Positive Feedback Research Articles

Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression.

An increase in the total choline-containing compound content is a common characteristic of cancer cells, and aberrant choline metabolism in cancer is closely associated with malignant progression. However, the potential role of choline-induced global transcriptional changes in cancer cells remains unclear. In this study, we reveal that an elevated choline content facilitates hepatocellular carcinoma (HCC) cell proliferation by reprogramming Krüppel-like factor 5 (KLF5)-dominated core transcriptional regulatory circuitry (CRC). Mechanistically, choline administration leads to elevated S-adenosylmethionine (SAM) levels, inducing the formation of H3K4me1 within the super-enhancer (SE) region of KLF5 and activating its transcription. KLF5, as a key transcription factor (TF) of CRC established by choline, further transactivates downstream genes to facilitate HCC cell cycle progression. Additionally, KLF5 can increase the expression of choline kinase-α (CHKA) and CTP:phosphocholine cytidylyltransferase (CCT) resulting in a positive feedback loop to promote HCC cell proliferation. Notably, the histone deacetylase inhibitor (HDACi) vorinostat (SAHA) significantly suppressed KLF5 expression and liver tumor growth in mice, leading to a prolonged lifespan. In conclusion, these findings highlight the epigenetic regulatory mechanism of the SE-driven key regulatory factor KLF5 conducted by choline metabolism in HCC and suggest a potential therapeutic strategy for HCC patients with high choline content.

GOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma.

Lenvatinib is a multiple receptor tyrosine kinases inhibitor (TKI) authorized for first-line treatment of hepatocellular carcinoma (HCC). However, Lenvatinib resistance is common in HCC clinical treatment, highlighting the urgent need to understand mechanisms of resistance. Here, we identified Golgi membrane protein 1 (GOLM1), a type II transmembrane protein originally located in the Golgi apparatus, as a novel regulator of Lenvatinib resistance. We found GOLM1 was overexpressed in Lenvatinib resistant human HCC cell lines, blood and HCC samples. Additionally, GOLM1 overexpression contributes to Lenvatinib resistance and HCC progression in vitro and in vivo. Mechanistically, GOLM1 upregulates CSN5 expression through EGFR-STAT3 pathway. Reversely, CSN5 deubiquitinates and stabilizes GOLM1 protein by inhibiting ubiquitin-proteasome pathway of GOLM1. Furthermore, clinical specimens of HCC showed a positive correlation between the activation of the GOLM1-EGFR-STAT3-CSN5 axis. Finally, GOLM1 knockdown was found to act in synergy with Lenvatinib in subcutaneous and orthotopic mouse model. Overall, these findings identify a mechanism of resistance to Lenvatinib treatment for HCC, highlight an effective predictive biomarker of Lenvatinib response in HCC and show that targeting GOLM1 may improve the clinical benefit of Lenvatinib.

Ice Darkening on Turner Glacier in Auyuittuq National Park, Nunavut

The glaciers of the Canadian Arctic are currently the third largest contributor to global sea level rise due to enhanced Arctic warming driving increased glacier melt and runoff (Zemp et al., 2019). Recent modelling suggests that the glaciers of the southern Qikiqtaaluk region, specifically Baffin and Bylot Islands, are 70% more sensitive to 1°C of warming (Brice et al., 2018). However, these studies lack field-based data to contextualize the drivers of glacier change in this region. Light absorbing particles (LAPs) such as dust, ash, and algae lower the albedo of snow and ice, which is the fraction of light a surface reflects, leading to an increase in the absorption of incoming radiation (Aubry-Wake et al., 2022). On glaciers in western Canada (Engstrom et al., 2022), the European Alps (Di Mauro et al., 2020) and south-western Greenland (Cook et al., 2020), positive feedback mechanisms have been discovered where summer snow and ice melt, augmented by LAPs, leads to the localized release of nutrients in ice and the subsequent enhanced growth of algae. Preliminary remote sensing analysis revealing a dark purple hue on glaciers in the Akshayuk Pass region of Auyuittuq National Park in Baffin Island, NU indicate these processes are likely occurring. The question of how this phenomenon is impacting glacier albedo, and therefore glacier melt which has implications for mass balance and regional sea level rise in the Canadian High Arctic has yet to be answered. Field-based sampling of LAPs on Turner Glacier, characterized through light microscopy and scanning electron microscopy, combined with in-situ hyperspectral spectroradiometer measurements (320nm-1100nm) of the sampled LAPs, and fine resolution (1cm) UAV surveys of sampling sites, are integral to develop a field-calibrated remote sensing approach to monitor LAP accumulation on the glacier surface and to assess the associated melt potential.

