Population Loss Research Articles

Tooth Loss and Systemic Diseases in the Slovenian Elderly Population: A Cross-Sectional Study of the Associaton Between Oral and Systemic Health.

This study aimed to assess the prevalence of edentulism and tooth loss in the Slovenian elderly population, along with the associated risk factors, and investigate the association between systemic and oral health. The study included 445 individuals aged 65 or older (average age: 79.7±8.9 years). Data on preserved teeth, dental history, chronic diseases, and medications were collected through clinical examinations. Height and weight were recorded in order to calculate body mass index (BMI), and the education level was also collected. Chronic systemic diseases and medications were categorized. Statistical analysis was conducted using linear regression and nonparametric tests. Participants had an average of 4.7±7.7 teeth, with no significant gender differences. Higher age (β=-0.185, p<0.001) and lower education level (p<0.001) were associated with fewer teeth, while higher BMI showed no correlation (β=-0.085, p=0.325). Diabetes mellitus (p=0.031), cardiovascular diseases (p=0.025), and thyroid diseases (p=0.043) were inversely related to retained teeth. This inverse relationship also applied to individuals who recovered from malignancies, not including head and neck malignancies (p=0.019). No significant relationship was found between osteoporosis and the number of teeth (p=0.573). Notably, antidiabetic drug use was inversely related to the number of teeth (p=0.004), while analgesics showed a positive relationship (p=0.022). This study highlights the association between specific sociodemographic factors, chronic diseases, and retained teeth among elderly individuals in Slovenia. High edentulism rates among the elderly emphasize the need for enhanced preventive measures and risk factor management, particularly for high-risk groups like the elderly.

Abstract P456: Loss of Renal Resident Tissue Macrophages Reduces Nitric Oxide-Mediated Relaxation during Salt-Sensitive Hypertension

Salt-sensitive hypertension (SS-HTN) associates with increased renal sodium reabsorption, arterial dysfunction, and heightened pro-inflammatory cytokines such as interleukin 6 (IL-6). Renal resident tissue macrophages (rRTMs) function to both maintain tissue homeostasis and once activated, can secrete IL-6. We reported that loss of the rRTM population prevents SS-HTN but their influence on arterial reactivity has not been tested. We hypothesize that rRTM-induced IL-6 production impairs endothelial function. Wild-type (Wt) or rRTM-depleted (CX 3 CR 1 - EGFP+/+ ) male mice (12wks) were used. Mice were given the nitric oxide synthase (NOS) inhibitor, L-NAME (0.5mg/mL, in drinking water, 2wks) and allowed to washout (1-2wks) before fed normal chow (NC), high salt (HS) chow (4%) for 2 days (early salt-sensitive, eSS) or for 3wks HS (SS-HTN). eSS mice were salt-sensitive, but not yet hypertensive. Mice were also given HS chow alone (3wks). Serum was collected for systemic cytokines (Meso-Scale Discovery; n=4-15) and second-order mesenteric resistance arteries (MRAs) were obtained (n=3-5). Concentration response curves (CRCs) to phenylephrine (Phe) and acetylcholine (ACh) were performed in the presence or absence of potassium chloride (KCl) or L-NMMA. Serum IL-6 levels were not increased following HS diet alone, but concentrations trended higher during SS-HTN (1.46 ± 0.2 pg/mL vs. 1.07 ± 0.2 pg/mL NC). The nadir was observed in eSS mice, before the development of SS-HTN, and was prevented in rRTM-depleted mice (1.81 ± 0.3 pg/mL vs. 0.58 ± 0.17, **p&lt;0.001, grouped ANOVA). No differences were observed between NC-fed Wt and rRTM-depleted MRAs, but the development of SS-HTN did impair relaxation responses. Overall, ACh-mediated relaxation responses were generally lower in MRAs from rRTM-depleted mice compared to Wt. Interestingly, rRTM-depleted MRAs from SS-HTN animals exhibited a near complete inhibition of all relaxation responses with NOS inhibition (R max 6.20% ± 8 rRTM SS-HTN vs. 63.0% ± 10 Wt SS-HTN, *p&lt;0.05), suggesting greater dependence on NO-mediated relaxation. Together, these data suggest that rRTMs contribute to an early, hypertension-independent spike in IL-6 which may reduce endothelial function later during SS-HTN. We also show that rRTM-depletion affects the function of the resistance vasculature, including loss of non-NO-mediated relaxation during SS-HTN. These data suggest that renal-derived cytokines, via rRTMs, may influence endothelial function.

