States Population Research Articles

Describing functional low back pain disability in the American population: a crowd-sourced evaluation of the Oswestry disability index

BACKGROUND CONTEXTThe Oswestry disability index (ODI) is widely utilized as a patient reported outcome (PRO) tool to assess patients presenting with low back pain (LBP) and following thoracolumbar spine surgery. No primary study has calculated the baseline range of ODI values in the diverse American population. Establishing age-adjusted normative values for ODI in the American population is crucial for assessing the utility of treatment strategies. PURPOSEThe purpose of this study is to describe the baseline range of functional low back disability as measured by the ODI in an American population. STUDY DESIGN/SETTINGCross-Sectional Observational Study. PATIENT SAMPLEA total of 1214 participants were recruited from the United States in January 2024 using a combination of the Connect and PrimePanel platforms by CloudResearch to complete a survey administered on a RedCap online database. The survey consisted of 10 demographic questions and the 10 ODI survey questions. The distribution of the survey was designed to obtain approximately 100 respondents in each of the following age groups: 18–29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, 70 to 79, and 80 to 89. The distribution of the sample was similarly designed to match the United States Census racial data with 78.1% White, 13.9% Black, and 7.9% other. OUTCOME MEASURESOswestry disability index (ODI). METHODSA crowd-sourcing platform called Cloudresearch was used to collect a representative sample of the US population by answering questions of the Oswestry disability questionnaire (ODQ), a 10-question survey. RESULTSThe final sample size was 797 participants including 386 (48.4%) males and 411 (51.6%) females; 169 participants were excluded that did not complete the survey and an additional 248 were excluded for failing attention check questions. The overall mean ODI score for the combined age groups was 14.35 (95% CI [13.33, 15.37]). The mean ODI scores increased with age, with the highest mean ODI in ages 70 to 79 at 18.0 (95% CI [14.76, 21.24]). Female participants reported higher mean ODI scores than their male counterparts in the 18 to 29 age group (p=.01), 50 to 59 age group (p=.01), and 60 to 69 age group (p=.02). Additionally, a weak positive correlation was found between Body Mass Index (BMI) and ODI scores (r = 0.22, p<.001). CONCLUSIONOur findings demonstrate a clear trend of increased disability with age. This study describes the baseline range of functional low back pain disability in the United States population. By defining these parameters, healthcare professionals can better tailor age and sex-specific interventions to manage disability in the aging US population, ultimately improving patient care and both operative and nonoperative treatment plans for LBP-related thoracolumbar pathology.

The association between ethylene oxide and testosterone in the United States population: a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) 2013-2016.

Ethylene oxide (EO) is a prevalent industrial contaminant found in the environment and is related to various diseases such as cancers and hypertension. To the best of our knowledge, the association between EO and testosterone has not been explored. The aim of this article was to evaluate the relationship between EO and total testosterone (TT) in the United States population. In this study, hemoglobin ethylene oxide (HbEO) levels were utilized to evaluate the exposure to EO. The data of this study were collected from National Health and Nutrition Examination Survey (NHANES) 2013-2016. A total of 3300 participants were enrolled in this study and were separated into 5 groups based on the quintile of HbEO. Weighted multivariable logistic regression was used to assess the association between HbEO and TT. Subgroup analysis was conducted to investigate the connection between HbEO and TT in different stratifications. In the results, there was a positive relationship between log10-transformed HbEO and TT in the fully adjusted model [β = 37.08, 95% confidence interval (CI): 18.15-56.01, p = 0.004]. After log10-transformed HbEO transferred into a categorical variable based on the quintiles (Q1-Q5), the positive association remained in the highest group (Q5) compared to the lowest group (Q1) [β = 46.09, 95%CI: 12.29-79.90, p = 0.013]. Moreover, subgroup analysis demonstrated that the positive connection between log10-transformed HbEO and TT was stronger in males than females. The level of HbEO was positively related to TT in the U.S. population and the relation was more obvious in men compared to women.