SP9.6 - Introduction of a Dedicated Motivational Movement Rehabilitation Service to Reduce Length of Stay in Emergency Laparotomy Patients

Abstract Aim Emergency laparotomy patients represent a high-risk group with the need for both physical and emotional recovery post operatively. National audit data demonstrated our institution has a longer length of stay than other health boards. The need to proactively support postoperative mobilisation within this patient group was identified and funding achieved for a period of one year to employ two heath care support workers to provide a dedicated motivational movement service with the aim to reduce overall length of stay (LOS). Method Feedback was sought from staff and patients to inform the roles. The team provide daily individual patient centred movement goals with 1:1 movement support, gain an understanding of 'what matters to you' for every patient and bring positivity, encouragement and enthusiasm to recovery by providing daily motivation and wellbeing support. Results First quarter data since implementation, from March to May 2023, demonstrated a reduction in average and median LOS by 9.5 days and 5.8 days respectively compared to same quarter data from 2022. This was reproduced for the second quarter with average LOS reducing by 9.0 days and median LOS by 6.2 days compared to previous year. 95% of patients were asked ‘What matters to you?’. Feedback from patients and staff about this service has been overwhelmingly positive. Conclusion The introduction of a dedicated 7-day motivational movement service has reliably reduced LOS in this patient group for the first two quarters since implementation. The service has received universally positive feedback indicating the increased quality of recovery felt by patients.

WP6.5 - Setting Up For Success: Supporting New General Surgical Registrars' Non-Operative Technical Skills Development

Abstract Aim Entry into Higher Surgical Training is associated with new challenges to trainees’ clinical, technical, professional and inter-personal skills. A three-day modular “bootcamp” course was designed for new General Surgery ST3s transitioning from Core Surgical Training to bridge the gap and support areas of developmental need. Methods Four varied modules were undertaken by candidates; one focussed on non-operative technical skills in surgery (NOTSS). Following pre-interviews with all stakeholders, immersive scenarios were developed. The programme encompassed operating in a stressful environment with a focus on crisis resource management principles, ward round leadership, theatre prioritisation, difficult communication, and a further workshop on managing bullying and sexual harassment. A multi-professional faculty included anaesthetists, theatre staff, psychiatrists and geriatricians alongside surgeons. Results All 26 trainees were invited to self-rate confidence using a 5-point Likert scale, as well as free text annotation. 13 (50%) completed both pre- and post-course confidence questionnaires. Data showed significant improvement in self-rated confidence across all NOTSS domains, particularly for operating in a stressful environment ("Confident"/ "Strongly Confident" = 69% pre-course to 100% post-course). Free text responses included highly positive feedback for high faculty to trainee ratio allowing detailed personalised feedback, exposure to multi-professional perspectives and opportunities to reflect on difficult professional scenarios. Conclusion Following the success of this course, it has now become part of ST3 Induction in Yorkshire - an opportunity to promote a positive working culture and strengthen professional relationships. A multi-specialty faculty allows for sharing of transferable inter-specialty skills. We recommend all transitional training stages would benefit from embedded induction courses.

Ecological Shifts: Plant Establishment in an Animal-Based Ecosystem

Shifts from saltmarsh to mangroves are well-documented at mangrove poleward boundaries. A regime shift from intertidal oyster (Crassostrea virginica) reefs to mangrove islands has recently been documented in transitional phases in Florida, USA. To understand the local drivers of an oyster/mangrove regime shift and potential tipping points leading to a permanent mangrove state, we tracked all mangrove propagules (n = 1681) across 15 intertidal oyster reefs with or without adult mangroves for 15 months in Mosquito Lagoon, FL. While no propagule bottleneck was observed, few (3.2%) mangrove propagules/seedlings survived on reefs with no prior encroachment, compared to 11.3% and 16.1% on reefs with established older (pre-1943) or newer (1943 to present) adult mangrove stands, respectively. In total, 90.6% of the arriving propagules were from the red mangrove Rhizophora mangle; 13.2% of these were alive at the end of this study. Survival was <1% for black (Avicenna germinans) and 0% for white (Laguncularia racemosa) mangroves. Factors that promoted red mangrove success included close proximity (≤0.3 m) to adult mangroves, especially black mangroves; partial, upright burial of propagules in sediment; and arrival on reefs after annual high-water season. Additionally, once reefs had 50% mangrove cover, the density of red mangrove seedlings increased from 0.04 to 0.46 individuals m−2. Although climate change has alleviated the impact of extreme freezes on mangroves, local factors determine whether the regime shift will be complete and permanent; positive feedback loops associated with established mangroves suggest mangrove recruitment on intertidal oyster reefs will continue to increase.

