Objective: The problem of poverty requires a social innovation-based assistance strategy that involves various parties or collaboration in solving a social problem. Poverty alleviation policies are not only centered on bureaucratic aspects but are also always human-centered (human-centered design) in defining and formulating innovative policies. This research aims to identify stakeholders in social innovation in order to overcome the impacts of poverty. Theoretical framework: This research uses 6 dimensions of social innovation in analyzing the impact of poverty in Indonesia. Apart from that, this research also explains the role of stakeholders through the Quintuple Helix concept where there is a continuous balance between government and society. Method: This research is a type of qualitative research with 50 research informants who refer to five requirements for selecting informants. Researchers conducted in-depth interviews with social practitioners so that researchers could get more concrete information about the problems that occurred. Results and conclusions: In the Social Exclusion Dynamics dimension, it was found that the Indonesian Government's policies were able to provide accelerated handling that was not trapped in bureaucratic, techno-technical aspects. By making the community work partners or volunteers who are socially active. The Mobilization of Resources dimension is related to the synergy aspect of multi-stakeholder involvement which is able to provide community capacity development, mastery and understanding of technological information so that it can improve the quality of life. In the Satisfaction of Human Needs dimension, pragmatism in the government system often causes a loss of innovation and creativity in exploring local resources in society. In the context of health service policy, it is often not possible to explore the source of the main problems in society. The dimension of empowerment is the creation of knowledge. Knowledge is data and information combined with ability, intuition, experience, ideas, and motivation from competent sources. In the dimension of Change in Social Relations, social innovation is ultimately able to determine permanent changes in the social environment, power, relations between social groups, government, and society, the state and the private sector. These dynamics are related to those displayed in the triangle of vision, intention, development culture, identity, organizational and institutional dynamics. Meanwhile, in the Territorial Specificity dimension, the research results show that funding for poverty alleviation activities is assisted by CSR programs from industry as well as social assistance from various elements of society, such as institutions, individuals, companies, zakat institutions, foundations, volunteers and others. Research implications: This research has implications for the involvement of stakeholders in social innovation in overcoming the impacts of poverty Originality/value: The value of this research lies in the application of the social innovation dimension through the role of multi-stakeholders in overcoming the impacts of poverty. The research results also provide new value to the role of organic intellectuals which refers to actors who play an important role in society.