Analogous to Landau quantization related to a neutral particle possessing an electric quadrupole moment, we generalize such a Landau quantization to include position-dependent mass (PDM) neutral particles. Using cylindrical coordinates, the exact solvability of PDM neutral particles with an electric quadrupole moment moving in electromagnetic fields is reported. The interaction between the electric quadrupole moment of a PDM neutral particle and a magnetic field in the absence of an electric field is analyzed for two different radial cylindrical PDM settings. Next, two particular cases of radial electric fields (E⃗=λρρ̂andE⃗=λρ2ρ̂) are considered to investigate their influence on the Landau quantization (of this system using the same models of PDM settings). The exact eigenvalues and eigenfunctions for each case are analytically obtained.