Polymer Shell Research Articles

New magnetic polymeric hybrid composite electrode material for amperometric nitrite sensor

ABSTRACT New modified electrode materials, based on a combination of hybrid nanocomposites such as magnetic nanoparticles, inorganic polymer (SiO2) and different types of organic polymers, were studied. Three types of organic polymers were used in order to find the effect that each of polymers has on the electrochemical properties of the final material. The electrochemical properties of the synthesised materials were investigated, the best electrochemical response was for pAAc covered nanoparticles compared to the other three tested materials. This favourable electrochemical response effect is due to the fact that in case of this material we succeed in obtaining a very uniform coverage of the polymeric shell with a favourable hydrogel structure and thicknesses which is perfectly suitable for adsorption of a relatively high concentration of TB in a very easi and homogenous way. By electrochemical measurements it was proved that this electrode presents electro-catalytic effect towards nitrite oxidation and can be used for nitrite detection. By comparing with other electrodes, the electro-catalytic effect of MNPs-SiO2-pAAc is better because the nitrite oxidation peak appears in this case at a potential closer to 0 mV vs. Ag/AgCl/KClsat, which is favourable to avoid interferences in amperometric nitrite detection in real samples.

Magnetothermally Activated Nanometer-level Modular Functional Group Grafting of Nanoparticles.

Nanoparticles with multifunctionality and high colloidal stability are essential for biomedical applications. However, their use is often hindered by the formation of thick coating shells and/or nanoparticle agglomeration. Herein, we report a single nanoparticle coating strategy to form 1 nm polymeric shells with a variety of chemical functional groups and surface charges. Under exposure to alternating magnetic field, nanosecond thermal energy pulses trigger a polymerization in the region only a few nanometers from the magnetic nanoparticle (MNP) surface. Modular coatings containing functional groups, according to the respective choice of monomers, are possible. In addition, the surface charge can be tuned from negative through neutral to positive. We adopted a coating method for use in biomedical targeting studies where obtaining compact nanoparticles with the desired surface charge is critical. A single MNP with a zwitterionic charge can provide excellent colloidal stability and cell-specific targeting.

Dynamic Nuclear Structure Emerges from Chromatin Cross-Links and Motors.

The cell nucleus houses the chromosomes, which are linked to a soft shell of lamin protein filaments. Experiments indicate that correlated chromosome dynamics and nuclear shape fluctuations arise from motor activity. To identify the physical mechanisms, we develop a model of an active, cross-linked Rouse chain bound to a polymeric shell. System-sized correlated motions occur but require both motor activity and cross-links. Contractile motors, in particular, enhance chromosome dynamics by driving anomalous density fluctuations. Nuclear shape fluctuations depend on motor strength, cross-linking, and chromosome-lamina binding. Therefore, complex chromosome dynamics and nuclear shape emerge from a minimal, active chromosome-lamina system.

Docetaxel in chitosan-based nanocapsules conjugated with an anti-Tn antigen mouse/human chimeric antibody as a promising targeting strategy of lung tumors

The aim of this work was to evaluate the physicochemical and biological properties of docetaxel (DCX) loaded chitosan nanocapsules (CS Nc) functionalized with the monoclonal antibody Chi-Tn (CS-PEG-ChiTn mAb Nc) as a potential improvement treatment for cancer therapy. The Tn antigen is highly specific for carcinomas, and this is the first time that such structure is targeted for drug delivery. The nanocapsules (Ncs), formed as a polymeric shell around an oily core, allowed a 99.9% encapsulation efficiency of DCX with a monodispersity particle size in the range of 200 nm and a high positive surface charge that provide substantial stability to the nanosystems. Release profile of DCX from Ncs showed a sustained and pH dependent behavior with a faster release at acidic pH, which could be favorable in the intracellular drug delivery. We have designed PEGylated CS Nc modified with a monoclonal antibody which recognize Tn antigen, one of the most specific tumor associated antigen. A biotin-avidin approach achieved the successful attachment of the antibody to the nanocapsules. Uptake studies and viability assay conducted in A549 human lung cancer cell line in vitro demonstrate that ChiTn mAb enhance nanoparticles internalization and cell viability reduction. Consequently, these ChiTn functionalized nanocapsules are promising carriers for the active targeting of DCX to Tn expressing carcinomas.

