The role of the vagus nerves in gastric microcirculation and the efficacy of vagotomy with direct spray of a polymerizing agent on bleeding gastric mucosa were studied. To assess the efficacy of vagotomy in diffuse hemorrhage from the gastric mucosa, microcirculatory responses of the stomach prior and after vagotomy were studied using an ultropak intravital microscope and microangiohistologic technics with silicon rubber injection compound in dogs. Vagotomy opened arteriovenous shunts and reduced the hemorrhage from the mucosa. Vagotomy followed by the application of cyanoacrylate tissue adhesive spray which polymerized at the bleeding mucosal surface provided complete hemostasis without ill effects.