Society Policy Research Articles

The Impact of Public Participation on Energy Policy: A Comparative Study

Large-scale participation from the public is essential for the development of energy policies that are effective, efficient, and sustainable. Public involvement in the policymaking process improves the openness, legitimacy, and social acceptance of energy policies. Nonetheless, the level of public participation in the development of energy policy varies considerably among countries and regions. This research looks at the impact of public engagement on energy policy using case studies in Germany, the United States, and China. This paper employs a case study comparison approach to analyze the benefits and drawbacks of public participation in energy decisions. Both theoretical and empirical approaches to the literature on public engagement with energy policy are discussed. The majority of the data was gathered via in-depth interviews with experts on energy policy, government officials, and representatives of civil society in the countries of concern. The information was examined via a thematic lens. According to the research, public participation in the development of energy policies may increase their social acceptability, legitimacy, and transparency. The shift to a more sustainable energy system may be aided by the discovery of novel and more effective policy choices, which can be uncovered via this process. The research did, however, point out a number of obstacles and restrictions to public participation, including a lack of resources, the difficulty of juggling multiple interests, and the possibility of conflicts. The amount and character of public participation in energy policy-making varies greatly among nations, as shown by the comparative study of case studies, reflecting disparities in political, social, and economic conditions. For instance, Germany's energy transition has been successful in part because of the country's long-standing system of public participation in energy policy. However, public participation is restricted in China's energy policy-making process, which has contributed to widespread mistrust and hostility to energy policies. The report finishes with a discussion of the results' implications for energy policy-making and ideas for increasing public participation in this area. Sustainable, democratic, and socially equitable energy policies are promoted in the research by emphasizing the necessity of public participation in the policymaking process.

The Policy of Collective Historical Memory in Modern Georgia in the Early 2020s

The aim of the study is to analyze the modern politics of memory in Georgia in the early 2020s. The author analyzes the role and place of liberal trends in modern Georgian social thought as a factor in the development and transformation of memorial culture and collective historical memory. The novelty of the study lies in the study of the current (modern) stage in the development of the historical policy of Georgian society in the context of an objective lack of interdisciplinary research focused on the analysis of the memorial cultures of the post-Soviet space, based of the original sources use. The article also shows that 1) the liberal segment of modern Georgian society makes a significant contribution to the developments and transformations of memorial culture; 2) the spectrum of memorial practices of Georgian intellectuals varies from historical revisionism to attempts to form a liberal memorial canon; 3) the participation of intellectuals in memorial policy contributes to a parallel co-development of various forms of historical memories. It is assumed that the role of Georgian civil society, including its liberal segment, in the historical politics of modern Georgia will increase, and the intellectual community will remain among the active participants in collective memorial politics.

Екосистема людських ресурсів організацій як концептологія та прикладна платформа людиноцентризму

The article provides argumentation regarding the the essence, composition and structure of the ecosystem of human resources of organizations in the contour of human-centeredness. The factors of paradigm changes in the management of human resources of organizations in the third decade of the XXI century are disclosed. Factual data of asymmetries and contradictions in the current state of the social and labor sphere in the global dimension, that become a threat to national security, are presented. The main drivers of the global economy have been allocated as evidence of the unattainability of social quality standards. The relevance of the ecosystem of human resources of organizations as the main focus of economic activity is substantiated. The understanding of the theoretical construct is revealed and the fundamental foundations of the conceptology of the ecosystem of human resources in the context of human-centeredness are outlined. Within the framework of the genesis, the components and semantic characteristics of the concept of «ecosystem» are highlighted. A comparative parallel is drawn between the ecosystem of human resources of organizations and traditional HR management. The innovations in social and labor relations, also in the in social and labor interaction of economic agents in the ecosystem are defined. The mental model of the ecosystem of human resources as one of the local components of the socioeconomic system and the «product» of economic convergence is disclosed. The actualization of new, non-standard, hybrid forms of relationships and interactions between socioeconomic agents is underlined. Emphasis is placed on the post-industrial type of social and labor convergence. A comprehensive map has been proposed, which clearly reflects the authors? own vision of the structure and component saturation of the ecosystem of human resources of organizations. The primacy and dominance of social policy in a human-oriented society are substantiated. The complex dimension of the human-centeredness model is emphasized and the components of this model are allocated. The authors? assessments of the future of man in the era of digitalization against the background of pessimistic forecasts of the gurus of modern economic thought are presented. The authors express the conviction of the need to establish a new worldview and human-oriented thinking for the sake of a balanced and agnostic perspective of sustainable socioeconomic, including socio-labor, development.

