Polar Profile Research Articles

Targeted and untargeted urinary metabolic profiling of bladder cancer

Bladder cancer (BC) is frequent cancer affecting the urinary tract and is one of the most prevalent malignancies worldwide. No biomarkers that can be used for effective monitoring of therapeutic interventions for this cancer have been identified to date. This study investigated polar metabolite profiles in urine samples from 100 BC patients and 100 normal controls (NCs) using nuclear magnetic resonance (NMR) and two methods of high-resolution nanoparticle-based laser desorption/ionization mass spectrometry (LDI-MS). Five urine metabolites were identified and quantified using NMR spectroscopy to be potential indicators of bladder cancer. Twenty-five LDI-MS-detected compounds, predominantly peptides and lipids, distinguished urine samples from BC and NCs individuals. Level changes of three characteristic urine metabolites enabled BC tumor grades to be distinguished, and ten metabolites were reported to correlate with tumor stages. Receiver-Operating Characteristics analysis showed high predictive power for all three types of metabolomics data, with the area under the curve (AUC) values greater than 0.87. These findings suggest that metabolite markers identified in this study may be useful for the non-invasive detection and monitoring of bladder cancer stages and grades.

Transport model for the propagation of partially coherent, partially polarized, polarization-gradient vector beams.

Recently we predicted and experimentally validated a new physical mechanism for altering the propagation path of a monochromatic beam [Opt. Express30, 38907 (2022)OPEXFF1094-408710.1364/OE.467678]. Specifically, we showed that by properly tailoring the spatial distribution of the linear state of polarization transverse to the direction of propagation, the beam followed a curved trajectory in free space. Here we extend the model to the partially coherent and partially polarized polychromatic case by redefining the beam amplitude, phase, and polarization angle as appropriate statistical quantities. In particular, the definition of polarization angle represents a fundamentally new quantity in modeling beam propagation and is shown to be consistent with recent works on energy and momentum flow. In the new model, the beam curvature matches that of our previous work in the fully coherent case but is predicted to vanish for an unpolarized, spatially incoherent beam. Simulated beam trajectories are shown for varying levels of initial partial coherence and for different polarization profiles. A new class of non-diffracting beams is also suggested by way of example.

Does social rigidity predict cognitive rigidity? Profiles of socio-cognitive polarization.

Recent research has proposed a relationship between rigid political ideologies and underlying 'cognitive styles'. However, there remain discrepancies in how both social and cognitive rigidity are defined and measured. Problem-solving, or the ability to generate novel ideas by exploring unusual reasoning paths and challenging rigid perspectives around us, is often used to operationalize cognitive flexibility. Thus, we hypothesized a relation between forms of social rigidity, including Socio-cognitive polarization (i.e., a factor capturing conservative political ideology, absolutism/intolerance of ambiguity, and xenophobia), bullshit receptivity (i.e., overestimating pseudo-profound statements), overclaiming (tendency to self-enhance), and cognitive rigidity (i.e., problem-solving). Our results showed differences in performance on problem-solving tasks between four latent profiles of social rigidity identified in our sample. Specifically, those low in socio-cognitive polarization, bullshit, and overclaiming (i.e., less rigid) performed the best on problem-solving. Thus, we conclude that social and cognitive rigidity may share an underlying socio-cognitive construct, wherein those who are more socially rigid are also more likely to be also cognitively rigid when processing non-social information.

The Magnetic Sensitivity of the (250–278 nm) Fe ii Polarization Spectrum

This paper presents a theoretical investigation of the polarization and magnetic sensitivity of the near-ultraviolet (near-UV) solar spectral lines of Fe ii between 250 and 278 nm. In recent years, UV spectropolarimetry has become key to uncovering the magnetism of the upper layers of the solar chromosphere. The unprecedented data obtained by the CLASP2 suborbital space experiment across the Mg ii h and k lines around 280 nm are a clear example of the capabilities of near-UV spectropolarimetry for magnetic field diagnostics throughout the whole solar chromosphere. Recent works have pointed out the possible complementary diagnostic potential of the many Fe ii lines in the unexplored spectral region between 250 and 278 nm, but no quantitative analysis of the polarization and magnetic sensitivity of those spectral lines has been carried out yet. To study the polarization signals in these spectral lines, we create a comprehensive atomic model including all the atomic transitions resulting in strong spectral lines. We then study the magnetic sensitivity of the linear and circular polarization profiles in a semiempirical model representative of the quiet Sun. We present a selection of Fe ii spectral lines with significant linear and circular polarization signals and evaluate their diagnostic capabilities by studying their formation heights and magnetic sensitivity through the action of the Hanle and Zeeman effects. We conclude that when combined with the CLASP2 spectral region these Fe ii lines are of interest for the inference of magnetic fields throughout the solar chromosphere, up to near the base of the corona.

