Polymerization Of Derivatives Research Articles

Complementary transcriptomic and metabolomics analysis reveal the molecular mechanisms of EGCG3″Me biosynthesis in Camellia sinensis

Epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me), naturally occurring in specific tea plant cultivars, is famous for its decent bioavailability and antiallergic activity. To investigate the molecular mechanisms of EGCG3″Me biosynthesis and transcriptional regulation in tea leaves, we combined multi-omics data from three tea plant cultivars (Fuding Dabaicha, FD; Mingke 1 (Jinguanyin), JGY; and Jinmudan, JMD). High-performance liquid chromatography analysis indicated that EGCG3″Me content was highest in JMD (7.78 mg/g), moderate in JGY (3.12 mg/g), and lowest in FD (0 mg/g), which was similar to the results of the non-targeted metabolic analysis. The high level of EGCG3″Me in JMD was concomitant with high levels of monomeric and polymerized catechin derivatives, but low levels of flavonols, flavones, and their glycosides, which was consistent with the expression levels of most catechin/flavonoid biosynthetic genes. Among them, the expression level of the CCoAOMT gene in the three tea plant cultivars was positively associated with the relative content of EGCG3″Me. Further verification revealed that CCoAOMT protein could directly catalyze the formation of EGCG3″Me. We further identified 38 transcription factors from transcriptome as promising regulatory candidates for regulating CCoAOMT gene expression in tea leaves. These findings provide an essential foundation for further research on the biosynthesis and transcriptional regulation of O-methylated catechins in tea leaves.

Assessment of bacterial pollution of closed water supply systems of galvanized productions

This work is devoted to assessment of the bacterial contamination of drainage systems in a galvanic production. In the course of the study, two strains of microorganisms which cause microbial contamination and lead to a decrease in the efficiency of the process equipment were isolated from water and wash sediment samples taken in the industrial water supply system of the enterprise and identified. Our study of the morphological and cultural properties of the isolated strains of bacteria has allowed them to be attributed to the genus Bacillus. As a result of a metagenomic analysis of the composition of microbial communities for the 16S rRNA gene (16S rDNA variable regions) according to the GenBank database on an ABI Prism 3730 automatic sequencer, the homology of the first strain with typical strains of the subgroup B. velezensis and B. amyloliquefaciens was established within 99.4–99.9%. When identifying the second isolated strain, the homology with B. altitudinis was 99.7%. Our study of the properties of the isolated strains has shown that they are neither pathogenic nor toxigenic. To reduce the microbial load in the technical water supply system, a series of experiments was carried out to select a biocide. Several variants of disinfectants of various groups were tested, namely: oxidizing ones (chloramine (a chlorine derivative of ammonia), hydrogen peroxide) and non-oxidizing ones (polymeric derivatives of polyhexamethylene guanidine (PHMG) produced by JSC NPK Mediana-filter and polyazolidine ammonium ionohydrate (PAG-M) produced by LLC “Constanta”). The polymeric compounds were found to be more effective than the chlorine-based disinfectants. An aqueous solution of polyhexamethylene guanidine had the best bactericidal effect on the microorganisms, therefore it was recommended to combat the existing bacterial contamination.

Polymerized Naphthalimide Derivatives as Remarkable Electron‐Transport Layers for Inverted Organic Solar Cells

Two polymerized naphthalimide derivatives, named as N-TBHOB and N-DBH, are prepared by quaternization. They exhibit excellent performance as electron-transport layers (ETLs) in inverted organic solar cells (i-OSCs). The results indicate N-TBHOB with a reticulated structure owns a superior performance on electron extraction, electron transport, thickness tolerance, and less carrier recombination compared with N-DBH with linear structure. The i-OSCs based on N-TBHOB with PTB7-Th:PC71 BM as the active layer achieve power conversion efficiencies (PCEs) of 10.72% and 10.03% under the thickness of 11 and 48nm respectively, which indicates N-TBHOB possesses better thickness tolerance than most of organic ETLs in i-OSCs. N-TBHOB also shows more competent performance than N-DBH and ZnO in nonfullerene i-OSCs for comprehensively improved Jsc , Voc , and fill factor (FF) values. Its i-OSC with PM6:Y6 blend presents a high PCE of 16.78%. The study provides an efficient strategy to prepare ETLs by combining conjugated and nonconjugated units with a reticulated structure in the backbone for high-performance i-OSCs.

