Polyvinyl Alcohol Microspheres Research Articles

Preparation of magnetic poly(vinyl alcohol) microspheres via inverse miniemulsion technique

Polyvinyl alcohol (PVA) micro- and nanospheres provide new options for drug delivery due to their biocompatibility, biodegradability and their tunable drug loading and release properties. PVA nanodroplets were fabricated by inverse miniemulsion process and then PVA microspheres were obtained by using glutaraldehyde (GA) as a cross-linking agent. Magnetic nanoparticles were in situ formed on the surfaces of PVA microspheres based on the classical coprecipitation procedure to fabricate magnetic PVA microspheres. The microspheres were characterized by FTIR, X-ray diffraction (XRD), transmission electron microscopy (TEM), light scattering equipment, and vibrating-sample magnetometry (VSM), respectively. The experimental results clearly show that PVA droplets were solidified after the cross-linking reactions to form PVA microspheres. The magnetic PVA microspheres are about 80–200nm with magnetic particle of about 18nm on the surfaces. The biocompatible and biodegradable nature of PVA indicates that this system seems to be a very promising vehicle for hydrophilic drug delivery.

Hepatic arterial embolization adopting polyvinyl alcohol microspheres preloaded with irinotecan versus systemic chemotherapy for hepatic metastases from colorectal cancer: A phase III clinical research trial of activity and quality of life.

587 Background: Patients with liver metastases (LM) from colorectal cancer (CRC) have a severe prognosis with the 5-year survival of 25% after radical resection; for not operable metastases the survival is poor. Embolization using polyvinil alcohol microspheres loaded with IRI 200 mgr (D) is a feasible procedure. FOLFIRI (CT) is active for the treatment of CRC. We planned this phase III study to assess survival as primary endpoint to increase median survival (MS) by 40% at 2-y (HR=0.72). QoL, responses, progression-free survival (PFS) and safety are secondary endpoints. Methods: Between December 2006 and December 2008, 74 pts were randomized, 37 patients to D and 37 to CT. Two D patients had early progression and two CT patients refused. 70 cycles of D were administered in 35 pts, with a dose intensity (DI) of 99%, and 292 CT cycles were delivered to 35 pts with a DI of 90%. Results: At a median follow up of 30 months ( 18-42) we reported (D vs CT): MS 48% vs 28%, Response Rate 70% vs 20%, Acute Toxicity 70% vs 20%, Late Toxicity 20% vs 80%, QoL improvement 65% vs 25%, Costs for each pt: 7,000 vs 24,000 euro. Conclusions: D increased the 30-Months MS difference of 20% compared to CT. D improved responses, Performance Status and reduced costs. D reported higher immediate toxicity, mainly fever and abdominal pain, than CT. Late toxicity, mainly haematological, diarrhoea, asthenia and alopecia, was more common in CT. We conclude that D compared to CT increases survival and palliative results in patients with LM from CRC.

Preparation and characterization of fouling-resistant composite membranes based on layer-by-layer self-assembly technique

This paper introduces a versatile approach for surface modification of 621-terylene filtration fabric (FF) self-assembled by a dynamic layer-by-layer technique. The hexadecyl trimethyl ammonium bromide (HTAB) and cross-linked polyvinyl alcohol microspheres (PVA-MS) were alternatively deposited on support membrane under a pressure of 0.01 MPa to modify FF. Morphological changes and hydrophilicity of the modified FF were characterized in detail by scanning electron micrograph and water contact angle measurements. Results revealed that PVA-MS could be adsorbed mainly on the surface of FF and water contact angle decreased with the increase of HTAB/PVA-MS bilayer numbers indicating an enhanced hydrophilicity for the modified FF. Backwash experiments of the modified FF exhibited much higher stability of PVA-MS. Protein adsorption experiments were conducted to evaluate the antifouling property of the modified FF. Results indicated that protein adsorption of the membrane surface could be obviously improved by modification, which exhibited superior antifouling property of the modified FF.

Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period

DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was to determine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static or agitated conditions and to assess the physicochemical stability over a period of 7 days. Commercially available topotecan hydrochloride powder (Hycamtin®) was reconstituted with water for injection to yield a nominal concentration of 1 mg/mL topotecan. Polyvinyl alcohol (PVA)-based microspheres (DC Bead™, 300-500 µm, 2 mL/vial) were mixed with 4 mL of the reconstituted topotecan solution. Vials were stored light protected at room temperature under static or agitated conditions for 7 days (n = 3, for each loading condition). At different time intervals, samples were taken from the excess solution and assayed via a stability-indicating HPLC assay. Drug-loading profiles were determined by measuring the remaining topotecan concentration in the excess solution. Under agitated conditions, topotecan was loaded into the microspheres rapidly after mixing. After 5 min 86.4 ± 0.1% of topotecan was loaded. Under static conditions, drug uptake was slower. Only 65.0 ± 0% were loaded after 5 min; 86.6 ± 0.1% drug uptake was achieved not until 1 h. Over a storage period of 7 days, topotecan remained loaded in the DC Bead™ microspheres at a level of >90%. Drug uptake of 4 mg topotecan (1 mg/mL solution) into DC Beads™ was faster under agitated loading conditions. Nevertheless, after 1 h, ∼90% of topotecan was loaded into the DC Bead™ microspheres independent from the type of loading condition. The loading rate remained >90% over the observation period of 7 days and light-protected storage at room temperature. Loading and stability of topotecan-loaded DC Beads™ is suitable and convenient for preparation in a pharmacy-based cytotoxic preparation unit.

Elasticity and viscoelasticity of embolization microspheres

The present study investigates the mechanical properties of three embolization microspheres (E-ms): tris-acryl gelatin microspheres (TG-ms), acrylamido polyvinyl alcohol microspheres (APVA-ms), and polyphosphazene-coated polymethylmethacrylate microspheres (PP-PMMA-ms). Compression and relaxation tests were performed on monolayers of particles and their Young’s moduli and relaxation half times (RHTs) were determined. The elasticity of E-ms was evaluated by applying Hertz theory with the assumptions of incompressibility and a Poisson’s ratio of 0.5. The Young’s moduli of TG-ms, APVA-ms, and PP-PMMA-ms were 39.6 ± 5.05 kPa, 18.8±4.00 kPa, and 13.6±1.98 kPa, respectively. The RHTs of TG-ms, APVA-ms, and PP-PMMA-ms were 52.3 ± 5.56 s, 59.1 ± 8.16 s, and 31.0 ± 7.01 s, respectively. TG-ms have a high rigidity and deform slightly under a sustained compression since they have a high elasticity. PP-PMMA-ms are soft and deform a lot under sustained compression. They are more viscous than the other two microspheres. APVA-ms have intermediate material properties, having the same low rigidity as PP-PMMA-ms and being more elastic than TG-ms.

Comparison of Clinical Outcomes of Tris-acryl Microspheres Versus Polyvinyl Alcohol Microspheres for Uterine Artery Embolization for Leiomyomas: Results of a Randomized Trial

Purpose To compare tris-acryl microspheres and polyvinyl alcohol (PVA) microspheres as embolic agents in uterine artery embolization (UAE) for uterine leiomyomas in terms of clinical outcome, inflammatory response, and adverse reactions. Materials and Methods A double-blinded randomized controlled trial was performed, with 27 patients in the tris-acryl microsphere group and 29 in the PVA microsphere group. The primary endpoint was clinical success, defined as a 2-year freedom from subsequent surgery as a result of persistent or deteriorated symptoms. Secondary endpoints included (i) posttreatment leiomyoma enlargement, (ii) leiomyoma volume reduction at 3 and 9 months, (iii) significant residual intratumoral perfusion, (iv) increase in inflammatory and stress markers, (v) incidence of complications, and (vi) duration of hospital stay. Results There was no statistically significant difference between the two groups in patient demographics, clinical presentation, initial tumor findings, change in inflammatory and stress markers after treatment, incidence of complications, and duration of hospital stay. Tris-acryl microspheres were associated with a higher rate of clinical success than PVA microspheres (96.3% [26 of 27] vs 69% [20 of 29]; P = .012), a lower incidence of posttreatment leiomyoma enlargement ( P = .030), and a lower incidence of significant residual intratumoral perfusion ( P = .030). Conclusions In the treatment of uterine leiomyomas, UAE with tris-acryl microspheres was associated with a higher clinical success rate, a lower incidence of tumor enlargement, and no significant differences in adverse reactions and inflammatory response compared with the use of PVA microspheres. Tris-acryl microspheres therefore represent the preferred agent for UAE of uterine leiomyomas.

Unilateral livedo reticularis after kidney graft embolization with polyvinyl alcohol microspheres

Unilateral livedo reticularis after kidney graft embolization with polyvinyl alcohol microspheres

Controlled release of oral drugs from cross-linked polyvinyl alcohol microspheres.

