BackgroundIn reverse total arthroplasty (rTSA), glenoid component positioning is a critical factor for outcomes especially in Asian population with smaller glenoid. The purpose of this study was to compare the clinical and radiologic outcomes of rTSA with and without the navigation system with a minimum follow-up of two years in Asian population. MethodsThis was a retrospective comparative study of 33 rTSA with the navigation system (NAV group) and 40 conventional rTSA (CON group). Radiologic measurements regarding the position of the glenoid component, glenoid vault perforation by the central cage, and scapular notching, as well as clinical outcomes including range of motion (ROM), functional scores and complications were compared. Number, length, and angulation of screws were assessed. ResultsThe mean age was 73.9 ± 5.9 years with a mean follow-up of 30.1 ± 6.4 months. The NAV group more frequently utilized augmented baseplate (P < 0.001), showed less superior inclination (P = 0.030) and had lower incidence of glenoid vault perforation (P = 0.040). The length of superior (P = 0.001) and inferior screws (P = 0.045) was longer in the NAV group. In the NAV group compared to the CON group, more inferior orientation of superior screws (P < .001), more anterior orientation for inferior screws (P = 0.031), and anterior screws (P = 0.003) were observed. The NAV group showed significantly less penetration into the suprascapular fossa by a superior screw (P = 0.007). Final ROM, functional scores, and complications showed no significant differences between two groups. ConclusionIn short-term follow-up, the use of a navigation system in rTSA showed no significant difference in clinical outcomes and complications compared to conventional implantation. However, it enabled a lower superior inclination and a reduced glenoid vault perforation by the central cage, simultaneously allowing for the insertion of longer peripheral screws in a safer direction compared to conventional implantation.