Creating Wavelength‐Selective Polarization Digital Numbers

AbstractPolarization and wavelength are two important properties of light for understanding optics. Engineered polarization and wavelength profiles have received considerable interest due to their unusual optical features and more degrees of freedom. However, to simultaneously control polarization and wavelengths, conventional methods suffer from big pixel size, complicated fabrication process, and limited levels in phase control. The unprecedented capability of metasurfaces in the light control has shown much promise to tackle these challenges. Polarization digital numbers with ten different wavelengths are proposed and experimentally realized. A geometric metasurface is used to simultaneously realize wavelength multiplexing, phase multiplexing, and polarization rotation, creating wavelength‐selective polarization digital numbers. A deep learning approach is used to increase the identification accuracy of the digital numbers. The approach can simultaneously control wavelength and polarization, providing more design flexibility. This work may find applications in many fields such as virtual reality, image steganography, and anti‐counterfeiting.

Domain wall state diagram for SrTiO3/BaTiO3 superlattice structures

The domain wall structure of ferroelectric/ paraelectric superlattices can be much more complex due to the influence of the superlattice stacking structure, the in-plane strain induced by the substrate and environmental temperature. In this study, we employed a phase field model to investigate the domain wall state of the SrTi[Formula: see text]/BaTi[Formula: see text] superlattice structure. The domain wall thickness for the SrTi[Formula: see text]/BaTi[Formula: see text] layer was measured using a hyperbolic function. Based on the simulation results, here, we show a domain wall state diagram to distinguish the hard and soft domain states. The polarization profiles across hard/ soft domain walls were illustrated and analyzed. Our simulation results offer a useful concept for the control of the domain wall state in the ferroelectric superlattice.

Dual-Band Circular-Polarized Microstrip Antenna for Ultrawideband Positioning in Smartphones With Flexible Liquid Crystal Polymer Process

This article proposes a dual-band circular-polarized (DBCP) microstrip antenna using flexible liquid crystal polymer (LCP) manufacturing process for ON-smartphone ultrawideband (UWB) positioning application. To achieve dual-band circular polarization in a low profile, the proposed antenna is designed with a cross-slot-loaded patch with four L-shaped feeding probes and a sequential phase feeding network. A circle of capacitive via fence is loaded surrounding the patch for area miniaturization, which is adaptive for the limited space of flexible printed circuit (FPC) in smartphones. Based on the UWB positioning protocol, a three-element antenna array is constructed in a low profile of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$0.015\lambda _{0}$ </tex-math></inline-formula> with required isolation of 17 dB. Experimental results show the overlapped bandwidth of the efficiency and the axial ratio (AR) covering the demand bands of 6.30–6.80 and 7.75–8.10 GHz. With the properties of dual wideband operation, circular polarization, and ultralow profile, the proposed antenna exhibits feasible solutions for the UWB positioning application in space-limited smartphones.

The Potential of the Wavelength-integrated Scattering Polarization of the Hydrogen Lyα Line for Probing the Solar Chromosphere

