Polyvalent Allergy Research Articles

Ребенок с пищевой анафилаксией. Как обеспечить полноценное питание?

This article presents a modern approach to developing a balanced personalized diet for a child with polyvalent food allergy and history of severe life-threatening allergic reactions, based on the results of molecular allergy diagnostics. Providing an adequate and safe nutrition for children who have experienced episodes of food-induced anaphylaxis becomes a serious problem for their family. This article describes the continuation of observation of a five-year-old patient with polyvalent food allergy and recurrent episodes of food-induced anaphylaxis. According to the component-resolved allergy diagnostics, it was found that the child was sensitized to many food allergens: milk and egg proteins, wheat, beans, peanuts, nuts, fruits, and some other products that make up a healthy diet. Based on the findings, a safe and balanced personalized elimination diet was developed with a specialized amino acid-based formula, which is presented in this publication. Key words: food anaphylaxis, children, polyvalent allergy, recurrent anaphylaxis, nutrition

Состояние здоровья близнецов с генотипом F508del/R334W при муковисцидозе и возможности таргетной терапии

The CFTR gene contains 27 exons and is located at position 31.1 of the long arm of chromosome 7 (7q31.1). More than 2000 variants of the CFTR gene have been described so far. The R334W variant is associated with the mild disease course. Objective. To perform comprehensive assessment of the health status, functional CFTR activity, and efficacy of CFTR modulators in twins with the F508del/R334W genotype. Materials and methods. Data from medical records, intestinal current measurement (ICM), intestinal organoid culture. Results. We examined two twins with moderate cystic fibrosis who had similar clinical manifestations, including rhinosinusitis with nasal polyps and respiratory infections caused by gram-negative bacteria. Both patients also had polyvalent allergy. One child presented with a decrease of pancreatic elastase 1 in stool from 500 μg/g to 125 500 μg/g, which required administration of pancreatin and dosage increase later. Both children had reduced chloride channel function as demonstrated by ICM. The administration of a corrector (VX-809) and a potentiator (VX-770) effectively restored the channel function; their simultaneous use ensured an additive effect. The quantitative results obtained in both cultures of intestinal organoids were very similar. Key words: cystic fibrosis, CFTR gene, pathogenic variant R334W, intestinal current measurement, intestinal organoids, forskolin-induced swelling assay, correctors, potentiators, targeted therapy, ivacaftor, lumacaftor

Structure of allergosensitization in children with allergopatologies in the Kaliningrad region

Allergic diseases (AD) are a widespread pathology. The largest proportion at AD is occupied by allergic rhinitis (24%), which in childhood is usually associated with enlargement of the adenoids and postnasal drip syndrome. In the examination of 3477 children with suspected AD, we included 1463 children aged more than 5 years in the SPC who had remission due to allergic pathology and no contraindications for examination. We detected reactions to household and epidermal allergens in 54% (n=675) and 38.3% (n=478) of the children, respectively. Diagnosis to plant aeroallergens revealed allergic sensitization to meadow and weed grasses in 55.5% (n=538) and 41.2% (n=399) of the children, respectively. According to the results of a comprehensive study with allergens, polyvalent hypersensitivity was found in 70.56% (n=441) of children. Thus, we found frequent polyvalent allergy sensitization by aeroallergens in children suffering from AD in Kaliningrad region.

Pacient se závažnou formou atopické dermatitidy, polyvalentní alergií a extrémní elevací IgE

Je uvedena kazuistika 37letého muže, který trpěl od 22 let věku závažnou formou atopické dermatitidy. Postupně byl léčen všemi dostupnými systémovými léky: cyklosporinem A intermitentně 5,5 roku, azathioprinem 11 měsíců a methotrexátem 2,3 roku. Později u něj byly 5 let prováděny výměnné plazmaferézy s limitovaným efektem. Teprve biologická léčba dupilumabem vedla nejprve k velmi výraznému zlepšení a později k dlouhodobé kompletní remisi. Zhojení trvá již 14 měsíců. Léčba dupilumabem je dobře tolerována. Pacient je velmi spokojen, jeho kvalita života je vynikající.