ОСОБЕННОСТИ ПУБЛИЧНОГО УПРАВЛЕНИЯ В УСЛОВИЯХ ГЛОБАЛИЗАЦИИ И СТАНОВЛЕНИЯ ИНФОРМАЦИОННОГО ОБЩЕСТВА

The urgent task of public policy in modern society is globalization and the formation of an information society. The solution to these issues lies in the digital transformation of the sphere of public administration through the formation of a “digital state” and the digitalization of economic and social sectors. The article examines the features of public administration in the context of globalization of public structures and the formation of the information society, its relationship with the processes in public life and the specifics of the activities of public authorities in the context of globalization.

Some aspects of the state information policy of the modern state: definitions of the future

It is necessary to underline that all civilized states link their future with the formation of a single information space. The group of the most informationally developed countries - the USA, Canada, Japan, Germany, France, England, Italy, Poland considering the creation of a single information space one of the priority tasks of the 21st century, agreed to cooperate in creating a global information infrastructure based on seven fundamental principles. Information policy is the use of information as a means to achieve political and other goals, the information impact of political actors on each other. It should be noted that information is currently one of the most important resources in the public administration system. The purpose of the research is to analyze the specific features of the formation and the development of the state information policy. Searching identified 65 articles from 2015 to 2021. In the context of the state information policy of the modern state 13 were selected for review. The main methods used in the work were: comparative, method of abstraction, deductive method, concretization. The study described in this paper provides a systematic review of the literature on the formation of the informative policy and the specific features of the policy of different countries of the world over the past decade. Based on a full-text analysis of 13 articles published in renowned databases and peer-reviewed journals, the study reveals the necessity to analyze the importance of the state information policy in the modern society. The results state that is impossible to overestimate the importance of information in business as far as it creates fortunes for its owners, and the lack of information or its misinterpretation destroys large financial corporations. The conclusion is oriented on the facts that the information forms a system of alliances and blocs of states, contributes to the overthrow of governments, affects the political life of billions of people around the world.

SEEING THROUGH A HOUSING LENS: STUDYING HOUSING-FOCUSED RESPONSES TO THE NEEDS OF OLDER ADULTS DURING THE PANDEMIC

Abstract This paper draws on a study of unindexed literature produced by local and state policymakers, Area Agencies on Aging, nonprofit organizations, for-profit companies, age-friendly initiatives, affordable housing providers, and other groups responding to the needs of older adults at home during the COVID-19 pandemic. By collecting and analyzing descriptions of how service providers pivoted or improvised to meet urgent challenges, we sought to identify promising practices and policy ideas preserved in reports, newsletters, websites, and other communications. This paper reviews study methods and recommendations, and explores a concept that emerged from this research: recognizing services and support for older adults at home as “housing-focused” care that relies on the affordability, accessibility, and safety of a person’s home. The applications of the “housing lens” to future research on housing, aging, and health and to making progress on better integrating housing policy and health policy in aging societies will be discussed.

