Polymeric Agents Research Articles

Highly Simplified FeCl3‐Assisted Copolymerization and Doping for Organic Thermoelectrics

ABSTRACTThe FeCl3 is a well‐known oxidizing agent for oxidative polymerization as well as a p‐type dopant for making conducting polymers, but no studies have yet explored the simultaneous use of FeCl3 for both polymerization and doping of organic soluble conjugated polymers (CPs) in organic thermoelectric (OTE) applications. In this study, soluble 4H‐cyclopenta[2,1‐b:3,4‐b′]dithiophene (CPDT)‐co‐3,4‐ethylenedioxythio‐phene (EDOT) polymers were successfully synthesized via a simple FeCl3‐assisted oxidative coupling reaction at room temperature. In addition, FeCl3 doping of the synthesized polymers enabled them to exhibit thermoelectric properties. The addition of 10% ~ 20% EDOT in a polymer chain gave a synergetic effect on the electrical conductivity and power factor (PF) in the OTE devices. In that ratio, the strong electron‐donating EDOT facilitates doping in the CPs, and the planar CPDT backbones stabilize the generated polaron/bipolaron species through efficient π‐electron delocalization, resulting in the highest electrical conductivity. At the optimal EDOT ratio of 20%, a more than 10‐fold enhancement in PFs was achieved reaching up to 0.182 ± 0.021 μW m−1 K−2. The EDOT moiety, except in PEDOT:PSS, is rarely found in conjugated copolymers, but its proper incorporation is expected to enhance thermoelectric properties of the organic soluble CPs.

Comprehensive Analysis and Emission Reduction Pathway of GHG Emissions at a Wastewater Treatment Plant in Suzhou

Taking a sewage treatment plant in Suzhou City, Jiangsu Province, as an example, the greenhouse gas （GHG） emissions generated in the sewage treatment system were calculated using the carbon balance method and the emission factor method. The environmental impacts and economic aspects of different treatment units in wastewater treatment plants were analyzed using life cycle assessment, cost-benefit analysis, and data envelopment analysis models, and emission reduction pathways were proposed. The results indicated that the total GHG emissions （in terms of CO2） from a certain municipal wastewater treatment plant in Suzhou were 6 653.08 kg·（104 m3）-1, with direct and indirect GHG emissions accounting for 29.22% and 74%, respectively. The reuse of treated effluent achieved a reduction of 3.3% in emissions. The biological treatment phase and the sludge treatment phase were the main impact stages for GHG emissions at a certain wastewater treatment plant in Suzhou, where the high-power equipment, specifically the blowers used in the biological treatment phase, and the use of polymeric ferric sulfate agents in the sludge treatment phase were the primary factors contributing to GHG emissions. Life cycle assessment analysis revealed that electricity consumption, direct CO2 emissions, pollutant concentration in the effluent, and the use of chemical agents at wastewater treatment plants had negative impacts on global warming, atmospheric acidification, and eutrophication of water bodies. Calculations indicated that for every 10 000 m3 of wastewater treated, the sewage treatment plant achieved a net benefit of 13 630 RMB. However, from April to May 2023, the scale efficiency of the sewage treatment plant was less than 1. This indicates that during this period, the proportion of output increase was less than that of input increase, demonstrating an irrational structure of input-output. After June, through enhancing the overall operational load, advancing technical improvements, and management efforts, the optimization of scale efficiency was achieved. A sewage treatment plant in Suzhou could achieve the goal of being "green and low-carbon" by installing high-efficiency pumps and fans, utilizing solar photovoltaic and water source heat pump systems, and making process improvements.

Fabrication and Performance Evaluation of a Novel Composite PVC-ZnO Membrane for Ciprofloxacin Removal by Polymer-Enhanced Ultrafiltration.

Water pollution is a major global issue, and antibiotic drugs released into aquatic environments by the pharmaceutical industry, such as ciprofloxacin, have negative consequences on both human health and the ecosystem. In this study, the performance of PVA as a polymer ligand for ciprofloxacin (CPFX) removal is evaluated through polymer-enhanced ultrafiltration using a novel composite PVC-ZnO membrane. The initial concentration of the ciprofloxacin solution, pH, ionic strength, ideal polymer concentration, duration, and maximum retention capacity were among the factors that were examined. In order to remove ciprofloxacin from water, PVA is utilized as a polymeric binding agent in a complex manufacturing process. In this instance, the PVC-ZnO membrane with 1.0 weight percent ZnO had a 96.77% ciprofloxacin clearance rate. PVA polymer has a high clearance rate of 99.98% in 1wt% of ZnO in this composite membrane when added to the ciprofloxacin solution. Fourier transform infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), ultraviolet spectroscopy, and X-ray diffraction (XRD) were used to analyze the production and features of composite PVC-ZnO membranes. It is anticipated that this study's discussion will be crucial to the development of higher-quality membrane technologies that remove pharmaceutical active chemicals from wastewater in an environmentally responsible manner without endangering the ecosystem. This investigation showed that composite PVC-ZnO membranes were effective materials for efficient removal of ciprofloxacin (CPFX).

