Quality Control Points Research Articles

Key Points of Construction Technology and Quality Control of Tall Formwork Building Engineering

Key Points of Construction Technology and Quality Control of Tall Formwork Building Engineering

Analysis and design of quality control system in ground coffee SMEs

Demands for quality assurance of food products are increasing due to the implementation of free trade. These demands require improvements in the application of food quality control process. SMEs in Indonesia inspect the quality of ground coffee manually, the subjectivity and long inspection time causing the SMEs have not been widely applying the consistent quality control system. This study aims to identify the quality control point of ground coffee, classify the quality following Indonesian National Standard (SNI) requirements and determine the corrective or preventive actions needed to produce a consistent, integrated quality control system for ground coffee SME. System requirements are analyzed based on their complexity in real-world using BPMN 2.0. The system made by clustering method with the K-means algorithm. K-Means divides the data into clusters, with data in one cluster sharing similar features but differing from other clusters. The data given is quality data from the bean and ground coffee quality testing. The final results of this study are three clusters of ground coffee quality and association rules determined by the Association Rule Mining method. These rules may use as a reference in taking corrective actions and preventive actions for a nonconformance product.

DEFINITION OF NEW ASPECTS OF CHANGING THE ECOLOGICAL STATE OF A SURFACE WATER OBJECT

The article analyzes the qualitative composition of the surface water body, namely the Seym River in Chernihiv and Sumy regions, to determine changes in its ecological status. Possible causes of its pollution have been identified. Statistical and systematic analysis of environmental change was conducted on the basis of the interactive map «Monitoring and Environmental Assessment of Water Resources of Ukraine» of the State Agency of Water Resources of Ukraine in the period from January 2012 to December 2020 based on data from four observation posts of the Seym. The purpose of the study is to identify new temporal and spatial trends in the concentration of major pollutants along the Seym River within Sumy and Chernihiv regions to ensure the possibility of using the results as baseline data in subsequent stages of the study to apply the basin principle of water management. The content of the main indicators was analyzed: polyphosphates, ammonium, nitrates and nitrites, phosphates and sulfates. Data on water intake control from four posts within the Seym River were studied. The increase in the content of ammonium ions every year indicates a deterioration in the sanitary condition of the water in the Seym River. According to the data on biological oxygen consumption in the Seym River, there is a constant deterioration of the oxygen regime at four posts. The increase in nitrate content is associated with an increase in the area of nitrate washout. The decrease in the content of phosphates and sulphates in the Seym River at the observation posts may be due to the fact that the population in the settlements is decreasing every year. From the point of view of basin management, it is expedient to establish an additional point of quality control of water discharges. In the future, the results of the study can be used in the development and implementation of a reliable and effective model for forecasting the ecological status of the Seym River. The results obtained during the study make it possible to state that the ecological condition of the Seyjm River, one of the important tributaries of the Dnieper River, is deteriorating today due to man-made impact. This leads to a deterioration of water quality and the regime of its river runoff.

Vaccines and Therapeutics: Quality System Approach to Clinical Applications

Molecular bio-science developments involve applications of mRNA vaccines focused on diagnostic, prophylactic, and therapeutic aspects of COVID-19 related infectious diseases. These applications offer potential solutions for many of the current challenges in treating virus related infectious diseases. The goal of vaccine design and development is to manufacture and consistently produce a vaccine that is safe and effective. The vaccine discovery starts with design input in terms of identification of etiologic agent, immunogenicity, adjuvant, basic scientific concepts, non-clinical and clinical studies, and finally vaccine licensure (FDA approvals). The Lipid Nanoparticle Technology (LNT) for messenger RNA is being used for COVID-19 vaccines. This technology comprises of identifying and mapping signature features of the virus which encompasses the readability of the virus’s blueprint, its neutralization and activation processes in order to deliver antibody proteins to protect the vaccine recipients’ bodies from encounters with the virus. The administering regimens are studied in clinical research laboratory and study materials are tested in suitable bench testing and biological models projecting vaccine candidate’s prophylactic immune response that is safe and effective. The vaccine manufacturing process requires critical quality control points (CQCPs) monitoring in order to maintain the steriochemical and immunological characteristics of the vaccine molecules and enable production of the vaccine in increasingly dosage quantities for ultimate human use. These aspects of vaccine development are well integrated into the total vaccinology life cycle (TVLC) regulatory requirements. The ultimate regulatory safety and efficacy requirements of the vaccine are proven through phases of clinical trials (class I, II, and III studies). The final process for human use to produce safe vaccine is part of pivotal clinical trials and data under the US FDA’s premarket approval process for full-scale production and availability of safe vaccines for clinical use.
 Keywords: mRNA Vaccines, Diagnosis, Prophylaxis, Therapy, COVID-19

