This study aimed to evaluate the mechanical performance of an asphalt stabilized base with natural asphalt mix (ASB-NA) with added contents of 1.0 %, 2.0 %, and 3.0 % of Hydrated Lime (HL) and Portland Cement (PC). Tests were employed under dry and wet conditions to analyze the response to monotonic loading in compression and indirect traction and evaluate the susceptibility to water. Additional tests were conducted to analyze the resistance to cyclic dynamic loading, employing resilient modulus, permanent deformation, and fatigue resistance testing. The results reported that adding HL and PC in ASB-NA significantly increased the mechanical performance under monotonic and dynamic loading. These increases were evidenced by higher compressive strength, indirect tensile strength, resilient modulus, fatigue resistance and permanent deformation. Regarding water susceptibility (durability), higher resistance values to moisture damage were presented for the samples with 2 % HL and PC contents. This paper presents new materials for pavement asphalt base courses, which would reduce asphalt consumption, save energy, cut costs, and protect the environment.