Polypyrrole Nanoparticles Research Articles

Nitrogen doped siloxene and composite with graphene for high performance fiber-based supercapacitors

Graphene fiber-based supercapacitors (FSCs), with excellent power and energy density, are promising candidates for powering smart flexible electronic devices. However, the low mass loading of active materials and slow diffusion of ions limit their electrochemical performance. Herein, we report a robust and facile strategy, aimed at constructing nitrogen-doped siloxene/graphene 2D/2D composites (N-SiNs@G) by the pyrolyzation of siloxene/polypyrrole to further enhance the electrochemical performance of fiber electrodes. The carbonization of polypyrrole nanoparticles offers an in-situ nitrogen source for doping siloxene to prepare nitrogen-doped siloxene (N-SiNs), which enhances the electronic conductivity and energy storage capacity of siloxenes. The N-SiNs@G composites exhibit a multi-component synergistic effect for enhancing ion diffusion. Furthermore, the graphene nanosheets maintain the integrity and stability of the hybrid fiber and offer flexibility. The nitrogen-doped siloxene/graphene hybrid fibers (N-SiGFs) electrodes designed in this study showed remarkable electrochemical performance and exceptional mechanical flexibility for fiber-based supercapacitor applications.

Synthesis of conducting molecularly imprinted polymer nanoparticles for estriol chemosensing

Herein, electrochemically active molecularly imprinted polypyrrole nanoparticles (PPy NPs) were synthesized with the aid of micelles. Iron(III) p-toluenesulfonate induced polymerization of pyrrole resulting in the imprinting of estriol in growing NPs. Two separate imprinted NPs were prepared with pristine and derivatized pyrrole monomers. Techniques such as scanning electron microscopy (SEM), and transmission electron microscopy (TEM), confirmed the synthesis of imprinted PPy NPs of ∼60 nm in size. NPs prepared with pristine pyrrole showed an imprinting factor of 4.2, while NPs prepared with derivatized pyrrole showed no imprinting. The electrochemical-based transduction allowed for the determination of estriol in the concentration range of 0.5–5 µM and 10–100 µM with the 0.16 µM limit of detection (LOD). Furthermore, the selectivity of the MIP NP-coated electrode toward estriol and its structural analogs, namely β-estradiol and estrone, was satisfactory.

Oomicidal activity of polypyrrole nanoparticles against Pythium insidiosum.

This study evaluated in-vitro action of a new molecule, the polypyrrole nanoparticles (Ppy-NP), against Pythium insidiosum isolates using M38-A2/CLSI; the minimal inhibitory (MIC) and minimal oomicidal (MOC) concentrations were also determined. Additionally, changes in the hyphae wall of P. insidiosum CBS 575.85 treated with Ppy-NP were evaluated by scanning electron microscopy (SEM). The MIC100 and MOC for all isolates ranged from 8 to 32μg mL-1, and the MIC90 and MIC50 were 16μg mL-1. The SEM showed structural damage to the hyphae of P. insidisoum treated with Ppy-NP, as hyphae surfaces with less turgidity were found, thereby showing scaling and ruptures compared to the control (untreated hyphae). Our findings highlighted the anti-P. insidiosum properties of Ppy-NP proved to be a promising candidate for research using pythiosis experimental models.

An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite.

To protect consumers from risks related to overexposure to sulfadiazine, total residues of this antibacterial agent in animal-origin foodstuffs not exceed international regulations. To this end, a new electrochemical sensor based on a molecularly imprinted polymer nanocomposite using overoxidized polypyrrole and copper nanoparticles for the detection of sulfadiazine is elaborated. After optimization of the preparation of the electrochemical sensors, their differential pulse voltammetric signal exhibits an excellent stability and reproducibility at 1.05 V, with a large linear range between 10-9 and 10-5 mol L-1 and a low detection limit of 3.1 × 10-10 mol L-1. The produced sulfadiazine sensor was successfully tested in real milk samples. The combination of the properties of the electrical conduction of copper nanoparticles with the properties of the preconcentration of the molecularly imprinted overoxidized polypyrrole allows for the highly sensitive detection of sulfadiazine, even in real milk samples. This strategy is new and leads to the lowest detection limit yet achieved, compared to those of the previously published sulfadiazine electrochemical sensors.