A new technique for the preparation of cross-linked polyvinyl alcohol (PVA) microspheres containing various drugs is described. An aqueous solution of PVA containing various concentrations of glutaraldehyde was dispersed as droplets in liquid paraffin using a suitable stabilizing agent. Cross-linking of PVA droplets with glutaraldehyde was induced by an acid catalyst (HCl) which was produced by the addition of small quantities of benzoyl chloride into the dispersion medium. Microspheres containing drugs such as aspirin, griseofulvin and nicotinic acid were prepared by carrying out the cross-linking reaction in the presence of such drugs. The drug release studies were carried out in simulated gastric and intestinal fluids without enzymes at 37 degrees C. It was observed that increase in the cross-linking density of the microspheres reduced the drug release rate considerably, suggesting that the release profiles could be controlled by changing the cross-linking density. It was also observed that a higher rate of release was obtained from smaller beads.

Abstract No. 169: Comparison of polyvinyl alcohol and tris-acryl gelatin microspheres for uterine fibroid embolization: Results of a single-center randomized study

To assess the efficacy of 2 embolic agents in treating symptomatic fibroids. Fibroids are the most common benign pelvic tumor successfully treated by uterine fibroid embolization (UFE). There is considerable interest in the shape, type and performance of embolic material. We will present 24 hour (h), 3- and 12-month (mo) outcomes after treatment with polyvinyl-alcohol microspheres (sPVA) versus tris-acryl gelatin microspheres (EMS).

Hemoptisis amenazante y arteria bronquial aberrante

Hemoptysis and pulmonary hemorrhage are rare pathological entities in childhood, however, both can be life threatening respiratory emergencies and can signify potentially serious underlying intrathoracic disease. We report an 11 year old female who had four episodes of hemoptysis (50 mL of bright red blood within 48 hours) without previous recurrent respiratory problems. The assessment by chest radiography, bronchoscopy and computed tomography (CT) was needed to diagnose the nature of the problem and to indicate the site and extent of the bleeding. The CT angiography of the thorax showed a right bronchial artery hypertrophy, abnormally originated from the aortic arch, next to an aberrant right subclavian artery. The bleeding was successfully controlled by right bronchial arterial embolization with 500-700 μm polyvinyl alcohol (PVA) microspheres. The course was uncomplicated. The bronchial artery embolization is effective in controlling hemoptysis and complications are uncommon in the hand of an experienced operator.

Water-soluble Polyvinyl Alcohol Microspheres for Temporary Embolization: Development and in Vivo Characteristics in a Pig Kidney Model

To preliminarily examine whether solubility of water-soluble polyvinyl alcohol (PVA) microspheres in blood plasma changes in proportion to their degrees of saponification. The study also examined their feasibility as a temporary embolic agents in the pig renal artery. Three types of PVA microspheres with the degrees of saponification of 97 mol% (S97), 98 mol% (S98), and 99 mol% (S99) were prepared. Seven kidneys in seven miniature pigs were embolized and divided into three groups so there would be at least two kidneys for each type of PVA. One animal in each group was euthanized immediately after angiography at 3 hours after embolization and the other one at 7 days after. In addition, one animal embolized with S99 microspheres was euthanized at 21 days after embolization. With S97 microspheres, the vascular network had recovered to the preembolic state by 3 hours after embolization. With S98 microspheres, blood flow in the third-order branch had been restored in the same period. With S99 microspheres, the second- and lower order branches remained occluded until 21 days. Histopathologic specimens harvested at 3 hours revealed only a trace of PVA for S97 microspheres. With S98 microspheres, the vascular lumen was still found to be filled with PVA gel. With S99 microspheres, swollen microspheres densely filled the vascular lumen even on day 21. Dissolution process in vitro and the duration of arterial occlusion in vivo were possibly related to the degree of saponification of PVA. This result may support feasibility of PVA microspheres as a temporary embolic agent.

