Porous Carrier Research Articles

Gelatin/PLGA Microspheres as a 3D Scaffold for Chondrocytes

Background: Osteoarthritis (OA) degrades cartilage and bone. Osteochondral autograft, allograft, and total replacement knee surgery have limitations, such as prompt immune responses, lack of cartilage tissue obtainability, invasiveness, and a loosening implant that may require further correction. Tissue engineering, which involves injecting chondrocytes into 3D porous scaffold carriers in the joint, seems promising for tissue repair and growth. Objective: To develop gelatin/poly DL-lactide-co-glycolide (PLGA) microspheres as a porous scaffold for chondrocyte carriers. Methods: The double emulsion method is one of the most popular and best methods for forming microspheres. In summary, in the PLGA oil phase, we emulsified a gelatin solution representing the inner aqueous phase. Next, in an external aqueous phase of polyvinyl alcohol (PVA), we emulsified the resultant first emulsion. The double emulsion was stirred to evaporate organic solvent and centrifuged to collect gelatin and PLGA microspheres. Results: The Mastersizer result showed polydispersed particles with 23.53% of the desirable cell injection size range between 1-300 µm. Scanning electronic microscope (SEM) images revealed spherical and porous microspheres with smooth surfaces. The average absolute zeta potential value was -30.7±4.895, indicating stable preparation. Conclusions: Gelatin and PLAGA polymers worked together to make 3D scaffold microspheres that were the right size, had the right number of holes, and were strong.

Review on the Catalytic Significance of Zr‐Based Metal‐Organic Frameworks as Potential Catalyst for Various Organic Transformations

AbstractWithin the extensive array of metal‐organic frameworks (MOFs), Zr‐based MOFs stand out as particularly promising materials due to their diverse structures, exceptional stability, and intriguing properties. These MOFs are currently in the early stages of development, but noteworthy strides have been achieved in recent years. This overview focuses on the progress in Zr‐MOFs since 2012, covering design, synthesis, and applications in various reactions such as C−H activation, oxidation, C−C, and C−N coupling approaches. Different Zr‐MOF structural variants are explained in terms of Zr‐based secondary building units and a variety of organic ligands. The review highlights the roles that Zr‐MOFs play in catalysis by highlighting their uses as porous carriers, molecule adsorption, and separation. It is anticipated that this kind of concentrated review on Zr‐MOFs would offer important direction for next studies investigating MOFs for catalytic applications.

Limbal stem cells carried by a four-dimensional -printed chitosan-based scaffold for corneal epithelium injury in diabetic rabbits.

Methods: Herein, we obtained and characterized deltaN p63- and adenosine triphosphate-binding cassette subfamily G member 2-expressing limbal stem cells (LSCs). Chitosan and carboxymethyl chitosan (CTH) were cross-linked to be an in situ thermosensitive hydrogel (ACH), which was printed through four-dimensional (4D) printing to obtain a porous carrier with uniform pore diameter (4D-CTH). Rabbits were injected with alloxan to induce diabetes mellitus (DM). Following this, the LSC-carrying hydrogel was spread on the surface of the cornea of the diabetic rabbits to cure corneal epithelium injury. Results: Compared with the control group (LSCs only), rapid wound healing was observed in rabbits treated with LSC-carrying 4D-CTH. Furthermore, the test group also showed better corneal nerve repair ability. The results indicated the potential of LSC-carrying 4D-CTH in curing corneal epithelium injury. Conclusion: 4D-CTH holds potential as a useful tool for studying regenerative processes occurring during the treatment of various diabetic corneal epithelium pathologies with the use of stem cell-based technologies.

Porous silicon and silica carriers for delivery of peptide therapeutics.

Peptides have gained tremendous popularity as biological therapeutic agents in recent years due to their favourable specificity, diversity of targets, well-established screening methods, ease of production, and lower cost. However, their poor physiological and storage stability, pharmacokinetics, and fast clearance have limited their clinical translation. Novel nanocarrier-based strategies have shown promise in overcoming these issues. In this direction, porous silicon (pSi) and mesoporous silica nanoparticles (MSNs) have been widely explored as potential carriers for the delivery of peptide therapeutics. These materials possess several advantages, including large surface areas, tunable pore sizes, and adjustable pore architectures, which make them attractive carriers for peptide delivery systems. In this review, we cover pSi and MSNs as drug carriers focusing on their use in peptide delivery. The review provides a brief overview of their fabrication, surface modification, and interesting properties that make them ideal peptide drug carriers. The review provides a systematic account of various studies that have utilised these unique porous carriers for peptide delivery describing significant in vitro and in vivo results. We have also provided a critical comparison of the two carriers in terms of their physicochemical properties and short-term and long-term biocompatibility. Lastly, we have concluded the review with our opinion of this field and identified key areas for future research for clinical translation of pSi and MSN-based peptide therapeutic formulations.

