Background: A four trocar laparoscopic cholecystectomy become the standard procedure since the first laparoscopic procedure was reported. But laparoscopic cholecystectomy has gained many steps such as reduction in port number and size. Objective: To compare Clinical results from three ports versus the traditional four ports in laparoscopic cholecystectomy. Patients and Methods: A prospective randomized clinical trial of 100 patients was done on those who were admitted for elective laparoscopic cholecystectomy in Baquba teaching hospital, between April 2014 and March 2015, patients were classified into two groups (A) for three ports and (B) for 4 ports. Variables such as, complications, operative time, postoperative pain, nausea, and vomiting were assessed. Results: One-hundred patients were included in this study, age of them ranged from 18-70 year and a male to female ratio was 1:9. There were no significant differences in demographic data between the two groups. Postoperative pain, analgesic requirements, nausea and vomiting, and hospital stay were slightly more in group B but statistically not significant. Postoperative return to activity was shorter in group A 6.10 versus 7.00 days for group B with (p= 0.021) which is statistically significant. There is no difference in the rate of complications. Conclusion: Three ports laparoscopic cholecystectomy is feasible as an alternative for four ports without any significant complication. Keywords: Laparoscopy; Cholecystectomy; Postoperative complications
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