Fabrication of three-dimensional nanocomposite with open cage fullerene polymer and MoS2 for enhanced electrochemical hydrogen evolution activity

Development of advanced materials for electrocatalytic water splitting to generate hydrogen is the key in utilization of renewable energy. In the present work, we constructed three-dimensional (3D) nanoparticles (P-PC60@MoS2) based on an open-cage fullerene polymer (P-PC60), on the surface of which two-dimensional (2D) molybdenum disulfide (MoS2) are grafted vertically. The rational design endows the nanocomposite materials with combined advantages of open-cage fullerenes and MoS2. Especially, compared with traditional fullerenes, polymeric fullerene derivatives are expected to have remarkable electronic, optical, or catalytic properties due to the formation of an interconnected continuous network. The results indicate that the few-layer MoS2 slices arranged vertically on the surface of the fullerene, showing an expanded layer spacing of 6.4 Å, which is beneficial for maximally exposing active edge sites. The hybrid P-PC60@MoS2 with proper synthetic engineering possesses superior catalytic kinetics with surpassing overpotential of 59 mV, Tafel slope of 37 mV dec−1, which are much lower than those of pure MoS2 and P-PC60. The small values indicate fast electrochemical hydrogen evolution reaction (HER) kinetics.

Synthesis and characterization of photo-crosslinkable cinnamate-functionalized pectin

The polysaccharide pectin (PC) was functionalized with the photo-responsive cinnamic acid hydrazide (CN) to produce the photo-crosslinkable PC-CN hydrogel material that was then evaluated as a carrier for encapsulation of the drug model aspirin. Cinnamic acid hydrazide was first prepared and then incorporated with the abundant –COOCH3 groups on the pectin chain via hydrazide linkage. The obtained polymeric derivatives have been characterized by means of instrumental techniques including FTIR and NMR. The obtained PC-CN hydrogels with different cinnamic functionality were also freeze-dried and examined by SEM, which indicated more coherent hydrogel texture by increasing the cinnamic functionalization. The effect of the photo-curing time, as well as the functionalization degree, on the swelling and gelation of the obtained hydrogel was also studied to evaluate the potential of the developed material in drug delivery systems using aspirin as a common and available drug model. The developed PC-CN hydrogel materials exhibited high potential as a drug carrier that enables the control of the drug release via optimizing both the degree of cinnamic functionality and the photo-curing time.

Berberine bridge enzyme-like oxidase-catalysed double bond isomerization acts as the pathway switch in cytochalasin synthesis

Cytochalasans (CYTs), as well as their polycyclic (pcCYTs) and polymerized (meCYTs) derivatives, constitute one of the largest families of fungal polyketide-nonribosomal peptide (PK-NRP) hybrid natural products. However, the mechanism of chemical conversion from mono-CYTs (moCYTs) to both pcCYTs and meCYTs remains unknown. Here, we show the first successful example of the reconstitution of the CYT core backbone as well as the whole pathway in a heterologous host. Importantly, we also describe the berberine bridge enzyme (BBE)-like oxidase AspoA, which uses Glu538 as a general acid biocatalyst to catalyse an unusual protonation-driven double bond isomerization reaction and acts as a switch to alter the native (for moCYTs) and nonenzymatic (for pcCYTs and meCYTs) pathways to synthesize aspochalasin family compounds. Our results present an unprecedented function of BBE-like enzymes and highly suggest that the isolated pcCYTs and meCYTs are most likely artificially derived products.

Hybrid iron(II) phthalocyaninatoclathrochelates with a terminal reactive vinyl group and their organo-inorganic polymeric derivatives: synthetic approaches, X-ray structures and copolymerization with styrene.