Evaluation of rheological properties of guar gum-based fracturing fluids enhanced with hydroxyl group bearing thermodynamic hydrate inhibitors.

Naturally occurring gas clathrates are a significant methane resource-the primary component of natural gas, regarded as the cleanest hydrocarbon and a key feedstock for producing gray and blue hydrogen. Despite the global abundance of gas hydrate reserves, extraction via depressurization has yet to achieve commercially viable production rates. The primary limitation lies in the low permeability of hydrate-bearing sediments, where solid clathrates obstruct porous pathways, hindering dissociation and slowing gas recovery. Hydraulic fracturing has emerged as a promising technique to enhance conductivity, with initial studies indicating substantial increases in production rates when stimulation is applied. This study investigates the integration of thermodynamic hydrate inhibitors (THIs), such as methanol and polyethylene glycol 200 (PEG-200), into conventional polymer-based linear and crosslinked fracturing gels to improve performance. By targeting both rock and the embedded gas hydrates, these inhibitor integrated fracturing gels aim to facilitate faster fracture propagation and accelerate hydrate dissociation. The rheological performance of THI-integrated gels at varying concentrations is analysed, crucial for fracture formation, propagation, and proppant transport efficiency. Additionally, microscopic observations of additive interactions followed by fluid disintegration according to time are compared to evaluate residue formation and long-term integrity. Results indicate that methanol slightly increased the viscosity of linear gels at low concentrations and improved stability, reducing residue and slowing degradation, while higher concentrations required additional polymerizing agents to maintain performance. PEG-200 enhanced viscosity and stability in guar-based gels at low concentrations but caused shear-thinning at higher levels, limiting its suitability for high-viscosity operations. Crosslinked gels demonstrated superior proppant suspension and stability, generating less sediment-damaging residue compared to linear gels, with methanol further enhancing performance. Optimized integration of PEG-200 during borate crosslinking is critical, as higher concentrations risk premature gel degradation.

In Situ Fluorescent Visualization of the Interfacial Layer of Induced Crystallization in Polyvinyl Chloride.

Despite the remarkable progress in the modification and application of polyvinyl chloride (PVC), developing processing aids for the induced crystallization of PVC and characterizing its interfacial layer remain challenges. Herein, we propose a new polymeric nucleating agent, polyamidea12-graft-styrene-maleic anhydride copolymer (PA12-g-SMA), which possesses high compatibility and crystallinity, effectively improving the crystallinity to 15.1%, the impact strength to 61.03 kJ/m2, and the degradation temperature of PVC to 267 °C through a single and straightforward processing step. Additionally, after the introduction of two different fluorescent sensors in PA12-g-SMA and PVC, the interfacial layer of the induced crystallization can be monitored in situ via a confocal laser scanning microscope (CLSM). This study highlights a rare strategy for significantly enhancing the physical properties of rigid PVC through simply adding a polymeric nucleating agent during processing, while also emphasizing the importance of visualizing the interfacial layer to understand various polymer crystallization processes.

Controlled fabrication of hierarchical porous carbon nanospheres with high doped nitrogen content for high-performance adsorbent of biomacromolecule