SİVİL TOPLUM VE GÖÇ ÇALIŞMALARINDA KÖPRÜLER KURMAK: TÜRKİYE ÖRNEĞİ

Son otuz yılda küreselleşmenin etkisiyle yaşanan dönüşümler, uluslararası göç ve sivil toplum alanlarında yeni tartışmaların gelişmesini beraberinde getirmiştir. Bu iki alana dair akademik çalışmalarda farklı kuramsal yaklaşımlar görülmekle birlikte, sivil toplumun göç süreçlerinde her geçen gün daha önemli bir aktör olarak yer alması iki alan arasında köprüler kurulmasını zaruri hale getirmektedir. Amaç: Bu makale, sivil toplum alanındaki kuramsal tartışmalardan yola çıkarak, liberal ve eleştirel yaklaşımlar üzerinden Türkiye örneğini ele almayı amaçlamaktadır. Makalede Türkiye’de uluslararası göç alanında faaliyet gösteren sivil toplum alanına dair akademik çalışmaların haritalandırılmasından faydalanılarak, üç tematik alan üzerinden –entegrasyon, ulusaşırı hareketler ve küresel yönetişim– sivil toplumun, göç süreçlerine etkisi analiz edilmektedir. Bu bağlamda Türkiye örneği üzerinden sivil toplum ve göç çalışmaları arasında teorik ve ampirik köprüler kurulması hedeflenmektedir. Yöntem: Makalede ilk olarak Türkiye’de göç alanında faaliyet gösteren sivil toplum alanına dair akademik çalışmaları haritalandırabilmek amacıyla sistemli bir literatür taraması yapılmaktadır. İkinci olarak, sivil toplum kuruluşlarının birincil dokümanları üzerinden tematik analiz gerçekleştirilmektedir. Bulgular: Türkiye’nin göç politikalarında yaşanan paradigma değişikliği, bu alanda çalışan sivil toplum kuruluşlarının sayıca artması ve çeşitlenmesini beraberinde getirmektedir. Ancak devletin hem göç yönetişimi hem de sivil toplum politikalarında merkezi otoritesini güçlendirmesi, sivil toplum kuruluşlarının sınırlı bir alanda ve kısa süreli stratejilere yönelik çalışabilmesine yol açmaktadır. Bu durum alandaki akademik çalışmaların da sivil toplumun hizmet sağlayıcılığı rolüne odaklanmasını beraberinde getirmektedir. Özgünlük: Türkiye’deki göç alanında yaşanan paradigma değişikliği üzerinden sivil toplum alanını kapsamlı olarak analiz etmesi açısından bu makale özgünlük taşımaktadır.

INSTITUTE OF BUSINESS REPUTATION IN UKRAINE: FEATURES OF FORMATION AND CANCELLATION CULTURE

Purpose. The purpose of this study is to improve the concept interpretation of “reputation institute”, to determine the level of its development in Ukrainian society, to generalize the main criteria characterizing the reputation of a business operating in Ukraine; definition of phenomena, trends of social responsibility, which concern Ukrainians; surveying the impact of the responsibility of the business as a whole and its employees on consumer purchase decisions and the formation of the main trends of the society’s rejection of business that does not meet its expectations and generally accepted norms. Design/methodology/approach. Such scientific theoretical research methods as a theoretical generalization to interpret the definitions of “business reputation institute” and “cancelation culture”; survey methods to determine the impact of business responsibility, its behavior on the market and in the social space on consumer decisions; methods of graphical presentation and generalization of data to display the generalization of the survey results and form conclusions regarding the determination of the main levers of application of the refusal policy concerning business. Findings. The concept of “business reputation” has been improved and the main criteria characterizing business reputation have been summarized. The phenomena and trends of social responsibility, which are important for Ukrainian society, are analyzed. A survey was considered on the influence of business responsibility on the purchasing decision of consumers, and the main trends of the policy of society's rejection of business that does not meet its expectations were formed. Practical implications. The results of this research have practical implications for businesses who want to reach competitive advantages in Ukraine market or succeed in developing social responsibility; future research can be provided on the basics of this publication. Originality/value. The importance of the research is raising the topic of the institution of reputation, social responsibility, and the development of Ukrainians as a united and strong nation. There are not many studies on this topic, while it is often raised only in the public space, as a discussion of a specific situation, so it is important to create research and scientific works, because this will raise the general level of consciousness of the Ukrainian population, and therefore promote social values and improve well-being, in particular at the economic level. This article analyzes the main factors that can influence the consumer’s opinion regarding the consumption of the products and services of this or that company, and also carries out its research in this regard to find out what worries citizens the most now, as well as to reveal the level of their awareness about those or other problems, world trends in the socio-cultural sphere