Phonon pumping by modulating the ultrastrong vacuum

The vacuum (i.e., the ground state) of a system in ultrastrong light-matter coupling contains particles that cannot be emitted without any dynamical perturbation and is thus called virtual. We propose a protocol for inducing and observing real mechanical excitations of a mirror enabled by the virtual photons in the ground state of a tripartite system, where a resonant optical cavity is ultrastrongly coupled to a two-level system (qubit) and, at the same time, optomechanically coupled to a mechanical resonator. Real phonons are coherently emitted when the frequency of the two-level system is modulated at a frequency comparable to that of the mechanical resonator and, therefore much lower than the optical frequency. We demonstrate that this hybrid effect is a direct consequence of the virtual photon population in the ground state. Within a classical physics analogy, attaching a weight to a spring only changes its resting position, whereas dynamically modulating the weight makes the system oscillate. In our case, however, the weight is the vacuum itself. We propose and accurately characterize a hybrid superconducting-optomechanical setup based on available state-of-the-art technology, where this effect can be experimentally observed.

A behavioral theory of Leviathan Inc: State firms’ responses to performance shortfalls

We examine the role of ownership in organizational responses to performance shortfalls. State owners prize performance stability over being competitive, and their firms thus frame performance shortfalls differently than private firms do. In particular, state firms’ performance-stability orientation makes them respond to small performance shortfalls more readily than private firms do. They largely disregard performance comparisons with industry competitors, which more readily trigger divestitures at private firms. Comparisons among state firms matter relatively more. We find empirical support for these propositions in the population of Chinese state and private firms publicly traded in Shanghai and Shenzhen Stock Exchanges from 2003 to 2019. The frame-contingent responsiveness we document extends theory of organizational behavior and adds important nuance to our understanding of state-firm inertia.

Can Positive Play Deficits Explain the Associations Between Posttraumatic Stress Symptoms, Gambling Motives, and Problem Gambling? Results of a National U.S. Sample.

Past research has demonstrated a consistent connection between symptoms of posttraumatic stress disorder (PTSD) and problematic gambling in both general and clinical United States (U.S.) populations. Little is known, however, about the mediating role that responsible gambling practices related to positive play might have in the relationships between symptoms of PTSD, problem gambling (PG) severity, and different motives for gambling. Therefore, using mediation analysis, this study investigated these associations within a census-matched national sample of U.S. adults (N = 2,806). Results indicated PTSD symptoms and PG often co-occur in this population (r = .43, p < .01), and coping motives for gambling were the key mechanism connecting PTSD symptoms to PG severity rather than deficits in positive play practices or other gambling motives. Moreover, it was found that the average gambler who had sought treatment for gambling in the past not only had more severe PTSD symptoms and PG but also had the strongest gambling motives, the largest deficits in positive play, and was more likely to be younger than 50years old. In this sample, approximately 1 in 10 people who gambled in the past year were classified as problem gamblers, 1 in 5 met criteria for a provisional PTSD diagnosis, and 1 in 33 sought out gambling treatment previously. These findings provide further evidence for the relationship between symptoms of posttraumatic stress and problematic gambling behaviors in the U.S. population and offer critical insights into the explanatory roles of coping motives and positive play practices in this connection.