Stimuli‐Responsive Nanoparticles Combining Photodynamic Therapy and Mitochondria Disruption Suppressed Tumor Metastasis

AbstractPhotodynamic therapy (PDT) is a kind of commonly used strategy for the treatment of cancer, but tumor hypoxia severely limits the efficiency of this oxygen (O2)‐dependent modality. Disrupting mitochondria may be a promising direction to reverse the tumor hypoxia. However, to date, very few studies utilize mitochondria inhibiting strategy to complement PDT, because low permeability of mitochondria impedes the entry of therapeutic agents. A stimuli‐responsive nanoparticle system that combines PDT and mitochondria disruption strategy is reported here. The nanoparticle consists of a gelatin core that accommodates photosensitizer chlorin e6 (Ce6) and a polymeric shell that chemically attaches with mitochondria‐targeted anticancer drugs (doxorubicin‐glycyrrhetinic acid conjugates, Dox‐GA). Specifically, Ce6 produces excessive reactive oxygen species to support Dox‐GA in escaping from lysosome. Then, thanks to mitochondria targeting, Dox‐GA contributes significantly to mitochondrial dysfunction and O2 consumption depression in tumor cells, resulting in enhanced PDT. As a result, the integration of mitochondria‐targeting drug delivery and PDT shows synergistic effects in apoptosis induction, tumor growth inhibition and anti‐metastasis. The tumor metastasis is almost completely inhibited without any lung nodules observed in vivo, making it a promising strategy by integrating mitochondria‐targeting drug and PDT for metastatic breast cancer treatment.

THE SYSTEM FOR COMPLEX MAGNETIC SUSCEPTIBILITY MEASUREMENT OF NANOPARTICLES WITH 3D PRINTED CARCASS FOR INTEGRATED RECEIVE COILS

The article concerns the research on the properties of core-shell superparamagnetic nanoparticles in the context of their use in medicine for diagnostics and therapy. The article presents a system for impedance (AC) spectroscopy of nanoparticles with a new arrangement of receive coils. A significant modification was the position of the reference coil in relation to the receive coils as well as the method of winding and routing the wires on the carcass. The 3D printing technique was used in the production of the measuring coil system. The aim of the work was to experimentally verify the developed measurement system and analyze its properties. The system tests were carried out at low frequencies ranging from 2 to 50 kHz. Complex magnetic susceptibility was measured for superparamagnetic iron oxide nanoparticles in polymer shells in a physiological saline solution. The obtained results confirmed the relevance of the concept of the measurements. In summary, the observed properties of the realized system are discussed and further directions of its development are proposed.

Effects of thermal aging on physical and wear properties of high density polyethylene (HDPE)/hazelnut shell (HS) polymer composites

Bu çalışmada, fındık kabuğu tozları yüksek yoğunluklu polietilen içerisine katılarak bir polimer kompoziti elde edilmiştir. Daha sonra elde edilen bu polimer kompozitine değişik ısıl yaşlandırma sürelerinde (15 ve 30 gün) yaşlandırma işlemi yapılmış ve fiziksel & mekaniksel özellikleri incelenmiştir. Fındık kabuğu tozları yüksek yoğunluklu polietilen matrisi içerisine dört farklı oranda (% 5-10-15 ve 20) katılmıştır. Yapılan testlerin sonuçlarına göre, matris içerisinde fındık kabuğu toz oranlarının artmasıyla; limit oksijen indeksi (LOI), erime akış indeksi (MFI), ısıl çarpılma sıcaklığı (HDT) ve Vicat yumuşama sıcaklığı değerlerinin düştüğü buna karşılık nem miktarı ve aşınma oranı değerlerinin yükseldiği tespit edilmiştir. Diğer yandan ısıl işlem süresinin artmasıyla da Vicat yumuşama sıcaklığı, ısıl çarpılma sıcaklığı, erime akış indeksi ve aşınma oranlarının arttığı belirlenmiştir. Buna karşılık ısıl yaşlandırma süresinin artması ile HDPE/FK kompozitinin nem emme ve limit oksijen endeksi değerleri düşmüştür.

Optimizing the Polymer Cloak for Upconverting Nanoparticles: An Evaluation of Bioactivity and Optical Performance.

