Polycystic Kidney Research Articles

Unveiling Kidney Disease Progression in Autosomal Recessive Polycystic Kidney Disease with Hypertension: Insights from the SS-PCK Rat Model

Unveiling Kidney Disease Progression in Autosomal Recessive Polycystic Kidney Disease with Hypertension: Insights from the SS-PCK Rat Model

Patient-Centered Insights on Treatment Adherence and Social Determinants of Health in Autosomal Dominant Polycystic Kidney Disease

Patient-Centered Insights on Treatment Adherence and Social Determinants of Health in Autosomal Dominant Polycystic Kidney Disease

Adeno-Associated Virus 1 (AAV1) CFTR Gene Therapy Successfully Reduces Cysts in a Mouse Model of Autosomal Dominant Polycystic Kidney Disease

Adeno-Associated Virus 1 (AAV1) CFTR Gene Therapy Successfully Reduces Cysts in a Mouse Model of Autosomal Dominant Polycystic Kidney Disease

Kidney Stone Incidence in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Kidney Stone Incidence in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Prevalence and Predictors of Bleeding Events in Patients with ESKD Who Have Autosomal Dominant Polycystic Kidney Disease: A National Database Analysis

Prevalence and Predictors of Bleeding Events in Patients with ESKD Who Have Autosomal Dominant Polycystic Kidney Disease: A National Database Analysis

A Young Woman with Autosomal Dominant Polycystic Kidney Disease and Recurrent Kidney Stones Coexisting with Gitelman Syndrome

A Young Woman with Autosomal Dominant Polycystic Kidney Disease and Recurrent Kidney Stones Coexisting with Gitelman Syndrome

Association between Nephrolithiasis and Kidney Disease Progression in Patients with Autosomal Dominant Polycystic Kidney Disease from a Single-Center, Prospective Cohort

Association between Nephrolithiasis and Kidney Disease Progression in Patients with Autosomal Dominant Polycystic Kidney Disease from a Single-Center, Prospective Cohort

Monoallelic PKHD1 Loss-of-Function Variants Could Be a Cause of Adult Polycystic Kidney Disease

Monoallelic PKHD1 Loss-of-Function Variants Could Be a Cause of Adult Polycystic Kidney Disease

Early Treatment with 2-Deoxy-D-Glucose Reduces Proliferative Proteins in the Kidney and Slows Cyst Growth in a Hypomorphic Pkd1 Mouse Model of Autosomal Dominant Polycystic Kidney Disease

Early Treatment with 2-Deoxy-D-Glucose Reduces Proliferative Proteins in the Kidney and Slows Cyst Growth in a Hypomorphic Pkd1 Mouse Model of Autosomal Dominant Polycystic Kidney Disease

Clinical Characteristics and Outcomes of Kidney Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease

Clinical Characteristics and Outcomes of Kidney Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease

Targeting Growth Hormone/JAK2 Signaling as a Novel Therapy for Polycystic Kidney Disease Treatment

Targeting Growth Hormone/JAK2 Signaling as a Novel Therapy for Polycystic Kidney Disease Treatment

Identification of Genetic Polymorphisms Associated with Interindividual Variability of Vitamin A Concentration in Adipose Tissue of Healthy Male Adults

BackgroundAdipose tissue vitamin A (VA), that is, mainly retinol (RET) and its esters, comes from preformed VA and proVA carotenoids present in our food. Adipose tissue VA acts as hormonal cue maintaining essential aspects of adipocyte biology, which includes fat mobilization and catabolism, energy balance, and glucose homeostasis, and it is thus of particular interest to study its determinants, including genetic ones. ObjectivesThis study aimed to identify genetic variations associated with adipose tissue VA concentration. MethodsForty-two healthy male adults received, in a randomized crossover design, 3 test meals. Periumbilical adipose tissue samples were collected on 6 occasions, that is, at fast and 8 h after consumption of each meal. RET concentration was measured in both plasma and the adipose tissue following saponification. Participants were genotyped using whole-genome microarrays. A total of 1305 single nucleotide polymorphism (SNPs) in or near 27 candidate genes were included for univariate analysis. Partial least squares (PLS) regression was carried out to find the best combination of SNPs associated with the interindividual variability in adipose tissue RET concentration. ResultsAdipose tissue RET concentration was not associated with plasma RET concentrations (r = –0.184, P = 0.28). Interindividual variability of adipose tissue RET concentration was high (coefficient of variation = 62%). Twenty-nine SNPs were significantly (P < 0.05) associated with adipose tissue RET concentration and a PLS regression model identified 16 SNPs as explanatory variables of this concentration. The SNPs were in or near peroxisome proliferator activated receptor gamma, retinoid X receptor alpha, signaling receptor and transporter of retinol, cluster of differentiation 36, free fatty acid receptor 4, aldehyde dehydrogenase 1 family member A1, monoglyceride lipase, diacylglycerol O-acyltransferase 2, and polycystic kidney disease 1-like 2. ConclusionsA combination of 16 SNPs has been associated with the interindividual of adipose tissue VA concentration in humans.This trial was registered at clinicaltrials.gov as NCT02100774.

Genetic Characteristics of Autosomal Dominant Polycystic Kidney Disease in a Greek Population

Genetic Characteristics of Autosomal Dominant Polycystic Kidney Disease in a Greek Population

Integrating Genotype and Phenotype Data Is Required for Kidney Survival Prediction in Autosomal Dominant Polycystic Kidney Disease

Integrating Genotype and Phenotype Data Is Required for Kidney Survival Prediction in Autosomal Dominant Polycystic Kidney Disease

Deletion of the Homeobox Gene Cux1 Decreases Ciliogenesis in a Mouse Model of Polycystic Kidney Disease

Deletion of the Homeobox Gene Cux1 Decreases Ciliogenesis in a Mouse Model of Polycystic Kidney Disease

Unraveling Rarity: Atypical Presentation of Polycystic Kidney Disease

Unraveling Rarity: Atypical Presentation of Polycystic Kidney Disease

PYC-003, a Peptide-Conjugated Oligonucleotide for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

PYC-003, a Peptide-Conjugated Oligonucleotide for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Small Interfering RNA (siRNA) Therapy Using Kidney Targeting Nanoparticles for Treating Polycystic Kidney Disease

Small Interfering RNA (siRNA) Therapy Using Kidney Targeting Nanoparticles for Treating Polycystic Kidney Disease

Graft Kidney Artery Stenosis in a Deceased Donor Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease: A Case Report

Graft Kidney Artery Stenosis in a Deceased Donor Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease: A Case Report

A Ketogenic Diet Alters Liver Cyst Progression in a Rodent Model of Polycystic Kidney Disease and Is Dependent on GPR109A

A Ketogenic Diet Alters Liver Cyst Progression in a Rodent Model of Polycystic Kidney Disease and Is Dependent on GPR109A