The In Space Manufacturing of sensors and electronics can directly addresses the logistic challenge for long-duration human spaceflight missions by reducing mission logistics mass, increase reliability, mitigate risk, while also offering a high degree of customization and tailorability. This manufacturing approach relies on additive manufacturing technologies, due to its versatility, low power consumption, automation, fast manufacturing time with low waste generation, and ability to print a variety of materials. To ensure the health and safety of crew members, developing human health portable diagnostic tools that can be manufactured during long duration missions is necessary to ensure that the crew members are monitored in real time so that countermeasures can be deployed as soon as possible. Here we report the development of Astrosense (Figure 1), a wearable wireless and fully printed platform that integrates several sensors, including, electrochemical sensor for the detection of cortisol in sweat, temperature, CO2 and humidity sensors, as well as, the required hardware required to control each individual sensor.Astrosense consists of two sections, a reusable, and a disposable section. The reusable section contains the CO2,temperature, humidity sensor, the potentiostat that controls the cortisol sensor and the printed antennas for data transmission. The cortisol sensor, sweat harvest component and printed batteries will be located on the disposable section of Astrosense, so that they can be easily replaced once the sensor is either saturated, degraded or when the batteries need to be replaced. The disposable section will interfase with the reusable section of Astrosense through several medical grade adhesives and pogo pins. This allows for the easy replacement of the cortisol sensor as well as mounting and dismounting of the device on the human skin. Figure 1