Analysis of the Key Points of Concrete Pouring Maintenance and Quality Control in Cast-in-Place Box Girder Project

Analysis of the Key Points of Concrete Pouring Maintenance and Quality Control in Cast-in-Place Box Girder Project

Assessing the fresh properties of printable cement-based materials: High potential tests for quality control

In the absence of a formwork, printable materials are expected to quickly increase their consistency in order to resist the self-weight of the structure being printed. Resolving this rheological requirement with the printing process is the key to successful printing. It is therefore necessary, from a material design, from a process design and from a daily quality control point of view, to have the ability to measure the relevant fresh properties. Because of the range of stresses of interest, there only exist a few standard tests in literature allowing for such an assessment while some new ones were developed in the last decade. The present paper aims at presenting some of these tests along with some preliminary data supporting their ability to capture the material properties of interest while discussing the remaining and related open research questions.

Key Points for Construction Quality Control of Steel Bar Concrete Structure

In view of the good effect of steel bars in improving the elastic-plastic and flexural properties of concrete structures, combined with the good compressive strength of concrete, steel bars in the traditional reinforced concrete column and shear wall structures can greatly improve the performance of the main stress-bearing structures of super high-rise buildings. In order to clarify the key points of construction quality control of steel bar concrete structure, the control points are analyzed by theoretical analysis method combined with an engineering example. The results show that it is feasible to replace the traditional solid web section steel with the scattered steel bars to solve the difficult problem of the layout of the stirrups and longitudinal bars of the solid web section steel reinforced concrete column, and the ear plate connection of the steel bars is feasible; BIM Technology can realize the accurate positioning of steel bars and greatly improve the construction quality of steel bar concrete structures; During the construction process, it is very important to strictly control the verticality of steel bars, the spacing between steel bars, the spacing between steel bars, the distance from the outside of steel bars to the reinforcement at the column edge, and strictly control the quality of formwork installation and concrete pouring to ensure the quality of steel bar concrete structure.

Miniaturized, green salting-out liquid–liquid microextraction coupled with GC–MS used to evaluate biogenic amines in wine samples

Monitoring of the biogenic amines (BAs) content in food products, including wine, is important due to the health and safety of consumers and from the quality control point of view. In a given study, simultaneous derivatization and salting-out liquid–liquid microextraction (SALLME) coupled with GC–MS for BAs determination from wine samples was developed. For the optimization the Box-Behnken design was applied, where three independent factors were evaluated: the amount of NaCl, amount of EtAc and vortexing time. The proposed approach is characterized by good sensitivity expressed in the detection limit between 1.5 and 8.1 µg/L, good recovery on the level 84 – 106% and good reproducibility, it is fast (20 min) and easy to perform. Moreover, the BAs index (BAI) was applied in order to assess the quality of examined wines. BAI value for most of wine samples were below 2 mg/L what indicates that selected wines were of high quality.

Discussion on the Necessity and Key Points of Quality Control of Housing Construction Supervision

Discussion on the Necessity and Key Points of Quality Control of Housing Construction Supervision