GLP-1 receptor agonists and weight loss in schizophrenia - past, present, and future.

People with schizophrenia experience three to five times higher prevalence of diabetes and obesity than the general population, contributing to a 20-year reduced lifespan. The impacts of weight gain extend beyond physical health, affecting people's self-esteem, quality of life, and triggering treatment nonadherence, leading to relapse and deteriorations in health. Clinical guidelines recommend patients with antipsychotic-induced weight gain are treated with cognitive behaviour therapy and lifestyle changes; however, effective treatments for obesity in schizophrenia are critically lacking. Glucagon-like peptide-1 receptor agonists (GLP-RAs) have shown large effects in weight loss in the general population; however, effects are less clear in people with schizophrenia. This review aims to assess the clinical trials that have been completed, are in progress, and directions for future trials. To date, six clinical trials have been completed, four of which have published their findings. Three further trials are currently in progress. Results from completed trials suggest that GLP-1RAs decrease weight in people with schizophrenia, however effect sizes are mostly smaller than studies based on the general population. Future trials could focus on dual or triple agonist agents, and/or explore the effects of GLP-1 s at antipsychotic medication commencement, to potentially prevent antipsychotic weight gain.

Family or career? Intergenerational differences in values

Structurally disadvantaged regions are looking for ways to attract and retain educated people who are the pillars in community for economic, social, and cultural prosperity. This research is aimed at gaining insight into the values and preferences of such people in order to better understand their decision-making. The study sample (n = 1350) was formed using quota-wide sampling (university-educated people). The data was collected by a specialized research agency using an electronic survey. The values and preferences were first determined using a semantic differential scale, and then the significance was verified by a Kruskal Wallis test followed by a post hoc test. Based on the statistical analysis, it was found for all generations that the ideal place to live is a quiet village or smaller town with good civic amenities, transport accessibility, and proximity to nature. This offers an opportunity for several villages that saw a large loss of population in the past when inhabitants left for big cities at the end of the last century. Another common value across generations is the preference for family over single life. However, Generation Z differs from Generation X and Y in their preference for career over family and even their preference for career over leisure time, which is not entirely consistent with Inglehart's theory on the preference for post-materialist values.

서울시 인구변화와 중고령기 수면건강 - 외국인 밀집정도와 지역사회 응집력의 상호작용을 중심으로

This study examines whether neighborhood demographic characteristics are associated with sleep health among Korean older adults and whether this association is moderated by neighborhood social cohesion. Data are drawn from the 2019 Seoul Survey Data (SSD) merged with various sources of contextual data to assess information on population loss, age structure and immigrant concentration at the Gu level (N=20,319). We defined poor sleep health as respondents reporting six hours or less of sleep (coded 1; otherwise 0) Results from multilevel logistic regression model indicated that older adults who live in neighborhoods with high levels of immigrant concentration are more likely to experience poor sleep health. However, this association was mitigated by neighborhood social cohesion, such that those who have high levels of neighborhood social cohesion appear to be less influenced by immigrant concentration. This study suggests that neighborhood social cohesion may play a buffering role in minimizing the negative influence of neighborhood immigrant concentration on sleep health among older adults in Korea. Social policy and intervention aimed at promoting social cohesion may help reduce further disparities in poor sleep health in later life.

Characterization of gut microbiota in the Uyghur osteopenia population

The objectives of this study were to investigate the composition of gut microbiota and its relationship with bone loss in the Uyghur osteopenia population, identify potential disease-related taxa and collect information for the prevention and treatment of osteopenia in different people by regulating gut microbiota. We selected Uyghur residents, measured their heel BMD, collected faeces and general information, grouped them by BMD level, obtained faecal 16S rRNA sequences, and compared and analysed the differences between the groups. This study showed that the numbers of OTUs and species in the gut microbiota in the osteopenia group were higher than those in the control. At the phylum level, Erysipelotrichia was more abundant in the osteopenia group. At the genus level, Phascolarctobacterium was less abundant, and Ruminiclostridium_5 was more abundant in the osteopenia group compared to the control. Phascolarctobacterium and Z-score were positively correlated, and Ruminiclostridium_5 was negatively correlated with T and Z score. The different composition of the gut microbiota in Uyghur osteopenia patients and controls found in this study fills a knowledge gap in this ethnic group. The relationship between Uyghur osteopenia and BMD-associated bacterial genera deserves further exploration.

