Poor Concentration Research Articles

Impact of Long COVID on Health-Related Quality of Life Among Patients After Acute COVID-19 Infection: A Cross-Sectional Study.

Concerns have been raised globally regarding the long-term effects of the novel coronavirus disease 2019 (COVID-19). This study aimed to investigate the impact of long COVID on the health of patients recovering from acute COVID-19 in China. We conducted a cross-sectional questionnaire survey from 1 February to 9 March 2023. Propensity score matching (PSM) was used to understand the differences in health utility values between individuals with and without long COVID. Factors associated with health-related quality of life (HRQoL) were determined using a multiple linear regression model. A chi-square test was used to compare differences between the 2 groups for each dimension of the EuroQoL-5 Dimension-5 Level (EQ-5D-5L) scale. In total, 307 participants were included in the analysis, of which 40.39% exhibited at least 1 persistent symptom. The common symptoms of long COVID were fatigue/weakness, coughing, memory decline, poor concentration, and phlegm in the throat. Most patients with long COVID reported mild effects from their symptoms. After propensity score matching, the long-COVID group had lower health utility scores than the non-long-COVID group (0.94 vs 0.97). In the multivariable linear regression analysis, persistent symptoms and low annual household income were associated with lower health utility values (P < .05). Anxiety/depression and pain/discomfort were the major problems experienced by the participants with long COVID. Long-COVID symptoms following acute COVID-19 infection have a serious impact on health-related quality of life. Therefore, it is necessary to implement interventions to improve patient health after the recovery from acute COVID-19.

A Study on Detection Methods of Multi-Featured Fusion Teaching Factors in Blended College English Teaching

Abstract The detection of teaching factors is mainly from the perspectives of both teachers and students, and the multi-feature fusion of the teaching factor detection method is used to add possibilities for the improvement of the quality of blended teaching of college English. The use of auditory features in this paper is to separate the teaching scene video and obtain the teacher and student video scenes. Teacher and student voice clustering algorithm based on teaching rules is proposed to complete the feature division, and the combination of visual and auditory features is used to extract the blended teaching behaviors of college English and classify the types of teacher and student behaviors and behavioral probabilities. Create a multi-feature fusion teaching factor detection model by optimizing the multi-feature fusion process and multi-feature fusion strategy. Design an experimental configuration to detect multi-feature teaching factors that affect students’ concentration, attention, and teaching state. The multi-feature fusion model’s recognition accuracy for excellent concentration, excellent concentration, and poor concentration all reached 75.29% and above, and the probability of correctly recognizing excellent concentration was the greatest, gaining 96.80%.

Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice.

Depression is a mental disorder characterized by depressive episodes, such as low mood, low self-esteem, feeling of guilt, and poor concentration. Depression has a high comorbidity with cognitive impairments. Studies have shown that cinnamon has anti-inflammatory antiviral, antihypertensive, antioxidant and anti-diabetic potentials. Therefore, the aim of the research was to assess the antidepressant effect of cinnamon on open-space forced swim-induced depression in mice. Twenty-five (25) Swiss albino mice were grouped into five groups (n=5). Group I: control (negative control) exposed to open-space forced swim test (OSFST) without any treatment, Groups II, III and IV received graded doses of Cinnamon 12.5, 25, and 50 mg/kg, group 5 (positive control) received fluoxetine 20 mg/kg orally. The animals were subjected to OSFST, Open Field Test (Line Crossing) and Novel Object Recognition Test (NORT). Administration of cinnamon showed decreased immobility time (behavioural despair) in OSFST compared to control and fluoxetine groups (p < 0.05). However, no statistically significant effect was observed in line crossing (locomotor activity) and the discrimination ratio of NORT (non-spatial short-term memory) between cinnamon administered groups and the control group. In conclusion, cinnamon has shown antidepressant-like effect in open-space forced swim-induced depression in mice. Keywords: Cinnamon, Depression, Cognitive impairment, Immobility time, Behavioural despair.