Oxidised porous starch carrier for caffeine delivery: preparation, characterisation, and in vitro release

SummaryThis work established an oxidised porous starch carrier system for the administration of caffeine by selectively oxidising the main hydroxyl groups at the C6 positions of porous starch to carboxyl groups using 2,2,6,6‐tetramethylpiperidoxyl (TEMPO) oxidation. The loading capacity and encapsulation efficiency of oxidised porous starch on caffeine rose as the oxidation degree (0%–90%) increased, increasing by 4.66 and 4.95 times, respectively, at 90% oxidation. The crystallinity of porous starch diminished after TEMPO oxidation, while the crystalline caffeine transferred into an amorphous state when loaded onto oxidised porous starch. Following oxidation, the absolute value of porous starch surface potential rose, enabling the granules avoided aggregation. Caffeine formed tighter bonds with oxidised porous starch in acidic conditions due to the dissociation of carboxyl groups, which lead to a peak loading capacity (8.02%) of oxidised porous starch with 90% oxidation at pH 4. Electrostatic interactions and hydrogen bonds were the driving forces. Long‐term gastrointestinal release of caffeine was achieved utilising oxidised porous starch as carriers.

The Preparation and Contact Drying Performance of Encapsulated Microspherical Composite Sorbents Based on Fly Ash Cenospheres.

Sorption technologies are essential for various industries because they provide product quality and process efficiency. New encapsulated microspherical composite sorbents have been developed for resource-saving contact drying of thermolabile materials, particularly grain and seeds of crops. Magnesium sulfate, known for its high water capacity, fast sorption kinetics, and easy regeneration, was used as an active moisture sorption component. To localize the active component, porous carriers with an accessible internal volume and a perforated glass-crystalline shell were used. These carriers were created by acid etching of cenospheres with different structures isolated from fly ash. The amount of magnesium sulfate included in the internal volume of the microspherical carrier was 38 wt % for cenospheres with ring structures and 26 wt % for cenospheres with network structures. Studies of the moisture sorption properties of composite sorbents on wheat seeds have shown that after 4 h of contact drying the moisture content of wheat decreases from 22.5 to 14.9-15.5 wt %. Wheat seed germination after sorption drying was 95 ± 2%. The advantage of composite sorbents is the encapsulation of the desiccant in the inner volume of perforated cenospheres, which prevents its entrainment and contamination and provides easy separation and stable sorption capacity in several cycles.

Enhanced activity of Ru-based catalysts for ammonia decomposition through nitrogen doping of hierarchical porous carbon carriers

Activated carbon (AC) materials, renowned for their high specific surface area, excellent conductivity, and customizable functional groups, are widely employed as catalyst carriers. However, enhancing the activity of Ru-based catalysts supported on AC (Ru/AC) for ammonia decomposition remains a challenge. In this study, commercial AC was utilized as a substrate, with glucose and urea employed as modifiers. Specifically, the surface of the AC was modified via a hydrothermal pyrolysis method, resulting in the successful post-treatment in situ co-doping of nitrogen (AC-GN). Experimental results revealed that Ru/AC-GN exhibited a hydrogen production rate 46% higher than that of Ru/AC at 475 °C, indicating improved activity and stability. The characterization of AC-GN demonstrated that nitrogen doping primarily occurred on the external surface and macropores of the AC, increasing the nitrogen content in the carrier, particularly pyrrolic nitrogen content, while preserving the original structural and morphological integrity of the AC. The enhanced dispersion of Ru, combined with the improved electronic transmission capabilities and strengthened interactions between the metal and the modified carrier, were identified as pivotal factors contributing to the enhanced low-temperature efficacy of Ru/AC-GN. This paper presents a novel direction for the large-scale preparation of efficient catalysts for ammonia decomposition.

