AbstractConducting polymers such as polypyrrole (PPy) offer a new class of material for trial use in biological applications. The plasma polymerization is the process mostly used for the deposition of thin polymer and polymer‐based composite films with a variable amount of functionalities available for reaction with biomolecules. Heparin (Hep) is a potent anticoagulant that can be immobilized on biomaterial surfaces to increase their hemocompatability. Efforts are to attach Hep to polymeric materials. In this context, the strategy followed in this work was based on a plasma deposition of PPy and PPy‐Hep films onto Ti substrate. The PPy and PPy‐Hep films were investigated using Fourier Transform Infrared Spectroscopy (FT‐IR) and Atomic Force Microscopy (AFM). (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)