The purpose of this study was to examine the effect of spinning technologies and weave design on fabric mechanical and surface properties. For this purpose, ring spun (combed, carded) and open-end (OE) techniques were used to manufacture yarns of polyester cotton (50:50) which were used in the weft, and 100% cotton yarn in the warp. Plain, twill, and satin weave designs were selected to construct woven samples on a projectile loom. The variation in fabric tensile strength is obvious with respect to weave designs. Higher interlacing of yarn produces more crimp in the load bearing, which may cause lower breaking strength and fewer broad floats. The mechanical and surface properties of these fabric samples were investigated and statistical analysis was performed, which showed a significant effect of the spinning technique and weave design on these properties.