneous group of diseases remains obscure, while the responsible initiating events might be infectious, genetic of environmental. To our knowledge this is a first case of vasculitis possibly related to a viral infection. Autoimmune responses rarely leading to vasculitis, have been reported as side effects of annual influenza vaccination. The influenza antigen might trigger the autoimmune mechanism by several mechanisms including molecular mimicry: a similarity between host and microbial antigen, leading to activation of autoreactive B and T cells which stimulate the autoimmune response. Our patient responded to the immunosuppressive therapy while the ECMO and CRRT support were used as time-buying strategies. CONCLUSIONS: Influenza A infection might be a precipitating factor for ANCA-associated vasculitis in predisposed patients. Further studies are required to examine the exact role of viral infections in the pathogenesis of autoimmune diseases Reference #1: Duggal T et al. ANCA vasculitis associated with Influenza vaccination.Am J Nephrol 2013;38:174-178 Reference #2: Daoud A et al. Pulmonary Complications of influenza infection: a targeted narrative review. Postgraduate Medicine 2019 DISCLOSURES: No relevant relationships by Apostolos Armaganidis, source=Web Response No relevant relationships by Evangelia Chrysanthopoulou, source=Web Response no disclosure on file for Chryssi Diakaki; No relevant relationships by Frantzeska Frantzeskaki, source=Web Response No relevant relationships by DIMITRIOS KONSTANTONIS, source=Web Response No relevant relationships by Maria Theodorakopoulou, source=Web Response No relevant relationships by Iraklis Tsangaris, source=Web Response
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