The intensity and the linear scattering polarization profiles of the hydrogen Lyα line encode valuable information on the thermodynamic and magnetic structure of the upper layers of the solar chromosphere. The Chromospheric Lyman-Alpha Spectro-Polarimeter (CLASP) sounding rocket experiment provided unprecedented spectropolarimetric data of this line, as well as two-dimensional broadband images in intensity and linear polarization. We theoretically investigate the potential of the Lyα broadband polarimetric signals for probing the solar chromosphere and its magnetic fields. We analyze the synthetic Stokes profiles obtained from a series of radiative transfer (RT) calculations out of local thermodynamic equilibrium, considering semi-empirical one-dimensional models of the solar atmosphere. The wavelength-integrated linear polarization signal is found to be dominated by the contribution from the wings when considering a Gaussian weighting function with a FWHM that corresponds to the CLASP slit-jaw broadband filter. These broadband linear polarization signals are strongly sensitive to magnetic fields of strengths on the order of 50 G, via the action of magneto-optical (MO) effects, and are expected to encode information on the middle–upper chromosphere. The two-dimensional broadband intensity and linear polarization images observed by CLASP can be suitably mimicked using synthetic wavelength-integrated signals obtained considering atmospheric models and magnetic fields that are representative of solar regions with different levels of activity, provided that the impact of MO effects is taken into account. Despite the limitations of a one-dimensional RT modeling, this work illustrates the diagnostic potential of filter-polarimetric Lyα signals for probing the solar chromosphere and its magnetism.

Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer

BackgroundThe CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction may promote cancer progression, but the expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised.MethodsWe used a custom 9-plex immunohistochemistry assay to quantify the expression patterns of PD-L1 and PD-1 in macrophages, T cells, and tumour cells in 910 colorectal cancer patients. We evaluated cancer-specific mortality according to immune cell subset densities using multivariable Cox regression models.ResultsCompared to PD-L1– macrophages, PD-L1+ macrophages were more likely M1-polarised than M2-polarised and located closer to tumour cells. PD-L1+ macrophage density in the invasive margin associated with longer cancer-specific survival [Ptrend = 0.0004, HR for the highest vs. lowest quartile, 0.52; 95% CI: 0.34–0.78]. T cell densities associated with longer cancer-specific survival regardless of PD-1 expression (Ptrend < 0.005 for both PD-1+ and PD-1– subsets). Higher densities of PD-1+ T cell/PD-L1+ macrophage clusters associated with longer cancer-specific survival (Ptrend < 0.005).ConclusionsPD-L1+ macrophages show distinct polarisation profiles (more M1-like), spatial features (greater co-localisation with tumour cells and PD-1+ T cells), and associations with favourable clinical outcome. Our comprehensive multimarker assessment could enhance the understanding of immune checkpoints in the tumour microenvironment and promote the development of improved immunotherapies.

Characterization of the Polar Profile of Bacon and Fuerte Avocado Fruits by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry: Distribution of Non-structural Carbohydrates, Quinic Acid, and Chlorogenic Acid between Seed, Mesocarp, and Exocarp at Different Ripening Stages.

Avocado fruit growth and development, unlike that of other fruits, is characterized by the accumulation of oil and C7 sugars (in most fruits, the carbohydrates that prevail are C6). There are five essential carbohydrates which constitute 98% of the total content of soluble sugars in this fruit; these are fructose, glucose, sucrose, d-mannoheptulose, and perseitol, which together with quinic acid and chlorogenic acid have been the analytes under study in this work. After applying an efficient extraction procedure, a novel methodology based on hydrophilic interaction liquid chromatography coupled to mass spectrometry was applied to determine the levels of these seven substances in tissues─exocarp, seed, and mesocarp─from avocado fruits of two different varieties scarcely studied, Bacon and Fuerte, at three different ripening stages. Quantitative characterization of the selected tissues was performed, and the inter-tissue distribution of metabolites was described. For both varieties, d-mannoheptulose was the major component in the mesocarp and exocarp, whereas perseitol was predominant in the seed, followed by sucrose and d-mannoheptulose. Sucrose was found to be more abundant in seed tissues, with much lower concentrations in avocado mesocarp and exocarp. Quinic acid showed a predominance in the exocarp, and chlorogenic acid was exclusively determined in exocarp samples.

Characterization of California olive pomace fractions and their in vitro antioxidant and antimicrobial activities

Olive oil production yields a massive amount of byproduct, olive pomace (OP). Hexane-defatted Arbequina olive pomace from California, United States, was extracted with water and loaded to a preparative C18 chromatography. Phenolic desorption was applied by acidified methanolic-water gradients. Phenolic compound profiles and antioxidant/antimicrobial activities were determined. Results showed that the total phenolic contents of the fractions increased with the increase of the percentage of methanol in water gradients; however, the polar phenolic compound profiles generally decreased, while less-polar phenolic compound profiles increased. Oleuropein-aglycone-di-aldehyde (3,4-DHPEA-EDA) detected in water extract was not found in the acidified 35 mL/100 mL and acidified 70 mL/100 mL methanol fractions, but there was a new peak tentatively assigned as 3,4-DHPEA-EDA dimer. The invitro antioxidant activities of water fractions were higher than that of higher methanolic fractions when they were compared at the same level of gallic acid equivalents; the same trend was observed for the antimicrobial activities evaluated using non-Shiga toxin-producing Escherichia coli O157:H7 and Listeria innocua. This study provides knowledge as data foundations for the practical valorization and industrial food applications of olive pomace extracts.