Constructing nitrogen-doped porous carbons with high specific surface area, rapid mass transfer channels, and positive charge is a crucial requirement for high-performance adsorbents. Herein, by the kinetic self-assembly synthesis strategy, we prepared nitrogen-doped hierarchical porous carbon spheres (N-HPCS) with adjustable pore structure, high specific surface area, and high nitrogen doping content (8.88 %). By using ethylenediamine as an assisted polymerization and assembly agent, the hydrolysis and condensation rate of tetraethyl orthosilicate (TEOS) as the silica source and the condensation rate of 3-aminophenol and formaldehyde as the phenolic resin precursor were controlled by adjusting ammonia volume as the alkaline catalyst to tune kinetic self-assembly of silica and phenolic resin components, thus achieving their simultaneous or sequential nucleus and growth. After carbonization and selective silica etching, three types of carbon nanospheres with center-radial pores, hollow center-radial pores and hollow structure were obtained. High nitrogen doping content endowed the nanospheres with positive charge. Through adsorption experiments on the bovine serum albumin (BSA) and Hemoglobin (Hb) as typical biological macromolecules, hollow carbon nanospheres with center-radial pores exhibited excellent adsorption performance for BSA(622.34 mg g−1) and Hb(759.96 mg g−1). Our fabricated N-HPCS may become a potential candidate for high-performance adsorption materials.

Copolymers of Vinylphosphonic and p‐Methacrylamidobenzoic Acids and their Complexes with Lanthanide Ions

AbstractNew copolymers of vinylphosphonic and p‐methacrylamidobenzoic acids of varying compositions were synthesized via free radical copolymerization. The structure of the obtained polymers was confirmed by NMR and FTIR spectroscopy. As the proportion of vinylphosphonic acid in the initial reaction mixture increased, the yield of the copolymer and its molecular mass both decreased. The synthesized copolymers were found to form stable soluble luminescent complexes in dilute aqueous solutions, with a concentration range of 0.002 to 0.02 mg/ml. An increase in the concentration of vinylphosphonic acid moieties in copolymers was accompanied by a noticeable decrease in the luminescence intensity. The new copolymers’ ability to bind efficiently with lanthanide ions renders them a promising material for the design of polymeric contrast agents, preparations for radioimmunotherapy and photodynamic therapy.

RAFT unchained — Scalable manufacturing of thiocarbonyl chain transfer agents

Here, we report an efficient approach for the manufacturing of chain-transfer agents (CTA) for RAFT polymerization using non-volatile organic compounds (VOC) in one pot with only water-washing as a work-up. Although the RAFT process is scientifically mature, nearly all RAFT CTAs are still produced through multi-step syntheses involving material- and energy-intensive separations. Today’s commercially available RAFT agents are high-value specialty products available only from fine chemical vendors, limiting RAFT’s industrial success. The current work illustrates a single-step one-pot approach to synthesize ethyl (3-oxo-2-butyl) carbonotrithioate and O-ethyl S-(3-oxobutan-2-yl) carbonodithioate at up to 10 L scale in various non-VOC solvents with varied degrees of potential for cross-reactivity: diethyl succinate, tributyl acetyl citrate, castor oil glycidal ether, and glycerol triglycidyl ether. We studied the purity and yield of these CTAs using NMR and LC-MS, and then conducted rigorous polymerization and kinetic studies to evaluate the efficacy of these molecules in maintaining the RAFT equilibrium. We found that the use of these non-VOC solvents impedes neither the synthesis of these molecules nor the RAFT control, thus enabling scalable and low-impact pathways to RAFT CTA manufacturing.

Electron Transfer Drives the Photosensitized Polymerization of Contrast Agents by Flavoprotein Tags for Correlative Microscopy.

Singlet oxygen generation has long been considered the key feature that allows genetically encoded fluorescent tags to produce polymeric contrast agents for electron microscopy. Optimization of the singlet oxygen sensitization quantum yield has not included the effects of electron-rich monomers on the sensitizer's photocycle. We report that at monomer concentrations employed for staining, quenching by electron transfer is the primary deactivation pathway for photoexcitations. A simple photochemical model including contributions from both processes reproduces the observed reaction rates and indicates that most of the product is driven by pathways that involve electron transfer with monomers─not by the sensitization of singlet oxygen. Realizing the importance of these competing reaction pathways offers a new paradigm to guide the development of genetically encodable tags and suggests opportunities to expand the materials scope and growth conditions for polymeric contrast agents (e.g., biocompatible monomers, O2 poor environments).

Hyperbranched Polymeric 19F MRI Contrast Agents with Long T2 Relaxation Time Based on β-Cyclodextrin and Phosphorycholine.