Exploring prevalence and risk factors association of osteoporosis among chronic obstructive pulmonary disease patients: a cross-sectional study in western Rajasthan

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition with progressive respiratory symptoms and systemic complications, including osteoporosis. It is characterized by decreased bone mass represents significant health risks among COPD patients. However, associated risk factors were partially understood requires further exploration. Methods: Study conducted at a tertiary care hospital in western Rajasthan, India, we aimed to assess the prevalence and risk factors association of osteoporosis among COPD patients. A cross-sectional study was conducted from January 2023 to December 2023, involving 102 COPD patients by Convenience sampling categorized according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA), and demographic and clinical data were collected. Results: Our findings revealed high prevalence of osteoporosis (48%) among COPD patients, showed significant associations with advancing age, female sex, underweight status, and more severe COPD stages. Female gender, older age, underweight status, higher Modified Medical Research Council (mMRC) dyspnea scores, and advanced GOLD stages were identified as significant risk factors for osteoporosis. Conclusions: These results underscore the importance of early screening and management of osteoporosis in COPD patients to mitigate its adverse effects on quality of life and morbidity. Implementing routine BMD measurements using DEXA in COPD management protocols can facilitate timely diagnosis and intervention, ultimately improving patient outcomes. Further research is warranted to elucidate the mechanistic links between COPD and osteoporosis and to explore targeted therapeutic strategies for mitigating bone loss and fracture risk in this vulnerable population.

Epidemiological evidence for the association between hearing loss and health in the community-dwelling population: a public health perspective on hearing loss prevention

Epidemiological evidence for the association between hearing loss and health in the community-dwelling population: a public health perspective on hearing loss prevention

3D printing birdhouses with ceramic clay using a six-axis palletizing robot

Over the past few decades, billions of adult breeding birds have been lost worldwide. The primary factors for this population loss are habitat loss and global warming. To aid the efforts for bird conservation, we have designed a simple birdhouse that can be 3D printed rapidly using a six-axis arm robot. We transformed a six-axis palletizing robotic arm into a ceramic 3D printer with the help of an extruder, stepper motor, and a custom Printed Circuit Board (PCB) consisting of an ESP32 and a motor driver. The ceramic clay is stored in a pneumatic pressure tank. An air compressor pump transports the clay from the tank to the extruder. We conducted various experiments at 8–10 bars of air pressure with different water-to-clay ratios. We found that the optimum air pressure, water-to-clay ratio, and nozzle sizes are 10 bars, 0.084, and 5 mm, respectively. After determining the appropriate printing parameters, we designed the birdhouse in the Mastercam software and generated the G-code. The G-code is loaded onto the robot controller, and the birdhouse is printed in parts. We dried the birdhouse for 24 h and then baked it in a kiln for 24 h at 1000 degrees Celsius. We then compared the ceramic birdhouse to a wooden birdhouse. The ceramic birdhouse maintains internal temperatures of 38 degrees Celsius or lower despite external temperatures reaching 43 degrees Celsius, which is on par if not better than the wooden birdhouse. This temperature will be beneficial for nesting, breeding, and egg development.

Effect of a carbohydrate-restricted diet on weight loss in overweight and obese pediatric population: a meta-analysis of randomized controlled trials

BackgroundThere are conflicting findings regarding the effect of low-carbohydrate diets on obesity-related factors. This study aimed to investigate the effect of a carbohydrate-restricted (CR) diet on changes in anthropometric indicators of adiposity and fat distribution in pediatrics populations.MethodsA systematic search was conducted in PubMed/MEDLINE, Web of Science, Scopus, and Embase electronic databases using predefined keywords to identify all randomized controlled trials examining the effects of CR on obesity-related factors. The pooled weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated using a random-effects model.ResultsFindings from 11 studies demonstrated significant reductions in weight (WMD: -2.31 kg; 95% CI: -4.44, -0.18), BMI (WMD:-1.08 kg/m2; 95% CI: -1.91, -0.26), and fat mass (WMD: -1.43%; 95% CI: -2.43 to -0.43) as well as a significant increase in adiponectin levels (WMD: 0.74 ng/ml; 95% CI: 0.02, 1.47) in the CR diet group compared to the control group. However, no significant effect was observed on BMI z-score (WMD:-0.10; 95% CI: -0.21, 0.01), waist circumference (WMD:-3.03 cm; 95% CI: -6.57, 0.51) or leptin levels (WMD: -0.82 ng/ml; 95% CI: -2.26, 0.61). Stratified analysis rrevealed a greater effect of CR on weight and BMI reduction in interventions ≤ 12 weeks and in very low-carbohydrate diets.ConclusionsIn conclusion, it appears that CR diet, along with other lifestyle factors, can lead to significant improvements in weight loss on pediatrics with obesity/overweight.