Polypyrrole-coated copper@graphene core-shell nanoparticles for supercapacitor application

The performance of supercapacitors strongly depends on the electrochemical characterizations of electrode materials. Herein, a composite material consisted of polypyrrole (PPy) and multilayer graphene-wrapped copper nanoparticles (PPy/MLG-Cu NPs) is fabricated on a flexible carbon cloth (CC) substrate via two-step synthesis process for supercapacitor application. Where, MLG-Cu NPs are prepared on CC by one-step chemical vapor deposition synthesis approach; thereafter, the PPy is further deposited on the MLG-Cu NPs/CC via electropolymerization. The related material characterizations of PPy/MLG-Cu NPs are well investigated by scanning electron microscopic, high resolution transmission electron microscopy, Raman spectrometer and x-ray photoelectron spectroscopy; the electrochemical behaviors of the pertinent electrodes are studied by cyclic voltammogram, galvanostatic charge/discharge and electrochemical impedance spectroscopy measurements. The flexible electrode with PPy/MLG-Cu NPs composites exhibits the best specific capacitance of 845.38 F g−1 at 1 A g−1, which is much higher than those of electrodes with PPy (214.30 F g−1), MLG-Cu NPs (6.34 F g−1), multilayer graphene hollow balls (MLGHBs; 52.72 F g−1), and PPy/MLGHBs (237.84 F g−1). Finally, a supercapacitor system consisted of four PPy/MLG-Cu NPs/CC electrodes can efficiently power various light-emitting diodes (i.e. red, yellow, green and blue lighs), demonstrating the practical application of PPy/MLG-Cu NPs/CC electrode.

SENSOR PARA DETECÇÃO DE PREDNISOLONA NO DOPING ESPORTIVO

ABSTRACT Introduction: Prednisolone causes pro-inflammatory impulses to be inhibited and anti-inflammatory signals to be promoted. As a result, it alters how the body's immune system reacts to certain diseases. The World Anti-Doping Agency, however, has banned SNP and other glucocorticosteroids. An electrochemical sensor can be developed using a gold nanocomposite, polypyrrole nanoparticles and synthesized carbon nanotubes (Au-PPy NPs@CNTs). Objective: Develop an electrochemical sensor to detect prednisolone. Method: Au-PPy NPs@CNTs nanocomposite was chemically synthesized with a modified glassy carbon electrode (GCE) surface. Results: According to SEM data, the nanocomposite was composed of amorphous Au NPs, and PPy NPs deposited in tubes strongly entangled in a CNTs network. The wide linear range and low detection limit of the Au-PPy NPs@CNTs/GCE as prednisolone sensors were attributed to the combined catalytic performance of the Au and PPy NPs@CNTs nanostructures. Conclusion: The results of prednisolone detection in each specimen using the amperometric method indicated good accuracy. The accuracy and precision of Au-PPy NPs@CNTs/GCE for prednisolone detection were explored in blood samples from 5 young athletes aged 20-24 years who used prednisolone tablets (RSD less than 4.25%). In addition to monitoring prednisolone concentrations in athletes’ serum, Au-PPy NPs@CNTs/GCE can be used as a reliable prednisolone sensor. Level of evidence II; Therapeutic studies - investigating treatment outcomes.

Light-driven MOF-based micromotors with self-floating characteristics for water sterilization.

Three-dimensional motion (especially in the Z-axis direction) of metal-organic frameworks (MOFs)-based micromotors (MOFtors) is essential but still in its infancy. Herein, we propose a simple strategy for designing light-driven MOFtors that move in the Z-axis direction and efficiently kill Staphylococcus aureus (S. aureus). The as-prepared polypyrrole nanoparticles (PPy NPs) with excellent photothermal properties are combined with ZIF-8 through a simple in situ encapsulation method, resulting in multi-wavelength photothermally-responsive MOFtors (PPy/ZIF-8). Under the irradiation of near-infrared (NIR)/ultraviolet (UV)/blue light, the MOFtors all exhibited negative phototaxis and high-speed motion behaviour with the highest speed of 2215 ± 338 μm s-1. In addition, it is proved that these MOFtors can slowly self-float up in an aqueous environment. The light irradiation will accelerate the upward movement of the MOFtors, and the time required for the MOFtors to move to the top is negatively correlated with the light intensity. Finally, efficient antibacterial performances (up to 98.89% against S. aureus) are achieved with these light-driven MOFtors owing to the boosted Zn2+ release by vigorous stirring motion and physical entrapment by the upward motion under light irradiation.

