Possible Role Of Histamine Research Articles

SPECIES RESISTANCE TO HISTAMINE AND ENDOTOXIN: THE RESPONSE OF THE CHICKEN.

SummaryHemodynamic and lethal effects of endotoxin in the chicken were studied. It was noted that the unanesthetized bird is highly resistant to endotoxin, all animals surviving intravenous doses up to 40 mg/kg. Systemic arterial hypotension and a slight degree of hemodilution were observed in the anesthetized chicken given 10 mg/kg endotoxin. The possible role of histamine is discussed.

Possible role of histamine in rat pregnancy

Possible role of histamine in rat pregnancy

A possible role for histamine in larval growth

Le rôle possible de l'histamine au cours de la croissance larvaire a été étudié. L'inhibition de l'oxydase des diamines au moyen de l'aminoguanidine, a fortement ralenti la croissance larvaire duTribolium confusum. Cette substance, cependant, ne s'est pas avérée toxique. D'autre part l'inhibition des décarboxylases par le semicarbazide ou le deoxypyridoxine ne modifie pas la croissance sans devenir toxique.

Production of peptone shock in mice following administration of H. pertussis vaccine.

SummaryPopulations of ABC and Swiss-Webster male and female mice were found to be resistant to peptone, but an increased susceptibility to peptone with a lethal outcome could be produced by prior treatment with pertussis vaccine. Mice rendered susceptible to peptone with pertussis vaccine could be protected with the antihistaminic agent, Benadryl, with chlorpromazine and with cortisone. The possible role of histamine in the increased susceptibility of mice to peptone, produced by pertussis vaccine, has been discussed.