Development of University General Education Classes using Microlearning and Analysis of Class Satisfaction

The purpose of this study is to present the development and operation of liberal arts classes using microlearning content and to analyze class satisfaction to examine the necessity and applicability of microlearning classes in university liberal arts education. Developed by reflecting microlearning characteristics, tClass is a one-credit class designed to be available in a nonlinear manner for five weeks. After this course, a satisfaction survey of all remote classes and tClass students was conducted to find out the level of satisfaction of learners and focus group interviews were additionally conducted with four applicants. As a result of the study, both timeliness and accessibility were high due to the nature of remote classes, and tClass showed a high level of satisfaction among the students, especially when it came to the learning materials and the accessibility of the items. On the other hand, poor concentration, boredom, and a lack of willingness to learn were found to be obstacles for remote classes. Based on the above research results, the suggestions are as follows. 1) In order to better implement the characteristics of microlearning, sufficient prior coordination is needed to determine whether or not we should change the academic system. 2) In order to develop microlearning, it is important to set an appropriate lecture topic and a suitable level of class difficulty. 3) There is a need to design learning activities that can help students take a leading role regarding their own learning and inspection. 4) In order to improve learners' concentration and understanding, video production methods need to be diversified and their level of completion needs to be increased. It is hoped that the results of this study will be used as basic data to develop microlearning classes in universities and to enhance learning effects.

Research on the Insomnia Drugs and Comparison

Insomnia has become very common now due to the increasing work pressure. Nowadays, people often work overtime until midnight or engage in jobs where day and night are often reversed. The emergence of this new working model is also one of the reasons why insomnia has become common. Insomnia has many disadvantages. Short-term insomnia can cause patients to have poor concentration the next day and feel weak. Long-term insomnia will lead to an increase in cardiovascular and cerebrovascular diseases, and it will also weaken the resistance and increase the patient's risk of disease. This article will mainly compare several common drugs for treating insomnia to analyze which drug is more competitive. During the comparison process, the author will compare advantages, prices, side effects, applicable groups, etc. The result of the comparison is to compare the two drugs in sequence and choose the one with more advantages. The author draws conclusions by reviewing a large amount of information.

Assessment of the state of children after COVID-19 and other acute respiratory infections using the ISARIC COVID-19 survey

Introduction. The state of children had suffered from COVID-19 causes various persistent symptoms affecting on patient well-being and quality of life which is a significant healthcare issue. &#x0D; The aim of the work. To assess health and well-being of children following COVID-19 and other acute respiratory infections. &#x0D; Materials and methods. This is a case-control study including children with history of PCR-confirmed COVID-19 (n = 261) and other acute respiratory infections (n = 198). Patients were assessed 6 months and 1 year after the infection using the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 questionnaire for children. The prevalence of symptoms including fatigue, weakness, lack of energy, as well as the emotional well-being, social relationships, and social activity of children was evaluated. &#x0D; Results. Children with history of COVID-19 in six months had significantly higher rates of weakness and decreased school attendance compared to children with other acute respiratory infections. 12 months after infection, children in the case group were significantly more likely to experience poor concentration, weakness, a decreased sense of belonging and school attendance. However, 12 months after infection, control group had significantly higher rates of fatigue. &#x0D; Conclusion. Children with a history of mild COVID-19 and other acute respiratory infections may experience ongoing health problems for 1 year after the infection, requiring greater attention from healthcare professionals and family members.

Neck pain, disability and mobile phone usage among physiotherapy students - a cross-sectional study.

