Population Of Dagestan Research Articles

ANALYSIS OF POLYMORPHISMS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND RELATION TO VASOPRESSORS IN ESSENTIAL SYSTEMIC HYPERTENSION WITH THE LEFT VENTRICLE HYPERTROPHY IN DAGESTAN REPUBLIC

Aim. To assess the prevalences of genotypes and alleles polymorphisms of reninangiotensin-aldosterone system, and β2-adrenoreceptors, and to evaluate the results in regard to vasopressor levels in blood serum in essential systemic hypertension (ESH) with the left ventricle hypertrophy (LVH) and with none, in Dagestan Republic population. Material and methods. To the assessment, 98 patients included with the diagnosis “essential systemic hypertension with or none LVH”. Genotypes were assessed, of polymorphism A1166C gene AGTR1 and polymorphism Arg16Gly gene ADRB2. The testing of the polymorphisms was performed with allele-specific polymerase chain reaction. Level of angiotensin (At) II, endothelin (et) 1-21 and aldosterone (AS) in blood serum was measured by the hard-phase IeA. Level of ACe was measured by enzymatic method. Statistics was done with the software statistica (version 6.0) and “Biostat 4.03”. Results. In EAH patients with LVH the prevalence of Arg/Arg polymorphism Arg16Gly gene ADRB2 was lower than in control. In EAH with no LVH there is significant decline of AC genotype prevalences of polymorphism A1166C gene AGTR1 and genotype Arg/Arg polymorphism Arg16Gly gene ADRB2. Level of EТ1-21 and АТ II in the group of EAH with no LVH patients was significantly higher than in controls. Level of AT II in EAH with LVH was significantly higher than none LVH group. Increase of the levels of these mediators of AH was followed by a decline of AS level in the groups of patients comparing to controls. In EAH group with LVH significant increase of et 1-21 was associated with the carriage of As polymorphism A1166C gene AGTR1, and genotypes АА and СС of the same polymorphism were associated with the decrease of levels of EТ1-21. In EAH with no LVH a significant decrease of At II level was found in the carriers of AA and AC genotypes of polymorphism A1166C gene AGTR1. Also, the association was found of all genotypes of polymorphism Arg16Gly gene ADRB2 with the decrease of АТ II. Conclusion. In Dagestan population, in EAH with and with no LVH, most significant are genotypes AA, AC and CC of polymorphism A1166C gene AGTR1, and genotypes Arg/Arg, Arg/Gly, Gly/Gly and alleles Arg and Gly polymorphism Arg16Gly gene ADRB2. Pathogenic significance of the mentioned polymorphisms is emphasized by the presence of polymorphism ET1-12, АТ II, Аs in blood serum.

ECOLOGICAL-GEOGRAPHICAL CONDITIONALITY AND PROGNOSIS DISEASE OF CANCER OF THE CHILDREN'S POPULATION OF DAGHESTAN REPUBLIC

For the first time in the study area carried out a comprehensive statistical analysis of child cancer rates in the period from 1991 to 2010 and its forecast for the next 10 years. Determined the dynamics and the predominant forms of locali-zation of child cancer.Also calculated the age structure of morbidity by malignant neoplasms of the child population of Dagestan.

Variation of the parameters of natural reproduction and Crow’s indices in the ethnic groups of Dagestan

Using the 2002 All-Russian population census data, the parameters of differential fertility as a component of natural selection (Crow's indices) have been calculated for women of seven age cohorts of the seven most numerous ethnic groups of the Republic of Dagestan. It has been shown that in the population of Dagestan in the second half of the 20th century the intensities of two types of selection tended to decrease, viz., intragroup selection relaxed in each ethnic group due to considerable reduction of interfamily variance in fertility and intergroup selection relaxed due to reduction ofinterethnic differences in fertility. A reduction of the average number of offspring (kappa) was observed in all ethnic groups, suggesting the spread of birth regulation practices (abortion and contraception). Nevertheless, all Muslim groups (aboriginal Dagestan ethnic groups and Azerbaijanis) are still characterized by an extended pattern of reproduction (2.7 < kappa < 3.3); in Russians kappa = 2.1. Interethnic differentials in natural reproduction rates, along with migration processes, account for the dynamics of the ethnic composition and gene-pool structure of the population of the Republic of Dagestan.

The dagestan gene pool: The genetic structure of the nine largest ethnic groups: Analysis based on data on the AB0 and Rhesus blood groups

Detailed analysis of the population structure of Dagestan ethnic groups based on data on the ABO and Rhesus blood groups has been carried out. A total of 32101 representatives of the nine largest ethnic groups of Dagestan (from 682 auls in 46 raions) have been examined. This allows a comprehensive genetic landscape of the Dagestan population to be drawn. Comparison of the ethnic groups studied with other Caucasian ethnic groups makes it possible to determine the position of the Dagestan gene pool in the total structure of the Caucasian gene pool.

Population analysis and determination of the ethnic background are necessary in the study of multifactorial diseases: A study using the Dagestan population as a model

Psoriasis, a multifactorial disease with genetic predisposition, has been used as an example to study the role of the ethnic background in multifactorial diseases in the Dagestan population. The individual information card (IIC) is proposed as the main tool for correct collection and processing of information. The results of the study demonstrate that the Dagestan population is a convenient and adequate model population for studying multifactorial diseases, such as psoriasis, and may serve as an object for studying the role of heredity in the etiologies and pathogeneses of this and other multifactorial diseases.

Recent Russian Federal Elections in Dagestan: Implications for Proposed Electoral Reform

THE RUSSIAN STATE DUMA ELECTION, on 7 December 2003, and the presidential election, on 14 March 2004, both showed particularly high levels of voter turnout and support in North Caucasian republics for the party of power. How should these results be interpreted? Dagestan's election results provide an interesting study, and suggest possible consequences of President Putin's proposed electoral changes. The Russian State Duma consists of 450 representatives. Half of these are currently elected in single-mandate territorial districts. The other half of the Duma representatives are chosen from electoral lists of federal political parties registered by the Justice Ministry of the Russian Federation and certified by the Central Electoral Commission for participation in the election. On 13 September 2004 President Putin proposed that all Duma representatives should be subsequently selected from party lists. According to the Central Electoral Commission, there are presently more than 108 million voters in Russia, or approximately 482,300 voters per territorial district.1 Each territorial electoral district should approximate this number, while not breaching the boundaries that separate the 89 administrative subjects of the Russian Federation. From the first Duma election, in December 1993, Dagestan was divided into two single-mandate territorial districts with approximately 550,000 voters in each. These were the Buinaksky electoral district, No. 10, and the Makhachkalinsky electoral district, No. 11, together giving Dagestan two seats in the lower chamber of the legislative organ. Prior to the 2003 Duma election, however, Dagestani leaders persuaded the Central Electoral Commission to add one district in Dagestan. The addition was justified in terms of a significant increase in Dagestan's population in the interval since the 1989 census. Designated as the Derbentsky district, No. 12, Dagestan's third electoral territory was established at the expense of other regions of Russia with declining populations.2 The addition of this third district offered improved prospects for the attainment of balanced ethnic representation, which is the perennial aim of Dagestani leaders. With this in view, Dagestan's internal raiony were redistributed among the three districts in order to create three electoral units with approximately the same number of voters. The new Derbentsky electoral district established in the southern regions of the Republic includes somewhat greater numbers of ethnic Lezgin than ethnic Dargin

Behcet's disease in Dagestan

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