Effect of Semaglutide in Individuals With Obesity or Overweight Without Diabetes.

This systematic review evaluates the efficacy and safety of semaglutide in individuals with obesity or overweight without diabetes. Obesity is a significant public health concern, associated with various comorbidities and reduced quality of life. Semaglutide, a glucagon-like peptide-1 receptor agonist, has emerged as a promising pharmacological intervention for weight management. This review synthesizes findings from multiple clinical trials, highlighting the impact of semaglutide on weight loss, metabolic parameters, and overall health outcomes in non-diabetic populations. The review also addresses methodological considerations, including study design, participant selection, and outcome measures, to assess the robustness of the evidence. Ethical considerations and potential conflicts of interest are discussed to ensure transparency in the research process. The findings indicate that semaglutide is associated with significant weight reduction and improvement in obesity-related health markers, suggesting its potential as a valuable treatment option for individuals struggling with obesity. Limitations of the current literature and recommendations for future research directions are also presented, emphasizing the need for further studies to explore the long-term effects and generalizability of semaglutide treatment in diverse populations.

Landscape change and alien invasions drive shifts in native lady beetle communities over a century.

Understanding causes of insect population declines is essential for the development of successful conservation plans, but data limitations restrict assessment across spatial and temporal scales. Museum records represent a source of historical data that can be leveraged to investigate temporal trends in insect communities. Native lady beetle decline has been attributed to competition with established alien species and landscape change, but the relative importance of these drivers is difficult to measure with short-term field-based studies. We assessed distribution patterns for native lady beetles over 12 decades using museum records, and evaluated the relative importance of alien species and landscape change as factors contributing to changes in communities. We compiled occurrence records for 28 lady beetle species collected in Ohio, USA, from 1900 to 2018. Taxonomic beta-diversity was used to evaluate changes in lady beetle community composition over time. To evaluate the relative influence of temporal, spatial, landscape, and community factors on the captures of native species, we constructed negative binomial generalized additive models. We report evidence of declines in captures for several native species. Importantly, the timing, severity, and drivers of these documented declines were species-specific. Land cover change was associated with declines in captures, particularly for Coccinella novemnotata which declined prior to the arrival of alien species. Following the establishment and spread of alien lady beetles, processes of species loss/gain and turnover shifted communities toward the dominance of a few alien species beginning in the 1980s. Because factors associated with declines in captures were highly species-specific, this emphasizes that mechanisms driving population losses cannot be generalized even among closely related native species. These findings also indicate the importance of museum holdings and the analysis of species-level data when studying temporal trends in insect populations.

The Vicious Circle of Corruption in the Human Side of the Enterprise

The vicious circle of corruption constitutes a bane in the business world. Corruption is a canker that must be eroded to create new incentives for innovative management system and improved productivity in the local and global economies. The dwindling economy many developing nations are facing today (Nigeria inclusive) has raised serious concern. This conference paper adopts historical and descriptive research methods. Many corrupt firms suffer morale decadence and counterproductive work behaviours which culminated in productivity downturn. Corruption had permeated many segments of the society, ravaged the corporate scene of nations and left many firms as travail of woes for investors. The code of morals and leadership ethnics had suffered for years. In Nigeria, illicit acts and counterproductive work behaviours have characterized many firms in recent times. Budgets and financial records do not only lack the attributes of truth and fairness but suffer credibility loss and unreliability in the business population for years. Corruption is cankerous and designated authorities, institutions and agencies (nationally and internationally) have made tremendous efforts to fight and erode this dreadful canker from the business environment. Yet, not much is achieved; rather much is required.