Demographic and clinical data of patients with spinal epidural angiolipomas

Spinal epidural angiolipomas are rare, benign, mesenchymal tumors. It remains unclear whether spinal epidural angiolipomas are genuinely rare or merely underreported. Herein, we assessed the demographic and clinical characteristics of patients with spinal epidural angiolipoma. We collected data from patients with spinal epidural angiolipoma from three sources. First, we retrospectively analyzed data from patients diagnosed with spinal epidural angiolipoma in our hospital between January 1, 2014, and December 31, 2023. Second, we performed a literature review of studies retrieved from PubMed. Third, we retrieved detailed data of patients with spinal angiolipoma from the Surveillance, Epidemiology, and End Results (SEER) database. We conducted a descriptive analysis to investigate the demographic and clinical characteristics of patients with spinal epidural angiolipoma. At our institution, three patients were diagnosed with spinal epidural angiolipoma. Additionally, we identified 116 patients from the literature review and 15 patients from the SEER database. We reviewed the treatment history and imaging features of the three patients from our institution. The descriptive analysis of the data collected from the literature review was consistent with previous reports. For example, 63.0% of lesions were located at the thoracic level. 31.9% of these lesions involved two vertebral bodies, while 75.6% involved 2–4 vertebral bodies. The most common symptoms experienced by patients were back pain, paraparesis, and numbness in the legs. Surgery was the primary treatment option for most patients, and complete tumor resection was achieved in the majority of patients. The male:female ratio was 1:1.4, the median age at diagnosis for the patients from the literature was 49 years old, and the median follow-up was 24 months. Notably, most of the reports came from Asia and there were few reports from Africa. The findings from the SEER database indicated a male:female ratio of 2:1. The peak incidence, which is typically reported in the fifth decade of life, was not observed. We presented three cases of spinal epidural angiolipoma and supplemented our findings with a literature review and population-based analysis according to the SEER database for the United States population. We believe that our research will enhance clinicians’ comprehension of this uncommon tumor.

Detailed structure of Sn131 populated in the β decay of isomerically purified In131 states

The excited structure of the single-hole nucleus Sn131 populated by the β− decay of In131 was investigated in detail at the ISOLDE facility at CERN. This new experiment took advantage of isomeric purification capabilities provided by resonant ionization, making it possible to independently study the decay of each isomer for the first time. The position of the first-excited νh11/2 neutron-hole state was confirmed via an independent mass spectroscopy experiment performed at the Ion Guide Isotope Separator On-Line facility at the University of Jyväskylä. The level scheme of Sn131 was notably expanded with the addition of 31 new γ-ray transitions and 22 new excited levels. The γ-emitting excited levels above the neutron separation energy in Sn131 were investigated, revealing a large number of states, which in some cases decay by transitions to other neutron-unbound states. Our analysis showed the dependence between the population of these states in Sn131 and the β-decaying In131 state feeding them. Profiting from the isomer selectivity, it was possible to estimate the direct β feeding to the 3/2+ ground and 11/2− isomeric states, disentangling the contributions from the three indium parent states. This made possible to resolve the discrepancies in logft for first-forbidden transitions observed in previous studies, and to determine the β-delayed neutron decay probability (Pn) values of each indium isomers independently. The first measurement of subnanosecond lifetimes in Sn131 was performed in this work. A short T1/2=18(4)−ps value was measured for the 1/2+ neutron single-hole 332-keV state, which indicates an enhanced l-forbidden M1 behavior for the ν3s1/2−1→ν3d3/2−1 transition. The measured half-lives of high-energy states populated in the β decay of the (21/2+) second isomeric state (In131m2) provided valuable information on transition rates, supporting the interpretation of these levels as core-excited states analogous to those observed in the doubly-magic Sn132. Published by the American Physical Society 2024

The effects of specific vegetable subtypes on constipation incidence in the general United States population.

While the intake of larger quantities of vegetables has been linked to a reduction in constipation risk, which vegetables in particular underlie this risk reduction remains incompletely understood. As such, the present study was developed to explore correlations between the intake of particular vegetable types and the risk of constipation. This cross-sectional analysis was based on data from the National Health and Nutrition Examination Survey (NHANES) collected from 2005-2010. Classifications and intake assessments for different vegetables were assessed with the Food Patterns Equivalents Database (FPED), while stool frequency or stool consistency was used to define constipation. Relationships between the intake of particular vegetable components and constipation were assessed through a weighted logistic regression approach. Subgroup and restricted cubic spline (RCS) regression analyses were further employed to explore associations between specific vegetable subtypes and constipation. This study included 13,860 eligible subjects, of whom 1,405 and 12,455 were respectively classified into the constipated and non-constipated groups. Following multivariate adjustment, the intake of non-starchy vegetables including orange, red, dark green, and other vegetables was found to be positively associated with a reduction in constipation risk. In contrast, constipation was unrelated to total starchy vegetable or potato intake. Tomatoes, in particular, were associated with a marked decrease in constipation risk (odds ratios: 0.80, 95% confidence interval: 0.71-0.91). These results were confirmed through RCS and subgroup analyses. Non-starchy vegetables, particularly tomatoes, were found to be associated with a pronounced reduction in constipation risk, which was unaffected by the intake of potatoes or starchy vegetables.