Heart Rhythm Society Policy Statement Update: Recommendations on the role of industry-employed allied professionals

In 2001, the North American Society of Pacing and Electrophysiology (now the Heart Rhythm Society) published a policy statement to provide guidance for industry-employed allied professionals (IEAPs) who provide technical assistance during pacemaker/implantable cardioverter defibrillator (ICD) implantations, programming, analysis of malfunctions, and follow-up1; the policy was updated in 2008 (Table 1).2 Since those publications, their principles have been incorporated in the other Heart Rhythm Society expert consensus statements that look at the role of the cardiac implantable electronic device (CIED) team and IEAPs in patient care delivery in our profession.

The market–society–policy nexus in sustainable agriculture

AbstractIntensive agriculture has led to several environmental impacts, such as soil erosion, water scarcity, and pesticide pollution. Despite the increasing research advocating greener agriculture, the transition into sustainable agriculture practices has been slower than expected. Then, why are we stuck in this transition? In this scientific essay, we aimed to answer this question not only by analyzing agricultural systems but also by the associated actors. Specifically, this scientific essay analyzed and discussed how agricultural systems integrate with the surrounding market, society, and policies. We made a literature review of the impacts of intensive agriculture on global change and an analysis of greener agricultural systems. Then, we analyzed how the market, society, and policies can influence the transition from intensive agriculture to greener agricultural systems. In addition, we complement that literature review with a survey made in Chile. Our analysis highlighted ecological intensification (EI) as the most promising production system in terms of sustainability. However, the most sustainable was not necessarily the most supported by the market and society. We found a disconnection between consumers' environmental concerns and what they support when buying foodstuff. Our survey showed that most people are aware of soil degradation and high-water consumption, but above all, they want pesticide-free and organic food attributes. The literature review and survey results suggested how policies can break the status quo of intensive agriculture predominance. Thus, we propose a market–society–policy nexus to promote sustainable agriculture. Our suggestions are: (1) Policies should support sustainable agricultural systems at the landscape level to safeguard the ecological processes involved in agricultural production. (2) Markets should standardize eco-labels, improve clarity in foodstuff information, and relate environmental benefits to consumer benefits. (3) A subsidy on sustainable food is needed to keep the regular market prices and attract new consumers, at least in the early stages.

ДЕРЖАВНА ЕКОЛОГІЧНА ПОЛІТИКА: ПРАВОВИЙ АНАЛІЗ

The article considers the main theoretical and methodological foundations of the formation of environmental policy of the state in terms of decentralization reform and the acquisition of appropriate powers by local governments. The components of environmental policy in a democratic society are identified, namely: proper and effective system of public administration in the field of protection, inexhaustible use and reproduction of natural resources; proper, state and public supervision over the observance of the current environmental legislation and international environmental obligations of the country; appropriate environmental information policy; appropriate level of ecological expertise of ecologically dangerous projects; an appropriate system of state decision-making on environmental issues, which would provide for mandatory public involvement; proper system of responsibility of the authorities, specific officials and citizens for violation of the principles of balanced development, norms and provisions of environmental legislation; proper educational and educational activities. The analysis of the legislative acts regulating the ecological policy in general and in separate directions of realization, in particular is carried out and in the field of nature management. It is noted that Ukraine as an integral participant in the development of the world economy is gradually directs its own efforts to implement resource-saving measures. The author concludes that it is necessary to improve the current environmental legislation of Ukraine through reform system of regulations to create effective tools for implementing the concept of sustainable development, which is possible only by assistance and in the context of integration of environmental policy into the socio-economic life of society and the state.