A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations.

Central metabolism has a profound impact on the clinical phenotypes and penetrance of neurological diseases such as Alzheimer's (AD) and Parkinson's (PD) diseases, Amyotrophic Lateral Sclerosis (ALS) and Autism Spectrum Disorder (ASD). In contrast to the multifactorial origin of these neurological diseases, neurodevelopmental impairment and neurodegeneration in Familial Dysautonomia (FD) results from a single point mutation in the ELP1 gene. FD patients represent a well-defined population who can help us better understand the cellular networks underlying neurodegeneration, and how disease traits are affected by metabolic dysfunction, which in turn may contribute to dysregulation of the gut-brain axis of FD. Here, 1H NMR spectroscopy was employed to characterize the serum and fecal metabolomes of FD patients, and to assess similarities and differences in the polar metabolite profiles between FD patients and healthy relative controls. Findings from this work revealed noteworthy metabolic alterations reflected in energy (ATP) production, mitochondrial function, amino acid and nucleotide catabolism, neurosignaling molecules, and gut-microbial metabolism. These results provide further evidence for a close interconnection between metabolism, neurodegeneration, and gut microbiome dysbiosis in FD, and create an opportunity to explore whether metabolic interventions targeting the gut-brain-metabolism axis of FD could be used to redress or slow down the progressive neurodegeneration observed in FD patients.

Observations for the Ionosphere Using European Incoherent Scatter (EISCAT) in the Dayside Polar Cap/Cusp and Auroral Region

Korea Polar Research Institute (KOPRI) and Korea Astronomy and Space Institute (KASI) have been participating in the European Incoherent Scatter (EISCAT) Scientific Association as an affiliate institution in order to observe the polar ionosphere since 2015. During the period of December 16–21, 2016 and January 3–9, 2018, the observations for the polar ionospheric parameters such as the electron density profiles, ion drift, and electron/ion temperature are carried out in the polar cap/cusp region by the EISCAT Svalbard radar (ESR). The purpose of the observations is to investigate the characteristic of the winter ionosphere in the dayside polar cap/cusp region. In this paper, we briefly report the results of the ESR observations for winter daytime ionosphere and also the simultaneous observations for the ionosphere-thermosphere system together with the balloon-borne instrument High-Altitude Interferometer WIND Experiment (HIWIND) performed by the High Altitude Observatory (HAO), National Center for Atmospheric Research (NCAR). We further introduce our research activities using long-term EISCAT observations for the occurrence of ion upflow and the climatology of the polar ionospheric density profiles in comparison with the mid-latitude ionosphere. Finally, our future research plans will briefly be introduced.

Tomography of a Solar Plage with the Tenerife Inversion Code

We apply the Tenerife Inversion Code (TIC) to the plage spectropolarimetric observations obtained by the Chromospheric LAyer SpectroPolarimeter (CLASP2). These unprecedented data consist of full Stokes profiles in the spectral region around the Mg ii h and k lines for a single slit position, with around two thirds of the 196″ slit crossing a plage region and the rest crossing an enhanced network. A previous analysis of these data had allowed us to infer the longitudinal component of the magnetic field by applying the weak-field approximation (WFA) to the circular polarization profiles, and to assign the inferred magnetic fields to different layers of the solar atmosphere based on the results of previous theoretical radiative transfer investigations. In this work, we apply the recently developed TIC to the same data. We obtain a stratified model atmosphere that fits the intensity and circular polarization profiles at each position along the spectrograph slit and we compare our results for the longitudinal component of the magnetic field with the previously obtained WFA results, highlighting the generally good agreement in spite of the fact that the WFA is known to produce an underestimation when applied to the outer lobes of the Mg ii h and k circular polarization profiles. Finally, we use the inverted model atmospheres to give a rough estimation of the energy that could be carried by Alfvén waves propagating in the chromosphere in the plage and network regions, showing that it is sufficient to compensate for the estimated energy losses in the chromosphere of solar active regions.