Designing a dual barrier-self-healable functional epoxy nano-composite using 2D-carbon based nano-flakes functionalized with active corrosion inhibitors

Graphene oxide (GO) nanosheets were in-situ functionalized via polypyrrole (POP) nanoparticles using ammonium persulfate and afterward doped with sodium molybdate (GPM) and finally incorporated into the epoxy resin for achieving a nano-composite coating with dual barrier and self-healing properties. The synthesized nanoparticles were characterized by field-emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD), and thermal gravimetric analysis (TGA) techniques. The release mechanism of the inhibitors from the GPM was investigated in both solution and coating phases. In addition, the modified coatings were tested electrochemically using electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization as well as the pull-off test, cathodic disbonding, and salt spray. Results from FE- SEM /EDS, FT-IR, TGA, and XRD investigations supported the successful synthesis of the GPM complex and molybdate adsorption on the surface of GP. Electrochemical measurements revealed that the release of MoO4−2 from GPM resulted in the creation of a compact protective layer on the steel surface, enhanced inhibitive ability, and a low corrosion rate (1.41 A cm−2). It was shown that the charge transfer resistance of the bare steel sample in the blank solution enhanced from 2360 Ω cm2 to 8530 Ω cm2 in the presence of GPM after 1 h immersion time. The epoxy coating's ability to prevent corrosion was also improved by the GPM nanoparticles, reaching 99%.

On-Off Phagocytosis and Switchable Macrophage Activation Stimulated with NIR for Infected Percutaneous Tissue Repair of Polypyrrole-Coated Sulfonated PEEK.

Intelligent control of the immune response is essential for obtaining percutaneous implants with good sterilization and tissue repair abilities. In this study, polypyrrole (Ppy) nanoparticles enveloping a 3D frame of sulfonated polyether ether ketone (SP) surface are constructed, which enhance the surface modulus and hardness of the sulfonated layer by forming a cooperative structure of simulated reinforced concrete and exhibit a superior photothermal effect. Ppy-coated SP could quickly accumulate heat on the surface by responding to 808nm near-infrared (NIR) light, thereby killing bacteria, and destroying biofilms. Under NIR stimulation, the phagocytosis and M1 activation of macrophages cultured on Ppy-coated SP are enhanced by activating complement 3 and its receptor, CD11b. Phagocytosis and M1 activation are impaired along with abolishment of NIR stimulation in the Ppy-coated SP group, which is favorable for tissue repair. Ppy-coated SP promotes Collagen-I, vascular endothelial growth factor, connective tissue growth factor, and α-actin (Acta2) expression by inducing M2 polarization owing to its higher surface modulus. Overall, Ppy-coated SP with enhanced mechanical properties could be a good candidate for clinical percutaneous implants through on-off phagocytosis and switchable macrophage activation stimulated with NIR.

Combined Photothermal Therapy and Lycium barbarum Polysaccharide for Topical Administration to Improve the Efficacy of Doxorubicin in the Treatment of Breast Cancer.

In order to improve the efficacy of doxorubicin in the treatment of breast cancer, we constructed a drug delivery system combined with local administration of Lycium barbarum polysaccharides (LBP) and photothermal-material polypyrrole nanoparticles (PPY NPs). In vitro cytotoxicity experiments showed that the inhibitory effect of DOX + LBP + PPY NPs on 4T1 cells under NIR (near infrared) laser was eight times that of DOX at the same concentration (64% vs. 8%). In vivo antitumor experiments showed that the tumor inhibition rate of LBP + DOX + PPY NPs + NIR reached 87.86%. The results of the H&E staining and biochemical assays showed that the systemic toxicity of LBP + DOX + PPY NPs + NIR group was reduced, and liver damage was significantly lower in the combined topical administration group (ALT 54 ± 14.44 vs. 28 ± 3.56; AST 158 ± 16.39 vs. 111 ± 20.85) (p < 0.05). The results of the Elisa assay showed that LBP + DOX + PPY NPs + NIR can enhance efficacy and reduce toxicity (IL-10, IFN-γ, TNF-α, IgA, ROS). In conclusion, LBP + DOX + PPY NPs combined with photothermal therapy can improve the therapeutic effect of DOX on breast cancer and reduce its toxic side effects.