Spatial-Temporal Evolution and Environmental Regulation Effects of Carbon Emissions in Shrinking and Growing Cities: Empirical Evidence from 272 Cities in China

Shrinking and growing cities are categories of cities characterized by population loss or add, and the issue of carbon emissions in these cities is often neglected. Environmental regulation, as an important influence on carbon emissions, plays an important role in promoting the low-carbon transition in Chinese cities. This study focused on the carbon emissions of 272 cities in China from 2012–2021, constructed a comprehensive indicator to classify four city types, and calculated carbon emissions. Spatial-temporal characteristics and evolution of carbon emissions and impacts of environmental regulation were investigated. Carbon emissions of rapidly growing cities showed a downward trend, whereas those of slightly growing, rapidly shrinking, and slightly shrinking cities showed upward trends. The more rapidly a city grew or shrunk, the higher its average carbon emissions. Growing cities’ center of gravity of their carbon emissions migrated northwest. Carbon emissions of rapidly and slightly shrinking cities were high in the northeast, and their carbon emission centers migrated northeast and southwest, respectively, with obvious spatial autocorrelation of city types. Strengthening environmental regulations significantly positively affected carbon emission reduction. The impact of environmental regulation on carbon emissions reduction was temporally and spatially heterogeneous and more significant in non-resource cities.

Smell and taste disorders in childhood: Diagnostic challenges and significant impacts on a child's well-being

AimSmell and taste are senses that contribute to a child's overall well-being. Disorders affecting these senses can impact a child's daily life from enjoying meals to detecting potential dangers through scent.The aim of this study is to describe patient characteristics and etiological causes of olfactory (OD) and/or gustatory disorders (GD) in children referred to a smell and taste clinic. Secondly, we aim to suggest a clinical work up. MethodsRetrospective study where data were collected from 57 children who were referred consecutively to the University Clinic for Flavour, Balance, and Sleep; Department of Otorhinolaryngology (ORL), Head and Neck Surgery; Goedstrup Hospital, Denmark, for assessment due to OD/GD from January 2017 to May 2023. ResultsMost of the children had anosmia (60 %), whereas sensation of the basic tastes was intact in all but eight children (16 %). The lowest TDI scores were in children with congenital OD. The underlying etiology was congenital followed by postinfectious mostly related to Covid-19. Picky eating including anorectic traits were seen in 16 % of patients. ConclusionThe focus on smell loss in pediatric population is low, and probably does not adequately reflect either underlying prevalence in this group or the possible consequences on a child's well-being. Moreover, increased awareness of children's smell and taste loss is needed, as it may be associated with eating disturbances.

Depopulation and deep aging: the former Yugoslav and Western Balkans space between the second demographic transition and emigration

The article introduces the tentative concept of deep aging – a label used for a situation when the overall ageing effects of the second demographic transition, due to fertility below replacement level, are topped by the excessive emigration of the fertile contingent (additional loss of active population). Deep ageing thus accelerates population decline. But the loss of fertile contingent may affect the total fertility rates and its apparent rise (TFR). Here, the tempo effect of fertility plays the decisive role. The article first assesses the demographic change in the European macroregions in the period after the fall of the Iron Curtain (1990–2020). It then analyses the changes in the area of former Yugoslavia to assess the extent of population change in the last intercensal period, 2011–2022. Building on the previous research of population loss and migration flows after the break-up of Yugoslavia, the overall population change in the region is being assessed. It is also shown that tempo distortion of fertility rates considerably affects the realistic level of fertility and that approximate completed fertility rates fell less dramatically. Since the migration data are less reliable, the analysis of intercensal change was applied to assess the migration losses across the ex-Yugoslav space. To assess the extent of deep ageing, the intercensal projection of fertile contingent was introduced. The stage of deep ageing is the most pronounced in Croatia and Serbia, especially at the younger fertile group, while the overall loss of fertile population is profound and will certainly affect the further future decrease in population. Similarly difficult demographic situation is in other post-Yugoslav countries, where only Slovenia has not yet slid into the stage of deep ageing.

Harnessing deep learning for detection of diabetic retinopathy in geriatric group using optical coherence tomography angiography-OCTA: A promising approach

The prevalence of diabetic retinopathy (DR) among the geriatric population poses significant challenges for early detection and management. Optical Coherence Tomography Angiography (OCTA) combined with Deep Learning presents a promising avenue for improving diagnostic accuracy in this vulnerable demographic. In this method, we propose an innovative approach utilizing OCTA images and Deep Learning algorithms to detect diabetic retinopathy in geriatric patients. We have collected 262 OCTA scans of 179 elderly individuals, both with and without diabetes, and trained a deep-learning model to classify retinopathy severity levels. Convolutional Neural Network (CNN) models: Inception V3, ResNet-50, ResNet50V2, VggNet-16, VggNet-19, DenseNet121, DenseNet201, EfficientNetV2B0, are trained to extract features and further classify them.Here we demonstrate:•The potential of OCTA and Deep Learning in enhancing geriatric eye care at the very initial stage.•The importance of technological advancements in addressing age-related ocular diseases and providing reliable assistance to clinicians for DR classification.•The efficacy of this approach in accurately identifying diabetic retinopathy stages, thereby facilitating timely interventions, and preventing vision loss in the elderly population.

