You have accessJournal of UrologyProstate Cancer: Markers (I)1 Apr 20132139 ASPIRIN USE REDUCES RISK OF TMPRSS2:ERG FUSION POSITIVE PROSTATE CANCER Jonathan Wright, Lisly Chery, Daniel Lin, Sarah Holt, Manuel Luedeke, Antje Rinckleb, Christiane Maier, and Janet Stanford Jonathan WrightJonathan Wright Seattle, WA More articles by this author , Lisly CheryLisly Chery Seattle, WA More articles by this author , Daniel LinDaniel Lin Seattle, WA More articles by this author , Sarah HoltSarah Holt Seattle, WA More articles by this author , Manuel LuedekeManuel Luedeke Ulm, Germany More articles by this author , Antje RincklebAntje Rinckleb Ulm, Germany More articles by this author , Christiane MaierChristiane Maier Ulm, Germany More articles by this author , and Janet StanfordJanet Stanford Seattle, WA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2048AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The TMPRSS2:ERG gene fusion (T2E) is the most common rearrangement seen in prostate cancer (PCa), present in approximately 50% of cases. Little is known about factors that may be associated with the presence of the fusion. Several reports suggest that aspirin use is associated with a reduction in the risk of PCa. Oxidative stress is one mechanism of DNA damage which can lead to gene rearrangement. As aspirin use reduces oxidative stress, we explored whether aspirin use is associated with a reduction in T2E fusion in a cohort of men undergoing radical prostatectomy from a population-based study of PCa. METHODS Men from two population-based case-control studies of PCa risk factors who underwent radical prostatectomy and had prostate tumor tissue available to make tumor micro arrays were included in the analysis. T2E fusion status was determined by FISH. Clinical and demographic characteristics were available. Aspirin use was determined from self-completed questionnaires regarding current use and duration. A multivariate polytomous model controlling for age, race, family history of PCa, PSA screening history and PSA level was used to evaluate the association of T2E fusion negative and T2E fusion positive tumors with aspirin use. RESULTS A total of 569 men had T2E fusion status determined. The fusion was present in 296 (52%) of samples. Caucasian men were more likely to have the T2E fusion as compared to African American men (54% vs. 32%, p < 0.01). With increasing age, the presence of fusion positive tumors declined from approximately 70% of men < aged 50 to 20% of men over the age of 70 (p < 0.001). Data on 942 age-matched controls without PCa were available for analysis. Use of aspirin was similar between controls and men with T2E negative tumors (45% and 42%, respectively, multivariate OR for risk of T2E negative PCa in current aspirin users compared to non-users was 0.99, 0.69 - 1.42). In contrast, men with T2E positive tumors less commonly reported current aspirin use (30%) than control men (45%). In the multivariate model, current aspirin use was associated with a 37% reduction in the risk of T2E positive tumors (OR 0.63, 95% CI 0.43 - 0.93). CONCLUSIONS Use of aspirin is associated with a reduction in the risk of T2E positive, but not T2E negative, PCa. Potentially, through a reduction in cellular stress, aspirin use may protect against DNA strand breaks necessary for T2E fusion. Further study of the effects of aspirin and other anti-inflammatory medications on the presence of T2E fusion in PCa is warranted, including related pathways that may be implicated in prostate carcinogenesis. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e876 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jonathan Wright Seattle, WA More articles by this author Lisly Chery Seattle, WA More articles by this author Daniel Lin Seattle, WA More articles by this author Sarah Holt Seattle, WA More articles by this author Manuel Luedeke Ulm, Germany More articles by this author Antje Rinckleb Ulm, Germany More articles by this author Christiane Maier Ulm, Germany More articles by this author Janet Stanford Seattle, WA More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...