The agency-structure problem in peacebuilding: constructing a niche in the Korean conflict

The structural dynamics of the Korean conflict has evolved not only with the inter-Korean rivalry, but also the geopolitics of great power rivalries. The conflict structure was reinforced going through the Korean War and the Cold War. There have been several South Korean initiatives to build peace with North Korea in the post-Cold War era, however the peace process fluctuated due to the escalation of the US-North Korean conflict over the nuclear and missile development of North Korea, and the dispute over North Korea policy in the South Korean society. Building on the sociological understanding of ‘duality of structure’ and the biological insight of ‘niche construction’, this article demonstrates the South Korean potential, as a democratic state, to construct a niche space for its citizens’ peacebuilding with North Korea under the ongoing Korean conflict structure, as well as its limitations in protecting the space before scaling out the disruption of the conflict structure, when governments do not have a clear sense of agency about their policy due to the lack of consensus among its citizens.

Digital Design With Children in Mind

A conversation between Nishan Chelvachandran, founder of Iron Lakes and chair of IEEE SA’s Trustworthy Technological Implementations of Children’s Online and Offline Experiences Industry Connections Programme, and Katina Michael, director of the Society Policy Engineering Collective in the College of Global Futures at Arizona State University.

A mobile application to protect groundwater during unconventional oil and gas extraction.

Unconventional oil and gas (UOG) is an important energy source for many countries, but requires large quantities of water for its development, and may pollute water resources. Regulations are one of the main tools to achieve government policy on natural resource protection. South Africa, which is energy-constrained, but also water-scarce, is currently considering UOG extraction as an additional energy resource. UOG development could commence as soon as regulations to protect natural resources such as water have been published. Such regulations are, however, often not effectively enforced, which negatively affects the protection of water resources during UOG extraction. This study addresses these enforcement challenges in South Africa. It focuses on the science–society–policy interface by proposing a civic informatics platform to assist with on-the-ground enforcement of regulations via a mobile application. This mobile application aims to address both groundwater monitoring and management as well as UOG extraction operations in a single platform, to enable regulators to protect groundwater resources more effectively during UOG extraction, while simultaneously enhancing transparency in the UOG industry.

A study on the current status of multicultural family policy and improvement tasks in Korea

이 연구는 다문화사회로 진입한 한국사회의 다문화가족정책의 현황을 살펴보고 정책의 문제를 통한 개선과제를 제시하는데 목적이 있다. 이러한 목적을 이루기 위해 먼저, 우리나라 다문화가족정책과 관련된 개념과 현황을 살펴보았다. 다음으로 다문화가족정책의 주요 내용과 이와 관련된 관련 법이나 제도를 정리하고, 해외의 다문화정책에 대한 사례를 살펴보았다. 다문화가족정책의 현황을 바탕으로 개선방안에 대한 쟁점을 고찰하였고, 우리나라 다문화가족정책의 발전을 위한 쟁점별 개선과제를 제시하면서 마무리하였다. 본 연구는 결혼이주여성, 이주노동자, 중도입국청소년 등 다양한 외국인이 유입되면서 다문화사회로 진입한 한국의 다문화정책에 대한 정책적 제언과 실천적 함의를 제공할 것으로 기대된다.The purpose of this study is to examine the current status of multicultural family policy in Korean society, which has entered a multicultural society, and to suggest improvement tasks through policy problems. To achieve this goal, first, the concept and current status of multicultural family policy in Korea were examined. Next, the main contents of the multicultural family policy and related laws and systems are summarized. In addition, we looked into multicultural policies abroad. Based on the current status of multicultural family policy, the issue of improvement measures was considered, and improvement tasks for each issue were presented for the development of multicultural family policy in Korea. This study is expected to provide policy suggestions and practical implications for multicultural policies, which are increasing due to the influx of various foreigners such as marriage migrant women, migrant workers, and mid-immigrant youth.

