ABSTRACT This article explores the intersection between civic activism and humanitarian action, two sets of practices which, in conflict settings, nvolve protecting life, supporting people’s ability to survive, and upholding dignity. Yet the logics that govern professionalized humanitarianism sometimes limit or work against the kinds of civic activism and political agency that enable resistance to powerful conflict dynamics. This article elaborates a concept of humanitarian activism that recasts the humanitarian encounter as a problem of political estrangement, to be overcome through a recognition of the political agency of humanitarians’ interlocutors. The starting point of humanitarian action in all its guises should be to see the human in the other, but it should also accept that humanity is political in both its construction and realization. The humanity of the other must be honoured, among other things, through the support of the other’s political voice through civic engagements in the fora relevant to those goals of protecting life and dignity. As contemporary conflict fuels itself by dehumanizing and depoliticizing, so must humanitarian activists situate themselves against both these dynamics, materially and discursively, from the level of local activism to global humanitarian funding flows, to open up genuine humanitarian space for change.