This work evaluated the effect of hydrolyzed jackfruit pulp, rice (Oryza sativa) bran extract, and pollen concentration as unconventional supplements on mead production by Saccharomyces bayanus. Fermentations were carried out in 500-mL Erlenmeyer flasks containing 250 mL of honey wort (30°Brix). The flasks were supplemented with hydrolyzed jackfruit pulp (10, 20, and 30%), rice bran extract (5, 32.5, and 60 g∙L−1), and pollen (0, 20, and 30 g∙L−1), inoculated with 0.2 g∙L−1 cells and incubated at 30°C for 288 h. Higher cell growth (11.5 g∙L−1 cells) and ethanol production (18.2 %v/v) were observed in the wort supplemented with 32.5 g∙L−1 rice bran extract, 20 g∙L−1 pollen, and 20% hydrolyzed jackfruit pulp. The highest substrate consumption (59%) was verified in the wort containing the highest concentration of hydrolyzed jackfruit pulp (30%). The S. bayanus Premier Blanc yeast had the best ethanol volumetric yield (1.982 g∙(L∙h)−1), product yield coefficient (0.427 g∙g−1), and fermentation efficiency (83.52%) after 48 h of fermentation.