Positive Effects Of Physical Activity Research Articles

The Positive Effects of Physical Activity on Quality of Life in Parkinson's Disease: A Systematic Review.

Physical activity can have positive effects on motor and non-motor symptoms in Parkinson's disease, but its benefits in terms of quality of life and function are uncertain and vary based on the specific forms of activities and interventions. We sought to assess the current evidence on the positive effects of physical activity in people with Parkinson's disease and more specifically in relation to its potential benefits for quality of life. This systematic review was conducted between January and April 2024 via the PubMed, Medline, and Scopus databases. Predetermined search criteria were used that included the following terms: "Parkinson's disease", "quality of life" and "physical activity". A total of 1669 articles were identified. After utilizing predetermined criteria, a total of fifteen articles met the selection criteria. Statistically significant improvements in quality of life were found in seven studies. Seven studies demonstrated a significant improvement in non-motor symptoms, while nine studies showed an improvement in motor symptoms. Despite heterogeneity in the study designs, interventions and clinical assessments, the articles identified in this review yielded mostly positive results in relation to physical activities. The findings reflect an improvement in motor and non-motor symptoms may translate to a better quality of life in people with Parkinson's disease.

Body composition, cardiovascular fitness and attention of school-aged male children practicing sports club activities: A cross-sectional

BACKGROUND: The positive effects of physical activity on physical fitness, bone health, academic achievement, cognitive functions, mental health, and reduced obesity have been proven. This study aims to investigate the relationship between sports club activities, physical activity selected health-related fitness, and the d2 attention test. MATERIALS AND METHODS: A cross-sectional study was conducted in different sports clubs. A total of 78 male students aged 10-13 years participating in various branches of sports clubs were included in the study, 42 of whom were assigned to the sports group and 36 to the control group. Questionnaires were administered to assess sports club participation and attention levels, while physical health profiles were tested with body composition and Yo-Yo IR1C performance measures. Data were analyzed according to sports participation and the five most frequently reported sports. The means and standard deviation of each study value were calculated for the total subjects and by participating in sports activity using the IBM SPSS (version 23) analysis program. Data normality was checked and confirmed by the Skewness and Kurtosis Tests. RESULTS: The results showed that boys enrolled in a sports activity had lower body mass (-17.9%, P < 0.05 d = 0.72), body mass index (-13.4%, P < 0.05, d = 0.87), and body fat (%) (-54.1%, P < 0.05, d = 1.38) and higher VO2max 32.3% (P < 0.05, d = 3.67), than the non-active group. The boys active in sports clubs also had better results in the total number of items processed (11%, P < 0.05 d = 0.50) and in concentration performance (17.7%, P < 0.05 d = 0.56) than the non-active group. In correlation analyses, VO2max was negatively associated with body mass, body mass index, and body fat (P = 0.011; P = 0.001 and P = 0.00, respectively) and positively related to the total number of items processed and concentration performance (P = 0.003 and P = 0.015, respectively). In the Pearson Correlation analyses, body fat showed a lower negative correlation with TN (r = 0.33; P = 0.003) and CP (r = 0.28; P = 0.015). CONCLUSIONS: Boys participating in regular sports have lower body mass, BMI, and BF values. In addition, boys who participated in sports showed higher imaginary fitness and selective attention and concentration capacity results, as expected, for any sports part compared to their body peers. Another attempt from this study is that body mass and body fat percentage recovery are negatively associated with fitness. Considering the increasing prevalence of obesity in children and adolescents due to sedentary living, which has become a worldwide epidemic, it is recommended that pedagogical and public health strategies and policies be developed based on the physical fitness level of children.

Effects of physical activity on self-efficacy of patients with bronchial asthma

Introduction: Due to higher exposures to fine dust, increased smoking and prevalence of obesity and stress, an increase in the diagnosis of bronchial asthma can be expected, which requires adequate, scientifically tested, alternative therapy methods. The current study investigated the effects of regular physical training on general and disease-specific self-efficacy. Materials and Methods: Overall 82 participants with mild to moderate medicated asthma (63% female, mean age = 41.88 ± 10.43 years) took part in the study. They were randomly divided into three groups: (1) no intervention, (2) progressive muscle relaxation and (3) physical activity intervention. Intervention lasted ten weeks with two units of physical activity or relaxation per week, each lasting 60min. Self-efficacy was measured using the German scales of general and COPD self-efficacy scales. Results: Analysis showed positive influence of group assignment and basic values on general self-efficacy with significant differences between physical activity intervention and control group (p < .001). Conclusions: The present study underlies positive effects of physical activity on the subjective well-being of patients with bronchial asthma. Therefore, it is advisable to consider physical activity as an important component in the treatment of patients with bronchial asthma.