Development and Psychometric Evaluation of the Lifestyle Medicine Health Behavior Scale

Purpose. The purpose of this study was to develop and validate a scale to measure health behavior across the six pillars of lifestyle medicine: sleep, social connectedness, physical activity, nutrition, substance use, and stress management. A pilot study (n = 94) investigated the construct, convergent, and content validity and reliability of the Lifestyle Medicine Health Behavior (LMHM) scale. Based on the pilot study results and literature, the scale was revised for further psychometric evaluation. Methods. A sample (n = 399) of participants completed the LMHB scale. Confirmatory factor analysis was used to assess construct validity. Face validity was assessed using qualitative feedback. Reliability was assessed using Cronbach’s alpha. Results. The final model included five latent dimensions and one observed to represent each of the distinct pillars in lifestyle medicine. The open-ended response item elicited preponderance of positive feedback (∼80%); the scale was perceived as easy to understand and complete. Overall, the scale was reliable (α = 0.84). Conclusion. The LMHB scale assesses health behaviors across all six lifestyle medicine pillars, addressing each one systematically and individually. The scale had sufficient validity and reliability to measure health behaviors in this sample of adults. This is the first lifestyle medicine survey instrument to evaluate content, face, and construct validity and reliability.

Examining Gen Z's intention using halal toiletries: Theory of planned behavior and perceived risk

Purpose – This study aimed to formulate a conceptual framework to investigate the influence of attitude, perceived behavioral control, subjective norms, financial risk, social risk, and security risk on the intention to use halal toiletries among Gen Z consumers in West Java.Methodology – Purposive sampling was used in this study. The respondents were 400 Gen Z Muslims residing in West Java Province. Data analysis was conducted using Structural Equation Modeling with Partial Least Squares (SEM-PLS).Findings – Variables from the Theory of Planned Behavior (attitude, subjective norms, and perceived behavioral control) positively influenced the intention to use halal toiletries. Financial, social, and security risks negatively impact Gen Z consumers' intentions to use halal toiletries.Implications – Halal toiletries should focus on enhancing product performance to receive positive consumer feedback and increase interest. Additionally, they need to promote community engagement; improve product accessibility and user-friendliness; and address security, social, and financial risks to effectively boost consumer intention.Originality – This research integrates components of risk perception with the Theory to create a comprehensive framework for understanding Gen Z’s intention to use halal toiletries. It contributes to the literature by highlighting how specific types of risks impact consumer intentions and offers actionable recommendations for the halal toiletries industry based on empirical evidence.

Enhancing knowledge transformation in digital education: an analysis of the SECI model’s application in course design and execution

This study investigates the application of the SECI model of knowledge dimensions in the design and execution of educational courses in “Innovation and Digitization Management” and “Data-Based Decision Making” microdegrees, developed within the rapidly evolving educational landscape of 2023 and 2024. The research incorporates a diverse sample of learners across multiple demographics to enhance generalizability. Leveraging natural language processing (NLP) and text analysis, the study explores patterns in course content that correlate with positive learner feedback and effective knowledge transformation. The methodology, combining both quantitative and qualitative approaches, includes data preprocessing, tokenization, vectorization, and clustering to compare and contrast course elements with learner feedback systematically. Preliminary findings indicate that the integration of the SECI model, emphasizing real-time content sharing and example-based learning, significantly enhances the transfer of knowledge from tacit to explicit forms. This research aims to identify a replicable cadence in content preparation that optimizes learning outcomes, applicable to a broad range of educational contexts including data-related courses, innovation, digital transformation or knowledge-management topics.