Hybrid metallo(IV)phthalocyaninate-capped tris-dioximate iron(II) complexes (termed as "phthalocyaninatoclathrochelates") with non-equivalent apical fragments and functionalized with one terminal reactive vinyl group were prepared for the first time using three different synthetic approaches: (i) transmetallation (capping group exchange) of the appropriate labile boron,antimony-capped cage precursors, (ii) capping of the initially isolated reactive semiclathrochelate intermediate, and (iii) direct one-pot template condensation of their ligand synthons on the iron(II) ion as a matrix. The obtained polytopic cage complexes were characterized using elemental analysis, 1H NMR, MALDI-TOF MS and UV-vis spectra, and the single-crystal X-ray diffraction experiments. One of the obtained vinyl-terminated iron(II) phthalocyaninatoclathrochelates and its semiclathrochelate precursor were tested as monomers in a copolymerization reaction with styrene as the main component. These vinyl-terminated (semi)clathrochelate iron(II) complexes were found to be successfully copolymerized with this industrially important monomer, affording the intensely colored copolymer products. Because of a low solubility of the tested zirconium(IV) phthalocyaninate-capped tris-nioximate monomer in styrene as a solvent, a molar ratio of 1 : 500 was used. The obtained copolymer products and the kinetics of their formation were studied using GPC, FTIR, UV-vis, TGA and DSC methods. Even at such a low concentration of the Fe,Zr-binuclear metallocomplex component, an increase in the rate of the UV-light degradation of the organo-inorganic products, as well as in their thermal stability, was observed.

The inhibition tendencies of novel hydrazide derivatives on the corrosion behavior of mild steel in hydrochloric acid solution

Three different simple and polymeric hydrazide derivatives have been synthesized, evaluated and investigated as corrosion inhibitors for mild steel in 1 M hydrochloric acid medium. The corrosion inhibition performance of these additives was evaluated using electrochemical impedance spectroscopy (EIS) and polarizations measurements. The inhibition efficiency obtained from polarization measurement followed the order of PACAH > ACAH > CAH. The inhibition efficiency of the polyhydrazide derivative (PACAH) at concentration of 50 and 500 ppm was found to be 90.66 and 96.79% respectively, while 500 ppm of cyanoacetohydrazide (CAH) was 39.79% and for the monomer N-acryloyl-N′-cyanoacetohydrazide (ACAH) was 88.66%.The surface morphology of the steel electrode was studied with and without the inhibitor after immersion in 1 M HCl solution for 6 h using SEM, EDAX and AFM measurements. The results showed an improvement in the surface morphology where the flawed regions were repaired and the cracks were healed. This improvement was attributed to the adsorption of the inhibitor molecules and the formation of a protective layer at the steel surface. The adsorption isotherm indicated a spontaneous physical adsorption of the inhibitor on the surface of mild steel electrode. Quantum chemical calculation was used to correlate the inhibition efficiencies data of the hydrazide derivatives with their electronic structural parameters. Theoretical calculations supported and elucidated the experimental results.

Injectable and In Situ Gelling Dextran Derivatives Containing Hydrolyzable Groups for the Delivery of Large Molecules.

Recently, we reported the synthesis and characterization of a new dextran derivative obtained by grafting polyethylene glycol methacrylate to a polysaccharide backbone through a carbonate bond. This moiety was introduced because it allows for the fabrication, through a photo-induced crosslinking reaction, of biodegradable hydrogels particularly suitable for the release of high molecular weight molecules. Here, we investigate the influence of the oxyethylene chain length and the molecular weight of the starting dextran on the main properties of the polymeric solutions as well as those of the corresponding hydrogels. All synthesized polymeric derivatives were characterized by FTIR, NMR, and rheological analyses. The photo-crosslinking reaction of the polymers allowed us to obtain biodegradable networks tested for their mechanical properties, swelling, and degradation behavior. The results showed that both the oxyethylene chain length as well as the molecular weight of the starting dextran influenced swelling and degradation of the hydrogel network. As a consequence, the different behaviors in terms of swelling and degradability were able to affect the release of a large model molecule over time, making these matrices suitable candidates for the delivery of high molecular weight drug substances.

Polymeric Blatter's Radical via CuAAC and ROMP

AbstractA Blatter radical‐containing polymer backbone is synthesized via copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) and consecutive ring‐opening metathesis polymerization. For this, an alkyne‐functionalized Blatter radical is synthesized and used for the described CuAAC, yielding a polymerizable derivative of the radical. The resulting polymer is electrochemically investigated in cyclic voltammetry experiments, paving the way for the possible utilization of triazinyl radicals in all‐organic polymer batteries. Furthermore, the simple modification of the alkyne bond makes further derivatization easily accessible.

