Background: Rabies is 100% preventable disease. Complete post-exposure prophylaxis is necessary among the animal bite victims for complete protection. But it takes about 1 month to complete the schedule therefore drop-outs arise. Proper counselling can be given to make them adherent. Therefore this study is done to determine the compliance rate in two different groups with and without Information Education and Communication (IEC) material counselling and also to determine the constraints for compliance to anti-rabies vaccination (ARV). Methods: A non-randomized trial was conducted in the anti-rabies clinic of Victoria Hospital, Bengaluru from March 1 st to June 30 th 2016. All the new cases were given routine oral counselling without IEC material during March and April month (Group I) and with IEC material during May and June month (Group II). The number of study subjects was 459 (169 + 290) after excluding those patients who could not be contacted through telephone, re-exposure and pre-exposure vaccination cases. Data was collected on record basis and through telephonic conversation. Descriptive statistics and chi-square test was used to analyze the data. Results: 119 (70.4%) from group I (169) and 263 (90.7%) from group II (290) were compliant to complete course of ARV. Compliance rate had increased by 20.3% in Group-II. Conclusions: Counselling with IEC material had made a significant impact on patient’s attitude and behaviour thereby reducing drop-outs.