Modern mobile devices have become tools used for educational, research, business or recreational purposes. Incorrect position during excessive use of a smartphone can lead to biomechanical changes, the most visible of which is the position of the head in protraction, characterized by the protrusion of the head and neck forward in relation to the shoulder girdle and trunk. The aim of the study was to analyze the relationship between disability, neck pain (NP), use of phones before bedtime, and hours of using smartphones. The study involved 146 physiotherapy students aged 18-26. Students were asked to complete pain surveys (VAS pain scale), and Neck Disability Index (NDI). Participants were also asked if their pain lasted longer than 3 months, how long they used their smartphone during the day, and whether they used it before bedtime. Statistically significant differences were found between groups with and without neck pain regarding NDI score (p<0.001). Participants who suffered from neck pain longer than 3 months had greater NDI scores (p=0.03), greater intensity of symptoms (p=0.04), greater problems with reading (p<0.01) and driving (p=0.04) than participants who experienced pain for less than 3 months. Using phones before bedtime was related to problems with focusing (p<0.01). There were statistically significant correlations between the time of phone use and disability in terms of reading (p=0.04), focusing (p<0.001), work (p<0.001) and sleeping (p=0.02). Dysfunctions associated with pain in the cervical section may affect the learning abilities of students and thus the acquisition of professional competencies. Not using a smartphone before bedtime is recommended, as it causes poorer concentration. The longer the time spent using the phone, the more significant the disability.

Molecular Docking Studies to Identify Inhibitors of Norepinephrine Reuptake from Marine Algae

Depression is one of the major mental health problems at prevalence nowdays. It can be characterized by poor concentration, low self-esteem, losing interest in family or social life, feeling tired or fatigued, suicidal thoughts and similar symptoms. There are treatments like psychotherapies, anti-depressants and electroconvulsive therapies available, but there is need to identify more effective treatments with lesser side effects. Marine organisms like algae, sponges or corals have been investigated to explore their potential as anti-depressants. This article aims to explore the potential of some compounds from marine algae by molecular docking and assessment of pharmacokinetics. Human norepinephrine transporter (hNET) was used as target for this study as this transporter is responsible to reuptake norepinephrine and disturbs the chemical balance of the brain, which can be a cause for depression. These compounds’ Binding affinity was compared with the binding affinity of prescribed levomilnacipran. From 14 selected compounds, 13 showed higher binding affinity towards hNET. Among all compounds, saringosterone has the highest binding score. Pharmacokinetics properties were constructive for most compounds. Compounds showed weaker druglikeness and drugs score but can be optimized to enhance it. Compounds identified as inhibitors of NET can be developed as drug molecules in the future or algal sources for it can be taken as a food supplement.

Antecedents of Depression among Undergraduates in Nigerian Private Universities

Prevalence of the effect of depression on young adults’ well-being has turned out to be a priority as a result of the simultaneous increase in mental health problems among individuals. Depression being a mental disorder that comes with unhappy mood, loss of interest, low self-worth, insomnia, and poor concentration seems to be ravaging the younger generation, especially undergraduates in tertiary institutions. Hence, this study investigated the antecedents of depression among undergraduates in Nigerian private universities. The research objectives were to (1) examine the level of depression among the undergraduates; (2) assess the past history of depression among the undergraduates;( 3) assess the level of perceived family support among the undergraduates; (4) determine the significant relationship between the history of depression and levels of depression; and (5) to assess the significant relationship between the history of depression and perceived family support. This research work made use of the quantitative source of data, through which data were gathered using a structured questionnaire and administered to 365 undergraduates. The findings showed that the majority of the undergraduates manifest one level of depression or the other, as about one-fifth of the respondents show signs of no form of depression and are thus regarded as normal. The study also showed that the level of perceived family support received by the undergraduates was found to be moderate, and there was a significant relationship between the history of depression and perceived family support. It was also found that there is a significant relationship between history of depression and levels of depression. The study recommends that counseling centers be provided in all institutions so as to give help to students battling with one issue or the other so as to avoid a high level of depression. In addition, parents are advised to show a positive and caring attitude to their children as the experiences a student experiences at home could have a significant influence on the student in school, which could lead to depression or otherwise.