Comparison of the Efficacy of the Embolic Agents Acrylamido Polyvinyl Alcohol Microspheres and Tris-Acryl Gelatin Microspheres for Uterine Artery Embolization for Leiomyomas: A Prospective Randomized Controlled Trial

To evaluate the efficacy of acrylamido polyvinyl alcohol microspheres (a-PVAM) as an embolic agent for uterine artery embolization (UAE) compared with Tris-acryl gelatin microspheres (TAGM). Prospective randomized double-blind noninferiority trial. Conducted at two sites both with regional UAE practices. Forty-six women with symptomatic leiomyomas. UAE procedure was performed with either of the two embolic agents. Either 700-900-μm a-PVAM or 500-700-μm TAGM was used. Changes in leiomyoma perfusion, overall uterine volume, and dominant leiomyomas volume measured by contrast-enhanced magnetic resonance imaging at 1 week, 3 months, and 6 months after UAE by a reader blinded to the embolic agent used. Changes in Uterine Fibroid Symptoms and Quality of Life questionnaire scores were measured at 3, 6, and 12 months after UAE. Forty-six patients were randomized and treated under the study protocol (a-PVAM n=22, TAGM n=24). There were no procedure-related complications. Two patients were excluded from analysis (one technical failure of the procedure, one withdrawal from study). Successful (>90%) leiomyoma devascularization was observed in 81% of subjects at 1 week after UAE, 97% at 3 months after UAE, and 95% at 6 months after UAE. No significant differences were observed in 14 of 15 outcome measurements, consistent with noninferiority. TAGM was slightly superior to a-PVAM on one comparison (overall quality of life at 3 months after UAE).

Preparation, structure, and catalytic activity of aluminum chloride immobilized on cross-linked polyvinyl alcohol microspheres

Aluminum chloride was covalently bound to cross-linked polyvinyl alcohol (CPVA) microspheres, giving rise to polymer-supported Lewis acid catalysts CPVA-AlCl 3 with a high loading (2.07 mmol/g). Their chemical structures were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, atomic absorption spectrometry, and chemical analysis methods. The catalytic activity of CPVA-AlCl 3 as well as the relationship between structure and activity was investigated by using Friedel–Crafts acylation reaction of polystyrene. These results suggest that during the immobilization process the structure of the bound aluminum chloride gradually changed from the monomeric form (–AlCl 2) to the dimeric form (–Al 2Cl 5). The presence of –Al 2Cl 5 gives rise to a catalytic activity enhancement, and the activities of various forms of CPVA-AlCl 3 follow an order: CPVA-Al 2Cl 5 > transitional form > CPVA-AlCl 2. In addition, this kind of immobilized Lewis acid catalyst has excellent recyclability and reusability, and in particular, CPVA-Al 2Cl 5 displayed an extremely low extent of catalyst deactivation in the repeated acylation reactions.

Study on complexation adsorption behavior of dibenzo-18-crown-6 immobilized on CPVA microspheres for metal ions

Dibenzo-18-crown-6 (DBC) was immobilized on crosslinked polyvinyl alcohol (CPVA) microspheres, resulting in polymer-supported crown ether DBC–CPVA. The complexation adsorption behaviors of DBC–CPVA microspheres towards diverse metal ions were investigated. The experimental results show that among alkali metal ions, the complexation adsorption ability of DBC–CPVA for K+ ion is the strongest, and crown ether-metal complex in 1:1 ratio is formed, exhibiting a high adsorption capacity. The adsorption capacities of alkali metal ions on DBC–CPVA are in the order: K+ ≫ Na+ > LI+ > Rb+ > Cs+. Among several divalent metal ions, DBC–CPVA exhibits stronger adsorption ability towards Zn2+ and Co2+ ions, and a “sandwich”-type complex is formed probably in a molar ratio of 2:1 between the immobilized DBC and Zn2+ ion as well as between the immobilized DBC and Co2+ ion. The adsorption capacities of the several divalent metal ions on DBC–CPVA are in the order: Zn2+ > Co2+ ≫ Cd2+ > Cu2+ > Ni2+ > Pb2+. The complexation adsorption is exothermic physical physisorption process, and raising temperature leads to the decrease of the adsorption capacity. At the same time, the entropy during the complexation adsorption decreases, so the adsorption process is driven by the decrease of enthalpy.