Языковая политика и языковой конфликт в современном российском обществе

Introduction. The problem of the state of national (native) languages ​​is one of the most urgent, because modern information society and the specifics of its development have contributed to appearance of a completely different model of language behavior and language consciousness. Theoretical justification. The language issue is acutely manifested in multi-ethnic education, because multilingualism requires the definition of the language of interethnic communication. The language problem was actualized in the post-Soviet period in combination with national problems and the growth of national self-consciousness, the designation by ethnical leaders of the vector of preserving ethno-cultural identity. At the same time, any problem in Russian society unjustifiably had an ethnic connotation. Among a lot of ethnic problems, the language one takes a special place, because the stable development of any society depends on the state of the national language, the attitude towards it, its status. The infringement of the national language, it is ignoring, prohibition of use forms intolerant attitudes in society. An important role in resolving the language issue should be played by language policy, which should fully take into account ethnic interests of all national entities, avoid infringing on the language rights of speakers of a particular language. Only the targeted implementation of the measures laid down in the language policy will make it possible to prevent the emergence of a language conflict, otherwise interethnic conflicts may arise under slogans of protecting the native (national) language, which can destabilize the interethnic sphere as a whole. Methods. An empirical research was conducted in 2021 by random selection. The object of the research is the urban population. The subject of the research is the language consciousness and language behavior of the urban population of Dagestan. Location of the survey – cities Derbent, Kaspiysk, Makhachkala, Khasavyurt, Kizlyar. The basis for including these cities in the sample of the study is the territorial parameter, which allows to cover the northern, plain and southern administrative entities evenly. N = 563. Results and its discussion. The analysis of the language policy in modern Russian society shows that this survey is one of the most relevant, because against the backdrop of an aggravation in the interethnic sphere, one of the factors that worsened the situation was precisely the status of national languages. Basic provisions. – the conducted research shows the dominance of the Russian language as the language of interethnic communication in the language behavior of the surveyed urban population; this fact testifies to the transformation of the language consciousness of the townspeople; – native language is mainly used by respondents in intra-family communication, while in an interethnic family it is practically not used for objective reasons. – the main informative sources for the surveyed population are publications in Russian, while there is no demand for publications in national languages. However, it should be noted that the decrease in the weight of publications in native languages ​​is due to the fact that electronic media prevail over print publications; – revealed inconsistency and inconsistency in the language behavior of the urban population: declaring the value of the national language is not consistent with their language preference.

Invisible researchers in the knowledge society – the Uberisation of scientific work in Portugal

ABSTRACT This paper discusses how the emergence and assumption of the knowledge society as an ideological integration in the European Union (EU) and in the European Research Area (ERA), along with Managerialism and Neoliberalism influences, resulted in precarious and insecure employment relations in the Portuguese scientific system. The knowledge society as a policy idea and discourse has been encouraging the European states to design political initiatives to foster Innovation and Research to promote economic prosperity and social advancement. As a result of Europeanisation policies aiming at fostering Science and Technology (S&T), there has been a significant increase in the number of PhD graduates. Drawing on a quantitative study based on the data analysis of secondary data, this study shows how the design of knowledge society policies transformed a higher education and research system and induced an increasing number of doctorates, leading, along with managerialism and neoliberalism to the Uberisation of their working conditions. These doctorates have been mainly integrated into the higher education system with short-term contracts to develop tasks within research projects. This association with research projects along with their precarious working conditions turned them into invisible workers inside Higher Education Institutions (HEI), questioning the sustainability of the system.

Children and Society Policy Review—A review of government consultation processes when engaging with children and young people about the statutory guidance for Relationships and Sex Education in schools in England

AbstractThis paper examines the participation of children and young people within government consultation processes. It considers the recent Department for Education consultation on its statutory guidance for schools for Relationships and Sex Education in England. The paper is based on a Freedom of Information request for the consultation responses categorised as from ‘young people’. We identify two issues in our interrogation of the data. First, there is evidence that a substantial proportion of responses were not submitted by young people. Second, the consultation approach did not include all the features necessary for meaningful consultation. We consider the implications for the youth consultation on policy matters that affect them.

Trends in places and causes of death among centenarians in Japan from 2006 to 2016.