Evidence for the Operation of the Hanle and Magneto-optical Effects in the Scattering Polarization Signals Observed by CLASP2 across the Mg ii h and k Lines

Radiative transfer investigations of the solar Mg ii h and k resonance lines around 280 nm have shown that, while their circular polarization (Stokes V) signals arise from the Zeeman effect, the linear polarization profiles (Stokes Q and U) are dominated by the scattering of anisotropic radiation and the Hanle and magneto-optical (MO) effects. Using the unprecedented observations of the Mg ii and Mn i resonance lines obtained by the Chromospheric LAyer Spectro-Polarimeter (CLASP2), here we investigate how the linear polarization signals at different wavelengths (i.e., at the center, and at the near and far wings of the k line) vary with the longitudinal component of the magnetic field (B L ) at their approximate height of formation. The B L is estimated from the V signals in the aforementioned spectral lines. Particular attention is given to the following quantities that are expected to be influenced by the presence of magnetic fields through the Hanle and MO effects: the sign of the U signals, the total linear polarization amplitude (LP) and its direction (χ) with respect to a reference direction. We find that at the center and near wings of the k line, the behavior of these quantities is significantly different in the observed quiet and plage regions, and that both LP and χ seem to depend on B L . These observational results are indicative of the operation of the Hanle effect at the center of the k line and of the MO effects at the near wings of the k line.

Sustainable development of fuel cell using enhanced weighted mean of vectors algorithm

Using the mathematical model of a Direct Methanol Fuel Cell (DMFC) stack, a new optimum approach is presented for estimating the seven unknown parameters i.e., (eo, α, R, jeid, C1, β,req) optimally. Specifically, a method is proposed for minimization of the Sum of Squared Errors (SSE) associated with the estimated polarization profile, based on the experimental data from simulations. The Enhanced Weighted mean of vectors (EINFO) algorithm is a novel metaheuristic method that is proposed to achieve this goal. An analysis of the results of this method is then compared to various metaheuristic algorithms such as the Particle Swarm Optimization (PSO), Sine Cosine Algorithm (SCA), Dragonfly Algorithm (DA), Atom Search Optimization (ASO), and Weighted mean of vectors (INFO) well known in literature. As a final step to confirm the proposed approach's effectiveness, the sensitivity analysis is carried out using temperature changes, along with comparison against different approaches described in the literature to demonstrate its superiority. After comparison of parameter estimation and different operating temperature a non-parametric test is also performed and compared with the rest of the metaheuristic algorithms used in the manuscript. From these tests it is concluded that the proposed algorithm is superior to the rest of the compared algorithms.

PSR J1910–5959A: A rare gravitational laboratory for testing white dwarf models

Context. PSR J1910−5959A is a binary millisecond pulsar in a 0.837 day circular orbit around a helium white dwarf (HeWD) companion. The position of this pulsar is 6.3 arcmin (∼74 core radii) away from the optical centre of the globular cluster (GC) NGC 6752. Given the large offset, the association of the pulsar with the GC has been debated. Aims. We aim to obtain precise measurements of the masses of the stars in the system along with secular orbital parameters, which will help identify if the system belongs to the GC. Methods. We have made use of archival Parkes 64 m ‘Murriyang’ telescope data and carried out observations with the MeerKAT telescope with different backends and receivers over the last two decades. Pulse times of arrival were obtained from these using standard pulsar data reduction techniques and analysed using state-of-the-art Bayesian pulsar timing techniques. We also performed an analysis of the pulsar’s total intensity and polarisation profile to understand the interstellar scattering along the line of sight, and we determined the pulsar’s geometry by fitting the rotating vector model to the polarisation data. Results. We obtain precise measurements of several post-Keplerian parameters: the range, r = 0.202(6) T⊙, and shape, s = 0.999823(4), of the Shapiro delay, from which we infer: the orbital inclination to be 88.9−0.14+0.15 deg; the masses of the pulsar and the companion to be 1.55(7) M⊙ and 0.202(6) M⊙, respectively; a secular change in the orbital period Ṗb = −53−6.0+7.4 × 10−15 s s−1 that proves the GC association; and a secular change in the projected semi-major axis of the pulsar, ẋ = −40.7−8.2+7.3 × 10−16 s s−1, likely caused by the spin–orbit interaction from a misaligned HeWD spin, at odds with the likely isolated binary evolution of the system. We also discuss some theoretical models for the structure and evolution of white dwarfs in neutron star–white dwarf binaries, using PSR J1910−5959A’s companion as a test bed. Conclusions. PSR J1910−5959A is a rare system for which several parameters of both the pulsar and the HeWD companion can be accurately measured. As such, it is a test bed for discriminating between alternative models of HeWD structure and cooling.