Evaluating the Impact of Hereditary Thrombotic Thrombocytopenic Purpura (hTTP) on Patients: A Patient Reported Outcomes (PROs) Study

Introduction: Hereditary thrombotic thrombocytopenic purpura (hTTP) is a rare inherited blood disorder caused by severe ADAMTS13 deficiency. There is a gender disparity with an increased incidence among women who are often diagnosed during pregnancy. Disease severity is variable with some patients requiring lifelong prophylaxis treatment while others require minimal or no treatment. Very little is known about the long-term impact of hTTP on psychological health, cognitive health and the quality of life of patients. In our previous study, patients frequently described neuropsychiatric symptoms such as depression, forgetfulness, and poor concentration (Borogovac, Blood 2022; 140:785-789). The goals of this study were to compare patient reported outcomes (PROs) between hTTP patients and the general population, compare hTTP to other disorders, and describe changes in these scores over time. Methods: hTTP patients were recruited from the United States (US) site of the international hTTP Registry. Following informed consent, PROMIS (Patient-Reported Outcomes Measurement Information System) fatigue, depression, anxiety, cognitive function, and positive affect/well-being measures were sent to patients via a secure REDCap link. Patients were assessed twice (baseline and 6-months). A one sample t-test compared mean scores in hTTP patients to the US population (mean 50, standard deviation 10). A paired t-test compared mean scores between the baseline and 6-month assessment. A literature search identified comparison disorders that reported PROMIS results. Descriptively, means and 95% confidence intervals (CI) were compared between hTTP and the other disorders. Results: Nineteen patients (16 adult; 3 pediatric) completed the baseline assessment. Their median age was 38 years (range 5 to 66 years), the majority were female (68.4%), had private insurance (63.2%) and lived near their hematologist (63.2% within 25 miles). Fifteen patients completed measures at both time points (baseline and 6-months). At baseline, hTTP patients were significantly worse than the US population on four domains of health: fatigue (p=0.0063), depression (p=0.02), anxiety (p=0.01), and cognitive function (p=0.02) (Figure 1). However, hTTP patient scores were not different from the US population for the domain of positive affect/well-being (p=0.78) (Figure 1). hTTP patients had similar PROMIS scores as patients with immune-mediated TTP, systemic lupus erythematosus, and rheumatoid arthritis (Table 1). However, hTTP patients had worse fatigue, depression, and anxiety than patients with hemophilia (Table 1). Among the 15 patients who completed both the baseline and 6-month assessments, there was no change in the mean fatigue (p=0.90), depression (p=0.29), anxiety (p=0.81), or cognitive function (p=0.89) scores. Conclusion: This is the first study to identify the impact of hTTP from the patient's perspective. Our results show that hTTP patients have significantly worse fatigue, depression, anxiety, and cognitive function than the US population with scores similar to patients with other chronic autoimmune disorders. However, hTTP patients had worse fatigue, depression, and anxiety than hemophilia patients which is a comparable genetic disorder. hTTP patients' scores did not improve over time which shows this disease has a persistent burden on patients. In future studies, it will be vital to incorporate the patient perspective to better understand the burden of both the disease and the treatment within this population. This approach will facilitate the development of new treatments that cater to patients' needs and preferences, ensuring a highly acceptable side effect profile and ultimately improving outcomes.

Peningkatan Pengetahuan Remaja Putri tentang Hipnoterapi dengan Musik Instrumentalia Melayu Jambi dalam Mengatasi Dismenore

Dysmenorrhea or menstrual pain is a stabbing pain that is felt in the lower abdomen and thighs, this occurs due to an imbalance of the hormone progesterone in the blood, resulting in pain arising. Almost all women have felt interference during menstruation in the form of menstrual pain (dysmenorrhea) with various levels, ranging from just aches in the pelvis from the inside to extreme pain. The prevalence of dysmenorrhea in adolescent girls is 74.42%. The highest proportion of dysmenorrhea was found in adolescents aged 14 and 16 years, had no family history of dysmenorrhea, menarche age 11-12 years, menstruation for 7 days or more, normal nutritional status, and adolescent girls who rarely exercised. The most complained and felt impact due to dysmenorrhea is limited physical activity, poor concentration and absence in the teaching and learning process. Non-pharmacologically, pain can be treated, one of which is with distraction techniques. The technique of distraction or distracting someone is the most effective to reduce pain by listening to classical music (mozart) and also back exercises. The purpose of this community service is to increase the knowledge of young women about hypnotherapy with Jambi Malay instrumental music in overcoming dysmenorrhea. The method / approach taken is to assess the knowledge of young women before and after education about hypnotherapy with Jambi Malay instrumental music in overcoming dysmenorrhea. After participating in a series of activities in accordance with the implementation plan, the results were obtained before good knowledge education was carried out 5 (23.8%) young women and less good 16 (76.6%) young women, after good knowledge education 21 (100%).