Amid the global aging, an establishment of healthcare policies for the aged population is a common issue to be addressed. However, few studies on centenarians have reported place and cause of death (PoD and CoD, respectively) as indicators of end-of-life care quality. This study aimed to analyze trends in PoD and CoD among centenarians in Japan. Data from death certificates from Japanese vital statistics were analyzed; 205 513 deaths occurred among centenarians (aged ≥100 years) in Japan during the period from 2006 to 2016. PoD prevalence was calculated for each CoD. Trends in PoD prevalence were analyzed using the Joinpoint regression model. Changing points, annual percentage changes, and average annual percentage changes (AAPCs) were calculated to examine trends. The number of deaths more than doubled from 10 340 in 2006 to 26 427 in 2016. PoDs were composed of hospitals (52.7%), nursing homes (31.4%), own homes (13.6%) and others (2.2%). Dementia and old age increased rapidly as CoD. Proportions of hospital and home deaths decreased, with AAPCs of -2.3% (95% confidence interval [CI], -2.6 to -1.9) and -2.3% (95% CI, -3.2 to -1.4), respectively. Conversely, the proportion of deaths in nursing homes rapidly increased, with an AAPC of 6.8% (95% CI, 6.0-7.7). The results revealed changes in PoD among centenarians in Japan. Understanding these transitions is indispensable for health policy in aging societies. Geriatr Gerontol Int 2022; 22: 675-680.

Abstract 3989: DSTYK inhibition sensitizes lung cancer cells to immunotherapy by collapsing cytoprotective autophagy and destroying mitochondrial wellness

Abstract Lung cancer is the leading cause of cancer-related death worldwide. The incidence and mortality associated to lung cancer is a major challenge of the Public Health Policy in advanced societies. Although the great effort has been done in NSCLC therapeutic strategies, there are still many NSCLC patients who cannot benefit either from molecular targeted or immune related therapies. Here, we identified DSTYK, a dual serine/threonine and tyrosine non-receptor protein kinase, as a novel candidate with a crucial role in NSCLC. According to data obtained from the TCGA, genomic alterations (mainly copy number alterations and mutations) of DSTYK are present in 40% of lung cancer patients, from which 4.7% LUAD and 3.4% LUSC correspond to copy number (CN) amplification (more than 3 genomic copies). Besides, DSTYK amplification is found to be a poor prognostic factor in lung cancer patients. Accordingly, high expression of DSTYK predicted both, a lower overall survival (OS) and poorer progression free survival (PFS). We next depleted DSTYK expression in both murine and human NSCLC cell lines. DSTYK abrogation prevented cytoprotective autophagy via mTOR regulation, accumulating LC3 and p-P62. In addition, DSTYK inhibition impaired lysosomal biogenesis and maturation, which contributed to dysfunctional autophagy. Furthermore, DSTYK depleted cells showed increased ROS levels caused by depolarized and damaged mitochondria. All together, these results demonstrate that knockdown of DSTYK promoted a dramatic reduction of mitophagy.As it has been shown that autophagy in cancer cells can limit antitumor immunity, we evaluated the role of immune-mediated tumor cell killing in an altered DSTYK context. We found that inhibition of DSTYK sensitized lung cancer cells to T cell–mediated cytotoxicity, via TNF-ɑ. More importantly, immunocompetent mouse models transplanted with DSTYK-inhibited tumors were sensitized to ɑnti-PD1 treatment.Finally, in a cohort of NSCLC patients that underwent immunotherapy (n=40), DSTYK amplification predicted resistance to the treatment, showing poorer PFS rates. The time to progression for DSTYK amplified patients was on average, around 50% faster than that for non-DSTYK altered patients, diminishing from 232 to 114 months.In conclusion, our results support that DSTYK is a new target and that its inhibition could be the base of new therapies, which could benefit a subgroup of NSCLC patients showing genetic amplification, both at early (adjuvant) or late (single or combined treatment) stages of the disease. Citation Format: Karmele Valencia, Mirari Echepare, Andrea Pasquier, Alvaro Teijeira, Cristina Bertolo, Cristina Sainz, Graziella Bosco, Roman K. Thomas, Jackeline Agorreta, Jose Maria Lopez-Picazo, Joan Frigola, Ramon Amat, Alfonso Calvo, Enriqueta Felip, Luis M. Montuenga. DSTYK inhibition sensitizes lung cancer cells to immunotherapy by collapsing cytoprotective autophagy and destroying mitochondrial wellness [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3989.