Constructing Heavy-Atom-Free Photosensitizers for Hypoxic Tumor Phototherapy Based on Donor-Excited Photoinduced Electron-Transfer-Driven Type-I and Type-II Mechanisms.

The spin-orbit charge transfer intersystem crossing (SOCT-ISC) photophysical process has shown great potential for constructing heavy-atom-free photosensitizers (PSs) for photodynamic therapy (PDT) of tumors. However, for almost all such PSs reported to date, the SOCT-ISC is driven by the acceptor-excited photoinduced electron transfer (a-PeT). In this work, for the first time the donor-excited photoinduced electron transfer (d-PeT)-driven SOCT-ISC mechanism is utilized to construct the heavy-atom-free PSs for PDT of tumors by directly installing the electron-deficient N-alkylquinolinium unit (as an electron acceptor) into the meso-position of the near-infrared (NIR) distyryl Bodipy chromophore (as an electron donor). In the less polar environment, the PSs exist as the monomer and promote the production of singlet oxygen (1O2) (Type-II) relying on the d-PeT-driven population of the triplet excited state via SOCT-ISC, whereas in the aqueous environment, they exist as nanoaggregates and induce the generation of superoxides (O2-•) and hydroxyl radicals (HO•) (Type-I) via the d-PeT-driven formation of the delocalized charge-separated state. The PSs could rapidly be internalized into cancer cells and induce the simultaneous production of intracellular 1O2, O2-•, and HO• upon NIR light irradiation, endowing the PSs with superb photocytotoxicity with IC50 values up to submicromolar levels whether under normoxia or under hypoxia. Based on the PSs platform, a tumor-targetable PS is developed, and its abilities in killing cancer cells and in ablating tumors without damage to normal cells/tissues under NIR light irradiation are verified in vitro and in vivo. The study expands the design scope of PSs by introducing the d-PeT conception, thus being highly valuable for achieving novel PSs in the realm of tumor PDT.

Compound-Nucleus and Doorway-State Decays of β-Delayed Neutron Emitters ^{51,52,53}K.

We investigated decays of ^{51,52,53}K at the ISOLDE Decay Station at CERN in order to understand the mechanism of the β-delayed neutron-emission (βn) process. The experiment quantified neutron and γ-ray emission paths for each precursor. We used this information to test the hypothesis, first formulated by Bohr in 1939, that neutrons in the βn process originate from the structureless "compound nucleus." The data are consistent with this postulate for most of the observed decay paths. The agreement, however, is surprising because the compound-nucleus stage should not be achieved in the studied β decay due to insufficient excitation energy and level densities in the neutron emitter. In the ^{53}K βn decay, we found a preferential population of the first excited state in ^{52}Ca that contradicted Bohr's hypothesis. The latter was interpreted as evidence for direct neutron emission sensitive to the structure of the neutron-unbound state. We propose that the observed nonstatistical neutron emission proceeds through the coupling with nearby doorway states that have large neutron-emission probabilities. The appearance of "compound-nucleus" decay is caused by the aggregated small contributions of multiple doorway states at higher excitation energy.

Representation and Race in Adolescent Idiopathic Scoliosis Research: Disparities in Curve Magnitude and Follow-Up.

