Positive Correlation Research Articles

CLINICAL CORRELATION OF MMSE AND TAU RESULTS FROM BLOOD OR IMAGING REPORTS

Abstract Background A novel blood test for Alzheimer pathology is now available. Abnormal tau measurements from blood or brain PET may indicate brain tau. We analyzed the correlation of Mini Mental Status Examination (MMSE) to tau results disclosed to patients in a memory clinic. Objectives To assess the correlation of blood or PET tau positivity to MMSE test scores. To evaluate an MMSE score cut-off that translates optimally to tau positivity. Method Retrospective observational chart review of patients attending a memory clinic in Boston, MA, with a MMSE test score and blood tau or tau-results were included for analysis. Baseline MMSE and a binary blood or PET scan result were analyzed with covariates age, sex and race. Spearman correlation of MMSE to blood/PET tau. Kruskal Wallis/Chi square tests for relationship of age, sex, gender and education with MMSE score and tau-PET status. ROC analyses and sensitivity/specificity were obtained. Results We disclosed 45 positive and 10 negative tau results. 58.2% were female and 82.7% were white. Mean age was 70.12 ± 14.17, mean MMSE was 21.35±7.36. Tau abnormality trended negatively with MMSE score (r= -0.26, p=0.07). A cut point of 28 for MMSE estimated tau deposition in the brain by PET scan or blood tau, with an AUC of 0.694 (95%CI 0.48 to 0.90). Conclusion In a small pilot study, tau blood or PET results trended negatively with MMSE scores, possibly indicating a ceiling effect as we only analyzed very mildly impaired subjects.

Neural markers of error processing relate to task performance, but not to substance-related risks and problems and externalizing problems in adolescence and emerging adulthood.

Detecting errors and adapting behavior accordingly constitutes an integral aspect of cognition. Previous studies have linked neural correlates of error processing (e.g., error-related negativity (ERN) and error-related positivity (Pe)) to task performance and broader behavioral constructs, but few studies examined how these associations manifest in adolescence. In this study, we examined neural error processing markers and their behavioral associations in an adolescent/emerging adult sample (N = 143, Mage = 18.0 years, range 11-25 years), employing a stop-signal task. Linear regressions were conducted using bootstrap resampling to explore associations between ERN/Pe peak amplitudes and latencies, stop accuracy, stop-signal reaction time (SSRT), and post-error slowing, as well as self-reported substance-related risks and problems and externalizing problems. After adjusting for age and sex, smaller frontocentral Pe amplitude and later Pe latency were associated with longer SSRT, and later Pe latency was associated with lower stop accuracy. This might indicate that the Pe, which is thought to reflect conscious error processing, reflects task performance on a response inhibition task better than the ERN, which reflects subconscious error processing. After correcting for multiple testing, there were no associations between ERN/Pe parameters and substance-related or externalizing problems, and no age interactions for these associations were detected.

Диагностическая эффективность и прогностическая значимость антропометрических параметров как маркеров гиперлептинемии у подростков

Leptin is an energy homeostasis marker synthesized by cells of adipose tissue (adipocytes) and gastric mucosa. The search for clinical and anthropometric parameters associated with energy homeostasis disorders in excess body weight (BW) and obesity is necessary for stratification of patients at risk for early implementation of energy homeostasis disorders. The purpose of this re-search was to evaluate the relationship between serum leptin concentration and anthropometric parameters reflecting the topography of subcutaneous fat in adolescents of different ethnicities with excess BW and obesity in order to identify the most informative anthropometric parameters of energy homeosta-sis disorders. Materials and methods used: a single-center cross-sectional study of 362 adolescents aged 11 to 17 y/o residing in the Republic of Buryatia and the Irkutsk Oblast of Russia was conducted in 2015-2016 that included the participants as follows: 186 Caucasians (46 boys/140 girls) and 176 Mongoloids (96 boys/80 girls); 136 adolescents in the control group (38%) and 226 adolescents with excess BW and obesity (62%). All par-ticipants had their linear height, BW, waist (WC) and hip (HC) circumference, skinfold thickness measured as well as the body mass index (BMI, in kg per m2) calculated. The concentrations of glucose, total cholesterol, high-density, low-density and very low-density lipoprotein cholesterol, triglycerides and in-sulin were determined. The HOMA index was calculated. Serum leptin was de-termined by enzyme immunoassay using DBC Leptin ELISA kit (Diagnostics Biochem Canada Inc., Canada) with detection using BioTek Elx808 Microplate Spectrophotometer (Agilent Technologies, Inc., USA). Results: a strong posi-tive correlation was found between serum leptin levels and SDS BMI and trip-onderal BMI in adolescents of both ethnic groups: in Caucasian boys r=0.747 (p<0.001), r=0.767 (p<0.001), in Caucasian girls r=0.687 (p<0.001) and r=0.695 (p<0.001); in Mongoloid boys r=0.765 (p<0.001), r=0.852 (p<0.001), in Mongoloid girls r=0.612 (p<0.001), r=0.667 (p<0.001), respectively. Ac-cording to the results of ROC analysis, AUC WC/height showed good diagnos-tic significance for detecting hyperleptinemia (AUC=0.8-0.9) in adolescents from all the studied groups. Conclusion: the triponderal index and the WC/height ratio are informative anthropometric indicators for energy metabo-lism disorders and hyperleptinemia in Caucasian and Mongoloid adolescents of both genders with excess BW and obesity.

