Background: A pneumonia outbreak with an unknown etiology broke out in Wuhan, China, and quickly spread worldwide. Coronavirus 2 is a new coronavirus that causes severe acute respiratory syndrome (SARS-CoV-2). This study will look at coronavirus in people who don’t have any symptoms and test the sensitivity, specificity, and accuracy of the tests used to detect COVID-19. Methods: This study included 300 people who appeared to be in good health. Nasal swabs were taken and placed in a viral transport media (VTM), which was then tested using real-time polymerase chain reaction (RT-PCR) and a rapid test for anti-COVID-19 antibody (IgM, IgG). The reverse method was used to look at blood groups. Finally, a Hemolyzer III was used to count total leukocytes and granulocytes in peripheral blood. Results: The present study included 176 males (58.7 %) and 124 females (41.3%). The age range was between 10 to 69 years. There is a non-significant difference (p ˃ 0.05) between the blood group and carry coronavirus in apparently healthy individuals. There was a highly significant decline (p ≤ 0.01) in total leukocytes count in positive RT-PCR subgroup was 4.1 ± 0.1*10⁹. Also total leukocytes count significantly decline (p ≤ 0.05) in positive of both RT-PCR and the rapid test was 4.5 ± 0.1*10⁹/L, a non-significant difference (p ˃ 0.05) between total leukocytes count and favorable rapid test subgroup comparison with negative test subgroup. This result shows a significant decrease (p ≤ 0.05) in granulocyte count in the positive RT-PCR test subgroup and in the positive of both RT-PCR and rapid test subgroup was 4.07 ± 0.11*10⁹/L, 4.1 ± 0.10*10⁹, respectively. There is a non-significant difference (p ˃ 0.05) in the positive rapid test subgroup 4.5 ± 0.12*10⁹/L and compared with the negative test subgroup. © 2021, Dr. Yashwant Research Labs Pvt. Ltd.. All rights reserved.