The ability of upconversion nanoparticles (UCNPs) to convert low-energy near-infrared (NIR) light into high-energy visible-ultraviolet light has resulted in their development as novel contrast agents for biomedical imaging. However, UCNPs often succumb to poor colloidal stability in aqueous media, which can be conquered by decorating the nanoparticle surface with polymers. The polymer cloak, therefore, plays an instrumental role in ensuring good stability in biological media. This study aims to understand the relationship between the length and grafting density of the polymer shell on the physicochemical and biological properties of these core-shell UCNPs. Poly(ethylene glycol) methyl ether methacrylate block ethylene glycol methacrylate phosphate (PPEGMEMAn-b-PEGMP3) with different numbers of PEGMEMA repeating units (26, 38, and 80) was prepared and attached to the UCNPs via the phosphate ligand of the poly(ethylene glycol methacrylate phosphate) (PEGMP) block at different polymer densities. The in vitro and in vivo protein corona, cellular uptake in two-dimensional (2D) monolayer and three-dimensional (3D) multicellular tumor spheroid (MCTS) models, and in vivo biodistribution in mice were evaluated. Furthermore, the photoluminescence of single-polymer-coated UCNPs was compared in solid state and cancer cells using laser scanning confocal microscopy (LSCM). Our results showed that the bioactivity and luminescence properties are chain length and grafting density dependent. The UCNPs coated with the longest PPEGMEMA chain, grafted at low brush density, were able to reduce the formation of the protein corona in vitro and in vivo, while these UCNPs also showed the brightest upconversion luminescence in the solid state. Moreover, these particular polymer-coated UCNPs showed enhanced cellular uptake, extended in vivo blood circulation time, and more accumulation in the liver, brain, and heart.

Встановлення закономірностей дифузії вологи через полімерну оболонку термічно модифікованої деревини

An analysis of the process of thermal modification of wood, which was obtained by a controlled heating process, was done. The unique technological properties (durability, low hygroscopicity and dimensional stability) of thermomodified wood make it possible to use it in various scope. Due to the influence of temperature there are some chemical changes in the structures of the wood cell wall components (lignin, cellulose and hemicellulose). This leads to an increase in density, hardness, improved hydrophobicity (water repellency), thereby reducing their ability to absorb moisture and swell. The products absorb moisture gradually, are less prone to swelling and shrinkage, but still need the elastic coatings application. It is proved that heat-treated wood turns gray over time under the influence of sunlight, and therefore requires additional surface treatment with a coating. Additional protective substances application on the thermo-modified wood products surface promotes dimensional stability and protects against rapid weathering of the surface in open air conditions. The use of transparent coatings and oils does not protect the surface from discoloration during weathering. They are recommended for products are manufactured from thermomodified wood, which are operated away from direct sunlight and rain. The parameters of moisture penetration into wood are mathematically modeled on the basis of the moisture diffusion quasi-stationary equation through the polymer coating on the flat sample surface. The dynamics of moisture content changes in thermally modified wood by different schedules parameters has been experimentally studied. The obtained mathematical relations based on the experimental studies results make it possible to calculate the moisture diffusion coefficient in thermally modified wood in the presence of a polymer shell. It is established that the wax coating application on the surface of the product reduces the moisture diffusion process more than 10 times for surfaces treated at a temperature of 160 °C for 1 hour. That is, such products can be used on objects with high humidity.

Designer Core-Shell Nanoparticles as Polymer Foam Cell Nucleating Agents: The Impact of Molecularly Engineered Interfaces.

The interface between nucleating agents and polymers plays a pivotal role in heterogeneous cell nucleation in polymer foaming. We describe how interfacial engineering of nucleating particles by polymer shells impacts cell nucleation efficiency in CO2 blown polymer foams. Core–shell nanoparticles (NPs) with a 80 nm silica core and various polymer shells including polystyrene (PS), poly(dimethylsiloxane) (PDMS), poly(methyl methacrylate) (PMMA), and poly(acrylonitrile) (PAN) are prepared and used as heterogeneous nucleation agents to obtain CO2 blown PMMA and PS micro- and nanocellular foams. Fourier transform infrared spectroscopy, thermogravimetric analysis, and transmission electron microscopy are employed to confirm the successful synthesis of core–shell NPs. The cell size and cell density are determined by scanning electron microscopy. Silica NPs grafted with a thin PDMS shell layer exhibit the highest nucleation efficiency values, followed by PAN. The nucleation efficiency of PS- and PMMA-grafted NPs are comparable with the untreated particles and are significantly lower when compared to PDMS and PAN shells. Molecular dynamics simulations (MDS) are employed to better understand CO2 absorption and nucleation, in particular to study the impact of interfacial properties and CO2-philicity. The MDS results show that the incompatibility between particle shell layers and the polymer matrix results in immiscibility at the interface area, which leads to a local accumulation of CO2 at the interfaces. Elevated CO2 concentrations at the interfaces combined with the high interfacial tension (caused by the immiscibility) induce an energetically favorable cell nucleation process. These findings emphasize the importance of interfacial effects on cell nucleation and provide guidance for designing new, highly efficient nucleation agents in nanocellular polymer foaming.