The Impact of the Nonlinear Integral Positive Position Feedback (NIPPF) Controller on the Forced and Self-Excited Nonlinear Beam Flutter Phenomenon

This article presents a novel approach to impact regulation of nonlinear vibrational responses in a beam flutter system subjected to harmonic excitation. This study introduces the use of a Nonlinear Integral Positive Position Feedback (NIPPF) controller for this purpose. This technique models the system as a three-degree-of-freedom nonlinear system representing the beam flutter, coupled with a first-order and a second-order filter representing the NIPPF controller. By applying perturbation analysis to the linearized system model, the authors obtain analytical solutions for the autonomous system with the controller. This study aims to reduce vibration amplitudes in a nonlinear dynamic system, specifically when 1:1 internal resonance occurs. The Routh–Hurwitz criterion is utilized to evaluate the system’s stability. Furthermore, the frequency–response curves (FRCs) exhibit symmetry across a range of parameter values. The findings highlight that the effectiveness of vibration suppression is directly related to the product of the NIPPF control signal after comparing with different controllers. Numerical simulations, conducted using the fourth-order Runge–Kutta method, validate the analytical solutions and demonstrate the system’s amplitude response. The strong correlation between the analytical and numerical results highlights the accuracy and dependability of the proposed method.

Fostering Equity, Diversity, and Inclusion in medical school admissions through pre-medical mentorship initiatives

Implication Statement ACCESS, a student-led mentorship program affiliated with Schulich School of Medicine & Dentistry, demonstrates a practical, effective approach to addressing inequity in medical education. ACCESS provides personalized, zero-cost mentorship to equity-deserving applicants who face social, financial, and medical barriers that result in underrepresentation in medical school. Our mentorship model showcases significant success in application and interview outcomes, as well as positive feedback from participants. Here, we offer a replicable blueprint for medical schools across Canada. This paper highlights the effectiveness of student-led initiatives in promoting diversity and inclusion in healthcare education and aims to inspire similar programs, fostering a more diverse and inclusive future healthcare workforce.

Osteogenic-Like Microenvironment of Renal Interstitium Induced by Osteomodulin Contributes to Randall's Plaque Formation.

Calcium oxalate (CaOx) kidney stones are common and recurrent, lacking pharmacological prevention. Randall's plaques (RPs), calcium deposits in renal papillae, serve as niduses for some CaOx stones. This study exploresthe role of osteogenic-like cells in RP formation resembling ossification. CaP crystals deposit around renal tubules, interstitium, and blood vessels in RP tissues. Human renal interstitial fibroblasts (hRIFs) exhibit the highest osteogenic-like differentiation potential compared to chloride voltage-gated channel Ka positive tubular epithelial cells, aquaporin 2 positive collecting duct cells, and vascular endothelial cells, echoing the upregulated osteogenic markers primarily in hRIFs within RP tissues. Utilizing RNA-seq, osteomodulin (OMD) is found to be upregulated in hRIFs within RP tissues and hRIFs following osteogenic induction. Furthermore, OMD colocalizes with CaP crystals and calcium vesicles within RP tissues. OMD can enhance osteogenic-like differentiation of hRIFs in vitro and in vivo. Additionally, crystal deposits are attenuated in mice with Omd deletion in renal interstitial fibroblasts following CaOx nephrocalcinosis induction. Mechanically, a positive feedback loop of OMD/BMP2/BMPR1A/RUNX2/OMD drives hRIFs to adopt osteogenic-like fates, by which OMD induces osteogenic-like microenvironment of renal interstitium to participate in RP formation. Weidentify OMD upregulation as a pathological feature of RP, paving the way for preventing CaOx stones.

Editorial for Special Issue “Advances in Computer-Aided Technology II”

The selection of the topic for this Special Issue, Advances in Computer-Aided Technology II, under the section “Mechatronic and Intelligent Machines”, has garnered positive feedback from the scientific community [...]

