The unsteady simulation of hydromagnetic radiative polar fluid, including thermophoresis, Brownian motion, and higher-order chemical reactions across a perpendicular permeable plate with heat radiation, is performed numerically. The nonlinear PDEs are solved by the explicit finite difference technique and studio developer FORTRAN. The stability and convergence of the present model and a comparison are done to obtain accuracy. The effects of various parameters such as Brownian motion, thermophoresis, radiative heat transfer, and higher-order chemical reactions on the velocity, temperature, and concentration fields are investigated. It is found that the parameters have a significant influence on velocity and temperature profiles, angular velocity, concentration, shear stress, angular momentum density, and Nusselt and Sherwood numbers. In addition, the local share stress rises with the chemical reaction, Eckert number, and thermophoresis, whereas it decreases with the magnetic field and porous medium. In addition, the Nu (local) intensifies with higher order chemical reactions and porous mediums, whereas it falls with Eckert number, Brownian effects, micro-rotation, and thermophoresis. The concentration profile decreases with higher radiation, and the Lewis number whereas it augments with higher radiation. With an Eckert number and thermophoresis, the temperature and velocity increase. Additionally, the higher order of chemical reaction and Brownian motion augment the Sherwood number, whereas the chemical reaction, magnetic field, and porous medium reduce it. Moreover, the study may help to understand the dynamics of flow and heat transfer for the design and optimization of various engineering applications such as heat exchangers, pollutant dispersion models, energy systems, biomedical, and so on.