Positive Effects of Physical Activity on Insulin Signaling.

Physical activity is integral to metabolic health, particularly in addressing insulin resistance and related disorders such as type 2 diabetes mellitus (T2DM). Studies consistently demonstrate a strong association between physical activity levels and insulin sensitivity. Regular exercise interventions were shown to significantly improve glycemic control, highlighting exercise as a recommended therapeutic strategy for reducing insulin resistance. Physical inactivity is closely linked to islet cell insufficiency, exacerbating insulin resistance through various pathways including ER stress, mitochondrial dysfunction, oxidative stress, and inflammation. Conversely, physical training and exercise preserve and restore islet function, enhancing peripheral insulin sensitivity. Exercise interventions stimulate β-cell proliferation through increased circulating levels of growth factors, further emphasizing its role in maintaining pancreatic health and glucose metabolism. Furthermore, sedentary lifestyles contribute to elevated oxidative stress levels and ceramide production, impairing insulin signaling and glucose metabolism. Regular exercise induces anti-inflammatory responses, enhances antioxidant defenses, and promotes mitochondrial function, thereby improving insulin sensitivity and metabolic efficiency. Encouraging individuals to adopt active lifestyles and engage in regular exercise is crucial for preventing and managing insulin resistance and related metabolic disorders, ultimately promoting overall health and well-being.

The Optimal Cut-Off Point of Physical Activity for the Prevention of Childhood Overweight and Obesity.

Childhood obesity might threaten children's current and adulthood health outcomes. Previous studies have illustrated the positive effects of physical activity on weight control; however, there is a lack of evidence on the optimal dose of physical activity. Therefore, we aimed to explore the relationship between physical activity and overweight and obesity, as well as the optimal threshold for physical activity. The median (interquartile range) and number (proportion) were used to describe the statistics. The Mann-Whitney U test and chi-square test were used for an univariable analysis. The generalized additive model with a smooth function was used to depict the preliminary relationship between physical activity and overweight and obesity. The cut-off level of physical activity was identified using AddFor algorithms, and a logistic regression model was applied to explore the multivariable relationship between physical activity and overweight and obesity after adjusting for control variables. According to the statistical analyses, 24.3% of 842 children and adolescents had overweight and obesity. The average number of days that the participants engaged in more than one hour of physical activity was three days a week. The optimal cut-off level of physical activity for the prevention of childhood overweight and obesity was 4 times a week. The participants who exercised more than four times a week (AOR(95% CI) = 0.56(0.38, 0.83), p = 0.004) were less likely to be overweight and obese. In the context of the general lack of physical activity among children and adolescents, we recommend that children and adolescents engage in 60 min of physical activity more than four times a week for a healthy weight.

“CLIMBING IS MY WEAPON” – A PSYCHOSOCIAL BOULDERING INTERVENTION FOR ADOLESCENTS AND ITS IMPACT ON THE PSYCHOLOGICAL WELL-BEING OF ADOLESCENTS IN LEBANON