Development and Evaluation of an Internet of Things Project for Preservice Elementary School Teachers

Programming education is gaining more attention in elementary schools, especially through the use of visual programming tools and development boards. However, the elementary school teacher education in Taiwan allows only limited time periods for training in visual programming and the use of development boards. Development boards are ideal for creating internet of things (IoT) projects, and project-based learning (PBL) is an effective teaching strategy in programming education to promote active learning. Therefore, to sustainably cultivate 21st-century teachers, this study developed an IoT PBL activity for preservice elementary school teachers in Taiwan, so as to improve their attitude toward programming and to enhance their content knowledge of programming teaching, including in computational thinking concepts and knowledge concerning the micro:bit and IoT. This project aimed to engage preservice elementary school teachers in using the micro:bit and electronic modules to create cardboard games with IoT features. A preliminary evaluation was conducted within a teacher education course to verify the project’s feasibility. Consequently, the preservice elementary school teachers participating in this project could develop various IoT cardboard games through teamwork. Their scores on the assessments of computational thinking concepts, development board knowledge, and attitude toward programming showed significant improvement after the project activity. They also expressed highly positive feedback on the project. These findings verify that the proposed PBL activity could be feasible for elementary teacher education.

Unveiling the drivers of satisfaction in mobile trading: Contextual mining of retail investor experience through BERTopic and generative AI

The proliferation of mobile stock trading has introduced various apps with distinct features, emphasizing the need to understand users’ evaluations after adopting the service. This study explores the determinants of retail investors’ satisfaction with mobile stock trading services by employing an advanced textual analysis of customer reviews for four leading trading applications. We utilized Bidirectional Encoder Representations from Transformers (BERT) based Topic modeling (BERTopic modeling) to identify key topics within customer reviews and used the results as input for generative AI to discern the theme and sentiment of each topic. Based on Service Quality (SERVQUAL) theory, topics are categorized into key quality dimensions: functionality, usability, information quality, customer service, and system quality. Regression models were employed to assess the impact of the quality dimensions on investor satisfaction, revealing positive feedback on usability, information quality, and service quality as primary enhancers of satisfaction. In contrast, negative feedback on service quality, system quality, and functionality was identified as the primary inhibitor of satisfaction. This study explores how the influence of each quality dimension varies among different types of brokers (full-service vs. online-only brokerages). Finally, we propose a visualization tool called Topic Rating Impact and Frequency Analysis (TRIFA), which is designed to categorize topics based on their frequency of occurrence and impact on satisfaction. This tool aids in identifying the strengths and areas for improvement in services by effectively visualizing the results of text review analysis. This research not only deepens our understanding of the quality dimensions of mobile financial services but also offers valuable insights for service providers by suggesting predictive models that could help increase customer retention.

Community Outreach, Engagement, and Mentoring Program for Underrepresented Scholars in Cancer Health Disparities.

Racial/ethnic minorities and women are affected by cancer and cancer risk factors at higher rates; however, they are largely underrepresented in scientific professions focused on health disparities. One way to reduce disparities is to increase diversity within the workforce by planning training activities for minority scholars and paying close attention to community outreach. This paper describes the outcomes of a robust community outreach plan engaging communities in education, research, and clinical trials to increase the number of underrepresented student scholars in cancer disparities research through research training, mentorship, and service-learning activities provided within local organizations. The program provided two cohorts of scholars from underrepresented communities with opportunities to attend seminars, present their research to community representatives, and connect with the local community. Cohort 1 consisting of ten scholars participated in a 2-year program that started in the summer of 2018. Cohort 2, consisting of seven scholars, participated in a 1-year program starting in June 2020. Overall, scholars provided positive feedback on all service-learning program activities and the effectiveness of the program in shaping career interests. New procedures developed in response to the COVID-19 pandemic continued the effective management of all components of the program and helped increase engagement with the community outreach staff. The outreach program evaluated here can prepare diverse scholars to enter the workforce with interdisciplinary training for mitigating cancer disparities and serve as a model for planning and implementing similar programs at other institutions.

Do Physicians Improve More from Positive or Negative Feedback?

We use clinical data on more than 240,000 surgeries and quasi-experimental methods to examine how physicians respond to the surprise release of a performance “report card.” Such feedback interventions are commonly used to encourage physicians to improve performance yet show limited evidence of success. Our results show that these limited effects mask heterogeneous behavioral responses to feedback valence. In particular, physicians improve more from positive feedback than from negative feedback, with negative feedback even reducing performance for a nontrivial share of patients. Experiments with laypersons replicate these results and show that struggles with negative feedback can be mitigated by giving incentives directly tied to improvement and by adding qualitative information that helps individuals interpret past performance. These results are consistent with behavioral models that suggest cognitive and emotional difficulties limit how well individuals use negative feedback. Thus, feedback interventions in healthcare should be carefully designed to mitigate these counterproductive behavioral responses. This paper was accepted by Ranjani Krishnan, accounting. Funding: We acknowledge generous funding provided by Tilburg University and the University of Massachusetts Amherst to run the laboratory experiments. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2023.01340 .