Промонтофиксация с использованием титанового имплантата у пациенток с поливалентной аллергией и комбинированной гинекологической патологией

Clinical observation of two patients with polyvalent allergy, uterine leiomyoma, and stage II apical prolapse who underwent a combined surgical intervention of subtotal/total hysterectomy followed by cervical stump/vaginal stump promontofixation using titanium mesh implants. Dynamic follow-up for 3–12 months after surgery showed the absence of pelvic organ prolapse during gynecologic examination, Valsalva maneuver, and transperineal ultrasound. A questionnaire survey of the patients revealed satisfaction with the results of surgery and improvement of the quality of life. Conclusion. The study demonstrated the efficacy and safety of combined laparoscopic surgery for uterine leiomyoma and stage II apical prolapse in premenopausal patients with polyvalent allergy. The surgery contributed to the normalization of anatomical relations in the small pelvis and relieving the apical prolapse symptoms. The use of titanium mesh implants minimized the risk of allergic reactions and mesh-associated complications, which resulted in satisfaction with the results of surgery and improvement in the quality of life of the patients. Key words: pelvic organ prolapse, apical prolapse, hysterectomy, titanium mesh implants

Иммунологические особенности пыльцевой и клещевой сенсибилизации у жителей Бишкека

The article presents the results of a study of the prevalence of pollen allergy and allergies to house dust mites among Bishkek population in 2019. The examined patients, aged 4 to 60 years, were divided into groups according to the age periodization of a person. Identification of general and specific IgE antibodies was carried out using modern methods of laboratory diagnosis of the immunological profile. Linked Immunosorbent Assay options such as Chemiluminescence Immunoassay (CLIA) and Immunoblotting were used. The obtained results indicate a widespread sensitization of Bishkek population to pollen allergens, sensitization to house dust mite allergens is more pronounced in the form of a polyvalent allergy. There is also a tendency to increase the prevalence of allergic diseases among the country’s child population. Pollinosis occupy a leading place among allergic diseases in the country due to the fact that weeds prevail in the city’s natural vegetation, which are highly allergenic. Data on the incidence of allergic diseases in Kyrgyzstan, as well as abroad, do not reflect the true spread of allergies, because like most patients with mild forms of allergic diseases do not go to the doctor. Therefore, the early detection, prevention and treatment of allergic diseases is one of the most important issues of modern medicine and biology. It is necessary to create annual flowering calendars of allergenic plants. Round the clock biomonitoring of the air to monitor pollen and air disputes is necessary to inform patients with hay fever. Preventive measures for patients with sensitization to house dust mite allergens include the prevention of mass reproduction of mites, namely the reduction of dust and humidity in rooms.

Surprises of food anaphylaxis: a clinical case

Anaphylaxis is a severe systemic hypersensitivity reaction that is characterized by rapid onset and life-threatening respiratory and blood circulation problems. We present to your attention a clinical case of the polyvalent allergy development in a three-year-old child with repeated episodes of food anaphylaxis. The child was born and he constantly lives in central Russia, but has a profile of sensitization unusual for a Ural resident. The clinical case is described in detail in order to demonstrate the stages of a child’s life, on which sensitization was likely to be first formed, and later the manifestation of clinical symptoms arose. Determination of the sensitization profile by means of the component allergy diagnostics methods (ISAC, ImmunoCAP) showed that the boy is sensitized to a large number of food allergens, including milk and egg proteins; storage proteins for peanuts, soy, hazelnuts and sesame; proteins related to the nsLTP-proteins. The obtained results made it possible to recognize and differentiate true IgE-mediated sensitization, to propose the optimal therapeutic tactics and to select an elimination diet. Application of molecular allergy diagnostic methods is useful in clinical practice in case of patients with multivalent sensitization and a history of severe allergic reactions.