Vaccinology: Design, Development and Approvals

The goal of vaccine design and development is to manufacture and consistently produce a vaccine that is safe and effective. The vaccine discovery starts with design input in terms of identification of etiologic agent, immunogenicity, adjuvant, basic scientific concepts, non-clinical and clinical studies, and finally vaccine licensure (FDA approvals). The administering regimens are studied in clinical research laboratory and study materials are tested in suitable bench testing and biological models projecting vaccine candidate’s prophylactic immune response that is safe and effective. The vaccine manufacturing process requires critical quality control points (CQCPs) monitoring in order to maintain the steriochemical and immunological characteristics of the vaccine molecules and enable production of the vaccine in increasingly dosage quantities for ultimate human use. These aspects of vaccine development are well integrated into the total vaccinology life cycle (TVLC) regulatory requirements. The ultimate regulatory safety and efficacy requirements of the vaccine are proven through phases of clinical trials (class I, II, and III studies). The final process for human use to produce safe vaccine is part of pivotal clinical trials and data under the US FDA’s premarket approval process for full-scale production and availability of safe vaccines for clinical use.
 Keywords: vaccine design and development, etiologic agent, immunogenicity

Balancing the customization and standardization: exploration and layout surrounding the regulation of the growing field of 3D-printed medical devices in China.

Medical devices are instruments and other tools that act on the human body to aid clinical diagnosis and disease treatment, playing an indispensable role in modern medicine. Nowadays, the increasing demand for personalized medical devices poses a significant challenge to traditional manufacturing methods. The emerging manufacturing technology of three-dimensional (3D) printing as an alternative has shown exciting applications in the medical field and is an ideal method for manufacturing such personalized medical devices with complex structures. However, the application of this new technology has also brought new risks to medical devices, making 3D-printed devices face severe challenges due to insufficient regulation and the lack of standards to provide guidance to the industry. This review aims to summarize the current regulatory landscape and existing research on the standardization of 3D-printed medical devices in China, and provide ideas to address these challenges. We focus on the aspects concerned by the regulatory authorities in 3D-printed medical devices, highlighting the quality system of such devices, and discuss the guidelines that manufacturers should follow, as well as the current limitations and the feasible path of regulation and standardization work based on this perspective. The key points of the whole process quality control, performance evaluation methods and the concept of whole life cycle management of 3D-printed medical devices are emphasized. Furthermore, the significance of regulation and standardization is pointed out. Finally, aspects worthy of attention and future perspectives in this field are discussed.

Analysis on Key Points of Construction Technology and Quality Control of Box Girder of High-speed Railway Bridge

Analysis on Key Points of Construction Technology and Quality Control of Box Girder of High-speed Railway Bridge

Research and Practice on the Quality Control of Medical Equipment Combined with the Overall Maintenance Service of Medical Equipment

<i>Purpose </i>In the face of the problems in medical equipment quality control, such as manpower shortage, lack of standardization, insufficient quality control equipment and weak information means, the implementation methods of medical equipment quality control are improved effectively by reorganizing the key points of quality control and introducing the overall maintenance service of medical equipment. <i>Methods</i> On the basis of researching and determining the quality control objects of medical equipment, formulating the work content of medical equipment quality control and supporting special quality control record sheets, formulating the work plan of medical equipment quality control, and adjusting the quality control content in time according to the actual clinical needs, our hospital has passed and the overall maintenance company of medical equipment cooperates closely and obtains the support of manpower, quality control equipment and information management tools to ensure that the quality control of medical equipment is in place. <i>Result </i>Through the standardization of medical equipment quality control, the efficiency of medical equipment quality control has been significantly improved, and the operation quality failure rate of quality control objects has decreased year by year, and we can find the hidden trouble of medical equipment operation quality and solve it accordingly. In addition, compared with hospital engineers, there is a certain gap in the medical equipment quality control ability of maintenance engineers in medical equipment overall maintenance service companies. At the same time, there are still some shortcomings in the coverage of quality control work. <i>Conclusion</i> Overall medical equipment maintenance service is conducive to the implementation of medical equipment quality control, and quality control is effective in improving the operation quality of medical equipment, and can guarantee the safety of medical service, but there is still a large space for improvement.

Recent Postharvest Technologies in the Banana Supply Chain

Postharvest technology plays a vital role in preserving fruits. In particular, banana is a climacteric fruit with a short shelf-life; thus, good postharvest practice through the supply chain is essential to maintaining its quality. Prior to applying proper postharvest technology, it is important to understand the physiological changes in banana during the ripening process. This review describes the physiological characteristics of banana after harvesting as well as the technologies being studied and adopted practically to achieve postharvest goals. The discussion herein highlights the critical quality control points in the banana supply chain, e.g., storage, artificial ripening, and transportation. By assembling the current knowledge, this review could contribute on quality improvement through applying the proper postharvest technologies.