Surface coating on aluminum substrate with polymeric guanidine derivative to protect jet fuel tanks from microbial contamination

Antimicrobial coatings can act as an effective barrier to microbial growth and colonization in jet fuel tanks, which can effectively avoid the safety problems and economic losses. In this study, we initially synthesized an antimicrobial and water-insoluble complex, poly (hexamethylene guanidine) hydrochloride-sodium stearate (PHMG-SS), and its minimum inhibitory concentrations (MICs) were measured as 0.25 g/L, 0.25 g/L, 0.25 g/Land 0.5 g/L against Escherichia coli , Staphylococcus aureus , Bacillus subtilis and Yarrowia lipolytica , respectively; then, PHMG-SS was facilely coated onto the surface of aluminum substrate by the aid of a green linker, polyvinyl butyral (PVB). The PHMG-SS-coated aluminum exhibited a powerful microbicidal activity against the above four microorganisms , and provided a greater than 99.999% (5 log) reduction in viable counts of experimental microorganisms within 30 min through contact. In addition, the antimicrobial performance could still be observed after 7 d of ultraviolet radiation or soaking in jet fuel. Furthermore, the antimicrobial mechanism was investigated and concluded as damaging the microbicidal morphologies and suppressing the activity of respiratory chain dehydrogenase . Finally, PHMG-SS-coated aluminum was evaluated as interior surface of jet fuel tanks to protect jet fuel, and the experimental results showed that PHMG-SS-coated aluminum achieved a greater than 99.9999% (6 log) reduction in viable counts of a mixed suspension of Escherichia coli , Staphylococcus aureus , Bacillus subtilis and Yarrowia lipolytica within 30 min. The outputs from this work represent a highly versatile approach to build an antimicrobial barrier to protect jet fuel from microbial contamination, and such approach is also worthy of wide application to treat other surfaces. • The antimicrobial coating and the coating technology were environmental-friendly and could be applied on a large scale. • The developed antimicrobial coating exhibited desirable biocidal efficacy without detectable PHMG leaching. • The antimicrobial aluminum sheet could quickly kill the mixed microorganisms and exhibited desirable UV resistance. • The antimicrobial aluminum sheet showed the potential to protect jet fuel tanks from microbial contamination.

Novel zinc-polymer complex with antioxidant activity for industrial lubricating oil

The development of lubricants requires antioxidants, which enhance their efficiency by minimizing waste products derived from oxidation processes. The present study aimed to synthesize (Zn-Complex) Zinc (N-Salicylidene Poly Methyl Acrylic Acid Hydrazide). These obtained polymeric derivatives were characterized by FTIR, XRD, SEM, BET and PSD. The antioxidant behavior was investigated by density, total amount of acid, viscosity and carbon residue. This investigation successfully managed to prepared new additive to the lubricant that does not contain Sulphur and Phosphorus with better lubricant antioxidant properties also has greater efficiency than traditional antioxidant (p-Cresol). This new synthetic antioxidant could be used by industrialists to replace the multipurpose lubricant additive, ZDDP and ZDDC which contain Sulphur and Phosphorus that produces and deposit ashes in the car exhaust pipe.

Interactional study of a polymeric organotin complex in micellar media

In this manuscript, a study on interactions of a polymeric derivative of Tributyltin(IV) with [(2-Methylpropanoyl)amino]propanoic acid (TMP) in micellar media is presented. The study was conducted using two surfactants viz. Sodium 2-ethylhexylsulphate (SES) and Cetyltrimethylammonium bromide (CTAB). The solubilization parameters in terms of partition constant (K c ), partition coefficient (K x ), binding constant (K b ), Gibb’s free energy of partition (ΔG p ), and binding (ΔG b ) were investigated by UV–Visible spectrophotometer. The estimation of micellization thermodynamics including entropy (ΔS m ), enthalpy (ΔH m ), and Gibb’s free energy (ΔG m ) were determined conductometrically. The compound showed more interaction with the cationic surfactant as compared to anionic participating surfactant due to comparative electrostatic interactions. The partition coefficient (K x ) in the micellar media of CTAB was significantly higher (4.22 × 107) than SES media (1.33 × 105). The Gibb’s free energies of partition. Binding and micellization were higher in CTAB as compared to SES.