Features of the development of diets for preschool children in celiac patients

The article presents the results of a study on the development of diets for feeding children with food polyvalent allergy, incl. and gluten at the age of 3–7 years for feeding children in pre-school educational organizations. Food allergies to gluten or gluten enteropathy (celiac disease) is a chronic human disease in which eating food from wheat, rye, and barley grain causes a wide range of pathological changes in the body: damage to the small intestine mucosa, a sharp deterioration in the digestion and absorption of nutrients. The developed 10 day menu, corresponding to the principles of the child's nutritional needs (physiological norms of consumption), distribution of nutrition during the day, the child's need for food. The data of caloric distribution of the diet for individual meals are presented. The evaluation of the nutrition balance of children was carried out on the basis of the SanPiN guidelines 2.4.1.3049-13. Satisfaction of diurnal physiological norms of consumption on the main macronutrients, vitamins, minerals and energy value of the diet on the basis of the analysis of menu-layouts is considered. It is shown that measures to form healthy food habits in preschool children as part of a healthy lifestyle should be systemic, ensuring continuity and continuity of this process, as well as taking into account the age and individual characteristics of children. Since the gluten-free diet is a health preventive for people with celiac compliance, it needs a long time.

Local allergic rhinitis to pollens is underdiagnosed in young patients.

Local allergic rhinitis (LAR) has been observed in patients without atopy. However, LAR is still underdiagnosed in patients with perennial or seasonal nasal symptoms. The aim of this study was to determine the prevalence of LAR in young patients with a previous diagnosis of nonallergic rhinitis or suspicion of allergy. A total of 121 patients, ages 12-18 years old, with confirmed nonallergic rhinitis and typical seasonal nasal symptoms were examined. Skin-prick tests; serum and nasal specific immunoglobulin E (IgE) measurements; and nasal provocation tests by using grass (Phleum partense), Artemisia, and birch pollens were performed. A control group of age-matched patients with a diagnosis of seasonal allergic rhinitis underwent the same procedures as the test group. LAR to grass pollen (P. partense), Artemisia, and birch was confirmed in 17 (16.6%), 6 (5.9%), and 9 (8.9%) of patients, respectively. Polyvalent allergy was established in 21 subjects (20.8%): grass and Artemisia, 11 patients (10.9%); and grass and birch, 10 patients (9.9%). The remaining 48 patients (47.5%) were diagnosed with nonallergic rhinitis. The results of the nasal provocation tests and the concentrations of nasal IgE were similar among the analyzed groups. Furthermore, the concentration of nasal IgE increased faster in patients with LAR than in patients with allergic rhinitis; however, this difference was not statistically significant. LAR is a serious problem in young patients; however, its significance is still unappreciated.

Modern Diagnosis and Therapy of the rhinitis allergica

The prevalence of allergic diseases is increasing worldwide. The highest increase rate is observed in rhinitis allergica. Apart from the anamnesis, the diagnosis relies mainly on skin tests, laboratory analyses and if necessary provocation tests. Symptomatic and causal therapy with abstention and specific immunotherapy are available as therapeutic means. Specific immunotherapy should be aspired as the method of choice. It is comprised of subcutane and sublingular immunity therapy. Usually native allergens and allergoids are used as therapeutics. Recombinant allergens are currently under development. Modern therapy procedures involving these drugs consist of year-round or pre- and co-seasonal treatment which spans at least 3-4 years. In cases of polyvalent allergy, different types of drugs and therapy procedures can be combined. The future of rhinitis allergica treatment lies in further development of specific immunotherapy.

POSSIBILITIES OF USING MEAT PRODUCTS OF INDUSTRIALLY MANUFACTURED BEIKOST FOR ALLERGY PREVENTION IN CHILDREN OF 0–1 YEARS OF AGE

научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных и вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии лекарственных средств на плод, о проводимых в

Efficiency of nebulizations of ionized silver solution in patients with chronic obstructive lung disease

The main problem in preventing exacerbations of chronic obstructive pulmonary disease (COPD) is high cost of medication for regular use and low income of the most patients. Frequent need in antibiotic therapy in COPD patients with concomitant polyvalent allergy, virus infections, antibiotic resistance of pathogens arises some problems in prevention and treatment of COPD. Today there is a great need not only in potent antibiotics but also in additional cheap treatment methods for use in regular basis. These methods should be applicable to other treatments and be active against not only bacterial flora but also other microorganisms. One of such methods meeting these requirements is nebulization of ionized silver solution. Aim of this study was clinical investigation of a new method for prevention of COPD exacerbations using nebulization of ionized silver solution. This double-blind, randomized, placebo-controlled study of long-term therapy with nebulization of ionized silver solution was carried out in 160 patients with mild to moderate COPD. The treatment duration varied from 30 to 180 days. Results showed positive changes in lung function and clinical symptoms. Number and duration of COPD exacerbations associated with acute respiratory virus infections decreased. The optimal daily dose of ionized silver via inhalations was 2 mg.

