Background: The most frequent post-cesarean consequences include pain and anxiety which is uncomfortable for women and has increased the use of natural remedies such as deep tissue massage. Aim: To investigate the effect of deep tissue massage on post-cesarean women's pain and anxiety. Design: A quasi-experimental design was utilized to accomplish this study. Setting: The study was conducted at the postpartum department at Sohag University Hospital. Subjects: Included 100 post-cesarean women of a convenient sample assigned into two equal groups study and control) were enrolled in the previously selected setting. Tools: I: Demographic and obstetric assessment sheet, II: Visual Analogue Scale, and III: State-Trait Anxiety Inventory. Results: a highly statistically significant difference was found in post-cesarean women's pain and anxiety between the two groups p<0.01. Conclusion: Deep tissue massage application has a vital role in reducing post-cesarean women's pain and anxiety. Recommendations: Deep tissue massage is recommended to be applied for post-cesarean women to reduce post-cesarean pain and anxiety.