ДОСЛІДЖЕННЯ ОСОБЛИВОСТЕЙ ГЕЛЕУТВОРЕННЯ ТА ВЛАСТИВОСТЕЙ ГІДРОГЕЛІВ ПРИ СТРУКТУРУВАННІ ФОРПОЛІМЕРІВ АКРИЛАМІДУ

The paper represents the results of the investigation of the formation of a polymeric matrix of hydrogel due to the structuring of polyacrylamide using its reactive polymeric derivative – poly-N- (hydroxymethyl) acrylamide. Research determined zones of optimum conditions of synthesis and characterized hydrogel depending on pH of media, the ratio between the concentration of prepolymers, and time of synthesis. The investigation of the reaction mixture showed that the hydrogen index of the synthesis of hydrogels is one of the important factors, which in the design of the polymer framework of hydrogels allows regulating their colloidal chemical properties in a wide range.

A convenient strategy to synthesize highly tunable gelatin methacryloyl with very low gelation temperature

Gelatin methacryloyl (GelMA) is a polymeric derivative of gelatin (Gel) widely used in tissue engineering, as well as in wound dressing and drug delivery field. This work offers an alternative and convenient method for the synthesis and characterization of GelMA. In particular, the methacrylation was carried out under homogeneous single-phase reaction conditions, which allows of obtaining a good reproducibility of the derivatization degree of the polymer in a simple and fast way. The experimental conditions were adequately optimized to have the methacrylation of only ε-amino groups of lysine and hydroxylysine, as confirmed by FT-IR and 1H NMR analysis. The degree of derivatization of GelMA was determined using an internal standard applied to 1H NMR analysis. Based on these measurements, it was found that the optimized reaction proceeds to complete functionalization of ε-amino groups of lysine and hydroxylysine. The effect of the reaction conditions on the rheological properties of GelMA was investigated through temperature sweep experiments and compared with those of the polymer obtained under traditional heterogeneous reaction conditions. A significant difference was found in the gelation temperature of GelMA synthesized following the two different procedures. In particular, the proposed single-phase synthetic protocol gave a polymer which behaves like a solution when used at 10% w/v concentration and even at temperatures as low as 5 °C, whereas the polymer obtained with the classic biphasic procedure behaves like a gel within the same range of temperatures and when used at the same concentration. These results are particularly interesting as they could open GelMA to new applications particularly in the biomedical field.

Depolymerized phosphorus-doped polymeric carbon nitride: A mercury (II) ion fluorescent probe

The fluorescence quenching effect of polymeric carbon nitride-based materials can be efficiently applied to the rapid detection of Hg2+. Herein, we chose dicyandiamide and sodium hypophosphite as precursors to prepare bulk phosphorous-doped polymeric carbon nitride through thermal polycondensation, and then a one-step hydrothermal treatment caused the depolymerization of the bulk products and the formation of the nanorod-like structures. The depolymerization resulted in the good aqueous colloidal stability of the polymeric carbon nitride-based derivative, and phosphorus-doping significantly improved its fluorescence. More terminal amino and abundant surface hydroxyl groups led to the enhanced selective fluorescence quenching of Hg2+ by the depolymerized products. Therefore, the depolymerized phosphorous-doped polymeric carbon nitride with a fluorescence quantum yield of 23.2% showed excellent Hg2+ detection capability. The limit of detection of the depolymerized polymeric carbon nitride to Hg2+ can reach 0.74 nmol L−1. And the depolymerized products also showed good accuracy in the Hg2+ detection of shrimp samples. This work broadens the scope of polymeric carbon nitride-based heavy metal ion fluorescent probes, and provides a new roadmap for the highly selective determination of Hg2+.

Synthesis and Post-Polymerization Modification of Poly(N-(4-Vinylphenyl)Sulfonamide)s.

Herein, a straightforward synthesis of a novel class of polymers, that is, poly(N-(4-vinylphenyl)sulfonamide)s, and their monomers is reported. A set of monomers with varying electron densities, fine-tuned by different substituents on the aromatic sulfonamide moiety, is polymerized by free radical polymerization featuring low molar masses (2300≤Mn ≤3200gmol-1 ) and low dispersities (1.15≤Đ≤1.47). Further, the post-polymerization modification of the obtained polymers via aza-Michael addition with electron-deficient alkenes is demonstrated using organic superbases as catalysts, paving the way toward the facile synthesis of novel polymeric protected β-amino acid derivatives.