Cellulose Nanofiber/Polyethylene Glycol Composite Phase Change Thermal Storage Gel Based on Solid-gel Phase Change

In this paper, cellulose nanofiber (CNF)/ polyethylene glycol (PEG) composite aerogel phase change materials (CNPCMs) were prepared utilizing porous carrier support and freeze-drying. The solid-liquid phase change to solid-gel phase change was realized, which solved the problems of PEG flow, leakage, and shape instability. The physical properties and chemical compatibility of CNPCMs were studied, and the results showed that CNPCMs ensured the overall structure stability through internal hydrogen bonding, and they were only a physical bond with each other without chemical reaction. With the increase in PEG content, the thermal conductivity of CNPCMs increased from 0.22 W/m·K to 0.33 W/m·K. The thermal exposure experiment and thermogravimetric analysis (TGA) experiment have shown that CNPCMs have good shape stability at 75 ℃ and good thermal stability below 320 ℃. In summary, the experimental results indicated that the maximum content of PEG in CNPCMs was 78 % with an optimal content of 66.7 %. The sample corresponding to the optimal content was CNPCM2 with an enthalpy of 167.9 J/g for melting and 146.1 J/g for solidification. As a thermal storage material with good thermodynamic performance, CNPCM2 has enormous potential in the storage of solar collectors.

High-density Co-Nx sites anchored on biomass-based carbon nanotubes for efficient removal of plant viruses in water

In this study, we selected rice straw, wheat straw and corn cob as raw materials to successfully prepare cobalt-nitrogen co-doped biomass-based carbon nanotubes composites (BM@CoNCNTs) with Co-Nx sites highly dispersed on porous biochar carrier, which could effectively activate peroxymonosulfate (PMS) to remove tobacco mosaic virus (TMV) in water. Particularly, BM@CoNCNTs-CC, with its confined carbon nanotubes and high-density Co-Nx sites, enhanced the Co2+/Co3+ cycle and direct adsorption of PMS to generate Co(IV)=O and 1O2, playing a dominant role. This led to the effective disruption of TMV coat protein and degradation of its genome within 5 min, achieving up to 6 log10 removal efficiency. Additionally, BM@CoNCNTs-CC/PMS system maintained efficient catalytic removal performance even in complex water matrices (river water and tap water). Overall, our research not only elucidates the production of efficient biomass-based catalysts for environmental remediation, but also highlights the application potential of biomass-based carbon nanotubes composites enriched with Co-Nx sites.

Highly sensitive fluorescent nitrobenzene gas sensing by nitrogen-doped graphene quantum dots embedded in ZIF-8 nanocomposite

This study introduces a straightforward and highly sensitive luminescence gas sensor designed for the detection of nitrobenzene in gaseous state. The sensor utilizes an innovative composite composed of nitrogen doped graphene quantum dots (nGQDs) as luminescent materials, successfully encapsulated within the stable porous carrier zeolitic imidazolate framework-8 (ZIF-8). The resulting nGQD@ZIF-8 nanocomposite showed highly sensitive luminescence sensing towards nitrobenzene gas, with a wide linear detection range from 8 to 320 ppm, and the detection limits of sensor as low as 0.44 ppm. Moreover, the nGQD@ZIF-8 sensor demonstrated enhanced ppm-level sensitivity and long-term stability for nitrobenzene detection at room temperature, while maintaining high stability under varying humidity levels and exposure to high temperatures. This enhancement is attributed to the increased contact area provided by ZIF-8 matrix, facilitating adsorption of nitrobenzene molecules on nGQDs. The nGQD@ZIF-8 exhibited good selectivity towards nitrobenzene gas (57 %) compared to other nitro volatile organic compound (VOC) vapors (nitromethane and nitropropane), and almost no significant responses were observed for the other tested VOC vapors (methanol, acetone, formaldehyde, benzene). This can be attributed to the strong interaction between the electron-deficient nitrobenzene and the nGQD@ZIF-8 nanocomposite. Overall, the proposed gas sensor in this study showed high potential for a simple, efficient, and reliable detection of nitrobenzene gas in environmental monitoring.