Correlations of Long COVID Symptoms and Inflammatory Markers of Complete Blood Count (CBC): A Cross-sectional Study.

Long-COVID refers to lasting unspecific symptoms like fatigue, decreased concentration and sleep issues after infection which persist for at least three months and cannot be attributed to other causes. Previous studies surveyed the association between inflammatory markers like C - reactive protein (CRP) at hospital admission and long-COVID symptoms in the preceding months. Post-COVID syndrome can affect one-third of patients. Thus early diagnosis can assist in reducing burdens on public health. We attempted to see any correlations between complete blood count (CBC) markers (like red blood cell (RBC), white blood cell (WBC), Neutrophil to lymphocyte ratio (NLR), etc.) at hospital admission and long COVID symptoms at a 6-month follow-up. 167 patients (44.9% females, mean age 49 years old) answered semi-structural interviews through telemedicine which focused on the three prominent symptoms: fatigue, loss of concentration and decreased libido. Results: Two third of patients have symptoms of long COVID and others do not have. NLR in the symptomatic group was statically higher. Patients who underwent decreased libido at a 6-month follow-up had significantly more severe lymphopenia (p = 0.028) and higher NLR values (p-value = 0.007). Poor mental concentration is associated with high WBC in numbers and polymorphonuclear (PMN) count. Other symptoms do not correlate with blood markers. Utilizing available data like CBC can help predict the upcoming symptoms of previously hospitalized patients and further measures like rehabilitation. Additional investigations should be done on the effect of COVID vaccination on converting long COVID. Different variants of the virus may have different results.

2 Examining the Role of Symptom Attribution on Neurobehavioral and Neurocognitive Outcomes in Treatment-Seeking Veterans with Remote History of Traumatic Brain Injury

Objective:Illness perception, or the ways in which individuals understand and cope with injury, has been extensively studied in the broader medical literature and has been found to have important associations with clinical outcomes across a wide range of medical conditions. However, there is a dearth of knowledge regarding how perceptions of traumatic brain injury (TBI) influence outcome and recovery following injury, especially in military populations. The purpose of this study was to examine relationships between illness perception, as measured via symptom attribution, and neurobehavioral and neurocognitive outcomes in Veterans with TBI history.Participants and Methods:This cross-sectional study included 44 treatment-seeking Veterans (86.4% male, 65.9% white) with remote history of TBI (75.0% mild TBI). All Veterans were referred to the TBI Cognitive Rehabilitation Clinic at VA San Diego and completed a clinical interview, self-report questionnaires, and a neuropsychological assessment. A modified version of the Neurobehavioral Symptom Inventory (NSI) was administered to assess neurobehavioral symptom endorsement and symptom attribution. Symptom attribution was assessed by having participants rate whether they believe each NSI item was caused by TBI. A total symptom attribution score was computed, as well as the standard NSI total and symptom cluster scores (i.e., vestibular, somatic, cognitive, and affective symptom domains). Three cognitive composite scores (representing mean performance) were also computed, including memory, attention/processing speed, and executive functioning. Participants were excluded if they did not complete the NSI attribution questions or they failed performance validity testing.Results:Results showed that the symptoms most frequently attributed to TBI included forgetfulness (82%), poor concentration (80%), and slowed thinking (77%). There was a significant positive association between symptom attribution and the NSI total score (r = 0.62, p &lt; .001), meaning that greater attribution of symptoms to TBI was significantly associated with greater symptom endorsement overall.Symptom attribution was also significantly associated with all four NSI symptom domains (r’s = 0.47-0.66; all p’s &lt; .001), with the strongest relationship emerging between symptom attribution and vestibular symptoms. Finally, linear regressions demonstrated that symptom attribution but not symptom endorsement was significantly associated with objective cognitive functioning. Specifically, greater attribution of symptoms to TBI was associated with worse memory (ß = -0.33, p = .035) and attention/processing speed (ß = -0.40, p = .013) performance.Conclusions:Results showed significant associations between symptom attribution and (1) symptom endorsement and (2) objective cognitive performance in Veterans with a remote history of TBI. Taken together, findings suggest that Veterans who attribute neurobehavioral symptoms to their TBI are at greater risk of experiencing poor long-term outcomes. Although more research is needed to understand how illness perception influences outcomes in this population, results highlight the importance of early psychoeducation regarding the anticipated course of recovery following TBI.