Sudden Hearing Loss in the Active Duty Population: An Epidemiological Study.

Hearing loss among military personnel is a well-known challenge, reported as the second most common VA service-connected disability. Although most hearing loss occurs gradually, a subset occurs suddenly and significantly impacts quality of life and military readiness and is considered as a medical emergency. This study aims to evaluate the incidence of sudden hearing loss among different subpopulations within the military system to better identify at-risk groups. This study was a retrospective population-based study reviewing all cases of diagnosed sudden hearing loss between January 1, 2016 and December 31, 2021 within active duty service members in the U.S. DoD. Statistical analysis of multiple subpopulations was performed. There were 2,650 cases of sudden hearing loss diagnosed in active duty service members during the study period, with an average incidence of 32.9 cases per 100,000 people per year, compared with 5 to 27 cases per 100,000 people per year reported in civilian populations. Senior officers demonstrated significantly increased rates of sudden hearing loss with 103.9 cases per 100,000 people per year, likely as a result of increased age, as did Air Force personnel with 45.1 cases per 100,000 people per year. There was no difference in incidence based on military occupational specialty, though service members located overseas were noted to have decreased incidence compared with those stationed within the USA. There was no significant difference during the years before coronavirus-19 pandemic (2016-2019) compared to the years following the start of the pandemic (2020-2021). Sudden hearing loss appears to occur more frequently in military personnel than in the civilian population. The increased incidence in senior officers is likely driven by increased age, though further evaluation into the discrepancies between reported incidence of hearing loss among enlisted service members and officers is warranted. Although military occupational specialty did not demonstrate any significant difference in incidence, for thus far unknown reasons those in the Air Force demonstrated increased rates of sudden hearing loss. Although other potentially at-risk groups were identified, focused efforts to better understand contributing factors to elevated incidence in senior officers and Air Force personnel will help to better mitigate the incidence and effects of sudden hearing loss.

Melanin-Like Nanomedicine Functions as a Novel RPE Ferroptosis Inhibitor to Ameliorate Retinal Degeneration and Visual Impairment in Dry Age-Related Macular Degeneration.

Ferrous ion accumulation and lethal oxidative stress mediate irreversible retinal pigment epithelial (RPE) cell ferroptosis and subsequent photoreceptor degeneration, a potential key pathogenic factor in the onset of dry age-related macular degeneration (dAMD), causing irreversible vision loss in the global elderly population. However, currently, no effective interventional treatment strategy exists in clinical practice. Herein, lesion site-targeted melanin-like nanoparticles, named ConA-MelNPs, are designed as a novel ferroptosis inhibitor for retinal degenerative diseases. ConA-MelNPs possessed chelating iron ion characteristics, alleviating severe mitochondrial damage caused by oxidative stress and protecting RPE cells from ferroptosis induced by sodium iodate (NaIO3). In a preclinical dAMD mouse model, a single intravitreal injection of ConA-MelNPs yielded significant responses in electroretinograms and visually-driven optomotor responses in visually impaired mice, resisting the challenge posed by secondary NaIO3-induced injuries, with the long-term sustainability of its therapeutic effect. Mechanistically, ConA-MelNPs achieve a therapeutic effect by interrupting the detrimental cascade involving "RPE cell ferroptosis, lethal oxidative stress, and microglial proinflammatory activation," affording the restoration of retinal homeostasis. The synthesized ConA-MelNPs demonstrated good biosafety, with no detected ophthalmic or systemic side effects. Collectively, ConA-MelNPs are proposed as a promising therapeutic option for atrophic retinal diseases such as dAMD.

The financial sustainability of public services as an instrument to combat depopulation in small and medium-sized municipalities

Previous research identified influencing factors in sustainability of public services but exclusively in large local governments, despite the fact that depopulation is currently a serious problem that affects rural areas of many European countries. However, despite that >80 % of European municipalities have fewer than 5000 inhabitants, more work is needed on the factors influencing the financial sustainability of small local governments, that are being greatly affected by the loss of population. This study identifies influencing factors in the financial sustainability of local governments of different population sizes. We analyse the behaviour of 3625 Spanish municipalities during 2009–2017. Our findings are useful for public managers interested in promoting the financial sustainability of small municipalities as an instrument to fight against depopulation and prevent effects of economics crisis in small and medium municipalities.