Intrinsically disordered proteins and liquid-liquid phase separation in SARS-CoV-2 interactomes.

This paper discusses the properties of proteins and their relations in the interactomes of the selected subsets of SARS-CoV-2 proteome-the membrane protein, nonstructural proteins, and, finally, full proteome. Protein disorder according to several measures, liquid-liquid phase separation probabilities, and protein node degrees in the interaction networks were singled out as the features of interest. Additionally, viral interactomes were combined with the interactome of human lung tissue so as to examine if the new connections in the resulting viral-host interactome are linked to protein disorder. Correlation analysis shows that there is no clear relationship between raw features of interest, whereas there is a positive correlation between the protein disorder and its neighborhood mean disorder. There are also indications that highly connected viral hubs tend to be on average more ordered than proteins with a small number of connections. This is in contrast to previous similar studies conducted on eukaryotic interactomes and possibly raises new questions in research on viral interactomes.

Exploring the Molecular Mechanism of Niuxi-Mugua Formula in Treating Coronavirus Disease 2019 via Network Pharmacology, Computational Biology, and Surface Plasmon Resonance Verification.

In China, Niuxi-Mugua formula (NMF) has been widely used to prevent and treat coronavirus disease 2019 (COVID-19). However, the mechanism of NMF for treating COVID-19 is not yet fully understood. This study aimed to explore the potential mechanism of NMF for treating COVID- 19 by network pharmacology, computational biology, and surface plasmon resonance (SPR) verification. The NMF-compound-target network was constructed to screen the key compounds, and the Molecular Complex Detection (MCODE) tool was used to screen the preliminary key genes. The overlapped genes (OGEs) and the preliminary key genes were further analyzed by enrichment analysis. Then, the correlation analysis of immune signatures and the preliminary key genes was performed. Molecular docking and molecular dynamic (MD) simulation assays were applied to clarify the interactions between key compounds and key genes. Moreover, the SPR interaction experiment was used for further affinity kinetic verification. Lipid and atherosclerosis, TNF, IL-17, and NF-kappa B signaling pathways were the main pathways of NMF in the treatment of COVID-19. There was a positive correlation between almost the majority of immune signatures and all preliminary key genes. The key compounds and the key genes were screened out, and they were involved in the main pathways of NMF for treating COVID-19. Moreover, the binding affinities of most key compounds binding to key genes were good, and IL1B-Quercetin had the best binding stability. SPR analysis further demonstrated that IL1B-Quercetin showed good binding affinity. Our findings provided theoretical grounds for NMF in the treatment of COVID-19.

Evidence from Machine Learning, Diagnostic Hub Genes in Sepsis and Diagnostic Models based on Xgboost Models, Novel Molecular Models for the Diagnosis of Sepsis.