Gd3+ Doped CoFe2O4 Nanoparticles for Targeted Drug Delivery and Magnetic Resonance Imaging

Nanoparticles of CoGdxFe2 − xO4 (x = 0%, 25%, 50%) synthesized via sol–gel auto combustion technique and encapsulated within a polymer (Eudragit E100) shell containing curcumin by single emulsion solvent evaporation technique were formulated in this study. Testing of synthesized nanoparticles was carried out by using different characterization techniques, to investigate composition, crystallinity, size, morphology, surface charge, functional groups and magnetic properties of the samples. The increased hydrophilicity resulted in sustained drug release of 90.6% and 95% for E1(CoGd0.25Fe1.75O4) and E2(CoGd0.50Fe1.5O4), respectively, over a time span of 24 h. The relaxivities of the best-chosen samples were measured by using a 3T magnetic resonance imaging (MRI) machine, and a high r2/r1 ratio of 43.64 and 23.34 for composition E1(CoGd0.25Fe1.75O4) and E2(CoGd0.50Fe1.5O4) suggests their ability to work as a better T2 contrast agent. Thus, these novel synthesized nanostructures cannot only enable MRI diagnosis but also targeted drug delivery.

A ball-in-ball type self-powered magnetoelectric inertial sensor for 3D multi-angle motion monitoring of humanoid robots

Abstract Motion monitoring stands as a powerful tool for humanoid robots to well adapt to nearby changing environment. However, despite the recent advance of inertial measuring units, both simplification of the sensors and free of power supply for 3D multi-angle monitoring remains elusive. Herein we demonstrate a facile & self-powered magnetoelectric inertial sensor for 3D multi-angle head motion monitoring of humanoid robots. A magnetic sphere could freely roll inside a smooth polymeric shell patterned with regionally distributed coils, allowing for monitoring the accelerations for 8 directions in the horizontal plane, the bowing angle for diverse directions in 3D space and rotations when tilting with multi-angle. It can detect an acceleration down to 0.06 m/s2 and a tilting angle of 2° in the vertical plane. Owing to these sensing capacities, the magnetoelectric inertial sensor can be placed inside a model head for detecting head bowing, head turning and even sudden strikes from diverse directions. Furthermore, when being placed in the humanoid robot’s head, it can monitor continuous motions like left-kicking, bending knees, standing on one leg and doing the splits. Such a single inertial sensor provides a building block for motion monitoring of humanoid robots and for future development of robotics.

Nanoproteomic Approach for Isolation and Identification of Potential Biomarkers in Human Urine from Adults with Normal Weight, Overweight and Obesity.

In this work, previously synthesized and characterized core-shell silica nanoparticles (FCSNP) functionalized with immobilized molecular bait, Cibacron blue, and a porous polymeric bis-acrylamide shell were incubated with pooled urine samples from adult women or men with normal weight, overweight or obesity for the isolation of potential biomarkers. A total of 30 individuals (15 woman and 15 men) were included. FCSNP allowed the capture of a variety of low molecular weight (LMW) proteins as evidenced by mass spectrometry (MS) and the exclusion of high molecular weight (HMW) proteins (>34 kDa) as demonstrated by SDS-PAGE and 2D SDS-PAGE. A total of 36 proteins were successfully identified by MS and homology database searching against the Homo sapiens subset of the Swiss-Prot database. Identified proteins were grouped into different clusters according to their abundance patterns. Four proteins were found only in women and five only in men, whereas 27 proteins were in urine from both genders with different abundance patterns. Based on these results, this new approach represents an alternative tool for isolation and identification of urinary biomarkers.

