Using the knowledge base theory, which classifies knowledge into analytical, synthetic, and symbolic types, this paper aims to analyze Brazil's spatial pattern of knowledge distribution in two periods, corresponding to a growth and a downturn phase. The methodology relies on occupational data segmented by knowledge types. Results show that the core region still creates a conducive environment for symbolic, synthetic, and analytical knowledge types, although the regional gap is reducing. Such a spatial pattern can only be understood as an intrinsic outcome of interconnections between Brazil's regional formation process and its position in the global economy. This paper contributes to the discussion on regional disparities by interpreting the results drawing on aspects of the evolutionary economic geography (EEG), the Latin American dependency theory, and the geographical political economy (GPE), together with the hypothesis of uneven and combined development.
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