Influence of the type and concentration of oxidant on the photoacoustic response of polypyrrole nanoparticles for potential bioimaging applications

The photoacoustic response of polypyrrole particles was studied in relation to the type and amount of oxidant used for their synthesis by photoacoustic spectroscopy. At the same time, a detailed study of the molecular structure of these particles was performed using infrared and Raman spectroscopy. It was found that the particles prepared using superstoichiometric amounts of the oxidizer, nPy:nOxi = 1:3, in the case of FeCl3 and stochiometric nPy:nOxi = 1:1, in the case of (NH4)2S2O8 - showed the best photoacoustic output. At ratios nPy:nOxi oxidants equal to or less than 1:2 in the case of FeCl3, oligomers and polypyrrole with a longer kinetic chain length might be formed, whereas the higher oxidant content no longer affects the quality of the product. In the case of oxidation by (NH4)2S2O8, amounts of oxidant higher than 1:2 led to the formation of over-oxidized products. Although nanoparticles prepared at the stoichiometric ratios of both oxidizing agents were equivalent in terms of the molecular structure determined by the IR and Raman spectra, the particles prepared by (NH4)2S2O8 show a slightly stronger PA signal.

Mangasese doped polypyrole nanoparticels for photothermal/chemodynamic therapy and immune activation

Photothermal therapy (PTT) is a promising treatment that efficiently suppresses local cancer, but fails to induce a robust antitumor immune response against tumor metastasis and recurrence. In this study, a NIR responsive nano-immunostimulant (Mn/A-HP NI) is fabricated by entrapping manganese and azo-initiator (AIPH) into hyaluronic acid-based polypyrrole nanoparticle. The as-prepared Mn/A-HP NIs with a high photothermal conversion efficiencey of 20.17% dramatically induced the imunogenic cell death of tumor cells and triggered the release ATP and HMGB1. Meanwhile, the hyperthermia induced AIPH decomposition to produce alkyl radicals which further destroyed cancer cells. Furthermore, the Mn/A-HP NIs were capable of promoting the maturation and antigen cross-presentation ability of dendritic cells. Consequently, the multifunctional Mn/A-HP NIs provided a combined treatment via integrating PTT/chemo-dynamic therapy and immune activation for tumor therapy.

Development of an Atmospheric Pressure Plasma Jet Device Using Four-Bore Tubing and Its Applications of In-Liquid Material Decomposition and Solution Plasma Polymerization.

In this study, we describe an atmospheric pressure plasma jet (APPJ) device made of four-bore tubing operable in inhospitable humid environments and introduce two potential applications of liquid material processing: decomposition of aqueous phosphorus compounds and solution-plasma polymerization. A four-bore tube was used as the plasma transfer conduit and two diagonal bores contained metal wires. In the proposed APPJ device, the metal wires serving as electrodes are completely enclosed inside the holes of the multi-bore glass tube. This feature allows the APPJ device to operate both safely and reliably in humid environments or even underwater. Thus, we demonstrate that the proposed electrode-embedded APPJ device can effectively decompose aqueous phosphorus compounds into their phosphate form by directly processing the solution sample. As another application of the proposed APPJ device, we also present the successful synthesis of polypyrrole nanoparticles by solution plasma polymerization in liquid pyrrole.

Enhanced photothermal and chemotherapy of pancreatic tumors by degrading the extracellular matrix

The degradation of extracellular matrix (ECM) to increase drug permeability is an attractive approach to enhancing pancreatic cancer therapy efficiency. Herein, polypyrrole nanoparticles (PPy NPs) were prepared by a template-guided chemical oxidation method. These PPy NPs with abundant surface pores were used to load the anticancer drug doxorubicin (DOX). In order to intelligently control the DOX release, PPy/DOX NPs were further entrapped with a thermoresponsive ligand, lauric acid (LA), to form PPy-LA/DOX NPs. Bromelain (BL) was then grafted onto the surface of PPy-LA NPs or PPy-LA/DOX NPs through an amidation reaction with the carboxyl group of LA. It was found that the DOX release of PPy-LA/DOX NPs was pH and temperature responsive, reaching a maximum amount of 85.9% within 48 h at pH = 5.4 and 50 °C. Moreover, it was demonstrated that the resultant PLB (PPy-LA-BL) NPs could efficiently hydrolyze the collagen in ECM and enhance the permeability of DOX to the pancreatic tumor. Remarkably, PLB NPs not only featured admirable photothermal conversion but also exhibited obvious photoacoustic imaging capability, which enabled imaging-guided enhanced tumor ablation. This study is anticipated to provide a feasible strategy to improve the permeability of nanoparticles to tumors.