Design and therapeutic application of trans‐sodium crocetinate‐loaded cyclodextrin metal–organic frameworks as an enteric preparation for treating chronic heart failure

Chronic heart failure (CHF) arises from structural and functional changes in the myocardial tissue attributable to various etiologies. Crocetin and its derivative trans‐sodium crocetinate (TSC) have exhibited cardioprotective attributes; however, their poor aqueous solubility and bioavailability impede clinical development. This study aimed to construct a cyclodextrin metal–organic frameworks (CDMOFs)‐based oral delivery system to enhance the pharmacokinetic profile and therapeutic efficacy of TSC for CHF treatment. TSC was loaded into the synthesized γ‐CDMOFs via vacuum adsorption. The CDMOFs@TSC formulation was characterized and evaluated in vitro. Pharmacokinetic and pharmacodynamic analyses were performed in beagle dogs and CHF rats induced by coronary artery ligation, respectively. Both TSC and CDMOFs@TSC elicited no discernible toxicity or pathological changes in major organs of rats, providing preliminary evidence for their biosafety. Pharmacokinetic study in beagle dogs demonstrated that CDMOFs@TSC capsules markedly increase the relative oral bioavailability by 198% versus free TSC capsules. In rats afflicted with CHF, the administration of CDMOFs@TSC yielded notable enhancements in cardiac function. Additionally, it precipitated a reduction in biomarkers linked to myocardial injury, manifested anti‐inflammatory and antifibrotic effects, and induced alterations in myocardial energy metabolism. This is the first report of CDMOFs‐based oral delivery to improve the TSC bioavailability and efficacy. The utilization of CDMOFs@TSC resulted in superior therapeutic outcomes in comparison to standalone TSC by optimizing pharmacokinetics and precise targeted delivery. These results highlight the clinical potential of CDMOF as porous carriers to enable oral delivery of natural products for CHF therapy.

Lipase in-situ immobilized in covalent organic framework: Enzymatic properties and application in the preparation of 1, 3-dioleoyl-2-palmitoylglycerol

In this study, the critical importance of designing an appropriate immobilized carrier and method for free lipase to ensure exceptional biological catalytic activity and stability was emphasized. Covalent organic frameworks (COF-1) were synthesized as a novel porous carrier with an azine structure (-CN-NC-) through the condensation of hydrazine hydrate and benzene-1,3,5-tricarbaldehyde at room temperature. Simultaneously, Rhizomucor miehei lipase (RML) was immobilized within the COF-1 carrier using an in-situ aqueous phase method. Characterization of the carrier and RML@COF-1 and evaluation of the lipase properties of RML and RML@COF-1 through p-Nitrophenyl palmitate hydrolysis were conducted. Additionally, application in the synthesis of 1, 3-dioleoyl-2-palmitoylglycerol (OPO) was explored. The results showed that RML@COF-1 exhibited a high enzymatic loading of 285.4 mg/g. Under 60℃ conditions, the activity of RML@COF-1 was 2.31 times higher than that of free RML, and RML@COF-1 retained 77.25% of its original activity after 10 cycles of repeated use, indicating its excellent thermal stability and repeatability. Under the optimal conditions (10%, 1:8 PPP/OA, 45℃, 5 h), the yield of OPO reached 47.35%, showcasing the promising application prospects of the novel immobilized enzyme synthesized via in-situ aqueous phase synthesis for OPO preparation.

Biomass Carbon Anchored Co‐N4 Single‐Atom Catalyst for Efficient Hydrogen Evolution, Oxygen Evolution and Alcohol Oxidation Reaction

AbstractGreat efforts have been made to boost the performance of electrochemical catalysts by regulating the electronic and geometric structures. However, the electrochemical catalytic properties have entered the bottleneck stage only depend on these methods, especially in alkaline or neutral conditions. It is highly desired to develop new strategy to make robust electrocatalysts. In this study, an atomic Co‐N4 catalyst embedded on nitrogen‐doped 3D hierarchically porous carbon has been prepared via a facile method of calcining the coordination compound. Benefiting from the unique properties of Co single‐atoms, they are coordinated with the heteroatom nitrogen of o‐phenylenediamine and melamine and anchored on the nitrogen‐doped porous carbon carriers. The as‐synthesized Co‐N‐LPC with a maximum Co single‐atom loading of 3.82 wt % features a high specific surface area of 196.6 m2 g−1 and exhibits decently high hydrogen evolution, oxygen evolution and alcohol oxidation catalytic activities in 1.0 mol L−1 KOH electrolyte with competitive overpotentials of 131, 318 and 124 mV at 10 mA cm−2 current density respectively. This study offers a cost‐effective electrocatalyst for water splitting or alcohol oxidation that can be used instead of noble metals in various renewable energy storage and conversion applications.