Prospective Cohort Study. The present study aims to determine if the racial representation of patients enrolled in a large prospective scoliosis registry is reflective of the general United States population. Further, we studied whether there was an association between race, pre-operative parameters, outcomes and loss to follow-up. Prospectively collected data for patients who underwent spinal fusion for adolescent idiopathic scoliosis (AIS) was reviewed, including self-reported race/ethnicity. The U.S. pediatric population and U.S. patients enrolled in the prospective registry were compared. The data obtained was analyzed for variations between races, for pre-operative variables and follow-up. Of the 2210 included patients in the registry 66% of patients reported as White, while 52% of the 2018 U.S. pediatric population reported as White. 15% of the registry reported as Hispanic/Latino compared to 22% of the U.S. pediatric population, 13% Black compared to 14% of the U.S. pediatric population, and 4% Asian compared to 5% of the U.S. pediatric population. Asian and White patients had statistically significant higher 2-year follow-up in all but one of six enrollment sites (P < 0.001). Native American, Other, and Hispanic/Latino patients had the highest BMIs. Native American and Black patients had the highest pre-op thoracic Cobb angles. Pre-op ages of Black, Hispanic, and Native American patients were statistically lower (P < 0.01). This study demonstrates the association between race and patient follow-up and pre-operative factors in patients who underwent surgery for AIS. Black, Native American, and Hispanic populations were underrepresented both at pre-op and follow-up when compared to their relative proportion in the U.S. pediatric population.

Age-based disparities in hearing loss diagnosis and treatment in the United States population

ObjectiveTo investigate age-related disparities in the diagnosis and treatment of borderline/mild hearing loss (HL) in the United States. Study designA cross-sectional epidemiologic study. SettingThe National Health and Nutrition Examination Survey (NHANES). MethodsMultivariable logistic regressions controlling for hearing level were performed to investigate the association between: (1) age and recent hearing test; (2) age and hearing aid use. Age was grouped into quartiles (<25, 25–49, 50–74, ≥75 years). The first quartile of life was used as a reference group in all odds ratios, controlling for hearing level. ResultsOf 2115 participants with borderline/mild HL, 3 % (n = 53) were in age quartile Q1; 7 % (n = 147) were in Q2, 56 % (n = 1190) were in Q3, and 34 % (n = 725) were in Q4. Compared to Q1, those in Q2, Q3, and Q4 had 4.06 times (95 % CI = 2.11–8.02, p < 0.001), 4.51 times (2.56–8.19, p < 0.001), and 4.56 times (2.55–8.39, p < 0.001) lower odds of a hearing test within the past 4 years. Similar, although slightly larger, odds ratios were obtained when the outcome was hearing test within 1 year. Compared to Q1, those in Q2, Q3, and Q4 respectively had 4.38 times (1.47–13.5, p < 0.05), 5.41 times (2.27–11.8, p < 0.001), and 3.95 times (1.65–8.72, p < 0.05) lower odds of using a hearing aid. ConclusionWe have characterized a large, unaddressed, and modifiable disparity in the treatment of borderline/mild HL as individuals age out of the first quartile of life. Future studies are needed to explore factors, such as ageism, that may underlie these findings.

Chimera states and information transfer in interacting populations of map-based neurons

We investigate the synchronization behavior and the emergence of chimera states in a system of two interacting populations of maps possessing chaotic neural-like dynamics. We characterize four collective states on the space of coupling parameters of the system: complete synchronization, generalized synchronization, chimera states, and incoherence. We quantify the information exchange between the two neuron populations in chimera states. We have found a well-defined direction of the flow of information in chimera states, from the desynchronized population to the synchronized one. The incoherent population functions as a driver of the coherent neuron population in a chimera state. This feature is independent of the population sizes or population partitions. Our results yield insight into the communication mechanisms arising in brain processes such as unihemispheric sleep and epileptic seizures that have been associated to chimera states.

Multiple Pathways in the Triplet States Population for a Naphthalenediimide-C60 Dyad.

The link of an antenna dye with an electron spin converter, in this case naphthalenediimide and C60, produces a system with a rich photophysics including the detection of more than one triplet state on the long timescale (tens of μs). Beside the use of optical spectroscopies in the ns and in the fs time scale, we used time-resolved Electron Paramagnetic Resonance (TREPR) to study the system evolution following photoexcitation. TREPR keeps track of the formation path of the triplet states through specific spin polarization patterns observed in the spectra. The flexibility of the linker and solvent polarity play a role in favouring either electron transfer or energy transfer processes.