Systemic multi-organ dysfunction resulting from dysregulated immune responses in the host triggered by microbial infection or other factors is a major cause of death in sepsis, and secretory pathways play an important role in it. GSE57065, GSE65682, GSE145227, and GSE54514 from Gene Expression Omnibus (GEO) were derived for this study. Secretory pathways single sample gene set enrichment analysis (ssGSEA) scores in sepsis and normal samples were exposed. Gene modules associated with secretory pathways were selected by weighted gene coexpression network analysis (WGCNA) for Protein-Protein Interaction Networks (PPI) assessment, and crossover genes in both were evaluated by eXtreme Gradient Boosting (XGBoost) model in feature selection to identify hub genes in sepsis. In addition, we explored the immune cells and signaling pathways regulated by hub genes. Remarkable dysregulation of secretory pathways was demonstrated in sepsis. The secretory pathways-associated gene modules were intimately involved in cytokine and immune responses in infection. Four crossover genes (CD163, FCER1G, C3AR1, ARG1) were present in WGCNA and PPI, and training in the XGBoost model revealed the best diagnostic performance of these 4 genes, meaning that these genes were the hub genes for sepsis. The 4-hub genes showed a significant negative correlation with T cell activity and a significant positive correlation with inflammatory immune cells. In addition, we found that the 4-hub genes markedly positively regulated INFLAMMATORY RESPONSE, IL6 JAK STAT3 SIGNALING. Based on WGCNA, PPI, and XGBoost models, we identified hub genes that play an important regulatory role in sepsis. We also developed novel molecular models for the diagnosis of sepsis.

Development of a Combined Oxidative Stress and Endoplasmic Reticulum Stress-Related Prognostic Signature for Hepatocellular Carcinoma.

Oxidative stress and endoplasmic reticulum stress are important components of the cellular stress process, which plays a critical role in tumor initiation and progression. First, the correlation between oxidative stress and endoplasmic reticulum stress was detected in 68 human hepatocellular carcinoma (HCC) tissue microarray samples by immunohistochemistry. Differentially expressed oxidative stress- and endoplasmic reticulum stressrelated genes (OESGs) then were screened in HCC. Next, an OESGs prognostic signature was constructed for HCC in the training cohort (TCGA-LIHC from The Cancer Genome Atlas), by least absolute shrinkage and selection operator Cox and stepwise Cox regression analyses, and was verified in the external cohort (GSE14520 from the Gene Expression Omnibus). The MCP counter was employed to evaluate immune cell infiltration. The C-index was used to evaluate the predictive power of prognostic signature. Finally, a prognostic nomogram model was constructed to predict the survival probability of patients with HCC based on the results of Cox regression analysis. We demonstrated a positive correlation between oxidative stress and endoplasmic reticulum stress in human HCC samples. We then identified five OESGs as a prognostic signature consisting of IL18RAP, ECT2, PPARGC1A, STC2, and NQO1 for HCC. Related risk scores correlated with tumor stage, grade, and response to transcatheter arterial chemoembolization therapy, and the higher risk score group had less T cells, CD8+ T cells, cytotoxic lymphocytes and natural killer cell infiltration. The C-index of our OESGs prognostic signature was superior to four previously published signatures. Furthermore, we developed a nomogram based on the OESGs prognostic signature and clinical parameters for patients with HCC that is an effective quantitative analysis tool to predict patient survival. The OESGs signature showed excellent performance in predicting survival and therapeutic responses for patients with HCC.

Assessment of Interleukin 17 in Egyptian Systemic Lupus Erythematosus Patients as a Biomarker in Disease Activity.

Systemic lupus erythematosus (SLE) is a chronic idiopathic systemic autoimmune disorder with dysregulation of adaptive and innate immune systems. Interleukin (IL)-17 is the prototypical pro-inflammatory cytokine of T helper 17 (Th17) cells. Therefore, it contributes to the pathogenesis of human SLE. The aim of the research paper was the evaluation of IL-17 level as a biomarker in the SLE cohort and its relation to disease activity and analysis of IL-17 concentration in patients with lupus nephritis and non-lupus nephritis. The research enrolled 45 SLE patients according to Systemic Lupus International Collaborating Clinics Classification Criteria (SLICC), and age and sex-matched. The patients underwent full history, clinical examination, laboratory investigation, and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) calculation. The mean age ± SD of the participants equaled 32 ± 11 years, and serum IL-17 in SLE cases was statistically significantly high (p < 0.001). No statistically significant correlations were reported between disease activity according to SLEDAI and IL-17. In addition, a statistically significant positive correlation was reported between IL-17 and ESR, and a high statistically significant negative correlation was reported between IL-17 and C3 and C4 (P < 0.001). A statistically significant positive correlation was reported between IL-17 and 24-hour urinary proteins with a Pvalue of 0.01. SLE cases demonstrated higher levels of serum IL-17, contributing to SLE pathogenesis. However, no statistically significant difference was reported between IL-17 and Lupus nephritis. IL-17 and SLE activity (SLEDAI) did not correlate. A statistically significant positive relation was reported between IL-17 and 24-hour urinary proteins. Additionally, a high statistically significant negative correlation was reported between IL-17 and C3 and C4.

