How negatively young adolescents feel is central to their well-being. Intuitively, better social relationships should be linked to less negative emotions. This study tested this assumption, using a sample of over 80,000 young adolescents from 32 countries (ages 10-12). Inconsistent with the notion that better social relationships are always related to better emotional experiences, we found that links between negative emotions and adolescents' relationships with friends or teachers critically depend on their relationships with family. When young adolescents had relatively better relationships with family, better relationships with friends or teachers predicted less negative emotions. However, when adolescents had relatively poorer relationships with family, better relationships with friends or teachers predicted more negative emotions. Results were consistent across adolescents' gender, age, culture, or socioeconomic status. Findings suggest that the broader social context should be considered for understanding how specific relationships predict negative emotions in early adolescence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).