Adsorption of Cr(VI) in aqueous solution by polypyrrole nanotube and polypyrrole nanoparticle; Kinetics, isotherm equilibrium, and thermodynamics

Hexavalent chromium is a toxic pollutant because it may harm human health. So, the effective removal of hexavalent chromium in wastewater is still an important problem. In this study, polypyrrole nanoparticles (PPynp) and polypyrrole nanotubes (PPynt) were prepared by different polymerization conditions of pyrrole monomers to compare the ability to adsorb Cr (VI) in an aqueous solution. The X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) results demonstrated that the two prepared polypyrrole were essentially identical, but the Transmission electron microscope (TEM) results demonstrated that the upper one is a nanotube and the other is a particle. Cr (VI) is highly pH-dependent on the adsorption of PPy adsorbent, and the removal efficiency of PPynt was much higher than PPynp. The adsorption kinetics follow a pseudo-second-order kinetic model, reaching equilibrium in 100 – 180 min. Langmuir isotherm model was adopted to match the adsorption isotherm data, and the maximum adsorbing capacity was 119.33–205.34 mg/g. The PPynt material can undergo three continuous adsorption–desorption cycles without the loss of the Cr (VI) removal efficiency. In addition, its large surface area, superior Cr (VI) adsorption properties and regeneration properties make the single component PPynt a good material for the removing of Cr (VI) from wastewater.

Hybrid Polyurethane/Polypyrrole Composite Coatings on Passivated 316L SS for Surface Protective Action against Corrosion in Saline Medium

Hybrid treatments consisting of surface modification and subsequent protective coatings have gained extensive attention among corrosion mitigation approaches for a wide variety of structural metallic materials. This study aims to review the enhancement of the corrosion protection performance of polyurethane (PU) coatings on 316L stainless steel (SS) specimens. This was achieved via a two-step strategic treatment, primarily by electrochemical passivation and subsequent deposition of PU composite coatings with the different feed ratio of synthesized polypyrrole (PPy) nanoparticles. The effect of different applied voltage on the surface features and the corrosion behavior of the passivated SS surfaces was systematically investigated using surface characterization techniques and a potentiodynamic polarization test in a NaCl solution. Surface morphological images revealed the porous structure on the passivated surface. It is inferred from the topographical surface results that homogeneous surface roughness was achieved with the applied voltage of 5 V. Infra-red spectroscopic results validate the formation of PU/PPy composite coatings and the intermolecular chemical interaction between the PU and PPy moieties. Furthermore, corrosion measurements corroborate the improved corrosion resistance of PU/30PPy coatings with higher values of charge transfer resistance, Rct (1.0869 × 107 Ω cm2), and film resistance, Rf (2.258 × 105 Ω cm2), with the lowest values of corrosion, icorr (4.7 × 10−3 µA cm−2) compared to that of the PU/Bare specimen. In conclusion, it is confirmed that the passivated surface enhances the corrosion resistance performance of PU coated SS, and this performance is further increased with the incorporation of PPy particles.

Vacuum plasma treatment on carbon nanoparticles for highly sensitive square wave voltammetric sensor of heavy metal ions

Heavy metal ions are dangerous pollutants since they are non-biodegradable and accumulate in ecological systems. The identification of these ions is extremely important in environmental quality monitoring. However, despite the importance of detecting heavy metals, research on sensor electrode materials for sensing them is still insufficient. In the present study, we suggest functional group introduced carbon nanoparticles (CNPs) using a simple vacuum plasma process. Polypyrrole nanoparticles (PPyNPs) are used as carbon precursors to produce CNPs and various functional groups are introduced following exposure with different gases (NH3, C4F8, and O2) during the vacuum plasma process. Plasma-treated CNPs show fast charge transfer and high sensitivity to the heavy metal ions (Pb2+ and Cu2+). Particularly, O2 gas-treated CNPs (O-CNPs) possess an excellent sensing ability as compared to the other treated CNPs. Under optimized conditions, O-CNPs show a limit of detection (LOD) of 0.005 μM for Pb2+ and 0.01 μM for Cu2+. O-CNPs also show a linearity for the detection signal of metal ions over a wide concentration range (0.01–100 μM for Pb2+ and 0.1–100 μM for Cu2+).

Redox-responsive hyaluronan-conjugated polypyrrole nanoparticles targeting chemo-photothermal therapy for breast cancer.