19F magnetic resonance imaging (19F MRI) is gaining attention as an emerging diagnostic technology. Effective 19F MRI contrast agents (CAs) for in vivo applications require a long transverse (or spin-spin) relaxation time (T2), short longitudinal (or spin-lattice) relaxation time (T1), high fluorine content, and excellent biocompatibility. Here, we present a novel hyperbranched polymeric 19F MRI CA based on β-cyclodextrin and phosphorylcholine. The influence of the branching degree and fluorine content on T2 was thoroughly investigated. Results demonstrated a maximum fluorine content of 11.85% and a T2 of 612 ms. This hyperbranched polymeric 19F MRI CA exhibited both great biocompatibility against cells and organs of mice and high-performance imaging capabilities both in vitro and in vivo. The research provides positive insights into the synthesis strategies, topological design, and selection of fluorine tags for 19F MRI CAs.

Lipidated DNA Nanostructures Target and Rupture Bacterial Membranes.

Chemistry has the power to endow supramolecular nanostructures with new biomedically relevant functions. Here it is reported that DNA nanostructures modified with cholesterol tags disrupt bacterial membranes to cause microbial cell death. The lipidated DNA nanostructures bind more readily to cholesterol-free bacterial membranes than to cholesterol-rich, eukaryotic membranes. These highly negatively charged, lipidated DNA nanostructures cause bacterial cell death by rupturing membranes. Strikingly, killing is mediated by clusters of barrel-shaped nanostructures that adhere to the membrane without the involvement of expected bilayer-puncturing barrels. These DNA nanomaterials may inspire the development of polymeric or small-molecule antibacterial agents that mimic the principles of selective binding and rupturing to help combat antimicrobial resistance.

Black phosphorus quantum dots functionalized with photochromic poly(vinylspiropyran)-grafted polydopamine for transient digital-type memristors

Abstract The covalent functionalization of black phosphorus quantum dots (BPQDs) with organic species or polymers will inevitably change or damage their electronic structure and intrinsic structure. To address this problem and explore the application of BPQDs in transient digital-type memristors, a polydopamine (PDA) thin film is first synthesized in situ onto the surface of BPQDs to produce a donor–acceptor-type BPQDs@PDA composite that is directly used to react with 2-bromoisobutyryl bromide to give BPQDs@PDA-Br. By using BPQDs@PDA-Br as an atom transfer radical polymerization agent, a large number of polyvinylspiropyran (PSP) chains are in situ grown from the PDA surface to yield BPQDs@PDA-PSP. Upon ultraviolet (UV)–visible light illumination, the 2 isomers of the spiropyran (ring-closed spiropyran form and ring-opened merocyanine) in the PSP moieties will interconvert into each other rapidly. As expected, the as-fabricated indium tin oxide (ITO)/BPQDs@PDA-PSP/ITO device exhibits typical nonvolatile digital-type memristive performance under visible irradiation, with a small turn-on voltage of −1.52 V, a turn-off voltage of +1.16 V, and an ON/OFF ratio current ratio of 1.02 × 104. Upon UV illumination, the information stored in the device is quickly and completely erased within 6 s. By utilizing a simple memristor-based convolutional neural network, one can easily realize handwritten digit recognition. After 10 epochs of training, numeral recognition accuracy can reach up to 96.21%.

Novel polymeric anti-scaling agents derived from herbaceous plant residues: synthesis, characterization, and efficacy against carbonate scaling via static assessment

Novel polymeric anti-scaling agents derived from herbaceous plant residues: synthesis, characterization, and efficacy against carbonate scaling via static assessment

In situ and post-synthesis polymer stabilization of ferromagnetic nanoparticles synthesized by a membrane or conventional reactor

Membrane reactors have been proven to be effective in producing nanoparticles with reduced polydispersity indices. Recently, our group has incorporated this technology into the synthesis of ferromagnetic nanoparticles. In the initial phase, we conducted post-synthesis stabilization experiments to assess the performance of various polymeric agents. Polyacrylic acid (PAA) was chosen because of its notable affinity for the functional groups on the nanoparticle surface. Subsequently, in situ stabilization experiments were conducted using a membrane reactor, with variations in PAA addition flow rates ranging from 0.33 to 1.5 mL/min and maturation times in an ultrasonic bath ranging from 0.5 to 2 h. The samples were characterized in terms of their hydrodynamic diameter, polydispersity, and Z-potential. Notably, the smallest particle size was achieved at the intermediate point with a PAA flow rate of 0.66 mL/min. However, the influence of maturation time did not follow a predictable pattern; the most favorable characteristics, based on the analyzed variables, were observed at 1.5 and 2 h.

