The therapeutic value of various immunotherapeutic preparations (gonovaccine, milk, own blood), which is now universally recognized, does not exclude, however, the possibility of disagreement on the issue of their dosage and the duration of the intervals between individual injections. In view of the great complexity and difficulty in applying the existing laboratory methods of determining the biphasic reaction of the body (opsonic index) in wide practice, the authors are trying to find a sub-method in the changes from the blood.