Exploring The Values and Practices Through Filipino Family Types among Grade 7 Students

This research delves into the intricate dynamics of Filipino family types, DepEd core values, and Filipino family practices. In the Philip-pines, family structures have undergone significant transformations over the years. Traditional Filipino family structures, deeply rooted in cultural heritage and communal ties, have coexisted alongside the emergence of modern family structures influenced by urbanization, globalization, and shifting societal norms. Understanding the impact of these family structures on individuals, particularly students, is an area ripe for exploration.The found a positive correlation between nuclear families and ad-herence to DepEd values and practices. Extended families show a posi-tive correlation with pro-environmental attitudes, while single-parent families exhibit mixed results, including a negative correlation with cultural preservation. The study's significance lies in its contribution to understanding Filipino family dynamics and its potential to positively impact Filipino society by promoting cultural understanding and stronger family relationships.This study's significance lies in its contribution to understanding Filipino family dynamics, offering insights for future research, and promoting cultural understanding and stronger family relationships. It holds the potential to positively impact Filipino society by enriching educational experiences and fostering a deeper appreciation for diverse family structures and cultures.

Metacognitive Skills and Academic Performance among Medical Students-An Analytical Cross Sectional Survey

Objective: The study objectives were to identify the metacognitive skills in medical students and to find its association with their academic performance. Study Design: Analytical cross-sectional study. Place and Duration of Study: Army Medical College, Rawalpindi Pakistan, from May to Sep 2022. Methodology: MBBS students from second, third and fourth year who had passed their last professional examination were included by convenience sampling. Sample size was calculated using WHO table and keeping 95% confidence level, d=0.05 and p= 0.20. Self-reported questionnaire Metacognitive Awareness Inventory was used to collect online data from 197 students. Hesitant students and incomplete questionnaires were excluded. Data analyzed through SPSS version 26. Mean and standard deviation for descriptive, independent t-test and one-way ANOVA were applied to find differences of mean among different groups (p&lt;0.05 statistically significant). Results: Among 115 males and 82 females, almost 92(46.70%) were from second year, 33(16.75%) from third year, and 72(36.54%) were from fourth year. Mean score and standard deviation of knowledge and regulation of cognition was 10±4.3 and 20.4±8.6 respectively. No significant difference of metacognition scores for two domains was found among both genders (p value 0.730, 0.509 respectively), four categories of percentage scores (p-value 0.290, 0.724respectively) and all years (p-value 0.077, 0.280 respectively). A significant strong positive linear correlation between knowledge and regulation was found (r=797; p&lt;0.001). Conclusions: Metacognitive skills in medical students were moderately developed in using strategies of both knowledge and regulation of cognition. No association was found between metacognitive skills and their academic performance.

Covid-19 Vaccine Hesitancy in Pakistan: A Cross-Sectional Study to Assess Resistance and Related Fears and Misconceptions

Objective: The purpose of this study was to assess willingness to receive COVID-19 vaccine in Pakistan and to understand the reasons causing hesitation towards vaccine administration. Study Design: A cross-sectional study was done through an online survey that was created using google forms. Place and Duration of Study: The study was conducted online from Mar to Aug 2021 in different cities of Pakistan employing nonprobability convenience sampling technique. The link to the questionnaire was shared on different social media platforms such as WhatsApp and Facebook. Methodology: Any individual over the age of 16 and willing to fill the questionnaire was enrolled. Questionnaire used were standardized Oxford COVID-19 vaccine hesitancy scale to assess intent and Oxford general vaccine hesitancy scale to assess attitude towards vaccinations in general. SPSS v25 was used for data analysis. Results: A total of 589 valid responses were finally analyzed. Among the respondents, 24%(141) showed at least some hesitancy regarding COIVD-19 vaccination and 9%(53) of the respondents showed extreme hesitancy. The Pearson correlation coefficient indicated a significant positive correlation (p&lt;0.000) between hesitancy to childhood vaccines and COVID vaccine hesitancy. There was also a significant correlation (p&lt;0.000) between belief in conspiracy’s related to COVID-19 virus and refusal to get vaccinated. Conclusion: Vaccine hesitancy is present in roughly 1/4th of the study population. Conspiracy theories and low vaccine acceptance among the general public pose a severe danger to COVID-19 vaccination success. Public vaccine education programs should be started to educate the public regarding their fear of vaccination.