Using popular culture to fill in the gaps in public health knowledge – the case of school toilets

Abstract Background Avoiding going to the toilets during the school day has serious implications on children's health and education. Concerns about using the toilets may also lead to reduce intake of fluid, resulting in dehydration and associated dizziness, fatigue and poor concentration, compromising children's education as well as their overall well-being. Yet, there is limited evidence on the reasons behind children's tendency to avoid using the school's toilets. To address this paper presents the representation of school in popular culture, as a way to understand how children perceive school toilets. Methods Popular culture play a significant role in shaping perceptions of places and people, serving as the primary way in which they learn about people's experiences. Thus, the way the toilets are represented in popular culture such as books or films may influence adolescents’ use of public toilets, even if they are not aware of that. This paper explores some films, young adults books and children books to identify the narratives around school toilets as portrayed in popular culture/ Results The narrative of school toilets in popular media can be divided to three main themes, toilets as a place that provides safety and privacy from the prying eyes of both peers and the authorities; toilets as a space for illegitimate activities, aggression and bullying; spaces where sub-cultures and anti-establishment activities emerge. While these themes are not mutually exclusive, each has its unique aspect in the perception and representation of the role that school toilets play in children's lives. Discussion This presentation will help shaping the conversation about a public health problem that is rarely discussed. It will shed a light on the perceived role of public toilets and will help finding way to address and alleviate concerns about using toilets in school.

Relevance of complement immunity with brain fog in patients with long COVID

IntroductionThis study aimed to elucidate the prevalence and clinical characteristics of patients with long COVID (coronavirus disease 2019), especially focusing on 50% hemolytic complement activity (CH50). MethodsThis retrospective observational study focused on patients who visited Okayama University Hospital (Japan) for the treatment of long COVID between February 2021 and March 2023. CH50 levels were measured using liposome immunometric assay (Autokit CH50 Assay, FUJIFILM Wako Pure Chemical Corporation, Japan); high CH50 was defined as ≥59 U/mL. Univariate analyses assessed differences in the clinical background, long COVID symptoms, inflammatory markers, and clinical scores of patients with normal and high CH50. Logistic regression model investigated the association between high CH50 levels and these factors. ResultsOf 659 patients who visited our hospital, 478 patients were included. Of these, 284 (59.4%) patients had high CH50 levels. Poor concentration was significantly more frequent in the high CH50 group (7.2% vs. 13.7%), whereas no differences were observed in other subjective symptoms (fatigue, headache, insomnia, dyspnea, tiredness, and brain fog). Multivariate analysis was performed on factors that could be associated with poor concentration, suggesting a significant relationship to high CH50 levels (adjusted odds ratio [aOR], 2.70; 95% confidence interval [CI], 1.33–5.49). Also, high CH50 was significantly associated with brain fog (aOR, 1.66; 95% CI, 1.04–2.66). ConclusionsHigh CH50 levels were frequently reported in individuals with long COVID, indicating a relationship with brain fog. Future in-depth research should examine the pathological role and causal link between complement immunity and the development of long COVID.