INTRODUCTION AND AIMS Previous research highlights the positive effects of physical activity, also climbing therapy, on mental health, including benefits on depression and self-esteem. Recognising the mental health challenges faced by young people in Lebanon, particularly in the context of multiple crises and forced displacement, this interventional study explores the benefits of a psychosocial climbing programme in eastern Lebanon. METHODS In collaboration with the non-profit organisation ClimbAID, this waitlist-controlled, partially randomised, mixed-methods study examines the effects of an eight-week psychosocial bouldering group intervention on overall mental well-being, levels of psychological distress, self-efficacy and social cohesion among a group of host and refugee youth in the Bekaa Valley. Qualitative interviews with 40 participants provide insights into their experiences, lessons learned and subjective outcomes. The intervention, delivered by 2 trained facilitators and up to 2 volunteers, took place weekly for 2 hours with groups of up to 12 young people. RESULTS With 233 participants, the trial had a dropout rate of approximately 33%. The intervention group showed significant improvements in overall mental well-being and psychological distress compared with the waitlist groups. Group allocation was the only significant predictor of improved mental well-being, in addition to baseline scores. While no significant differences in self-efficacy and social cohesion were observed, qualitative analysis revealed that participants highly valued the non-judgmental approach, highlighting significant benefits in interpersonal relationships and mental well-being. CONCLUSION In the challenging humanitarian context of forced displacement, the psychosocial bouldering intervention effectively enhanced well-being and reduced psychological distress among host and refugee youth in Bekaa, Lebanon. As a group intervention, bouldering emerges as a valuable option for supporting host and refugee populations in low-income countries.

Influence of professional sports activities on bone mineral density (<i>literature review</i>)

Introduction. The positive effect of physical activity on the state of bone has been proven by many researchers. Professional sports activity is a model of the constant impact of physical activity on the human body, acting as the most powerful mechanism for activating and mobilizing the functional reserves of an athlete, which, against the background of a progressive increase in the volume, intensity and duration of exposure, shows an increase in the incidence of injuries and stress fractures, one of the leading causes of which is a decrease in bone mineral density (BMD) up to the development of osteoporosis. The risk factors for the development of the pathology of the musculoskeletal system, which have a direct impact on the formation of the BMD, in elite sports include the volume and intensity of training loads, the stereotype of the main competitive exercise, the daily balance of energy intake.The aim is to study is to analyze modern scientific publications on the impact of professional sports activities on bone mineral density.Materials and methods. The review is based on publications from the PubMed, Google Scholar, Cyberleninka, eLIBRARY databases. Preference was given to articles published in refereed sources over the past 10 years.Results. The specificity of the main competitive exercise determines the presence of asymmetry in the distribution of the BMD in athletes, in addition, the level of BMD is higher in the leading limb compared to the opposite. Increasing the qualifications, experience and age of an athlete shows a positive impact on the performance of the BMD, with the exception of certain specializations. A different effect of sports with a high osteogenic effect of shock and weight load on the state of the BMD was noted compared to the general population. Power athletes, combat and game sports athletes have higher levels BMD compared to representatives of cycling, swimming, rowing, triathlon and long-distance running, characterized by the limitation of gravitational (shock) load or a large amount of low-intensity training exposure. Lower BMD were noted in athletes in sports specializations with weight categories, aesthetic and cyclic sports, where the problem of a relative energy deficiency in sport, which negatively affects bone metabolism.Conclusions. In athletes, the volume and intensity of training loads, the stereotype of performing the main competitive exercise, the daily balance of energy intake have a direct impact on the formation of the BMD with the allocation of risk groups for the pathology of the musculoskeletal system in elite sports.

Physical activity and endogenous pain modulation in older people: a scoping review protocol.

This scoping review aims to provide an overview of the existing literature on physical activity and endogenous pain modulation (EPM), assessed using conditioned pain modulation (CPM), with a specific focus on older people with chronic pain. Approximately 20% of the European population reports chronic pain, highlighting the problem of chronic pain in the general population. This prevalence increases to 50% in older people. Physical activity is one of the most frequently used treatments for pain management and relief. A possible mechanism underlying the positive effects of physical activity on pain may be related to its influence on EPM. The review will map i) types of physical activity used to study its effect on EPM in older people; ii) intervention protocols investigating physical activity and EPM, measured using CPM, in older people experiencing pain; and iii) knowledge gaps requiring further research or interventions adapted to older people with pain. This review will consider studies of people aged 60 years or older, using CPM to examine the effect of physical activity on EPM. All types of care settings will be eligible. This review will be conducted in accordance with the JBI methodology for scoping reviews. The following databases will be searched: MEDLINE (Ovid), CINAHL (EBSCOhost), Embase, Cochrane Library, Web of Science, JBI Evidence Synthesis , PsycINFO, and PEDro. Open Science Framework https://osf.io/e7ndy/.

Adolescent mental health interventions: a narrative review of the positive effects of physical activity and implementation strategies.

