This study analyzed the effect of people’s perceptions of government capabilities on the government’s response to COVID-19 and the moderating effect of people’s satisfaction with COVID-19 information on the effect of government capabilities on government response. Government response was defined in terms of people’s perceptions of government performance and institutional responses and satisfaction with COVID-19 policies. Government capabilities consisted of management capabilities, political capabilities, and agility. The results of the analysis showed that political capacity, government agility, and people’s perceptions of COVID-19 information had positive effects on government performance, institutional response, and policy satisfaction. In addition, satisfaction with COVID-19 information reduced the strength of the positive effects of management capacity on government performance and satisfaction with COVID-19 policies. Information satisfaction reduced the strength of the negative effect of political capacity on government performance, institutional response to COVID-19, and policy satisfaction. Information satisfaction reduced the strength of the positive effect of government agility on institutional response. Therefore, it can be concluded that in the event of a large-scale disaster or a disaster with high uncertainty, strategic management of government capabilities and information is necessary to respond to the disaster.