In this study, toluene degradation efficiency and carbon dioxide (CO2) selectivity in a spouted bed reactor with a porous draft tube were optimized using the response surface methodology. For this purpose, titanium dioxide (TiO2) was used as a catalyst for photocatalytic degradation of gaseous toluene in a dynamic mode under ultraviolet (UV) irradiation. The influence of draft tube parameters' (including height, diameter, gap, and porosity) on toluene degradation efficiency and CO2 selectivity (as the response variables) was investigated by central composite design. Analysis of variance (ANOVA) was applied to evaluate the significance of the variables' effects and the interaction between them. Results showed that maximum toluene degradation efficiency of 78.1 % and maximum CO2 selectivity of 88.7 % were obtained at 1.99 cm draft tube height, 1.3 cm draft tube diameter, 1.3 cm gap, and 60 % draft tube porosity. The highest F-values indicated that the gap is the most important variable affecting the toluene degradation efficiency and CO2 selectivity, while the draft tube diameter is the second important variable. The results of experiments at optimal levels of parameters with three replications showed a maximum toluene degradation efficiency of 78.8% (SD= 0.62) and maximum CO2 selectivity of 89.1 % (SD= 0.46). The study revealed that the spouted bed reactor with a porous draft tube has a good stability for volatile organic compounds (VOCs) degradation and mineralization.