Stimuli-responsive nanoparticles based on poly acrylic derivatives for tumor therapy

Serve side effects caused by discriminate damage of chemotherapeutic drugs to normal cell and cancer cells remain a main obstacle in clinic. Hence, continuous efforts have been made to find ways to effectively enhance drug delivery and reduce side effects. Recent decades have witnessed impressive progresses in fighting against cancer, with improved understanding of tumor microenvironment and rapid development in nanoscale drug delivery system (DDS). Nanocarriers based on biocompatible materials provide possibilities to improve antitumor efficiency and minimize off-target effects. Among all kinds of biocompatible materials applied in DDS, polymeric acrylic derivatives such as poly(acrylamide), poly(acrylic acid), poly(N-isopropylacrylamide) present inherent biocompatibility and stimuli-responsivity, and relatively easy to be functionalized. Furthermore, nanocarrier based on polymeric acrylic derivatives have demonstrated high drug encapsulation, improved uptake efficiency, prolonged circulation time and satisfactory therapeutic outcome in tumor. In this review, we aim to discuss recent progress in design and development of stimulus-responsive poly acrylic polymer based nanocarriers for tumor targeting drug delivery.

Metabolic Profiling and Gene Expression Analyses of Purple-Leaf Formation in Tea Cultivars (Camellia sinensis var. sinensis and var. assamica).

Purple-leaf tea cultivars are known for their specific chemical composition that greatly influences tea bioactivity and plant resistance. Some studies have tried to reveal the purple-leaf formation mechanism of tea by comparing the purple new leaves and green older leaves in the same purple-leaf tea cultivar. It has been reported that almost all structural genes involved in anthocyanin/flavonoid biosynthesis were down-regulated in purple-leaf tea cultivars when the purple new leaves become green older leaves. However, anthocyanin/flavonoid biosynthesis is also affected by the growth period of tea leaves, gradually decreasing as new tea leaves become old tea leaves. This leads to uncertainty as to whether the purple-leaf formation is attributed to the high expression of structural genes in anthocyanin/flavonoid biosynthesis. To better understand the mechanisms underlying purple-leaf formation, we analyzed the biosynthesis of three pigments (chlorophylls, carotenoids, and anthocyanins/flavonoids) by integrated metabolic and gene expression analyses in four purple-leaf tea cultivars including Camellia sinensis var. sinensis and var. assamica. Green-leaf and yellow-leaf cultivars were employed for comparison. The purple-leaf phenotype was mainly attributed to high anthocyanins and low chlorophylls. The purple-leaf phenotype led to other flavonoid changes including lowered monomeric catechin derivatives and elevated polymerized catechin derivatives. Gene expression analysis revealed that 4-coumarate: CoA ligase (4CL), anthocyanidin synthase (ANS), and UDP-glucose: flavonoid 3-O-glucosyltransferase (UFGT) genes in the anthocyanin biosynthetic pathway and the uroporphyrinogen decarboxylase (HEME) gene in the chlorophyll biosynthetic pathway were responsible for high anthocyanin and low chlorophyll, respectively. These findings provide insights into the mechanism of purple-leaf formation in tea cultivars.

The effect of initiator concentrations on corrosion inhibition activity of polymeric derivatives of 2-vinylpyridin

This study aims to investigate the effect of initiator concentrations of polymeric derivatives of 2-vinylpyridine, P(2VP) as corrosion inhibitors of mild steel in CO2-satured brine solution. Polymerization of the monomer was conducted using hydrogen peroxide initiator with four different concentrations of 0.25; 0.33; 0.50; and 0.80 mole, to produce four oligomers referred to as P(2VP)A, P(2VP)B, P(2VP)C, and P(2VP)D, respectively. A series of corrosion experiments was conducted to determine the corrosion rate of the mild steel using weight loss and linear polarization resistance (LPR) methods. The effect of inhibitor concentration, and temperature, on the corrosion rate was also investigated. The oligomers synthesized were found to have different physical appearance. Two oligomers, the P(2VP)A and P(2VP)B, were found as yellow viscous liquids, with O(2VP)B is more viscous than P(2VP)A, while the other two oligomers, P(2VP)C and P(2VP)D exist as yellow solids. The experimental results reveal that the use of monomer led to higher corrosion rate compared to that of blank experiment, but reduced corrosion rate was achieved with the use of the oligomers. P(2VP)A as an oligomer synthesized with the lowest concentration of H2O2 initiator inhibited the corrosion more effective than the higher concentrations. It was also found that the higher the concentration of the oligomer, the better the protection. For temperature, the opposite is true, indicating that the oligomer was physically adsorbed onto the surface of mild steel.