Pore Opening Process Research Articles

A molecular model of low-voltage-activated calcium conductance

1. T-type or low-voltage-activated Ca2+ channels (IT) expressed in the mammalian thalamus play an important physiological role in the induction of membrane potential oscillations and in the regulation of the timing of synaptic signaling. On the basis of recent molecular studies on Ca2+, Na+, and K+ channels, a structure-kinetic model has been proposed for IT. 2. The model considers that the pore-opening process of IT is governed by three of the four protein domains that are arranged asymmetrically across the membrane plane. The three cytoplasmic linkers connecting individual channel domains serve as inactivation gates. On a membrane voltage change, each domain may engage independently into a sequential, thermodynamically coupled conformational change, thereby causing channel activation and inactivation. 3. A linear Marcov chain reaction with coupled channel activation and inactivation was adopted to test the kinetic feasibility of this trimeric model in a single-compartmental thalamic cell. The differential equations for voltage-dependent rate constants and transitional rates were solved to produce macroscopic T-type Ca2+ current. 4. Our simulation results indicate that this novel structure-kinetic model produces excellent predictions of the macroscopic behaviors of IT, and, more importantly, it provides some new insights into the microscopic mechanism underlying channel recovery.

The pore opening process and its influence on conductivity measurements of irradiated polymer films by application of the electrochemical etching method

The technique of the electrochemical etching of irradiated polymer films is an useful method to investigate structures of the track cores. The transversale etching rate as a function of the radius, derived from the time-dependence of the radius of the etching pore, can be interpreted as a corresponding magnitude of the degree of the damage within the track core. In the case of polymer films irradiated by a high track density, the influence of the time distribution of the breakthroughs (pore opening process) of the etching microchannels on the conductivity changes during the etching process is to be discussed. First represented results lead to statements about the statistical nature of the pore opening process.

Latent track structure in polymers as observed by a highly sensitive electrolytical conductivity measurement

First results of a new electrolytical conductivity cell are reported concerning the initial stage of the pore opening process during track etching in vitreous solids. On the basis of the soft mode (low-energy excitation) model for track etching, a distribution function for the number of perforated micropores as function of time is calculated by accounting for the radial etch rate as function of the effective pore radius.

Latent track structure in polymers as observed by a highly sensitive electrolytical conductivity measurement

First results of a new electrolytical conductivity cell are reported concerning the initial stage of the pore opening process during track etching in vitreous solids. On the basis of the soft mode (low energy excitation) model for track etching, a distribution function for the number of performed micropores as function of time is calculated. The results account for the radial etch rate as function of the effective pore radius.