The combination of chemo-photothermal therapy has a wide application prospect in the intensive treatment of cancer. In this study, we developed a complex nanoparticle consist of polypyrrole, cystine dihydrochloride and hyaluronan. The polypyrrole nanoparticles loaded with paclitaxel exhibited good photothermal effects, and the drug release can be triggered by combined response of temperature and redox. In vitro biological studies indicated the nanoparticles could effectively induced apoptosis of MDA-MB-231 breast cancer cells involved in the potential mechanism of inhibition of biological expression of heat shock proteins and JAK-STAT signaling pathway. In addition, the nanoparticles have a significant inhibitory effect on cancer growth in breast tumor-bearing mice model, indicating that they have great potential for synergistic chemo-photothermal therapy.

An amperometric electrochemical sensor based on hierarchical dual- microporous structure polypyrrole nanoparticles for determination of pyrogallol in the aquatic environmental samples

Pyrogallol (PY) is commonly found as inherent toxicity of industrial effluents which easily enter to the aquatic environment; owing to its oxygen free radicals which causes several health issues. We report a highly sensitive and selective pyrogallol (PY) sensor using hierarchical dual-microporous polypyrrole nanoparticle-modified screen-printed carbon electrode (MPNPs/SPCE). The proposed electrode material for the cost-effective and rapid estimation of PY in the environmental water samples. Hierarchical dual-microporous polypyrrole nanoparticles were prepared through the simple chemical polymerization of pyrrole using Pluronic F-127 as the surfactant. The MPNPs possess well-defined dual micropore (∼0.52 and ∼ 0.67 nm) and a large BET surface area (183 m2/g). The electro-oxidation behavior of PY was examined by cyclic voltammetry and amperometric technique. Hierarchical structure with dual-microporous networks, and large specific surface area of MPNPs were assumed to be greatly enhanced the adsorption rate and a fast facilitate ion transfer for PY sensor. Owing to the effective coupling of hydrogen bonding (interaction between –OH group of PY and –NH group of polymer chain) and π -π interactions (between PPy rings and the PY aromatic rings) can offer more accessible electrochemical active sites and electrolyte/electrode contact interfaces for rapid electro-oxidation response. As a result, wide linear range (0.05–130 μM), good detection limit (0.03 μM), and high sensitivity (1.213 μA μM−1 cm−2) toward PY surpass those of other modified electrodes. Furthermore, MPNPs/SPCE system exhibited desirable selectivities, good steady stabilities, and reproducibilities as PY sensors. Real domestic, industrial, and sewage environmental water samples were analyzed, with quantification data compared with those obtained by HPLC.

Enhancement of polypyrrole electrochemical performance with graphene quantum dots in polypyrrole nanoparticle/graphene quantum dot composites

• The synthesis of polypyrrole decorated with GQDs in a form of spherical nanoparticles by chemical polymerization in the presence of a surfactant. • The optimization of the polymerization time and amount of GQDs added during the polymerization. • The influence of these factors on the size, dispersibility, textural parameters, and electrochemical properties of composite nanoparticles. • Voltammetric and theoretical studies on the actual influence of GQDs on the electrochemical behavior of polypyrrole nanoparticles. The influence of graphene quantum dots (GQDs) on the physicochemical properties of polypyrrole nanoparticles (PpyNPs) was investigated experimentally and theoretically. The synthesis of the non-covalent PpyNPs/GQDs material was based on the known procedure of chemical pyrrole polymerization in the presence of a strong oxidant (ammonium persulfate, APS) and a surfactant (decyltrimethylammonium bromide, DeTAB). The obtained hybrids were in the form of spherical polymeric particles coated with GQDs with a diameter depending on the polymerization time and the amount of GQDs added during the synthesis. The morphology and porosity of the obtained materials were also influenced by the polymerization conditions, namely, composites with a higher GQD content showed higher BET specific surface area. On the other hand, the greatest attention was paid to the study of electrode processes taking place on the electrode modified with the PpyNPs/GQDs composite compared to the modification with pristine PpyNPs. GQDs incorporated into the polymeric network significantly change the energy level distribution at the interphase between Ppy and GQDs. Electronic interaction between both components results in GQDs participation in the Ppy-involved charge transfer processes. In consequence, oxidation of the mixed PpyNPs/GQDs system is much easier compared to the polymer itself. The charge transfer processes involving PpyNPs/GQDs composites are also much faster than those involving electroactive films formed only from PpyNPs. Additionally, a significant increase in the double-layer capacitance current is observed for composite materials. In conclusion, a clear improvement in the electrochemical behavior of polypyrrole in the composite material was observed, which was undoubtedly the result of the introduction of GQDs.