Alginate aerogels by spray gelation for enhanced pulmonary delivery and solubilization of beclomethasone dipropionate

Aerogel technology is an emerging platform that offers alternative and cost-effective dry carriers with advanced performances for the pharmaceutical industry. The innovative combination of compressed air-assisted spray gelation and “green” supercritical fluid (SCF) technology was used in this study to produce alginate aerogel microparticles with adequate properties for pulmonary drug delivery. Beclomethasone dipropionate (BDP), a poorly water-soluble anti-inflammatory drug for asthma treatment, was loaded into alginate aerogel particles by SCF-assisted impregnation ensuring high loading, as well as the amorphization of the drug. The production of aerogels was optimized through the fine-tuning of parameters in compressed air-assisted spray gelation, specifically adjusting the air flow rate and the pump speed. Alginate aerogels were aimed to be produced with an appropriate aerodynamic diameter from 1 to 5 µm, measured by in vitro deposition tests with Next Generation impactor and potential for deep lung penetration. Nuclear magnetic resonance (NMR) relaxometry was used to assess aerogel hydration and unveiled structure–property relationships leading to the sudden release of the drug. Finally, in vitro cytotoxicity tests in fibroblasts and ex vivo permeability tests were conducted. These biological tests confirmed the excellent biocompatibility of the aerogel formulations and demonstrated the efficient deposition of BDP in porcine bronchial tissues assisted by the porous alginate aerogel carrier.

Effect of La2O3 adding on Properties of SiC Porous Ceramic Support

In this paper, 80-90 grains of SiC as the main raw material, doped La2O3 into the binder composed of potassium feldspar, kaolinite and quartz, and then graphite and activated carbon as pore-making agents to prepare silicon carbide porous ceramic carrier. The effects of doped La2O3 content on the bending strength, porosity and filtration pressure drop of porous SiC ceramics were studied. The results show that the formation of mullite phase and the bending strength of SiC porous ceramics can be improved by adding proper amount of La2O3. Under the sintering temperature of 1300°C for 90 minutes, when the content of La2O3 in the binder is 2.5wt%, the comprehensive performance is the best, the porosity is 21.5%, the bending strength is 53.5MPa, and the filtration pressure drop is low.

Impact of catalyst carrier with TPMS structures on hydrogen production by methanol reforming

As the core part of a microreactor, the reaction carrier provides reaction site and energy supply for hydrogen production. Among various types of reaction carriers, porous reaction carriers with complex flow path structures can effectively improve hydrogen production performance, and thus are widely applied in fuel cells. To optimize the structure of catalyst carriers and improve the efficiency of hydrogen production of methanol reforming, we designed four TPMS porous carrier structures, namely structures D, G, P and IWP, and analyzed the effect of carrier structure and parameters on hydrogen production reaction in theory. After that, we manufactured TPMS carriers with varied structures and parameters using 3D printing, and designed and carried out loading tests, flow velocity simulation experiments and pressure drop calculation to study the influence of the structure morphology on load intensity, heat and mass transfer and other performance indexes with catalyst load. Finally, we carried out hydrogen production experiments in microreactors with different TPMS structures, from which we obtained an pattern influence of hydrogen production conversion rate and hydrogen velocity etc. At different velocities and temperatures. The experimental results indicate that structure type and parameters of TPMS node and porosity have a great effect on the performance of hydrogen production. Specifically, structure D performs the best and structure P performs the worst in hydrogen production. When the velocity is 1.7 ml/h and the temperature is 250 °C, the maximum difference of the hydrogen conversion rate between D and P structure can reach to 22 %, and that of the hydrogen velocity can reach to 0.02 mol/h.

Carrier-based immobilization of Aerococcus viridansl-lactate oxidase

l-Lactate oxidase has important applications in biosensing and finds increased use in biocatalysis. The enzyme has been characterized well, yet its immobilization has not been explored in depth. Here, we studied immobilization of Aerococcus viridansl-lactate oxidase on porous carriers of variable matrix material (polymethacrylate, polyurethane, agarose) and surface functional group (amine, Ni2+-loaded nitrilotriacetic acid (NiNTA), epoxide). Carrier activity (Ac) and immobilized enzyme effectiveness (ɳ) were evaluated in dependence of protein loading. Results show that efficient immobilization (Ac: up to 1450 U/g carrier; ɳ: up to 65%) requires a hydrophilic carrier (agarose) equipped with amine groups. The value of ɳ declines sharply as Ac increases, probably due to transition into diffusional regime. Untagged l-lactate oxidase binds to NiNTA carrier similarly as N-terminally His-tagged enzyme. Lixiviation studies reveal quasi-irreversible enzyme adsorption on NiNTA carrier while partial release of activity (≤ 25%) is shown from amine carrier. The desorbed enzyme exhibits the same specific activity as the original l-lactate oxidase. Collectively, our study identifies basic requirements of l-lactate oxidase immobilization on solid carrier and highlights the role of ionic interactions in enzyme-surface adsorption.