Discussion on Key Points of Quality Control in Measuring Process of Pressure Instrument

Discussion on Key Points of Quality Control in Measuring Process of Pressure Instrument

Key Points of Quality Control of Mountain Highway Retaining Wall Construction

Key Points of Quality Control of Mountain Highway Retaining Wall Construction

Quality Control of Appliance Products of Medical Devices for Human Assisted Reproductive Technology

Infertility has become one of the global problems, with the continuous improvement and penetration of human assisted reproductive technology, appliance products of medical devices for assisted reproductive technology, such as aspiration needles, micromanipulator and embryo transfer catheter, have been widely used. In order to ensure the safety and effectiveness of such products, it is necessary to establish an appropriate quality control system. This paper mainly discusses the quality control points of human assisted reproductive medical devices from the aspects of raw materials, product design, production process, key performance, packaging, preservation and transportation, so as to provide technical reference for the research and development, production and supervision of such products.

Evaluation of cochlear implant electrode scalar position by 3 Tesla magnet resonance imaging

The estimation of scalar electrode position is a central point of quality control during the cochlear implant procedure. Ionic radiation is a disadvantage of commonly used radiologic estimation of electrode position. Recent developments in the field of cochlear implant magnets, implant receiver magnet position, and MRI sequence usage allow the postoperative evaluation of inner ear changes after cochlear implantation. The aim of the present study was to evaluate the position of lateral wall and modiolar cochlear implant electrodes using 3 T MRI scanning. In a prospective study, we evaluated 20 patients (10× Med-El Flex 28; 5× HFMS AB and 5× SlimJ AB) with a 3 T MRI and a T2 2D Drive MS sequence (voxel size: 0.3 × 0.3 × 0.9 mm) for the estimation of the intracochlear position of the cochlear implant electrode. In all cases, MRI allowed a determination of the electrode position in relation to the basilar membrane. This observation made the estimation of 19 scala tympani electrode positions and a single case of electrode translocation possible. 3 T MRI scanning allows the estimation of lateral wall and modiolar electrode intracochlear scalar positions.

A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples.

Next-Generation Sequencing (NGS) is widely used to investigate genomic variation. In several studies, the genetic variation of Mycobacterium tuberculosis has been analyzed in sputum samples without previous culture, using target enrichment methodologies for NGS. Alignments obtained by different programs generally map the sequences under default parameters, and from these results, it is assumed that only Mycobacterium reads will be obtained. However, variants of interest microorganism in clinical samples can be confused with a vast collection of reads from other bacteria, viruses, and human DNA. Currently, there are no standardized pipelines, and the cleaning success is never verified since there is a lack of rigorous controls to identify and remove reads from other sputum-microorganisms genetically similar to M. tuberculosis. Therefore, we designed a bioinformatic pipeline to process NGS data from sputum samples, including several filters and quality control points to identify and eliminate non-M. tuberculosis reads to obtain a reliable genetic variant report. Our proposal uses the SURPI software as a taxonomic classifier to filter input sequences and perform a mapping that provides the highest percentage of Mycobacterium reads, minimizing the reads from other microorganisms. We then use the filtered sequences to perform variant calling with the GATK software, ensuring the mapping quality, realignment, recalibration, hard-filtering, and post-filter to increase the reliability of the reported variants. Using default mapping parameters, we identified reads of contaminant bacteria, such as Streptococcus, Rhotia, Actinomyces, and Veillonella. Our final mapping strategy allowed a sequence identity of 97.8% between the input reads and the whole M. tuberculosis reference genome H37Rv using a genomic edit distance of three, thus removing 98.8% of the off-target sequences with a Mycobacterium reads loss of 1.7%. Finally, more than 200 unreliable genetic variants were removed during the variant calling, increasing the report’s reliability.

Key Points of Asphalt Pavement Construction Technology and Quality Control in Highway Engineering

Key Points of Asphalt Pavement Construction Technology and Quality Control in Highway Engineering