Dauricine Inhibits Non-small Cell Lung Cancer Development by Regulating PTEN/AKT/mTOR and Ras/MEK1/2/ERK1/2 Pathways in a FLT4-dependent Manner.

Non-small cell lung cancer (NSCLC) is still a solid tumor with high malignancy and poor prognosis. Vascular endothelial growth factor receptor 3 (FLT4, VEGFR3) is overexpressed in NSCLC cells, making it a potential target for NSCLC treatment. In this study, we aimed to explore the anti-cancer effects of dauricine on NSCLC cells and its mechanism targeting FLT4. We found that dauricine inhibited the growth of NCI-H1299 cells by blocking the cycle in the G2/M phase through flow cytometry analysis. In addition, dauricine also inhibited the migration of NCI-H1299 cells by wound healing assay and transwell migration assay. More importantly, our empirical analysis found the anti-cancer effect of dauricine on NCI-H1299 cells and the protein level of FLT4 had a distinctly positive correlation, and this effect was weakened after FLT4 knockdown. It is suggested that dauricine suppressed the growth and migration of NCI-H1299 cells by targeting FLT4. Furthermore, dauricine inhibited FLT4 downstream pathways, such as PTEN/AKT/mTOR and Ras/MEK1/2/ERK1/2, thereby regulating cell migration-related molecule MMP3 and cell cycle-related molecules (CDK1, pCDK1-T161, and cyclin B1). Dauricine may be a promising FLT4 inhibitor for the treatment of NSCLC.

어머니가 지각한 아버지 양육참여가 유아 자기조절력에 미치는 영향: 어머니 양육스트레스와 유아 스마트폰 과의존의 순차적 이중매개효과

Objectives This study aims to examine whether maternal parenting stress and preschoolers’ smartphone over-dependence exhibit a sequential dual mediation effect in the relationship between mothers' perception of fathers' parenting involvement and preschoolers’ self-regulation. Methods The study analyzed responses from 297 mothers of 5- to 7-year-old children attending four daycare centers in the Busan-Gyeongnam area, collected over a 14-day period from October 12 to 26, 2023. A total of 33 respondents were excluded due to non-responses or unreliable answers, leaving 297 valid responses. Pearson’s product-moment correlation analysis was conducted to examine the relationships between the variables, and Hayes (2018) PROCESS macro model 6 was employed to analyze the sequential dual mediation effect. Results A positive correlation was observed between mothers' perception of fathers' parenting involvement and preschoolers’ self-regulation, while maternal parenting stress and preschoolers’ smartphone overdependence were negatively correlated with preschoolers’ self-regulation. Maternal parenting stress showed a positive corre-lation with preschoolers’ smartphone overdependence and a negative correlation with preschoolers’ self-regulation. Preschoolers' smartphone overdependence was also negatively correlated with preschoolers’ self-regulation. Furthermore, the mediating effects of maternal parenting stress and preschoolers’ smartphone overdependence in the relationship between mothers' perception of fathers' parenting involvement and preschoolers’ self-regu-lation were significant. The sequential dual mediation effect of maternal parenting stress and preschoolers' smart-phone overdependence was also confirmed to be significant. Conclusions These results confirm that a synergistic effect occurs when maternal parenting stress and infant's smartphone overdependence sequentially mediate the relationship between mothers' perception of fathers' pa-renting involvement and preschoolers’ self-regulation.

Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease.

Myeloid cells, including monocytes, macrophages, microglia, dendritic cells and neutrophils are a part of innate immune system, playing a major role in orchestrating innate and adaptive immune responses. Both Alzheimer's disease (AD) and inflammatory bowel disease (IBD) susceptibility loci are enriched for genes expressed in myeloid cells, but it is not clear whether these myeloid risk factors are shared between the two diseases. Leveraging results of genome-wide association studies, we investigated the causal effect of IBD (including ulcerative colitis (UC) and Crohn's disease (CD)) variants on AD and its endophenotypes. Microglia and monocyte expression Quantitative Trait Locus (eQTLs) were used to examine the functional consequences of IBD and AD variants. Our results revealed distinct sets of genes and pathways of AD and IBD susceptibility loci. Specifically, AD loci are enriched for microglial eQTLs, while IBD loci are enriched for monocyte eQTLs. However, we also found that genetically determined IBD is associated with a protective effect against AD (p<0.03). Yet, a genetic propensity for the CD subtype is associated with increased amyloid accumulation (beta=7.14, p-value=0.02) and susceptibility to AD. Susceptibility to UC was associated with increased deposition of TDP-43 (beta=7.58, p-value=6.11×10-4). The relation of these gastrointestinal inflammatory disease to AD is therefore complex; while the different subsets of susceptibility variants preferentially affect different myeloid cell subtypes, there do appear to be certain shared pathways and the possible protective effect of IBD susceptibility on the risk of AD which may provide therapeutic insights.

