World certainly has a warning and alarming situation due to the global pandemic outbreak of COVID-19 pathogen since December 19 taking along human cost, mentally and physically with economic cost too. The spread of this contagion is deadly worldwide without any proven official medical treatment. Governments around the world are taking measures of country lockdown and stay at home for social distancing, leading to drastic increase in unemployment conditions, economic loss of trillions dollar, poor job satisfaction, reduced motivation and workplace depression crisis among organization’s employees with far reaching impacts. At this time of global critical waves, companies and organizations need their human resources officials to help the employees out of this badly driven health and economic crisis. The human resource representatives and their behaviors are the pillars of strength and biggest support center of companies to combat the unpredictable circumstances and to overcome the human depression among employees at plenty of work places around the globe. During the badly stricken circumstances and to face the challenges, leaders & Human resource managers are highly concerned about their work force from encouraging the employees to reduce the impacts on their personal as well as professional life by applying various leadership & behavioral aspects in these critically hit phase of COVID-19. Organizations are dealing this outbreak situation in various ways ,one of the fundamental qualities of leaders is behavioral science which is being followed by managers in this eclipsed time, it builds an understanding of how people react psychologically and respond behaviorally to environments & situations. This paper reveals how leaders and managers using behavioral science to boost their employees spirit mentally and physically to fight Corona Virus surroundings.