In response to the low efficiency of a muzzle brake for a certain 30 mm airplane gun, a new type of muzzle brake with side ports tilted towards the rear of the barrel is proposed. Taking the flow state of the internal gas at the moment the projectile reaches the muzzle as the initial condition, a dynamic mesh method combining polyhedral stationary region and hexahedral structured mesh moving region is used to perform three-dimensional numerical simulation of the muzzle brake flow field considering the motion of the projectile. The influence of the number of side port rows and the angle of inclination of the side ports on the brake efficiency is analyzed. The results show that within a certain range, the brake efficiency increases with the increase in the number of side ports, but the increment gradually narrows. When the number of side port rows is 6, the brake efficiency can be increased to 42.3%. With the increase of the side hole inclination Angle, the braking efficiency increases first and then decreases. The optimal angle for this muzzle brake is between 115 degrees and 135 degrees. This study provides a reference for accurate efficiency calculation, design, and optimization of the new multi-row inclined side port muzzle brake.