THIS study has been an attempt to modify the degeneration of fresh arterial homografts using the dog's femoral artery by treatment of the recipient animal with modern immunosuppressive drugs. The use of homografts for peripheral arterial replacement and bypass has been abandoned because of the high incidence of poor long-term results,1 2 3 which are to a large extent attributable to the inevitable degenerative changes that occur with time. In contrast, experimental work has amply confirmed that fresh autogenous arterial tissue undergoes little appreciable long-term change and heals as a living structure with retention of a practically normal histologic appearance.4 5 6 7 8 9 The facetious . . .