Dielectric and structural properties of polyaniline-tungsten trioxide nanocomposites: For the packing of nano-electronic devices and EMI shielding

Polymer nanocomposites (PNCs) have showed the significant applications in the fields of packing, energy, safety, defense, sensors, EMI shielding, optoelectronics etc. Tungsten trioxide nanoparticles (NPs) were prepared by propellant chemistry technique using Azadirachta indica extracts as a fuel/surfactant. Conducting polyaniline (PANI) was prepared using aniline monomer and suitable polymerizing agents. Ex-situ nanocomposites were prepared by mixing the different weight percentage of NPs into PANI matrix. For the better dispersion of NPs in to the matrix, solvents like Dodesyl benzene sulphonic acid (DBSA) and Camphor sulphonic acid (CSA) were used. Crystal structure, morphological features and their dielectric response at room temperature were reported. Electromagnetic Shielding (EMI) studies were compared between the PANI-WO3 composites prepared by CSA and DBSA solvents. Composites showed worthy shielding response of 80 dB with CSA and 38 dB with DBSA. Here, the protonation of the solvent and the dispersion of NPs with the polymer matrix matters for the shielding efficiency. Hence, prepared materials are suitable for packing of electronic devices which provides the better EMI shielding and also suppress the heat through effective absorption of EM waves of X-Band.

Highly acid-stable polyvinyl alcohol/chitosan/phytic acid aerogel for selective separation of uranium from actual wastewater

Conventional adsorption materials encounter difficulties in achieving optimal selectivity in uranium-containing wastewater (UCW) because of the low uranium concentration and the presence of diverse coexisting ions. Aerogel, renowned for its abundance of adsorption sites and remarkable structural flexibility, is widely regarded as an innovative material. Nonetheless, its stability in solution hinders its utility in the separation of uranium during wastewater treatment. To counter this limitation, a polyvinyl alcohol/chitosan/phytic acid aerogel (PCPA) was synthesized by employing several polymerization agents. An exceptional degree of selectivity, speed, and stability was achieved in the separation of low concentration uranium from UCW. The results indicated that polyvinyl alcohol (PVA) proved to be the most effective in generating stable aerogels, even when immersed in 0.1 M HCl or acidic UCW. PCPA displayed the highest efficacy in isolating U(VI) in UCW at a pH of 6.0. The novel aerogel exhibited remarkable resistance to ion interference during adsorption, leading to an impressive 96.3 % efficiency in the separation of U(VI) from actual low-concentration UCW. Even after five desorption, PCAC could still achieve U(VI) separation efficiencies of more than 80 %. The adsorption of U(VI) in this aerogel is characterized by chemisorption. PVA plays a crucial role in the condensation process of the aerogel, resulting in an increase in the presence of easily dissociable -OH groups. This, in turn, effectively improves the selectivity of the aerogel. PCPA has demonstrated successful capability in the efficient recovery of uranium from UCW.

Ring-opening polymerization of lactide catalyzed using metal-coordinated enzyme-like amino acid assemblies.

Polylactide (PLA), a biocompatible and biodegradable polymer, is widely used in diverse biomedical applications. However, the industry standard for converting lactide into PLA involves toxic tin (Sn)-based catalysts. To mitigate the use of these harmful catalysts, other environmentally benign metal-containing agents for efficient lactide polymerization have been studied, but these alternatives are hindered by complex synthesis processes, reactivity issues, and selectivity limitations. To overcome these shortcomings, we explored the catalytic activity of Cu-(Phe)2 and Zn-(Phe)2 metal-amino acid co-assemblies as potential catalysts of the ring-opening polymerization (ROP) of lactide into PLA. Catalytic activity of the assemblies was monitored at different temperatures and solvents using 1H-NMR spectroscopy to determine the catalytic parameters. Notably, Zn-(Phe)2 achieved >99% conversion of lactide to PLA within 12 h in toluene under reflux conditions and was found to have first-order kinetics, whereas Cu-(Phe)2 exhibited significantly lower catalytic activity. Following Zn-(Phe)2-mediated catalysis, the resulting PLA had an average molecular weight of 128 kDa and a dispersity index of 1.25 as determined by gel permeation chromatography. Taken together, our minimalistic approach expands the realm of metal-amino acid-based supramolecular catalytic nanomaterials useful in the ROP of lactide. This advancement shows promise for the future design of simplified biocatalysts in both industrial and biomedical applications.