The psychological well-being of adolescents is a global concern due to increasing societal pressures and mental health issues. Physical activity is known to enhance physical health and has potential benefits for mental health, including reducing symptoms of anxiety and depression, boosting self-esteem, and improving social skills. This narrative review explores how physical activity can serve as an intervention to help adolescents manage psychological stress and prevent mental health issues. An extensive literature search was conducted using databases such as PubMed, PsycINFO, Web of Science, and Scopus. Keywords included "adolescent mental health," "physical activity," "psychological intervention," "types of exercise," "anxiety," "depression," "self-esteem," "social skills," and "emotional regulation." Studies were included based on relevance, peer-reviewed status, and involvement of adolescent populations. Data were extracted and analyzed qualitatively, focusing on the psychological impacts of different types of physical activity. Sixty one articles were eventually included. The review identified multiple studies highlighting the positive effects of various physical activities on adolescent mental health. Aerobic exercises were found to improve mood and cognitive function, strength training reduced depressive symptoms and increased self-efficacy, team sports enhanced social skills and a sense of community, and mind-body practices like yoga and tai chi improved stress management and emotional regulation. The findings suggest that physical activity can play a significant role in promoting adolescent mental health. Implementation strategies in school and community settings, including integrating physical activity into school curricula, offering diverse activity options, training professional instructors, encouraging family and community involvement, and regular monitoring and evaluation, are recommended. Future research should address limitations such as sample diversity and long-term effects. This narrative review underscores the importance of physical activity in enhancing adolescent mental health. Effective implementation strategies and multi-sector collaboration are essential for maximizing the benefits of physical activity interventions.

ДВИГАТЕЛЬНАЯ АКТИВНОСТЬ КАК ФАКТОР ПОВЫШЕНИЯ УСПЕВАЕМОСТИ СТУДЕНТОВ

The purpose of this study is to identify the effect of weekly physical activity on the mental abilities of students. The objective of the study is to collect a sample of students of the same age group, but from different specialties, and then evaluate the impact of physical activity on academic performance. Research methods: questionnaires, mathematical data processing. The study revealed a positive effect of physical activity on students’ achievements.

Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review.

In mammals, the timing of physiological, biochemical and behavioral processes over a 24-h period is controlled by circadian rhythms. To entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm, environmental zeitgebers are used by the circadian system. This is done primarily by signals from the retina via the retinohypothalamic tract, but other cues like exercise, feeding, temperature, anxiety, and social events have also been shown to act as non-photic zeitgebers. The recently identified myokine irisin is proposed to serve as an entraining non-photic signal of exercise. Irisin is a product of cleavage and modification from its precursor membrane fibronectin type Ⅲ domain-containing protein 5 (FNDC5) in response to exercise. Apart from well-known peripheral effects, such as inducing the "browning" of white adipocytes, irisin can penetrate the blood-brain barrier and display the effects on the brain. Experimental data suggest that FNDC5/irisin mediates the positive effects of physical activity on brain functions. In several brain areas, irisin induces the production of brain-derived neurotrophic factor (BDNF). In the master clock, a significant role in gating photic stimuli in the retinohypothalamic synapse for BDNF is suggested. However, the brain receptor for irisin remains unknown. In the current review, the interactions of physical activity and the irisin/BDNF axis with the circadian system are reconceptualized.

Towards implementing physical activity guidelines into clinical practice in persons with mild cognitive impairment