Cross-Linking of Sugar-Derived Polyethers and Boronic Acids for Renewable, Self-Healing, and Single-Ion Conducting Organogel Polymer Electrolytes.

This report describes the synthesis and characterization of organogels by reaction of a diol-containing polyether, derived from the sugar d-xylose, with 1,4-phenylenediboronic acid (PDBA). The cross-linked materials were analyzed by infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), scanning electron microscopy (FE-SEM), and rheology. The rheological material properties could be tuned: gel or viscoelastic behavior depended on the concentration of polymer, and mechanical stiffness increased with the amount of PDBA cross-linker. Organogels demonstrated self-healing capabilities and recovered their storage and loss moduli instantaneously after application and subsequent strain release. Lithiated organogels were synthesized through incorporation of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) into the cross-linked matrix. These lithium-borate polymer gels showed a high ionic conductivity value of up to 3.71 × 10-3 S cm-1 at 25 °C, high lithium transference numbers (t + = 0.88-0.92), and electrochemical stability (4.51 V). The gels were compatible with lithium-metal electrodes, showing stable polarization profiles in plating/stripping tests. This system provides a promising platform for the production of self-healing gel polymer electrolytes (GPEs) derived from renewable feedstocks for battery applications.

MOJAVE – XX. Persistent linear polarization structure in parsec-scale AGN jets

ABSTRACT We analysed the parsec-scale linear polarization properties of 436 active galactic nuclei (AGNs) based on 15 GHz polarimetric Very Long Baseline Array observations. We present polarization and total intensity images averaged over at least five epochs since 1996 January 19 through 2019 August 4. Stacking improves the image sensitivity down to ∼30 μJy beam−1 and effectively fills out the jet cross-section both in total intensity and linear polarization. It delineates the long-term persistent magnetic field configuration and its regularity by restoring spatial distributions of the electric vector position angle (EVPA) and fractional polarization, respectively. On average, about 10 yr of stacking period is needed to reveal the stable and most-complete polarization distribution of a source. We find that the degree of polarization significantly increases down and across the jet towards its edges, typically manifesting U or W-shaped transverse profiles, suggesting a presence of a large-scale helical magnetic field associated with the outflow. In some AGN jets, mainly BL Lacs, we detect quasi-constant fractional polarization profiles across the jet, accompanied by EVPAs that closely follow the outflow. BL Lacs show higher fractional polarization values in their cores and jets than those in quasars up to hectoparsec de-projected scales, while on larger scales, they become comparable. High-synchrotron-peaked BL Lac jets are found to be less polarized than intermediate and low-synchrotron-peaked BL Lacs. The spatial distribution of the EVPAs in BL Lacs tend to align with the local jet direction, while quasars show an excess of orthogonal polarization orientation.

Photonic Majorana quantum cascade laser with polarization-winding emission

Topological cavities, whose modes are protected against perturbations, are promising candidates for novel semiconductor laser devices. To date, there have been several demonstrations of topological lasers (TLs) exhibiting robust lasing modes. The possibility of achieving nontrivial beam profiles in TLs has recently been explored in the form of vortex wavefront emissions enabled by a structured optical pump or strong magnetic field, which are inconvenient for device applications. Electrically pumped TLs, by contrast, have attracted attention for their compact footprint and easy on-chip integration with photonic circuits. Here, we experimentally demonstrate an electrically pumped TL based on photonic analogue of a Majorana zero mode (MZM), implemented monolithically on a quantum cascade chip. We show that the MZM emits a cylindrical vector (CV) beam, with a topologically nontrivial polarization profile from a terahertz (THz) semiconductor laser.