Making and Unmaking Migrants’ Family Relationships in Finland: A Study of Nordic Welfare State Population Registration and Statistics Production

Making and Unmaking Migrants’ Family Relationships in Finland: A Study of Nordic Welfare State Population Registration and Statistics Production

Controlling 229Th isomeric state population in a VUV transparent crystal

The radioisotope thorium-229 (229Th) is renowned for its extraordinarily low-energy, long-lived nuclear first-excited state. This isomeric state can be excited by vacuum ultraviolet (VUV) lasers and 229Th has been proposed as a reference transition for ultra-precise nuclear clocks. To assess the feasibility and performance of the nuclear clock concept, time-controlled excitation and depopulation of the 229Th isomer are imperative. Here we report the population of the 229Th isomeric state through resonant X-ray pumping and detection of the radiative decay in a VUV transparent 229Th-doped CaF2 crystal. The decay half-life is measured to 447(25) s, with a transition wavelength of 148.18(42) nm and a radiative decay fraction consistent with unity. Furthermore, we report a new “X-ray quenching” effect which allows to de-populate the isomer on demand and effectively reduce the half-life. Such controlled quenching can be used to significantly speed up the interrogation cycle in future nuclear clock schemes.

Weight-adjusted-waist index is positively associated with urinary incontinence: results from the National Health and Nutrition Examination Survey (NHANES) 2001–2018

BackgroundUrinary incontinence (UI) is closely related to obesity. The aim of this study is to evaluate the association of a novel anthropometric indicator weight-adjusted-waist index (WWI) with UI.MethodsThis cross-sectional study used the data from National Health and Nutrition Examination Survey (NHANES) 2001–2018. Weighted multivariable logistic regression was used to evaluate the relationship between WWI and three types of UI [stress UI (SUI), urgency UI (UUI), and mixed UI (MUI)]. The receiver operating characteristic (ROC) curve and Delong et al.’s test were utilized for comparison of the predictive capability for UI between WWI and body mass index (BMI), waist circumference (WC).ResultsA total of 41,614 participants were included in this study, of whom 23.57% had SUI, 19.24% had UUI, and 9.43% had MUI. In the fully adjusted model, WWI was positively associated with three types of UI [SUI: odds ratio (OR) = 1.19, 95%Confidence interval (CI) 1.13–1.25; UUI: OR = 1.18, 95%CI 1.13–1.24; MUI: OR = 1.19, 95%CI 1.11–1.27, all p < 0.001]. Compared to the lowest WWI interval, the positive correlation between WWI and UI still existed in the highest WWI group after converting WWI to a categorical variable by quartiles (SUI: OR = 1.52, 95%CI 1.35–1.71, p < 0.001; UUI: OR = 1.50, 95%CI 1.33–1.69, p < 0.001; MUI: OR = 1.55, 95%CI 1.32–1.83, p < 0.001). WWI had a stronger prediction for three types of UI than BMI and WC (all p < 0.001).ConclusionA higher WWI was linked with an increased likelihood of three types of UI (SUI, UUI, and MUI) in the United State population. Compared to BMI and WC, WWI had a stronger predictive power for UI. WWI may be a better adiposity parameter for evaluating UI.

COVID-19 vaccination hesitance and adverse effects among US adults: a longitudinal cohort study.