Characteristics of gut microbiota and metabolic phenotype in patients with major depressive disorder based on multi-omics analysis

Depression is a chronic, relapsing mental illness, often accompanied by loss of appetite, increased fatigue, insomnia and poor concentration. Here, we performed serum and urine metabolomics and fecal 16S rDNA sequencing studies on 57 unmedicated patients with major depressive disorder (MDD) and 57 healthy controls to characterize the metabolic and flora profile of MDD patients. We observed significant differences in serum and urinary metabolome between MDD patients and healthy individuals. Specifically, glycerophospholipid metabolism, primary bile acid biosynthesis and linoleic acid metabolism were significantly disordered in serum, and aminoacyl-tRNA biosynthesis, arginine biosynthesis, purine metabolism, phenylalanine metabolism, alanine, aspartate and glutamate metabolism, and pyrimidine metabolism were significantly impaired in urine. On this basis, we identified four potential diagnostic biomarkers for carnitine and four fatty acid classes in serum and urine, respectively. In addition, we observed significant disturbances of the gut microbiota in MDD patients. Spearman correlation analysis showed that imbalances in the gut microbiota were associated with metabolic disturbances, suggesting an important role of the gut microbiota in the pathogenesis of MDD. Our study provides a theoretical basis for further understanding of the pathogenesis of depression and for future clinical diagnosis and screening, as well as a basis for targeting the gut flora to optimize its structure for the prevention and treatment of depression.

The development of a behaviour-change intervention for health professionals during the Covid-19 pandemic

BackgroundIn May 2020, a National Health Service (NHS) hospital within the East Midlands requested a needs analysis and development of an intervention to optimise the wellbeing of healthcare professionals (HCPs).MethodUsing the Behaviour Change Wheel (BCW), the Capability, Opportunity, and Motivation Behaviour( COM-B) model, and the Areas of Worklife model we conducted a needs analysis (two independent surveys assessing wellbeing and behavioural contributors to wellbeing) for the Pulmonary Rehabilitation (PR, N=11), Cardiac Rehabilitation (CR, N=19), COPD nurse specialist (N=6), Home Oxygen (N=6), and Research teams (N=10) between June-July 2020. The results were used in conjunction with the taxonomy of Behaviour Change Techniques (BCTv1) to identify the most appropriate strategies for facilitating behaviour change in our intervention. To identify what needed to change for HCPs to engage in each target behaviour, HCPs were asked to complete the COM-B self-evaluation questionnaire.A multidisciplinary team guided intervention delivery (trainee Health Psychologist, N=1, Health Psychologist, N=2, NHS clinical lead, N=1).ResultsIn survey one (N=25), 52% of HCPs reported client-related burnout, 92% reported work-related burnout. In survey two (N=19), HCPs reported poor focus and concentration, insufficient time to attend to self-care/oneself, and an inability to ‘switch off conscious thoughts about work at the end of the working day’ at the end of the day as fundamental contributors to burnout. Due to theorised spill over effects, our behavioural target was enabling HCPs to ‘switch off conscious thoughts about work at the end of the working day’. From the BCW steps and BCTv1, we developed a three-pronged behaviour change intervention involving a relaxation toolkit, an educational webinar, and wellbeing one-to-ones.ConclusionThe BCW, COM-B model, and BCTv1 can be used successfully to develop a workplace intervention to tackle HCPs perceived burnout. We hypothesise our intervention will increase HCPs attentional rest and self-care behaviours, thereby reducing their perceived burnout. Results of a pilot study will be reported soon.

The Contribution of Parents Involvement towards Students’ Academic Performance at Ugandan Certificate of Education in Public Secondary

The research aimed to evaluate parental influence on students' academic achievement in high school. It investigated academic performance, parental involvement, and their impact on secondary school students. Using a cross-sectional survey with 357 participants including head teachers, teachers, students, and BOG members, a self-administered questionnaire was utilized. Results indicated 80-89% score improvements in reading and writing skills, though fluency requires over 90%. Homework had 80-98% accuracy, but stronger focus was needed. Poor concentration and attendance highlighted the necessity for more support. Students struggled with question comprehension and irregular achievement. Parental engagement in health programs scored neutrally, signaling a need for increased involvement. Involvement in learning-related responsibilities was hindered by behavioral issues. Positive correlations existed between parental engagement and academic success, including safety, diversity, and regulatory aspects. Writing materials positively impacted, while reading materials showed a decline. Counseling services exhibited a weak correlation. Overall, parental involvement significantly predicted UCE students' academic improvement (B = 0.502; p = .000 &lt; 0.05), contributing to 50.2% positive changes.