STUDIES ON GRAFTING POLY(AMIDOXIME) ON CROSSLINKED POLYVINYL ALCOHOL MICROSPHERES VIA GRAFT POLYMERIZATION-POLYMER REACTION METHOD

The graft polymerization of acrylonitrile on crosslinked polyvinyl alcohol(CPVA) microspheres was performed by using cerium ammonium sulfate as initiator,and grafted microspheres CPVA-g-PAN were prepared.Subsequently,the grafted PAN was converted into poly(amidoxime)(PAO) via amidoximation reaction with hydroxylamine hydrochloride as reagent,resulting in the functional microspheres CPVA-g-PAO.The chemical structure and physicochemistry characters of CPVA-g-PAO microspheres were adequately characterized by infrared spectrum(FTIR),scanning electron microscope(SEM) and determining zeta potential.The effects of main factors on the amidoximation transform reaction of the grafted PAN were studied with emphasis,and the adsorption property of the functional microspheres CPVA-g-PAO for some biomolecules was examined preliminarily with uric acid as a model biomolecule.The experimental results show that in the a midoximation transform reaction of nitrile groups,medium pH and reaction temperature are two main factors.For this system,the adequate pH value and temperature are 6 ～ 7 and 70℃.Under the fitting conditions,the conversion ratio of the nitrile group of the grafted PAN reaches 72% for 4 h.In a wider pH range,the zeta potential of the microspheres CPVA-g-PAO is a greater positive value.They exhibit strong adsorption ability for uric acid,a toxic endogenrsis molecule,and the adsorption capacity can get up to 95 mg /g.

Uterine Artery Embolization With Trisacryl Gelatin Microspheres in Women Treated For Leiomyomas: A Clinicopathologic Analysis of Alterations in Gynecologic Surgical Specimens

To characterize the histologic range of alterations due to uterine artery embolization with trisacryl gelatin microspheres in gynecologic specimens containing leiomyomas in detail, we report our clinicopathologic experience with 26 cases (longest postuterine artery embolization interval, 1.9 yr). Microspheres were observed in 85% of cases and could be seen up to 1.9 years after embolization. They were mainly present in leiomyomas and nonneoplastic myometrium but could be found in other nontargeted sites, such as the cervix, endometrium, ovaries, and fallopian tubes; however, infarction (present in 96% of cases) was confined to leiomyomas and did not involve other nonneoplastic tissues. The appearance of the infarcts was correlated with time after embolization, and coagulative necrosis/necrosis of indeterminate type was restricted to the early period after uterine artery embolization (before 10 wk postuterine artery embolization) whereas hyaline necrosis was seen predominantly in the late period (mostly after 10 wk, up to 1.9 yr). Of the 14 hysterectomy specimens with microspheres in extravascular spaces (almost all of which were in close proximity to the arteries), pseudoaneurysms were also focally present in 8 (57%) specimens. Microspheres were usually associated with mild inflammatory reactions, which persisted >1 year after embolization but did not become more severe over time. Morphologic and histochemical features of trisacryl gelatin microspheres were compared with other embolization agents, which can also be encountered in surgical specimens [polyvinyl alcohol (PVA) particles and PVA microspheres]. Trisacryl gelatin microspheres were negative with periodic acid-Schiff and orange-pink with Movat stains whereas PVA was positive with periodic acid-Schiff and black with Movat. Our study, the largest histologic analysis to date, confirms and extends the observations of earlier studies of trisacryl gelatin microspheres. In addition, we conclude that, as expected, the histologic appearance of microsphere-induced infarcts is a function of time, similar to healing of infarcts in nongynecologic sites. Pseudoaneurysms are a likely mechanism for the production of microspheres in extravascular spaces. Inflammation associated with microspheres can persist in gynecologic tissues but does not seem to result in the destruction of nontargeted sites. Finally, trisacryl gelatin microspheres can be distinguished from PVA particles and PVA microspheres based on a combination of morphologic features and histochemical stains.

Periadventitial Rapamycin-Eluting Microbeads Promote Vein Graft Disease in Long-Term Pig Vein-Into-Artery Interposition Grafts

Neointima formation and atherosclerosis compromise long-term graft patency in aortocoronary and peripheral vein bypass grafts. We investigated the short- and long-term effects of periadventitial application of a sustained-release formulation of rapamycin on experimental pig vein grafts with similar dimensions and kinetics to human saphenous vein bypass grafts. Periadventitial application of rapamycin-eluting polyvinyl alcohol microspheres (60 microg . cm(-2)) to porcine saphenous vein-to-carotid artery interposition grafts inhibited vein graft positive and vascular smooth muscle cell proliferation in 1-week grafts. It also decreased neointima formation and wall thickening in 4-week vein grafts compared with controls. The inhibition of vein graft thickening was not sustained; however, a catch-up phenomenon was observed, and there was no therapeutic benefit evident in 12-week grafts. Increasing the dose of rapamycin to 120 microg . cm(-2) was associated with significant local toxicity manifest by high rates of graft rupture (25%), inhibition of adventitial neoangiogenesis, and a paradoxical acceleration of vein graft disease as evidenced by increased vascular smooth muscle cell proliferation. Local toxicity and poor long-term efficacy limits the clinical applicability of locally applied, sustained rapamycin release in vein graft disease.