Although Coronavirus disease 2019 (COVID-19) vaccination is critical to control its spread, vaccine hesitancy varies significantly among the United States population; moreover, some vaccine recipients experienced various adverse effects. We aim to assess the impact of COVID-19 vaccine hesitancy in a university-affiliated community, the factors affecting participants' decisions, and their adverse effects. A pre-vaccination online Institutional Review Board IRB-approved survey was emailed in Nov/Dec 2020, 2 months before the implementation of state-policy protocols for COVID-19 vaccination. A post-vaccination survey was emailed in May/June 2021, two months after protocol execution. A third follow-up survey was sent in Nov/Dec 2021, and a fourth was sent in June/July 2022. The study population included three groups of adult participants: university students, faculty, and staff-(MS), university health system patients-(MP), and Cancer Center patients-(MCP). The study was designed as a longitudinal cohort study. Statistical analyses were performed using SPSS. With a combined response rate of 26% (40,578/157,292) among the four surveys, 15,361 participants completed the first survey (MS = 4,983, MP = 9,551, and MCP = 827). 2/3 of participants (63.5%) were willing to get vaccinated, with a significant difference in acceptance among groups, MS:56.6%, MP:66.2%, and MCP:71.6% (p < 0.05). Vaccine acceptance rates reached 89% in the second survey after the vaccine's approval, with a lower acceptance rate of MS:84.6% than with MP:90.74% and MCP:92.47% participants (p < 0.05). Safety and effectiveness concerns were the main factors affecting participants' decisions in all the first three surveys; however, participants reported these concerns decreased between pre-vaccination, post-vaccination, and follow-up surveys with 87%, 56%, and 46%, respectively(p < 0.05). More than two-thirds of the participants (70%) reported having either minor/moderate symptoms (61.6%) or major symptoms (8.6%) after getting some of the vaccine doses (p < 0.05). The hesitance of COVID-19 vaccination was associated with concerns regarding its safety and efficacy. Vaccine acceptance rose higher than expected after protocol execution, likely due to continuous education, whereas safety and efficacy remain factors hindering vaccine acceptance. Continuous education focusing on safety and efficacy of the vaccine can reduce vaccine hesitancy and raise the rates of vaccination.

Practice Of Shifting Cultivation and Its Implications in The Hill Districts of Manipur, North-East India

This paper highlights the practices of shifting cultivation and its implications in North-East India with special references to Manipur hill districts. Agriculture is the main and single largest source of livelihood in the state. About 70 percent of the total population is engaged in agriculture and allied activities. The Manipur Hill region comprises five districts, viz. Chandel, Churachandpur, Senapati, Tamenglong, and Ukhrul. It has a total population of 6, 51,156 which represents 35.45 percent of the state's total population. The hill districts occupy about 90 percent (20089 sq. km) of the total area of the state. The data about the area under shifting cultivation is not the same as it varies from year to year. Out of the total net shown area shifting cultivation covers 46%. Rice is the main staple food crop in this region. Shifting cultivation has both problems and prospects and impact on the forest and landscape in the environment. The average fallow period is 7-8 years as per the data collected through key informant interviews from the study area.

Synthetic datasets for open software development in rare disease research

BackgroundGlobally, researchers are working on projects aiming to enhance the availability of data for rare disease research. While data sharing remains critical, developing suitable methods is challenging due to the specific sensitivity and uniqueness of rare disease data. This creates a dilemma, as there is a lack of both methods and necessary data to create appropriate approaches initially. This work contributes to bridging this gap by providing synthetic datasets that can form the foundation for such developments.MethodsUsing a hierarchical data generation approach parameterised with publicly available statistics, we generated datasets reflecting a random sample of rare disease patients from the United States (US) population. General demographics were obtained from the US Census Bureau, while information on disease prevalence, initial diagnosis, survival rates as well as race and sex ratios were obtained from the information provided by the US Centers for Disease Control and Prevention as well as the scientific literature. The software, which we have named SynthMD, was implemented in Python as open source using libraries such as Faker for generating individual data points.ResultsWe generated three datasets focusing on three specific rare diseases with broad impact on US citizens, as well as differences in affected genders and racial groups: Sickle Cell Disease, Cystic Fibrosis, and Duchenne Muscular Dystrophy. We present the statistics used to generate the datasets and study the statistical properties of output data. The datasets, as well as the code used to generate them, are available as Open Data and Open Source Software.ConclusionThe results of our work can serve as a starting point for researchers and developers working on methods and platforms that aim to improve the availability of rare disease data. Potential applications include using the datasets for testing purposes during the implementation of information systems or tailored privacy-enhancing technologies.