In this study, the effects of the core layering of sandwich structures, as well as arrangements of these layers on the ballistic resistance of the structures under high-velocity impact, were investigated. Sandwich structures consist of aluminum face-sheets (AL-1050) and polyurethane foam core with different densities. Three sandwich structures with a single-layer core of different core densities and four sandwich structures with a four-layer core of different layers arrangements were constructed. Cylindrical steel projectiles with hemispherical nose, 8 mm diameter and 20 mm length were used. The projectile impact velocity range was chosen from 180 to 320 m/s. Considering constant mass and total thickness for the core, the results of the study showed that the core layering increases the ballistic limit velocity of the sandwich structures. The ballistic limit velocity of the panels with a four-layer core of different arrangements, compared to the panel with the single-layer core, is higher from 5% to 8%. Also, for the single-layer core structure, by increasing the core density, the ballistic limit velocity was increased. Different failure mechanisms such as plugging, petaling and dishing occurred for the back face-sheet. The dishing area diameter of back face-sheets was proportional to the ballistic resistance of each sandwich structure.