Hippocampal storage and recall of neocortical "What"-"Where" representations.

A key question for understanding the function of the hippocampus in memory is how information is recalled from the hippocampus to the neocortex. This was investigated in a neuronal network model of the hippocampal system in which "What" and "Where" neuronal firing rate vectors were applied to separate neocortical modules, which then activated entorhinal cortex "What" and "Where" modules, then the dentate gyrus, then CA3, then CA1, then the entorhinal cortex, and then the backprojections to the neocortex. A rate model showed that the whole system could be trained to recall "Where" in the neocortex from "What" applied as a retrieval cue to the neocortex, and could in principle be trained up towards the theoretical capacity determined largely by the number of synapses onto any one neuron divided by the sparseness of the representation. The trained synaptic weights were then imported into an integrate-and-fire simulation of the same architecture, which showed that the time from presenting a retrieval cue to a neocortex module to recall the whole memory in the neocortex is approximately 100 ms. This is sufficiently fast for the backprojection synapses to be trained onto the still active neocortical neurons during storage of the episodic memory, and this is needed for recall to operate correctly to the neocortex. These simulations also showed that the long loop neocortex-hippocampus-neocortex that operates continuously in time may contribute to complete recall in the neocortex; but that this positive feedback long loop makes the whole dynamical system inherently liable to a pathological increase in neuronal activity. Important factors that contributed to stability included increased inhibition in CA3 and CA1 to keep the firing rates low; and temporal adaptation of the neuronal firing and of active synapses, which are proposed to make an important contribution to stabilizing runaway excitation in cortical circuits in the brain.

Development and Validation of the "Program to Promote Positive Nursing Practice Environments": Modified Delphi Study.

Positive nursing practice environments benefit clients, professionals, and institutions, specifically for professionals, by improving professional visibility, recognition, retention intentions, well-being, commitment, job satisfaction, and reducing stress and burnout. Clients experience better quality care, safety, satisfaction, engagement, and fewer care omissions. Institutions favored reduced absenteeism and turnover, improved efficiency, lower costs, and better health outcomes. This study aimed to document the development of the "Program to Promote Positive Nursing Practice Environments" and analyze expert perceptions to reach a consensus. Using a two-round modified online Delphi technique with 22 experts, we examined perspectives on the program's goals, duration, organization, and content. Initial feedback showed agreement on the program's duration but mixed opinions on the number and length of sessions due to concerns about participant workload and fatigue. Adjustments led to a strong consensus and positive feedback on the program's coverage of essential nursing practice environment constructs. The program includes sessions on client, professional, and institutional dynamics, focusing on key attributes and outcomes for fostering positive nursing environments. By equipping nurses with knowledge and skills, the program aims to enhance work environments effectively. These findings provide a substantial advancement in the field, offering a robust framework for future initiatives.

Strategi Komunikasi Digital: Media Sosial Instagram Sebagai Sarana Promosi di MI Unggulan Darul Mujtaba

This research aims to identify and analyze effective digital communication strategies through Instagram social media that can be implemented by MI Unggulan Darul Mujtaba as a promotional tool. In the current digital era, social media plays an important role in building an image and attracting public interest in educational institutions. However, the challenge faced is how to optimally utilize Instagram social media to achieve these promotional goals. This research uses descriptive qualitative research with data collection methods in the form of interviews and in-depth observations of research subjects and objects. The research results show that the success of the digital communication strategy at MI Unggulan Darul Mujtaba can be seen from increased visibility, high levels of engagement, positive feedback, and an increase in the number of new student registrations. With a well-planned and implemented strategy, MI Unggulan Darul Mujtaba can make maximum use of Instagram's potential to build a positive image and attract public interest. This research contributes to the development of literature on digital communication and promotional strategies in the era of social media, as well as providing practical guidance for other educational institutions that wish to optimize the use of social media for promotional purposes.