Tailoring the polarity of polymer shell on BaTiO3 nanoparticle surface for improved energy storage performance of dielectric polymer nanocomposites

Nanocomposites comprising flexible polymers and high dielectric constant inorganic nanoparticles are considered to be one of the promising candidates for electrostatic capacitor dielectrics. However, the effect of interfacial property on electrical energy storage of dielectric polymer nanocomposites is still not clear. Herein, the role of the polarity of the interfacial region is investigated. For this purpose, three polymers with different polarity, polymethyl methacrylate (PMMA), polyglycidyl methacrylate, and polymethylsulfonyl ethyl methacrylate (PMSEMA) are attached onto BaTiO3 (BT) nanoparticle surface via surface-initiated reversible addition-fragmentation chain transfer polymerization. It is found that the polarity of shell polymers shows an apparent effect on the dielectric and energy storage of dielectric polymer nanocomposites. For example, PMSEMA@BT (shell polymer possesses the highest polarity) increases dielectric loss and decreases the breakdown strength of the nanocomposites, leading to lower energy storage capability. However, PMMA@BT (shell polymer possesses the lowest polarity) can induce higher breakdown strength of the nanocomposites. As a result, the PMMA@BT nanocomposite exhibits the highest electrical energy storage capability among the three nanocomposites. This research provides new insight into the design of core-shell nanofillers for dielectric energy storage applications.

A molecularly imprinted polymer on chromium (ΙΙΙ) oxide nanoparticles for spectrofluorometric detection of bisphenol A

A unique fluorescent probe for the detection of bisphenol A (BPA) was established by creating a molecularly imprinted polymer (MIP) shell on chromium (ΙΙΙ) oxide nanoparticles (Cr2O3 NPs). The advantages of high selectivity of MIPs and the strong fluorescence property of Cr2O3 NPs were combined for the preparation of the probe. MIPs-coated Cr2O3 NPs were composed by anchoring MIP layer on the surface of Cr2O3 NPs using one-pot precipitation polymerization. Acrylic-based monomer and cross-linker were used to prepared MIP. The MIP-coated Cr2O3 NPs were characterized by spectrofluorometery, Fourier transform infrared spectroscopy, transmission electron microscopy, field transmission electron microscopy, dynamic light scattering, EDX and elemental mapping. The prepared NPs showed strong fluorescence emission at 360 nm excited at 300 nm which quenched in the presence of BPA. The dynamic range of the optical sensor was in the range of 0.04–4.4 μmol L−1 and the detection limit was 0.015 μmol L−1. The relative standard deviation was 2.2 and 1.3% for the concentration levels of 0.14 and 3.1 μmol L−1, respectively. The probe had a great selectivity in the determination of BPA with an imprinting factor of 6.3. The sensor was applied for the quantification of bisphenol A in water samples.

PH-Triggered Poly(ethylene glycol)-Poly(lactic acid/glycolic acid)/Croconaine Nanoparticles-Assisted Multiplexed Photoacoustic Imaging and Enhanced Photothermal Cancer Therapy.

The most advantageous and attractive property of photoacoustic imaging is its capability to visualize and differentiate multiple species according to their unique absorbance profiles simultaneously in a single mixture. We here report the pH-sensitive near-infrared (NIR) croconaine (Croc) dyes-loaded copolymeric PEG-PLGA nanoparticles (NPs) for in vivo multiplexed PA imaging and pH-responsive photothermal therapy (PTT) in an orthotopic xenograft model. PEG chains on the polymeric NPs shell were conjugated with iRGD in another set of NPs to realize efficient tumor targeting. The distribution and the intensity of two sets of iRGD-targeted and nontargeted NPs inside tumors are simultaneously imaged and monitored in vivo. Meanwhile, the utilization of iRGD-targeted PPC815 NPs as a pH-active photothermal agent with promising tumor-inhibition efficacy was demonstrated. As a result, this nanoplatform is capable of assisting multiwavelength unmixing of PA imaging as well as providing remarkable photothermal ablation for anticancer treatment.

Simultaneous Nanolocal Polymer and In Situ Readout Unit Placement in Mesoporous Separation Layers.