5051 Clinical Correlation between TSH levels and TAU Imaging

Abstract Disclosure: S. Sunil: None. Background: Tau-PET Scan measures brain tau deposition. TSH levels related to cognitive impairment. We analyzed the correlation of TSH levels to tau-PET imaging in a memory clinic. Hypothesis: Tau-PET positivity correlates with lower TSH values in the clinic patients. Objectives: To assess the correlation of tau-PET positivity to TSH levels in memory clinic patients. Method: Retrospective observational chart review study of patients attending a memory clinic in Boston, MA, with TSH levels and tau-PET scan included for analysis. No stratification based on initial or final diagnosis, severity of cognitive impairment, or tracer used. Baseline TSH levels and a binary PET scan result were analyzed with covariates age, sex and race. Analysis done on ‘R’ v. 2.4.0. Pearson correlation estimated TSH levels to tau-PET status. Kruskal Wallis/Chi square tests for relationship of age, sex, gender and education with TSH levels and tau-PET status. ROC analyses and sensitivity/specificity were obtained. Results: Tau PET positivity did not correlate significantly with TSH levels (r= 0.0655, 95%CI -0.388 to 0.494, p=0.78). Conclusion: Tau PET does not correlate with TSH levels, possibly due to a ceiling effect in the mild impairment subjects. Presentation: 6/2/2024

Plasma Interleukin-13 Levels Correlate With the Severity of Symptoms Induced by Functional Dyspepsia.

Functional dyspepsia (FD) is a gastrointestinal functional disorder of the upper gastrointestinal tract that affects the quality of life of patients and poses a significant economic burden. It has been proposed that the local inflammatory immune response at the duodenum is associated with an increase in intestinal permeability, favoring the recruitment of Th2 cells and granulocyte degranulation. Moreover, systemic immune response could also be related to the symptoms of FD. The objective of this study was to evaluate the systemic immune response in Uruguayan patients with FD by analyzing the cytokine levels in plasma and the frequency of circulating T cells associated with duodenal recruitment. An analytic and cross-sectional study in 30 patients with FD and 15 healthy controls (HCs) was carried out. Patients were diagnosed with FD according to the Roma IV Committee definition. Cytokine levels were measured in plasma by a specific assay. Expression of α4β7 and CC chemokine receptor9 in circulating T cells was evaluated by flow cytometry. Higher levels of interleukin (IL)-5, IL-13, and IL-8 and lower levels of IL-10 and IL-12p70 were detected in patients with FD than in HC. Furthermore, a positive linear correlation between IL-13 and the severity of FD symptoms was found. CD4 + T cells from patients with FD expressed higher levels of α4β7 and CC chemokine receptor9 than those from HC. An increase of Th2-like cytokines and a positive correlation between the levels of plasma IL-13 and the severity of symptoms in patients with FD from Uruguay were detected.

Effect of Mindfulness on Treatment Motivation in Patients with Substance Use Disorder

Objective: This research aimed to assess the mindfulness levels among individuals with substance use disorder (SUD) and investigate its influence on treatment motivation.&#x0D; Method: A descriptive and cross-sectional study was carried out involving 184 SUD patients. Data collection utilized a Personal Information Form, The Mindful Attention Awareness Scale (MAAS), and the Treatment Motivation Questionnaire (TMQ).&#x0D; Results: A strong positive correlation was identified between MAAS and TMQ levels (r: 0.796, p

A Study on the Effects of Socio-Cultural Pressure and Health Beliefs on Scalp and Hair Care Awareness and Behavior