Autoclaving Achieves pH-Neutralization, Hydrogelation, and Sterilization of Chitosan Hydrogels in One Step

Conventionally, chitosan hydrogels are acidic and contain toxic chemicals because chitosan is soluble only in acidic solvents and requires toxic additives such as chemical crosslinkers and polymerization agents to fabricate chitosan hydrogels. These properties prevent chitosan hydrogels from being used for medical applications. In this study, chitosan hydrogels were prepared by a simple and versatile process using urea hydrolysis by autoclaving (steam sterilization, 121 °C, 20 min). When autoclaved, urea hydrolyzes in an acidic chitosan aqueous solution, and ammonia is produced, which increases the pH of the solution, and chitosan becomes insoluble, leading to the formation of a chitosan hydrogel. The pH and osmotic concentration of chitosan hydrogels could be adjusted to be suitable for physiological conditions (pH: 7.0–7.5, and osmotic concentration: 276–329 mOsm/L) by changing the amount of urea added to chitosan solutions (chitosan: 2.5% (w/v), urea: 0.75–1.0% (w/v), pH: 5.5). The hydrogels had extremely low cytotoxicity without the washing process. In addition, not only pure chitosan hydrogels, but also chitosan derivative hydrogels were prepared using this method. The autoclaving technique for preparing low-toxic and wash-free sterilized chitosan hydrogels in a single step is practical for medical applications.

FABRICATION OF HIGH STRENGTH PAPER FROM DIFFERENT TYPES OF PHOSPHORYLATED FIBERS USING HOT PRESSING AND FORMING AGENTS

Phosphorylated fibers offer a broad range of applications, particularly in thermal insulation, notably with wood fibers, provided they exhibit improved mechanical characteristics. Despite encountering challenges in applying traditional papermaking methods, the creation of paper or board sheets with phosphorylated pulp fibers remains a challenge. Findings suggest that phosphorylation-modified fibers show increased roughness. Moreover, in comparison with unbeaten kraft sheets (KF) and thermomechanical pulp sheets (TMP), those made from phosphorylated kraft fibers (PKF), using a cationic coagulant and a flocculant, demonstrate significant enhancements in burst index, break index, and tensile energy absorption by 2.12 times, 1.7 times, and 2.77 times, respectively. Similarly, phosphorylated TMP sheets, prepared with a dual polymeric system (coagulant/flocculant), exhibit improvements of 1.42 times, 1.33 times, and 1.82 times, respectively, in these properties. The study emphasizes the ameliorating effect of cationic polymeric agents on the charge impact of phosphorylated fibers on overall sheet quality, while also highlighting the substantial influence of hot-pressing lignin-containing paper on all determined physical properties.

L-PTMI-co-L-PEI copolymers obtained through copolymerization of cyclic imino ethers and their chain modification: Antibacterial properties and cytotoxicity

Polymeric antimicrobial agents are intensively investigated as potential novel antibiotics. In this work we use copolymerization of 2-propyl-2-oxazine (PrOzi) and 2-methyl-2-oxazoline (MeOx) combined with hydrolysis of the polymer side chains as a tool to obtain various linear polymeric derivatives of polytrimethylenimines (L-PTMI) and polyethylenimine (L-PEI). To obtain well-defined polymers, initially we determined copolymerization rates, and subsequently, we investigated the hydrolytic rates of various repeating units, namely PrOzi, MeOx, and 2-methyl-2-oxazine (MeOzi) in both homo- and copolymers. We observed that the structure of the polymeric main chain significantly influences the rate of acidic hydrolysis. In particular, the protonated L–PEI repeating unit (r.u.) accelerates the hydrolytic cleavage of the amide bond more than the protonated L-PTMI r.u., due to the shorter distance between amine centers.The biological activity of the polymers was assessed against three model microorganisms, namely Escherichia coli, Staphylococcus aureus and Candida albicans, and benchmarked in toxicity test against human lung fibroblast cell line. The antibacterial activity of L-PTMI-co-L–PEI increases monotonically with the increasing content of PTMI r.u., indicating an additive effect of covalently bonded L-PTMI and L-PEI. The antimicrobial activity of the copolymers is almost identical to that of the tested polymer blends in the corresponding ratios.The introduction of up to 40 % of PrOzi r.u. into the polyamine structure of PTMI (PPrOzi–co-L-PTMI copolymer) does not decrease the antimicrobial activity, compared to L–PTMI. The molecule remains active, particularly against Staphylococcus aureus (MIC = 4 μg/mL). At the same time, the presence of amide r.u. reduces toxicity. The highest observable selectivity index can reach values as high as 20 (PPrOzi40%–co-L-PTMI60%).