AbstractThe positive effects of physical activity and exercise on general health, well‐being, and physical and cognitive functioning in persons with mild cognitive impairment (MCI) are well documented and resulted in respective guidelines [1, 2]. To support the implementation of these guidelines into clinical practice, we developed and evaluated a training manual for physiotherapists and allied health professionals and an accompanying handout for independent training for persons with MCI.The development process included a systematic literature search and patient and public involvement in design aspects. The training manual and handout were determined in four half‐day workshops with experienced physiotherapists. The goal was to describe specific exercises for every training dimension, i.e., endurance, strength, balance, and flexibility, including variations for progression and degression. For better comprehensibility, the handout was illustrated with pictures. Subsequently, both documents were evaluated in five geriatric clinics. The comprehensibility, acceptance, and usefulness of persons with MCI and physiotherapists’ perspectives were evaluated using structured questionnaires, including specific implementation outcomes.Overall, both, the physiotherapists and persons with MCI found the manual useful and acceptable. However, the responses on comprehensibility indicated a need for optimization. Accordingly, we revised the training manual and handout, e.g., by simplifying the language or reducing the descriptive text. The revised documents are now freely available to physiotherapists and patients.The training manual and accompanying handout may support the implementation of the physical activity recommendations into clinical practice and may be used in future research projects. In a subsequent project, we will implement the training manual and handout in a smartphone and tablet application to improve ease of customization and usability.[1] Chong TWH, Curran E, Ellis KA, et al. Physical activity for older Australians with mild cognitive impairment or subjective cognitive decline ‐ A narrative review to support guideline development. J Sci Med Sport. 2020;23(10):913‐920.[2] Izquierdo M, Merchant RA, Morley JE, et al. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021;25(7):824‐853.

Step-by-step to more creativity: The number of steps in everyday life is related to creative ideation performance.

Research indicated an association of acute and chronic physical activity with creative ideation performance. However, no study to date applied ecologically valid ambulatory methods with the potential to generalize these positive relationships to everyday life contexts. This study assessed acute and chronic physical activity (i.e., number of steps assessed via acceleration sensors) as well as creative ideation performance (in the verbal and figural domain) with an ecological momentary assessment approach in a sample of 157 young adults. We found that both single bouts of walking and walking regularly were associated with more original verbal ideas. Positive affect did not mediate this association; however, for figural creativity, the indirect path of acute physical activity via acute positive affect was significant. Although the relationship between walking and creativity seems to be domain-specific, the study findings suggest that the positive effects of physical activity on creativity transfer to everyday life contexts. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

The relationship between physical activity and subjective well-being in Chinese university students: the mediating roles of perceived health, social support and self-esteem.

The intent of this paper is to understand the effect of Physical Activity on university students' Subjective Well-being and to explore whether Perceived Health, Social Support, and Self-esteem play roles as mediating variables. Self-reported data from 404 college students (147 males and 257 females) were analyzed using structural equation modeling (SEM). The relationships between the study variables were tested by mediation models and 5,000 bootstrap samples using AMOS version 24. (1) The six hypotheses were supported in the measurement model in the results (P < 0.05). Physical Activity was related to Social Support, Perceived Health, and to Self-esteem; Social Support, Perceived Health, and Self-esteem were all related to Subjective Well-being. However, the direct positive effect of Physical Activity gradually decreased in the order of Self-esteem, Social Support, and Perceived Health. The direct effect of Perceived Health, Social Support, and Self-esteem on Subjective Well-being also decreased sequentially. (2) In the Structural Equation Model (χ2 = 825.451, p < 0.001, df = 455, CMIN/df = 1.814, CFI = 0.942, RMSEA = 0.045), the three hypotheses of mediation were supported (P < 0.05), showing positive indirect effects between Physical Activity and Subjective Well-being. Of the three mediating effects, Social Support and Self-esteem were not different, and the mediating effect of Perceived Health showed the largest impact. This indicates that Social Support, Perceived Health, and Self-esteem mediate the effects of Physical Activity, and Subjective Well-being regulation has positive indirect effects. This study demonstrates the importance of meeting the needs of Social Support, Perceived Health, and Self-esteem when designing interventions to promote college students' sports participation to enhance Subjective Well-being.

Positive effects of physical activity in autism spectrum disorder: how influences behavior, metabolic disorder and gut microbiota.

Autism spectrum disorder is a neurodevelopmental disorder characterized by social interactions and communication skills impairments that include intellectual disabilities, communication delays and self-injurious behaviors; often are present systemic comorbidities such as gastrointestinal disorders, obesity and cardiovascular disease. Moreover, in recent years has emerged a link between alterations in the intestinal microbiota and neurobehavioral symptoms in children with autism spectrum disorder. Recently, physical activity and exercise interventions are known to be beneficial for improving communication and social interaction and the composition of microbiota. In our review we intend to highlight how different types of sports can help to improve communication and social behaviors in children with autism and also show positive effects on gut microbiota composition.

Physical Exercise as Disease-Modifying Alternative against Alzheimer's Disease: A Gut-Muscle-Brain Partnership.