Bioinspired solid-state nanopores and nanochannels have attracted interest in the last two decades, as they are envisioned to advance future sensing, energy conversion, and separation concepts. Although much effort has been made regarding functionalization of these materials, multifunctionality and accurate positioning of functionalities with nanoscale precision still remain challenging. However, this precision is necessary to meet transport performance and complexity of natural pores in living systems, which are often based on nonequilibrium states and compartmentalization. In this work, a nanolocal functionalization and simultaneous localized sensing strategy inside a filtering mesoporous film using precisely placed plasmonic metal nanoparticles inside mesoporous films with pore accessibility control is demonstrated. A single layer of gold nanoparticles is incorporated into mesoporous thin films with precise spatial control along the nanoscale layer thickness. The local surface plasmon resonance is applied to induce a photopolymerization leading to a nanoscopic polymer shell around the particles and thus nanolocal polymer placement inside the mesoporous material. As near-field modes are sensitive to the dielectric properties of their surrounding, the in situ sensing capability is demonstrated using UV–vis spectroscopy. It is demonstrated that the sensing sensitivity only slightly decreases upon functionalization. The presented nanolocal placement of responsive functional polymers into nanopores offers a simultaneous filtering and nanoscopic readout function. Such a nanoscale local control is envisioned to have a strong impact onto the development of new transport and sensor concepts, especially as the system can be developed into higher complexity using different metal nanoparticles and additional design of mesoporous film filtering properties.

Polysaccharide Nanocapsules for Drug Delivery Applications, Current Status and Future Perspectives

In recent years pharmaceutical formulations using polymeric nanocapsules have been widely studied for developing novel drug delivery strategies. Nanocapsules provide a unique core-shell nanostructure, consisting of a liquid/solid core surrounded by a polymeric shell. Natural or modified polysaccharides are prime candidates for use as building blocks of the nanocapsule shells, due to their demonstrated safety, versatility and low cost and to the fact that they are widely used as excipients in classical drug formulations. The aim of this paper is to present the recent advances in drug delivery strategies using polysaccharidic nanocapsules and to discuss future opportunities and challenges in developing modern pharmaceutical formulations using such systems.

Poly(Vinyl Alcohol)-Hydrogel Microparticles with Soft Barrier Shell for the Encapsulation of Micrococcus luteus.

The encapsulation of bacteria in polymers results in hybrid materials that are essential for the long-term biological activity of bacteria and formulations in practical applications. Here, the problem of bacterial escape and the exchange of metabolism products from hydrogel microparticles within an aqueous environment are addressed. Bacteria are encapsulated in chemically cross-linked poly(vinyl alcohol) (PVA) hydrogel-microparticles followed by their encapsulation in a pH-responsive and soft antibacterial shell of poly(N,N-diethylamino ethyl methacrylate) (PDEAEMA). This polymer shell acts selectively with regards to the mass transport in and out of the microparticle core and is affected by environmental parameters, such as pH and antibacterial effect. The pH-responsive PDEAEMA shell forms an open porous structure that accelerates nutrient transfer into the PVA core containing living Micrococcus luteus (M. luteus). Results show that the antibacterial effect of PDEAEMA retards the escape of bacteria up to 35 days when the shell is open. Additionally, the permeation of a small molecule into the gel, for example, methylene blue dye through the core/open-shell structure, certifies a flexible barrier for mass transport, which is required in the long term for the biological activity of encapsulated M. luteus.

Microfluidic-assisted synthesis of uniform polymer-stabilized silver colloids

We report the controlled synthesis of polymer-stabilized silver nanoparticles (AgNPs) by using microfluidic devices. The microfluidic-based method enabled the preparation of sub-50 nm AgNPs which are much more homogenous compared to those produced in batch reactors where the control over flow and mixing conditions was not performed. The concentration of the silver precursor (silver nitrate - AgNO3) can be tuned to reach smaller or larger nanoparticles, although within a fairly narrow range. Regardless of the polymeric shell, the reducing agent concentration influences the size and polydispersity of the manufactured silver colloids, and relatively lower amounts allow for the manufacturing of more homogeneous nanoparticles. Notably, the use of the block copolymer PEO-b-P2VP as stabilizing agent leads to larger nanoparticles (23–51 nm) compared to those stabilized by PVP (7–14 nm) as possibly linked to different arrangements of the polymer chains at the interface between the precursor solutions. The produced AgNPs are highly uniform, with size distribution width influenced by the polymer concentration (FWHM < 100 nm were determined at higher concentrations), although this variable does not have a distinguished effect on the final size of the manufactured colloids. Overall, we provide relevant new knowledge within the framework of polymer-stabilized AgNPs since a variety of other polymer chains can be probed, possibly with different outcomes regarding the final particle size. The reported findings can thus guide to significant advances towards the manufacturing of highly homogeneous polymer-coated metallic colloids, particularly when a target size is required.