Purpose: In modern society, with economic development and improvement of living standards, beauty is no longer solely aimed at physical appearance, but there is a lot of interest in scalp and hair care based on health. This study aims to investigate the influence of socio-cultural pressure and health beliefs on the perception of scalp and hair care.&#x0D; Method: In modern society, with economic development and improvement of living standards, beauty is no longer solely aimed at physical appearance, but there is a lot of interest in scalp and hair care based on health . This study aims to investigate the influence of socio-cultural pressure and health beliefs on the perception of scalp and hair care.&#x0D; Results: Pearson's correlation analysis was performed to determine the correlation between the variables. All the variables showed a significant positive correlation with each other. Next, multiple regression analysis was conducted to determine the effects of scalp and hair sociocultural pressure and health beliefs on perception and behavior of scalp and hair care, and it was found that sociocultural pressure from acquaintances, sociocultural pressure from media, intention to use, and maintenance had a significant positive effect on Perception and Behavior of scalp and hair care. Maintenance (β=.403, p&lt;.001), sociocultural pressure from acquaintances (β=.246, p&lt;.001), sociocultural pressure from the media (β=.240, p&lt;.001), and intention to use (β=.129, p&lt;.05) were found to affect perception and behavior of scalp and hair care.&#x0D; Conclusion: In order to improve 'Perception and Behavior of Scalp and Hair Care', it can be interpreted that it is necessary to pay attention not only to scalp and hair health beliefs but also to socio-cultural pressures. It can be said that this study proves that idealized appearances in the media and relationships can influence not only behaviors such as dieting, but also individuals' perceptions and actual behaviors regarding scalp and hair.

Do nursing students' attitudes to clinical practice training affect the levels of vocational motivation?

It is extremely important for nursing students to be professionally motivated to train qualified future professional nurses. Students' vocational motivation is affected by their experiences in clinical and academic learning environments. The aim of this study was to investigate the correlation between the vocational motivation levels of nursing students and their attitudes toward clinical practice. 292 nursing students participated in the cross-sectional, descriptive study. The Student Information Form, Nursing Students' Attitudes Towards Clinical Practices Scale, Motivation Sources and Problems Scale (MSPS) were used to gather the data. The average score for students' attitudes toward clinical practice was 107.08±18.13, while the total score for MSPS stood at 3.80±0.63. A positive correlation was identified between the attitude toward clinical practice and vocational motivation levels (r = 0.367; p < 0.001). There were positive correlations between the intrinsic motivation (r = 0.572; p < 0.001) and extrinsic motivation (r = 0.58; p < 0.001), and negative correlations were observed between the negative motivation (r=-0.324; p < 0.001) and the attitude toward clinical practice scale. There were positive correlations between belief and expectation (r = 0.492; p < 0.001) and positive approach (r = 0.532; p < 0.001) with the MSPS. In the multiple regression analysis, intrinsic motivation, extrinsic motivation, satisfaction with studying nursing, and participation in vocational courses were determined as effective predictors of attitudes towards clinical practice and explained 60.4% of the variance. The study concluded that nursing students' attitudes toward clinical practices affect vocational motivation. Clinical learning environments should be arranged in a way to increase the motivation level of students towards professional learning.

The impact of identity conflicts among Chinese knowledge-based miners on unsafe behavior: A moderated chain mediation model.

In the context of smart mine construction, coal mine safety management is imposing stringent requirements on the safety competence of miners. To meet these demands, coal mine enterprises have initiated proactive measures to recruit a new generation of knowledge-based miners who possess high qualifications and specialized backgrounds. This study aims to explore the underlying mechanisms of identity conflict (IC) and its influence on unsafe behavior (USB) among KBMs within the context of China's smart mining initiatives, as well as to identify the role of potential mediating and moderating variables in this relationship. An empirical study was conducted on a sample of 304 KBMs with a college degree or above, selected from multiple coal mines in Shanxi Province, China. Hierarchical regression analysis and the Bootstrap method were employed for data analysis. This model incorporated IC as the antecedent variable and meticulously investigated the mediating effects of role breadth self-efficacy (RBSE) and psychosocial resources (PSR), along with the moderating effect of positive explanatory bias (PEB). The findings indicate a significant positive correlation between IC and USB among KBMs. RBSE and PSR were found to mediate the relationship between IC and USB. Moreover, this mediating effect further influenced the relationship between IC and USB through a chain mediating effect. Additionally, PEB strengthened the positive impact of KBMs' RBSE on PSR. These results provide a broader perspective on the antecedent variables associated with KBMs' USB and provide valuable insights and practical management strategies enhancing the safety management practices within coal mining enterprise.