Alzheimer's disease (AD) is a common cause of dementia characterized by neurodegenerative dysregulations, cognitive impairments, and neuropsychiatric symptoms. Physical exercise (PE) has emerged as a powerful tool for reducing chronic inflammation, improving overall health, and preventing cognitive decline. The connection between the immune system, gut microbiota (GM), and neuroinflammation highlights the role of the gut-brain axis in maintaining brain health and preventing neurodegenerative diseases. Neglected so far, PE has beneficial effects on microbial composition and diversity, thus providing the potential to alleviate neurological symptoms. There is bidirectional communication between the gut and muscle, with GM diversity modulation and short-chain fatty acid (SCFA) production affecting muscle metabolism and preservation, and muscle activity/exercise in turn inducing significant changes in GM composition, functionality, diversity, and SCFA production. This gut-muscle and muscle-gut interplay can then modulate cognition. For instance, irisin, an exercise-induced myokine, promotes neuroplasticity and cognitive function through BDNF signaling. Irisin and muscle-generated BDNF may mediate the positive effects of physical activity against some aspects of AD pathophysiology through the interaction of exercise with the gut microbial ecosystem, neural plasticity, anti-inflammatory signaling pathways, and neurogenesis. Understanding gut-muscle-brain interconnections hold promise for developing strategies to promote brain health, fight age-associated cognitive decline, and improve muscle health and longevity.

A prospective analysis of physical activity and mental health in children: the GECKO Drenthe cohort

BackgroundMental health problems in young people have become a global health burden. The positive effects of physical activity on mental health in adults are well known but still not clear in children. The aim of this study was to investigate to what extent physical activity in early childhood would affect mental health in middle childhood.MethodsFrom the Dutch GECKO Drenthe birth cohort, 850 children (51.5% boys) were enrolled in this analysis. Physical activity and sedentary time were measured at age 5–6 using ActiGraph GT3X. Mental health was assessed using the Strengths and Difficulties Questionnaire (SDQ) at age 5–6 and age 10–11. Multiple linear regression models were used to estimate the associations between physical activity, sedentary time and SDQ subscales, stratified by gender, adjusting for age, BMI, maternal education level, family size, accelerometer wear time and season, and additionally adjusting for SDQ scores at age 5–6 to take tracking of mental health over time into account.ResultsGreater physical activity volume at age 5–6 was associated with lower peer problems scores at age 10–11 in boys and girls. An increase in MVPA was associated with lower peer problems scores in boys (b = -0.445, -0.713 to -0.176) and girls (b = -0.354, -0.601 to -0.107), however, increased sedentary time was linked to higher peer problems scores in boys (b = 1.18, 0.455 to 1.906) and girls (b = 0.870, 0.191 to 1.550). For hyperactivity, higher levels of physical activity volume and MVPA were associated with higher hyperactivity scores in boys. Increased sedentary time was related to lower hyperactivity scores in boys. Further adjustment for SDQ scores at age 5–6 attenuated associations between physical activity and hyperactivity in boys but hardly changed the relationships with peer problems. No significant associations between physical activity and other SDQ subscales or total difficulties scores were observed, neither in boys nor in girls.ConclusionsChildren who are more physically active at age 5–6 have fewer peer problems at age 10–11, and for boys, greater activity levels at age 5–6 could be an indicator of hyperactivity at age 10–11.

Positive Effects of Physical Activity on Prescription on Glycemic Control, Fitness, and Quality of Life in Newly Diagnosed Type 2 Diabetic Patients.