Contact allergy in patients with chronic venous leg ulcers – possible role of chronic venous insufficiency

The purpose of this study was to evaluate frequency of contact allergy in patients with chronic venous leg ulcers (CVLU) and to estimate possible relationships between allergic contact reactions and characteristics of both chronic venous insufficiency (CVI) and CVLU. We performed patch tests with the European standard series, antibiotics, glucocorticosteroids and ointment vehicles in 50 patients with CVLU. Patients underwent detailed CVI diagnostics using colour flow duplex ultrasound examination, ankle brachial pressure index determination and leg ulcers area measurement. Positive patch tests results were found in 80% and polyvalent allergy in 56% of patients. Statistically significant correlations were recorded between CVI and CVLU duration, CVLU duration and CVLU area and between CVI duration and polyvalent allergy frequency. Statistically significant differences were observed between coexistence of superficial and deep system insufficiency and CVLU duration, characteristics of contact allergic reactions and CVI duration, frequency of allergic contact reaction and presence or absence of long saphenous vein insufficiency, incidences of vein thrombosis and characteristics of contact allergic reactions as well as between characteristics of contact allergic reactions and both CVLU duration and area. Complex pathophysiological processes, including inflammatory reactions, in course of CVI may influence development of allergic contact reaction in CVLU patients.

Increase in the Incidence of Allergy to Prosthetic Materials and Local Anesthetics: Immunophysiology and Laboratory Diagnostics of Intolerance

Combined analysis of drug sensitivity in vitro and in vivo is necessary for reliable diagnosis of the intolerance to prosthetic materials and local anesthetics as an intrinsic allergic reaction, especially in the cases of generally weak allergic reactions. Changes in peroxidase release from granulocytes in response to a corresponding substance is an effective in vitro test, and the provocative mucosal-gingival test (MGT) is used in vivo. During the past decade, a growth was observed in the population developing allergies to prosthetic materials and local anesthetics, which is expressed in an increased number of patients with intolerance to these materials against the background of increasing hyperresponsiveness to the drugs which have usually been tolerated well, as well as an increased proportion of patients with a polyvalent allergy to many prosthetic materials and anesthetics. At the same time, the amount of weak responses to drugs in the in vitro test has increased. Some of these patients exhibit a pathologic response to the given drug, which can be detected using the MGT. In most cases, polyvalent allergies to prosthetic materials or anesthetics and a pathological response accompanied by a weak in vitro reaction are found in patients with bronchial asthma and other chronic allergies, chronic candidosis of the oral cavity, and chronic Helicobacter and Giardia lamblia infections.

Aeropalynological monitoring in Bishkek, Kyrgyzstan

The pollen spectrum of Bishkek was investigated by a gravity method, during March-October in 1984, 1988 and 1992. The recovered pollen types belong to 20 families and 26 taxa. Only 4 types reach significant levels of deposition of over 10% as annual average. These include: Artemisia, Chenopodiaceae/Amaranthaceae, Quercus and Poaceae. Pollinosis in Bishkek is mainly induced by Artemisia and Poaceae pollen. Hay fever patients showed polyvalent allergy to Artemisia and Poaceae pollen (32 to 51%), Artemisia and Atriplex pollen (34.5%).

Treatment of deep burns with human fetal tissues

Treatment of third (AB) degree burns by applying a suspension prepared from human placenta and fetal skin proves as effective as plastic surgery. This approach is particularly helpful when supplies of donor skin are limited, in the therapy of patients with polyvalent allergy, elderly and senile patients with a severe somatic pathology hampering autodermaplasty, in the therapy of children, and in cases of untreatable infected burns.