THU240 A Study Of 21 Cases Of Graves Disease In Childhood Presenting At Our Hospital For The First Time

Abstract Disclosure: T. Kashima: None. N. Ujita: None. H. Konno: None. A. Fujioka: None. H. Miyagi: None. M. Igarashi: None. H. Doi: None. K. Yoshii: None. Y. Naiki: None. R. Horikawa: None. M. Noordin: None. Although Graves disease is most common among women in their 20s and childhood-onset cases account for less than 5% of all cases of Graves disease, they account for the majority of hyperthyroidism in children. We report here a retrospective review of data on pediatric patients with Graves' disease who visited our hospital for the first time at the time of their initial examination. Methods We analyzed 21 pediatric patients with Graves disease who visited our hospital between November 2004 and January 2022. The electronic medical records of 21 patients were retrospectively reviewed for sex, age, height SD score, weight SD score, underlying disease, blood test results, and treatment initiation. Results There were 17 girls and 4 boys. The median age was 11 years and 5 months. Symptoms such as fever, feverishness, palpitations, weight loss, hyperactivity, and irritability were observed in 5 of the patients. Four patients had symptoms related to academic performance, such as low grades and poor concentration. Median physical findings were height SD score 0.62 (N=21), weight SD score 0.06 (N=21), and body mass index -4.4%. Two patients had bronchial asthma and atopic dermatitis, and one had myasthenia gravis and trisomy21 as underlying diseases. One patient was considered to have attention deficit hyperactivity disorder and was receiving antipsychotic medication. The median blood test values at the first visit were ALP 857 U/L (N=19), total cholesterol level 122 mg/dL (N=19), fT3 14.31 pg/mL (N=21), fT4 4.60 ng/dL (N=21), thyroid stimulating antibody 668 % (N=7), TSH receptor antibody 16.6 IU/L (N=20 TSH was less than sensitive in all cases. Nineteen patients received thiamazole. Fourteen patients received propranolol. Five patients received inorganic iodine. Five patients received inorganic iodine, starting at a median of 0.926 mg/kg/day of body weight. Discussion As with adults, females were more common. The symptoms were similar to those of attention deficit hyperactivity disorder, and thus warranted attention. Symptoms related to poor academic performance were also considered important. Anti-thyroglobulin antibodies and anti-TPO antibodies were also detected, suggesting that we should be careful about the possibility of the disease progressing to Hashimoto's disease. Presentation: Thursday, June 15, 2023

Frequency and Characteristics of Depression and Its Association with Diminished Quality of Life in a Cohort of Individuals with Post-Acute Sequelae of COVID-19.

Approximately one-third of COVID-19 survivors will experience persistent symptoms, which may include neurological and psychiatric disturbances. Previous research has suggested that up to 45% of people develop clinically significant depressive symptoms post-COVID. This study sought to determine frequency, symptom profile, and clinical correlates of depression post-COVID. Seventy-five participants who had recovered from COVID-19 underwent neurocognitive, psychiatric, medical, and cognitive testing/screening. The primary measures of interest in this report included the Patient Health Questionnaire (PHQ-9), a 9-item depression-screening tool, and the Endicott Quality of Life Enjoyment and Satisfaction Questionnaire. One-third of study participants screened as positive on the PHQ-9 for clinically significant depression, with the most commonly reported symptom being fatigue, followed by sleep disturbance and poor concentration. Also reported were decreased satisfaction in employment, sexual life, and mood. Depressed patients described greater illness severity during COVID-19 infection and subjective cognitive impairment, which was not found on neurocognitive testing. The only significant predictor of depression was COVID-19 illness severity. A significant portion of participants was a clinical population with specific post-COVID complaints and was predominately comprised of white females. Formal psychiatric evaluation was not performed. Many individuals may experience depression after COVID-19 infection, with symptoms appearing to be predominately somatic in nature and correspond with COVID-19 illness severity.