Coaxial 3D printed Al2O3 ceramic continuous-flow fixed-bed reactor with bionic core-shell structure

Continuous-flow fixed-bed reactors (CFBR) have attracted considerable attention owing to their high efficiency and low energy consumption; however, the integrated fabrication of CFBR with core-shell structures remains a great challenge at present. Herein, a facile coaxial three-dimensional (3D) printing strategy was developed for the first time to rapidly and efficiently construct a CFBR with Al2O3 powder and aluminum dihydrogen phosphate (AP) as the outer shell ink, and Al2O3 powder, AP, and polymethyl methacrylate as the inner core ink that is extruded through a customized coaxial needle. Coaxial 3D printing realizes the integral fabrication of ceramic shells and inner porous ceramic carriers. CFBR with an outer wall thickness of 1.2 mm, core diameter of 3.7 mm, and variable length were fabricated, which were enabled with excellent catalytic properties by simply impregnating precious metal particles. The catalytic efficiencies for the reducing of 4-nitrophenol (4-NP) in the 3-cm-length Pd/CFBR, Pt/CFBR, and Ag/CFBR were found 96.9 %, 97.4 %, and 93 % after 10 min, respectively. Combining integrated fabrication, rapid prototyping, and complex architecture formation, coaxial 3D printing provides a novel strategy for directly integrating multifunctional CFBR.

Structurally engineered 3D porous graphene based phase change composite with highly efficient multi-energy conversion and versatile applications

Micro-nano encapsulation strategy combining three-dimensional (3D) porous carriers and phase change materials (PCMs) has been widely investigated due to its structure stability, high efficiency, and designability. However, the current 3D scaffolds suffering from structure regularity are hard to meet the urgent requirements of high energy conversion efficiency and versatile applications. Herein, a 3D porous graphene scaffold (2LrGO@LIG), which is fabricated from polybenzoxazine/graphene oxide (GO) composite using laser irradiation that structurally engineers a gully-shaped surface and a 3D overlapped graphene networks, was employed for PCMs encapsulation. The addition of GO is proved to enhance the quality of produced laser induced graphene (LIG), which could also be reduced into laser-reduced graphene oxide (LrGO) and connect the adjacent LIGs as thermal bridges. As a consequence, the obtained phase change composite (2LrGO@LIG/MA) showed photo-thermal and electro-thermal conversion efficiency of 94.1 % and 99.1 %, respectively. In addition, benefiting from the surface hydrophobicity (135°), high energy storage density (167.7 J/g) and electrical conductivity (307.9 S/m), 2LrGO@LIG/MA also demonstrated great potential in smart building materials and wearable electronic devices. This study provides a facile method for designing advanced PCM composites with multi-energy conversion capacity and application versatility.

Fabrication of shape-stable glycine water-based phase-change material using modified expanded graphite for cold energy storage

A shape-stable glycine water-based phase-change material (GPCM) was fabricated herein via natural adsorption using modified expanded graphite (MEG) as a porous carrier. Cetyltrimethylammonium bromide (CTAB) was introduced as a modifier on the surface of expanded graphite (EG) to synthesise MEG, which improved compatibility between EG and GPCM. Furthermore, the adsorption capacities of EG and MEG on GPCM were compared and analysed. The thermophysical properties of the as-prepared MEG/GPCM composite were evaluated using differential scanning calorimetry. Results revealed that MEG modified with 0.1 g of CTAB (MEG-0.1) had the best compatibility with GPCM and its adsorption capacity increased from 73.96% to 84.05% compared with that of unmodified EG. When the MEG content was 14%, the MEG/GPCM composite had a suitable melting temperature of −5.06 °C and high latent heat of 243.80 J/g. Moreover, the thermal conductivity was 1.836 W/(m⋅K), 216.33% higher than that of GPCM. After 100 thermal cycles, and the melting temperature and latent heat of the MEG/GPCM composite only decreased by 1.38% and 6.15% to −5.13 °C and 228.79 J/g, respectively. Thus, the prepared composites exhibited excellent thermal properties and showed great potential in the application of low-temperature cold energy storage and cold-chain transportation.