Arterial Distribution of Calibrated Tris-Acryl Gelatin and Polyvinyl Alcohol Embolization Microspheres in Sheep Uterus

The purpose of this study was to compare, after embolization, the distribution in the uterine arterial vasculature of tris-acryl gelatin microspheres (TGMS) and polyvinyl alcohol microspheres (PVAMS). A limited bilateral uterine artery embolization was performed in six adult sheep under fluoroscopic control by injecting in each uterine artery 0.25 ml of 500- to 700-microm TGMS of PVAMS suspended in 50/50 saline/contrast medium. Sacrifices were performed 1 week after embolization and uteri were analyzed histologically. The number and size of microspheres and vessels were measured, as well as the histological location according to a classification in four zones of the uterus. One hundred sixty-five vessels (69 vessels occluded with TGMS and 96 vessels occluded with PVAMS) were measured. The size of the occluded vessels decreased significantly from proximal to distal zones of the uterine vasculature (P < 0.0001). The location of TGMS and PVAMS within the vasculature was significantly different (P < 0.0001) since PVAMS blocked significantly more distally than TGMS. Deformation of the microspheres within the tissue was greater for PVAMS (18.0% +/- 12.3%) than for TGMS (8.7% +/- 9.2%) (P < 0.0001). In conclusion, PVAMS have a more distal distribution in the sheep uterine vasculature, compared to TGMS. Such differences in partition, already described in the kidney embolization model, can ultimately explain the different clinical outcome reported with these two types of microspheres in uterine fibroid embolization.

Preparation and recognition performance of uric acid-imprinted material prepared with novel surface imprinting technique

Acrylonitrile (AN) was first graft-polymerized on the surfaces of crosslinked polyvinyl alcohol (CPVA) microspheres by initiating of cerium salt, and then the grafted polyacrylonitrile (PAN) was transformed to polyamidoxime (PAO) via amidoximation transform reaction, resulting in the functional microspheres PAO/CPVA. By adopting the novel surface-molecular imprinting technique put forward by us, uric acid molecule -imprinted material MIP -PAO/CPVA was prepared with glutaraldehyde as crosslinking agent The binding character of MIP -PAO/CPVA towards uric acid was investigated in depth with both batch and column methods and using guanine as a contrast substance whose chemical structure is similar to uric acid to a certain extent. The experimental results show that the surface imprinted material MIP -PAO/CPVA has excellent binding affinity (a great binding capacity of 104 mg/g) and high recognition selectivity for the template molecule, uric acid. The selectivity coefficient of PAO/CPVA microspheres (non-imprinted material) for uric acid relative to guanine is only 1.273, displaying no recognition selectivity for uric acid. However, after imprinting, the selectivity coefficient of MIP -PAO/CPVA for uric acid in respect to guanine is remarkably enhanced to 14.00, displaying the excellent recognition selectivity and binding affinity towards uric acid molecules.

Performance of a novel dynamic membrane bioreactor in treating synthetic domestic wastewater

This article introduced an approach using cross-linked polyvinyl alcohol microspheres (PVA-MS) to form dynamic membrane on the surface of the industry filter cloth instead of the conventional MF/UF membrane to build a membrane bioreactor (MBR) for wastewater treatment. The performance of the dynamic MBR for treating synthetic domestic wastewater and membrane fouling were investigated. For treating synthetic domestic wastewater sequentially, the results of the batch tests showed that the effluent turbidity was less than 4 NTU and SS was zero at the most operation time. The average removal efficiency of CODCr and NH4+-N were 93.18 and 98.6%, respectively. Membrane fouling was mainly caused by sludge layer. The sludge cake and precoated dynamic membrane could be easily removed by brushing. The support membrane permeate flux was almost recovered fully and could be reused again. These results indicated that the precoated dynamic membrane could prevent pollutants and biomass intervening to the surface and interior of the support membrane which was helpful to alleviate support membrane fouling. The experimental results demonstrated that the novel dynamic membrane showed highly anti-fouling characteristics in the MBR and could be a potential technology for wastewater treatment.