First class delivery: Core–shell structured nanoassemblies could be constructed from a hydrophilic–hydrophilic block copolymer with one block containing β-cyclodextrin in the presence of hydrophobic guest compounds (see picture). The polymer can host various guest molecules, while the difference in sensitivity can be utilized to regulate release rate. By selecting appropriate guests, polyion complex (PIC) micelles could also be assembled. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.