Catalysts based on metal-organic frameworks (MOFs) are promising candidates to enable fuel cells with higher performance and durability. Our recently developed PtCo catalyst on porous carbon support produced by pyrolysis of Ce-doped-ZIF (PtCo/Ce-ZIF) shows record-high outstanding performance and durability in fuel cell testing. The cell was operated under the conditions prescribed by the Million Mile Fuel Cell Truck Consortium (M2FCT) consortium (250 kPa, 85% relative humidity (RH), 90 C cell temperature, and 15% oxygen). At application-relevant operating voltages of 0.7 V and higher, the PtCo/Ce-ZIF exhibited higher performance than the commercial catalyst. The PtCo/Ce-ZIF catalyst at 0.7 V achieved a life beginning-of-life (BOL) performance level of 1.38 A/cm2; even more importantly, it showed substantially higher durability. The PtCo/Ce-ZIF catalyst provided a current density of 1.25 A/cm2 at 0.7 V after 90K accelerated stress test (AST) cycles, exceeding the M2FCT target of >1.07 A/cm2. The PtCo/Ce-ZIF also showed higher mass activity and greatly improved retention of mass activity of 0.77 A/mgPt vs. 0.54 A/mgPt, at BOL and ending of life (EOL), respectively, ~34 % mass activity loss after 90K AST cycles, exceeding the DOE target of <40% loss after 30K AST cycles. This study demonstrates that MOF-based catalysts are the leading candidates to enable fuel cell commercialization and deployment in support of the global effort to reduce greenhouse gas emissions.