Background and Objectives: One of the foundations of the health system are nurses. Migration is one of the factors of reducing and losing this valuable capital. Methods: In this systematic review study, PubMed, Scopus, Web of Science, SID, Magiran and Google Scholar databases were searched without time limit and based on the Prisma method, and in order to evaluate the quality of the articles, critical evaluation checklists of the Joanna Briggs Institute (JBI) were used. Results: First, 265 articles were extracted. After screening and removing duplicate articles, unrelated, without complete text, the qualitative evaluation stage was performed, and finally 17 articles were included in the study. No intervention was reported in the articles and no study prioritized the identified effective factors. The causes affecting migration were classified into two main categories: Causes related to the country of origin (push factors) and causes related to the destination country (pull factors). The factors in the countries of origin and destination were counted in three areas: individual factors, social factors and cultural factors. Income, job position, job security, continuing education facilities and educational technology, team relations and facilities in the work environment and family status were identified as the most important factors affecting migration. Conclusion: Nurses and especially young nurses from third world countries had a high desire to immigrate. Considering the multi-dimensional causes affecting the migration of nurses, in order to manage this phenomenon effectively, special attention and structural reforms in the social, cultural, political and economic dimensions are needed