The aim was to investigate the effects of physical activity on prescription (PAP) compared with standard care (SC) in adult drug-naïve T2D patients. A randomized control trial was conducted with drug-naïve T2D patients attending an out-patient clinic Vietnam. Participants were randomly assigned to the PAP group (n+=+44) or the SC group (n+=+43). The PAP group received individualized recommendations for PA, intensive face-to-face training every two weeks. The SC group received the standard recommendations according to WHO guidelines. The mean HbA1c level change was larger (-10.6±6.4 mmol/mol) in the PAP group than in the SC group (-2.4±5.8 mmol/mol) (p<0.001). A one thousand step counts per day increase was significantly associated with a decrease of -2.43 mmol/mol in HbA1c [β=-2.43, 95%CI: (-2.94, -1.92]) in the PAP group. The fasting plasma glucose levels of the PAP group decreased significantly compared with the SC group. The VO2-max increased significantly more in the PAP group than in the SC group. PAP had clear positive effects on health-related Quality of Life [mean between group difference: 9.54 (95%CI 5.84,13.23)]. Insulin resistance, BMI, waist circumference, total cholesterol, LDL cholesterol and triglycerides were significantly more decreased in the PAP group than in the control group. In conclusion, the fact that even a small change in mean step counts over three months had a beneficial effect on health-related outcomes in drug-naïve T2D patients can have large implications for treatment and management practices, not least in a middle-income country like Vietnam.

Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate.

Methotrexate (Mtx) is used to treat various diseases, including cancer, arthritis and other rheumatic diseases. However, it induces oxidative stress and pulmonary inflammation by stimulating production of reactive oxygen species and cytokines. Considering the positive effects of physical activity, our goal was to investigate the preventive and therapeutic role of continuous training (CT) on Mtx-induced lung injury in rats. The rats were divided into five groups of 14 animals: a control group (C); a continuous exercise training group (CT; healthy rats that experienced CT); an acute lung injury with Mtx group (ALI); a pretreatment group with CT (the rats experienced CT before ALI induction), and a post-treatment group with CT (the rats experienced CT after ALI induction). One dose of 20mg/kg Mtx intraperitoneal was administered in the Mtx and training groups. Forty-eight hours after the last exercise session all rats were sacrificed. According to our results, the levels of tumour necrosis factor-α (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO), GATA binding protein 3 (GATA3) and caspase-3 in the ALI group significantly increased compared to the control group, and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), interleukin-10 (IL-10), forkhead box protein 3 (FOXP3), and T-bet decreased. In contrast, compared to the acute lung injury group, pretreatment and treatment with CT reduced TNF-α, MDA, MPO, GATA3 and caspase-3 and increased SOD, GPX, TAC, IL-10, FOXP3 and T-bet levels. The effects of CT pretreatment were more significant than the effects of CT post-treatment. Continuous exercise training effectively reduced oxidative stress and inflammatory cytokines and ameliorated Mtx-induced injury, and the effects of CT pretreatment were more significant than the effects of CT post-treatment. NEW FINDINGS: What is the central question of this study? Considering the high prevalence of lung injury in society, does exercise as a non-pharmacological intervention have ameliorating effects on lung injury? What is the main finding and its importance? Exercise can have healing effects on the lung after pulmonary injury through reducing inflammation, oxidative stress and apoptosis. Considering the lower side effects of exercise compared to drug treatments, the results of this study may be useful in the future.

Preventive nutritional supplementation with furan fatty acid in a DIO mouse model increases muscle mass and reduces metabolic disorders

The increase in obesity has become a major global health problem and is associated with numerous metabolic dysfunctions. Furan fatty acids (FuFAs) are minor lipids present in our diet. Recently we showed that FuFA-F2 extracted from Hevea brasiliensis latex stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. While skeletal muscle is essential for energy metabolism and is the predominant site of insulin-mediated glucose uptake in the post prandial state, our results suggested that FuFA-F2 could have favorable effects against obesity. The aim of this work was therefore to study whether a preventive nutritional supplementation with FuFA-F2 (40 mg or 110 mg/day/kg of body weight) in a diet-induced obesity (DIO) mouse model may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. We showed that 12 weeks of FuFA-F2 supplementation in DIO mice decreased fat mass, increased lean mass and restored normal energy expenditure. In addition, we found that FuFA-F2 improved insulin sensitivity. We revealed that FuFA-F2 increased muscle mass but had no effect on mitochondrial function and oxidative stress in skeletal muscle. Furthermore, we observed that FuFA-F2 supplementation reduced liver steatosis without impact on mitochondrial function and oxidative stress in liver. Our findings demonstrated for the first time that a preventive nutritional supplementation with a furan fatty acid in DIO mice reduced metabolic disorders and was able to mimic partly the positive effects of physical activity. This study highlights that nutritional FuFA-F2 supplementation could be an effective approach to treat obesity and metabolic syndrome.